cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2013-5-34-39cardiovascular-232Research ArticleИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦАCORONARY HEART DISEASEОЦЕНКА СЕРДЕЧНО-ЛОДЫЖЕЧНОГО СОСУДИСТОГО ИНДЕКСА У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА: ВЛИЯНИЕ ПЕРИФЕРИЧЕСКОГО АТЕРОСКЛЕРОЗАCARDIO-ANKLE VASCULAR INDEX IN PATIENTS WITH CORONARY HEART DISEASE: ROLE OF PERIPHERAL ATHEROSCLEROSISСуминА. Н.SuminA. N.

д. м.н., заведующий лабораторией патологии кровообращения

Тел.: (3842) 64–44–61; факс: (3842) 64–27–18 

tel.: (3842) 64–44–61; факс: (3842) 64–27–18

sumian@cardio.kem.ruКарповичА. В.KarpovichA. V.

м. н.с. лаборатории

БезденежныхА. В.BezdenezhnykhA. V.

н. с. лаборатории

БарбарашО. Л.BarbarashO. L.

д. м.н., директор

ФГБУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний СО РАМН, КемеровоResearch Institute for Complex Cardiovascular Disease Issues, Siberian Branch, Russian Academy of Medical Sciences, Kemerovo2013201020131253439Copyright © Сумин А.Н., Карпович А.В., Безденежных А.В., Барбараш О.Л., 20132013Сумин А.Н., Карпович А.В., Безденежных А.В., Барбараш О.Л.Sumin A.N., Karpovich A.V., Bezdenezhnykh A.V., Barbarash O.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/232Цель

Цель. Оценить сердечно-лодыжечный сосудистый индекс (СЛСИ) у больных ишемической болезнью сердца (ИБС) в зависимости от наличия периферического атеросклероза.

Материал и методы

Материал и методы. Обследованы 182 больных ИБС (161 мужчина и 21 женщина, средний возраст 58,5±7,5 лет). Исследовали состояние периферических артерий с помощью прибора VaSera VS-1000 (Fukuda Denshi, Япония) с оценкой лодыжечно-плечевого индекса (ЛПИ) и СЛСИ. Больные разделены на группы (гр.): I гр. (n=93) – СЛСИ 0,9, II гр. (n=32)– СЛСИ9,0 и ЛПИ>0,9. Гр. сопоставлены по клиническим признакам, данным коронароангиографии (КАГ), наличию признаков поражения некоронарных сосудистых бассейнов при ультразвуковом исследовании.

Результаты

Результаты. У больных ИБС значения СЛСИ > 9,0, отражающие повышенную жесткость артерий, выявлены в 31,3% случаев. При КАГ в I гр. несколько чаще выявлено однососудистое поражение (32,3%), по сравнению со II и III (15,6% и 17,5%; р=0,07). По частоте выявления 3-сосудистого поражения различий между гр. не отмечено – 29%, 25% и 28%, соответственно (р=0,9). Поражение 3 сосудистых бассейнов наиболее часто отмечено во II (46,9%) и III (14%) гр. (p<0,00001). При множественном логистическом регрессионном анализе с повышенным СЛСИ были связаны возраст и индекс массы тела (ИМТ).

Заключение

Заключение. Наличие высокого СЛСИ у больных ИБС ассоциировалось с увеличением возраста обследованных, снижением ИМТ. Не отмечено взаимосвязи выраженности коронарного атеросклероза и СЛСИ, однако большее число пораженных сосудистых бассейнов выявлено у больных ИБС с высоким СЛСИ и/или со снижением ЛПИ.

Aim

Aim. To study the association between cardio-ankle vascular index (CAVI) and peripheral atherosclerosis in patients with coronary heart disease (CHD).

Material and methods

Material and methods. The study included 182 CHD patients (161 men and 21 women; mean age 58,5±7,5 years). The examination of peripheral arteries was performed using the VaSera VS-1000 device (Fukuda Denshi, Japan). Ankle-brachial index (ABI) and CAVI were calculated. All participants were divided into three groups: Group I (n=93): CAVI <9,0 and ABI >0,9; Group II (n=32): CAVI <9,0 and ABI <0,9; and Group III (n=57): CAVI >0,9 and ABI >0,9. Clinical parameters, coronary angiography (CAG) data, and ultrasound signs of peripheral artery atherosclerosis were compared across groups.

Results

Results. CAVI <0,9, which reflected increased arterial stiffness, was observed in 31,3% of CHD patients. According to CAG results, Group I participants had a slightly higher prevalence of one-vessel pathology (32,3%) than their peers from Groups II and III (15,6% and 17,5%, respectively; p=0,07). The prevalence of three-vessel pathology was similar in all three groups (29%, 25%, and 28%; p=0,9). Atherosclerosis of three vascular basins was more prevalent in Group II (46,9%) and Group III (14%; p<0,00001). In multivariate logistic regression analyses, increased CAVI was associated with age and body mass index (BMI).

Conclusion

Conclusion. In CHD patients, high CAVI values were linked to older age and lower BMI. There was no clear association between CAVI and coronary atherosclerosis severity; however, CHD patients with high CAVI and/or low ABI demonstrated a higher number of atherosclerosis-affected vascular basins.

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The authors declare that there are no conflicts of interest present.