cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-2442Research ArticleОБЗОРЫREVIEWSСвязь обструктивного апноэ сна и сердечно-сосудистых заболеваний с позиций доказательной медицины. Часть 2The relationship of obstructive sleep apnea and cardiovascular diseases from the perspective of evidence-based medicine. Part 2https://orcid.org/0000-0002-4982-628XАгальцовМ, В.AgaltsovM. V.

Агальцов Михаил Викторович — кандидат медицинских наук, старший научный сотрудник отдела фундаментальных и прикладных аспектов ожирения

Москва

agaltsov@rambler.ruhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Драпкина Оксана Михайловна — доктор медицинских наук, профессор, член-корреспондент РАН, руководитель отдела фундаментальных и прикладных аспектов ожирения, директор

Москва

ODrapkina@gnicpm.ruФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава РоссииNational Medical Research Center for Therapy and Preventive Medicine20200105202019324052405Copyright © Агальцов М.В., Драпкина О.М., 20202020Агальцов М.В., Драпкина О.М.Agaltsov M.V., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2442

В обзоре, посвященном ассоциациям обструктивного апноэ сна (ОАС) и сердечно-сосудистых заболеваний, проанализированы данные проспективных исследований, метаанализов и систематических обзоров. Вторая часть обзора посвящена анализу взаимосвязей ОАС и таких сердечно-сосудистых заболеваний как ишемическая болезнь сердца, цереброваскулярные заболевания, хроническая сердечная недостаточность, легочная гипертензия. Все они с разной степенью достоверности ассоциированы с обструктивными нарушениями дыхания во сне. Среди этих заболеваний наиболее тесные ассоциации показаны для ОАС и хронической сердечной недостаточности ОАС и цереброваскулярных заболеваний. Отдельно рассматривается вопрос о взаимосвязи ОАС с сердечно-сосудистой смертностью. В большинстве наблюдательных исследований показано, что ОАС без последующей коррекции влияет на ее увеличение.

The results of prospective studies, meta-analyzes and systematic reviews on the associations of obstructive sleep apnea (OSA) with various cardiovascular diseases (CVD) were analyzed. The second part is devoted to the analysis of the relationship between OSA and CVD such as coronary artery disease, cerebrovascular disease, heart failure, pulmonary hypertension. All of them are associated with breathing-related sleep disorders. Among these diseases, the most significant associations were revealed for OSA and heart failure, OSA and cerebrovascular disease. Separately, the relationship of OSA with cardiovascular mortality is discussed. Most observational studies have shown that OSA without treatment increases mortality rate.

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The authors declare that there are no conflicts of interest present.