cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2019-6-62-68cardiovascular-2328Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMДисфункция эндотелия при артериальной гипертензии: причина или следствие?Endothelial dysfunction in hypertension: cause or effect?https://orcid.org/0000-0002-1423-214XГоршковА. Ю.GorshkovA. Yu.

Горшков Александр Юрьевич — кандидат медицинских наук, заместитель главного врача.

Москва.

Тел.: +7 (916) 310-91-84

Moscow.

aygorshkov@gmail.comhttps://orcid.org/0000-0001-5140-568XФедоровичА. А.FedorovichA. A.

Федорович Андрей Александрович — кандидат медицинских наук, старший научный сотрудник отдела фундаментальных и прикладных аспектов ожирения.

Москва.

Moscow.

faa-micro@yandex.ruhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Драпкина Оксана Михайловна — доктор медицинских наук, профессор, член-корреспондент РАН, директор.

Москва.

Moscow.

drapkina@bk.ruНациональный медицинский исследовательский центр профилактической медицины Минздрава РоссииРоссияNational Medical Research Center for Preventive MedicineRussian Federation2019151020191866268Copyright © Горшков А.Ю., Федорович А.А., Драпкина О.М., 20192019Горшков А.Ю., Федорович А.А., Драпкина О.М.Gorshkov A.Y., Fedorovich A.A., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2328

Артериальная гипертензия продолжает оставаться пандемией XXI века, являясь основным фактором развития преждевременной смерти. Внедрение визуализирующих методов обследования в клиническую практику выявило высокую распространенность поражения “органов-мишеней”, опосредованного гипертензией. Одним из системных “органов-мишеней” при артериальной гипер­тензии является эндотелий, повреждение которого играет важную роль в инициации сердечно-сосудистого континуума. С другой сто­роны, нарушение структуры и функции эндотелия рассматривается как возможная причина повышения артериального давления. В этой статье систематизированы данные о причинно-следственной связи между артериальной гипертензией и эндотелиальной дисфункци­ей, и рассматривается направление дальнейшего изучения функ­ции сосудистого эндотелия.

Hypertension remains a pandemic of the 21st century, being a major factor of premature death. The introduction of imaging methods into clinical practice revealed a high prevalence of target organ damage mediated by hypertension. One of the systemic target organs in hypertension is endothelium. Its damage plays an important role in the initiation of the cardiovascular disease continuum. On the other hand, structure and function defects of the endothelium is considered as a possible reason for the increase in blood pressure. This literature review systematizes data on a causal relationship between hypertension and endothelial dysfunction, and discusses the direction of further study of vascular endothelium function.

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The authors declare that there are no conflicts of interest present.