cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2020-2474cardiovascular-2474Research ArticleОБЗОРЫREVIEWSФеномен проницаемости кишечной стенки и его взаимосвязь с сердечно-сосудистыми заболеваниями. Современные представления о проблемеThe phenomenon of intestinal permeability and its association with cardiovascular disease. Current statushttps://orcid.org/0000-0001-8977-4384КаштановаД. А.KashtanovaD. A.

Каштанова Дарья Андреевна — старший научный сотрудник лаборатории трансляционных исследований в геронтологии

Москва

dr.kashtanova@gmail.comhttps://orcid.org/0000-0002-4193-688XТкачеваО. Н.TkachevaO. N.

Ткачева Ольга Николаевна — директор

Москва

tkacheva@rambler.ruФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава России Обособленное структурное подразделение «Российский геронтологический научно-клинический центр»Russian Clinical and Research Center of Gerontology, Pirogov Russian National Research Medical University20200105202019324742474Copyright © Каштанова Д.А., Ткачева О.Н., 20202020Каштанова Д.А., Ткачева О.Н.Kashtanova D.A., Tkacheva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2474

Возможные изменения проницаемости кишечного барьера при различных патологиях широко обсуждаются в научном сообществе. До сих пор нет единого мнения, может ли высокая проницаемость кишечной стенки приводить к хроническим неинфекционным заболеваниям, однако появляется все больше сведений, что повышенная проницаемость может усугублять течение некоторых из них. В статье рассмотрено современное видение проблемы проницаемости, в т.ч. его потенциальный вклад в развитие сердечно-сосудистых патологий, которые по сей день являются причиной смертности номер один как в России, так и во всем мире.

Changes in the intestinal permeability in various pathologies are widely discussed in the scientific community. There is still no consensus on whether high intestinal permeability can lead to chronic noncommunicable diseases, but there is much evidence that increased permeability can aggravate some of them. The article discusses a modern vision of the intestinal permeability including its potential contribution to the development of cardiovascular pathologies, which are the number one mortality cause both in Russia and around the world.

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The authors declare that there are no conflicts of interest present.