cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2019-3-94-106cardiovascular-2271Research ArticleОБЗОРМенопаузальная гормональная терапия и сердечно-сосудистая профилактика: желаемое или действительное?Menopausal hormone therapy and heart disease prevention: desired or valid?https://orcid.org/0000-0002-0758-5609ПодзолковВ. И.PodzolkovV. I.

Подзолков Валерий Иванович — доктор медицинских наук, профессор, заведующий кафедрой факультетской терапии № 2

Москва

podzolkov@list.ruhttps://orcid.org/0000-0002-2699-1610БрагинаА. Е.BraginaA. E.

Брагина Анна Евгеньевна — доктор медицинских наук, профессор кафедры факультетской терапии №2, профессор

Москва

anna.bragina@mail.ruhttps://orcid.org/0000-0001-9183-7030ПодзолковаН. М.PodzolkovаN. M.

Подзолкова Наталия Михайловна — доктор медицинских наук, профессор, заведующая кафедрой акушерства и гинекологии

Москва

podzolkova@gmail.comФГАОУ ВО Первый Московский государственный медицинский университет им.И.М.Сеченова (Семеновский Университет) Минздрава РоссииI. M. Sechenov First Moscow State Medical UniversityФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииRussian Medical Academy of Continuing Professional Education20191306201918394106Copyright © Подзолков В.И., Брагина А.Е., Подзолкова Н.М., 20192019Подзолков В.И., Брагина А.Е., Подзолкова Н.М.Podzolkov V.I., Bragina A.E., Podzolkovа N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2271

Cardiovascular diseases are the main cause of death for women in older age groups. For many decades, specialists have tried to prevent their development by the use of estrogen. The review of the literature presents current data on the effect of menopausal hormone therapy (MHT) on the risk of cardiovascular complications. The results of the main randomized clinical and observational studies in this area, conducted over several decades, are discussed. We described the concept of “window of opportunities”, in accordance with which an improvement in cardiovascular prognosis can be expected only at the onset of MHT in women under the age of 60 years in early postmenopause (menopause duration <10 years). There are experimental and clinical data explaining the different effects of estrogen on the cardiovascular prognosis in women of various age groups and different duration of postmenopause. The recommendations given in the review on the use of MHT are based on modern international guidelines.

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The authors declare that there are no conflicts of interest present.