cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2020-2420cardiovascular-2420Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESРоль микроРНК в развитии фибрилляции предсердий у пациентов с клапанной патологией сердцаRole of miRNA in the development of atrial fibrillation in patients with valvular heart diseasehttps://orcid.org/0000-0003-2892-2827АбдульяновИ. В.AbdulyanovI. V.

Врач сердечно-сосудистый хирург отделения кардиохирургии № 2; кандидат медицинских наук, доцент кафедры кардиологии, рентгенэндоваскулярной и сердечно-сосудистой хирурги.

Казань, Тел.: +7 (987) 421-90-09

Kazan

ildaruna@mail.ruhttps://orcid.org/0000-0003-0009-9103АмировН. Б.AmirovN. B.

Доктор медицинских наук, профессор кафедры поликлинической терапии и общей врачебной практики.

namirov@mail.ruhttps://orcid.org/0000-0002-0977-0840ГайсинМ. Р.GaisinM. R.

Врач сердечно-сосудистый хирург отделения кардиохирургии № 2.

Казань

Kazan

miwkao4enlybitmed@gmail.comhttps://orcid.org/0000-0001-8531-1315КаиповА. Э.KaipovA. E.

Ассистент кафедры сердечно-сосудистой и эндоваскулярной хирургии.

Казань

turik4martn@mail.ruhttps://orcid.org/0000-0003-0769-3682АбдрахмановаА. И.AbdrakhmanovaA. I.

Врач отделения кардиологии, кандидат медицинских наук, доцент кафедры фундаментальных основ клинической медицины Института фундаментальной медицины и биологии.

Казань

Kazan

alsuchaa@mail.ruФАУЗ Межрегиональный клинико-диагностический центр; Казанская государственная медицинская академия — филиал ФГБОУ ДПО РМАНПО Минздрава РоссииInterregional Clinical Diagnostic Center; Kazan State Medical AcademyФГБОУ ВО "Казанский государственный медицинский университет" Минздрава РоссииKazan State Medical UniversityФАУЗ Межрегиональный клинико-диагностический центрInterregional Clinical Diagnostic CenterФГБОУ ВО Казанский государственный медицинский университет Минздрава РоссииKazan State Medical UniversityФАУЗ Межрегиональный клинико-диагностический центр; ФГАОУ ВО Казанский (Приволжский) федеральный университетInterregional Clinical Diagnostic Center; Kazan (Volga Region) Federal University20201411202019524202420Copyright © Абдульянов И.В., Амиров Н.Б., Гайсин М.Р., Каипов А.Э., Абдрахманова А.И., 20202020Абдульянов И.В., Амиров Н.Б., Гайсин М.Р., Каипов А.Э., Абдрахманова А.И.Abdulyanov I.V., Amirov N.B., Gaisin M.R., Kaipov A.E., Abdrakhmanova A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2420

Фибрилляция предсердий (ФП) — распространенное нарушение ритма сердца, которое нередко встречается в общей клинической практике. У пациентов, находящихся в отделении кардиохирургии, ФП наиболее часто развивается на фоне клапанной патологии, а также в послеоперационном периоде. Современные методы хирургической коррекции клапанных пороков позволяют избавиться от ФП. Многообразие механизмов возникновения ФП и отсутствие возможности их точного выявления у каждого конкретного пациента указывает на нерешенные вопросы тактики лечения, выбора типа процедуры и правильного отбора пациентов на хирургическое лечение. С целью поиска ответа на эти вопросы изучается влияние микрорибонуклеиновых кислот (микроРНК) на развитие и течение ФП. В статье представлен аналитический обзор научных работ в области сердечно-сосудистой хирургии и кардиологии, посвященных влиянию микроРНК на возникновение, регуляцию и течение ФП у пациентов с пато-логией клапанов до хирургического лечения и в послеоперационном периоде.

Atrial fibrillation (AF) is a common type of arrhythmia that is frequently observed in clinical practice. In patients admitted to the cardiac surgery department, AF most often develops due to valvular heart disease, as well as in the postoperative period. Modern surgical techniques for valvular defects make it possible to get rid of AF. However, there are still unresolved issues of treatment tactics, the selection of procedure and the correct selection of patients for surgery. In order to find answers to these questions, the influence of microribonucleic acids (miRNAs) on the development and course of AF is being studied. The article presents an analytical review on the influence of miRNA on the occurrence, regulation and course of AF in patients with valvular heart disease before surgery and in the postoperative period.

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The authors declare that there are no conflicts of interest present.