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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2021-2539</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2539</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>Коморбидность хронической обструктивной болезни легких и сердечно-сосудистых заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Comorbidity in chronic obstructive pulmonary disease and cardiovascular disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2712-0227</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чаулин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Chaulin</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чаулин Алексей Михайлович — врач клинической лабораторной диагностики клинико-диагностической лаборатории, ассистент кафедры гистологии и эмбриологии.</p><p>Самара.</p></bio><bio xml:lang="en"><p>Chaulin Aleksey Michailovich.</p><p>Samara.</p></bio><email xlink:type="simple">alekseymichailovich22976@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6453-2976</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дупляков</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Duplyakov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дупляков Дмитрий Викторович — доктор медицинских наук, заместитель главного врача по медицинской части, профессор кафедры кардиологии и сердечно-сосудистой хирургии Института профессионального образования.</p><p>Самара.</p></bio><bio xml:lang="en"><p>Duplyakov Dmitry Victorovich.</p><p>Samara.</p></bio><email xlink:type="simple">duplyakov@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский областной клинический кардиологический диспансер; Самарский государственный медицинский университет Минздрава России</institution></aff><aff xml:lang="en"><institution>Samara Regional Clinical Cardiology Dispensary; Samara State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>11</day><month>02</month><year>2021</year></pub-date><volume>20</volume><issue>3</issue><fpage>2539</fpage><lpage>2539</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чаулин А.М., Дупляков Д.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Чаулин А.М., Дупляков Д.В.</copyright-holder><copyright-holder xml:lang="en">Chaulin A.M., Duplyakov D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2539">https://cardiovascular.elpub.ru/jour/article/view/2539</self-uri><abstract><p>Коморбидность — одна из самых значимых проблем современного здравоохранения. В многочисленных исследованиях анализируются возможные патогенетические механизмы и взаимосвязи между самыми различными заболеваниями. Сердечно-сосудистые (ССЗ) и бронхолегочные заболевания, в частности хроническая обструктивная болезнь легких (ХОБЛ), имеют целый ряд одинаковых факторов риска и патогенетических звеньев, посредством которых утяжеляют течение друг друга. Более того, ССЗ и ХОБЛ являются одними из самых распространенных заболеваний в мире. В настоящем обзоре приводятся современные сведения о распространенности, факторах риска и патофизиологических механизмах, лежащих в основе данного неблагоприятного сочетания болезней. Также обсуждаются некоторые проблемы диагностики и лечения коморбидных пациентов, страдающих ХОБЛ и ССЗ.</p></abstract><trans-abstract xml:lang="en"><p>Comorbidity is one of the most significant problems of modern healthcare. Numerous studies have analyzed the possible pathogenetic mechanisms and relationships between a wide variety of diseases. Cardiovascular (CVD) and pulmonary diseases, in particular chronic obstructive pulmonary disease (COPD), have a number of the same risk factors and pathogenetic links, which aggravate each other's course. Moreover, CVD and COPD are among the most common diseases in the world. This review provides up-to-date information on the prevalence, risk factors and pathophysiological mechanisms underlying this unfavorable combination of diseases. Some problems of diagnosis and treatment of patients with COPD and CVD are also discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоваскулярные заболевания</kwd><kwd>хроническая обструктивная болезнь легких</kwd><kwd>факторы риска</kwd><kwd>курение</kwd><kwd>воспаление</kwd><kwd>окислительный стресс</kwd><kwd>пожилой возраст</kwd><kwd>патофизиология</kwd><kwd>диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>chronic obstructive pulmonary disease</kwd><kwd>risk factors</kwd><kwd>smoking</kwd><kwd>inflammation</kwd><kwd>oxidative stress</kwd><kwd>old age</kwd><kwd>pathophysiology</kwd><kwd>diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тарловская Е.И. Коморбидность и полиморбидность — современная трактовка и насущные задачи, стоящие перед терапевтическим сообществом. 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