cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2020-1-2394cardiovascular-2394Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMПерспективы применения метода спектроскопии комбинационного рассеяния света (рамановской спектроскопии) в кардиологииProspects for Raman spectroscopy in cardiologyhttps://orcid.org/0000-0002-2503-9580РафальскийВ. В.RafalskyV. V.

Рафальский Владимир Витальевич — директор центра клинических исследований, профессор кафедры терапии Медицинского института.

Калининград

Kaliningrad

v.rafalskiy@mail.ruhttps://orcid.org/0000-0002-9766-1408ЗюбинА. Ю.ZyubinA. Yu.

Зюбин Андрей Юрьевич — старший научный сотруднк.

Калининград

Kaliningrad

azubin@mail.ruhttps://orcid.org/0000-0003-4052-1604МоисееваЕ. М.MoiseevaE. M.

Моисеева Екатерина Михайловна — аспирант.

Калининград

Kaliningrad

emoiseeva@kantiana.ruhttps://orcid.org/0000-0001-5026-7510СамусевИ. Г.SamusevI. G.

Самусев Илья Геннадьевич — заместитель проректора по научной работе, руководитель службы организации НИД.

Калининград

Kaliningrad

ISamusev@kantiana.ruФГАОУ ВО Балтийский федеральный университет имени Иммануила КантаImmanuel Kant Baltic Federal University2020030320201917077Copyright © Рафальский В.В., Зюбин А.Ю., Моисеева Е.М., Самусев И.Г., 20202020Рафальский В.В., Зюбин А.Ю., Моисеева Е.М., Самусев И.Г.Rafalsky V.V., Zyubin A.Y., Moiseeva E.M., Samusev I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2394

Спектроскопия комбинационного рассеяния света (КР-спектро-скопия; спектроскопия КР) является перспективным методом диагностики, обладающим информативностью и чувствительностью. Кроме того, КР-спектроскопия является неразрушающим и минимально-инвазивным методом, а также требующим минимальной пробоподготовки, что открывает широкие перспективы применения in vitro и in vivo. У данного метода существует ряд возможностей будущего применения в кардиологии. С помощью КР-спектроско-пии возможно идентифицировать ранее изученные маркеры сердечно-сосудистых заболеваний, а также производить поиск новых. Спектроскопия КР является чувствительным методом выявления и биохимической оценки атеросклеротических поражений сосудов на ранних этапах и может использоваться in vivo. Большой интерес представляет возможность использования спектроскопии КР с целью контроля количества элюируемого вещества из внутрисосудистых стентов для оценки клинической эффективности. При исследовании мембран тромбоцитов с помощью метода КР-спектроскопии выявлены структурные изменения у пациентов с артериальной гипертензией. С помощью данного метода возможна оценка жизнеспособности миокарда в пограничной зоне после инфаркта миокарда, причем полученные данные коррелируют с интраоперационной картиной. Подробнее о перспективах применения метода будет раскрыто в тексте обзора.

Raman spectroscopy (RS) is a promising diagnostic method with high informative value and sensitivity. In addition, it is non-destructive and minimally invasive, and also requires minimal sample preparation, which opens up wide prospects for in vitro and in vivo use. There are some perspectives for this method in future cardiology practice. RS may allow to identify previously studied markers of cardiovascular disease, as well as to search for new ones. It is a sensitive method for the detection and biochemical assessment of early-stage atherosclerotic lesions and can be used in vivo. Of great interest is the possibility of using the RS to control the amount of eluted substance from drug-eluting stents to assess clinical efficacy. Study of platelet membranes using the RS technique revealed structural changes in patients with hypertension. This method makes it possible to assess myocardial viability in the border zone after myocardial infarction, and the obtained results correlate with the intraoperative data. More details about the prospects of using the RS will be described in the review.

Спектроскопия комбинационного рассеяния света (КР-спектро-скопияспектроскопия КР) является перспективным методом диагностикиобладающим информативностью и чувствительностью. Кроме тогоКР-спектроскопия является неразрушающим и минимально-инвазивным методома также требующим минимальной пробоподготовкичто открывает широкие перспективы применения in vitro и in vivo. У данного метода существует ряд возможностей будущего применения в кардиологии. С помощью КР-спектроско-пии возможно идентифицировать ранее изученные маркеры сердечно-сосудистых заболеванийа также производить поиск новых. Спектроскопия КР является чувствительным методом выявления и биохимической оценки атеросклеротических поражений сосудов на ранних этапах и может использоваться in vivo. Большой интерес представляет возможность использования спектроскопии КР с целью контроля количества элюируемого вещества из внутрисосудистых стентов для оценки клинической эффективности. При исследовании мембран тромбоцитов с помощью метода КР-спектроскопии выявлены структурные изменения у пациентов с артериальной гипертензией. С помощью данного метода возможна оценка жизнеспособности миокарда в пограничной зоне после инфаркта миокардапричем полученные данные коррелируют с интраоперационной картиной. Подробнее о перспективах применения метода будет раскрыто в тексте обзора.spectroscopycardiovascular diseasesbiomarkersdetectiondiagnosticsВыполнено при поддержке РНФ 19-15-00132This study was supported by Russian Science Foundation 19-15-00132ReferencesTimmis A, Gale CP, Flather M, et al. Cardiovascular disease statistics from the European atlas: inequalities between high- and middle-income member countries of the ESC. Eur Heart J Qual Care Clin Outcomes. 2018;4(1):1-3. doi:10.1093/ehjqcco/qcx045.Timmis A, Gale CP, Flather M, et al. Cardiovascular disease statistics from the European atlas: inequalities between high- and middle-income member countries of the ESC. 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The authors declare that there are no conflicts of interest present.