<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2020-2571</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2571</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕЧЕНИЕ ПАЦИЕНТОВ С СЕРДЕЧНО-СОСУДИСТЫМИ ЗАБОЛЕВАНИЯМИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MANAGEMENT OF CARDIOVASCULAR PATIENTS</subject></subj-group></article-categories><title-group><article-title>COVID-19: состояние системы гемостаза и особенности антитромботической терапии</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19: hemostatic parameters and specifics of antithrombotic treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2816-1183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Явелов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yavelov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, ведущий научный сотрудник отдела клинической кардиологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">yavelov@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, член-корреспондент РАН, директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">odrapkina@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>06</day><month>05</month><year>2020</year></pub-date><volume>19</volume><issue>3</issue><fpage>2571</fpage><lpage>2571</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Явелов И.С., Драпкина О.М., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Явелов И.С., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Yavelov I.S., Drapkina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2571">https://cardiovascular.elpub.ru/jour/article/view/2571</self-uri><abstract><p>В обзоре рассматриваются изменения показателей системы гемостаза у больных COVID-19 и анализируется их практическое значение. Рассматриваются современные подходы к профилактике и лечению тромботических/тромбоэмболических осложнений при COVID-19.</p></abstract><trans-abstract xml:lang="en"><p>In this review changes of hemostatic parameters in patients with COVID19 and their practical value are discussed. Current approaches to prevention and treatment of thrombotic/thromboembolic complications in patients with COVID-19 are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромбоз</kwd><kwd>гемостаз</kwd><kwd>антитромботическая терапия</kwd><kwd>гепарин</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombosis</kwd><kwd>hemostasis</kwd><kwd>antithrombotic therapy</kwd><kwd>heparin</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up. JACC. 2020. doi:10.1016/j.jacc.2020.04.031.</mixed-citation><mixed-citation xml:lang="en">Bikdeli B, Madhavan MV, Jimenez D, et al. COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up. JACC. 2020. doi:10.1016/j.jacc.2020.04.031.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kloka FA, Kruipb MJHA, van der Meerc NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020. doi:10.1016/j.thromres.2020.04.013.</mixed-citation><mixed-citation xml:lang="en">Kloka FA, Kruipb MJHA, van der Meerc NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020. doi:10.1016/j.thromres.2020.04.013.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020. doi:10.1111/JTH.14830.</mixed-citation><mixed-citation xml:lang="en">Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020. doi:10.1111/JTH.14830.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Poissy J, Goutay J, Caplan M, et al. Pulmonary Embolism in COVID19 Patients: Awareness of an Increased Prevalence. Circulation. 2020. doi:10.1161/CIRCULATIONAHA.120.047430.</mixed-citation><mixed-citation xml:lang="en">Poissy J, Goutay J, Caplan M, et al. Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence. Circulation. 2020. doi:10.1161/CIRCULATIONAHA.120.047430.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dolhnikoff M, Duarte-Neto AN, Monteiro RAA, et al. Pathological evidence of pulmonary thrombotic phenomena in severe COVID19. J Thromb Haemost. 2020. doi:10.1111/JTH.14844.</mixed-citation><mixed-citation xml:lang="en">Dolhnikoff M, Duarte-Neto AN, Monteiro RAA, et al. Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19. J Thromb Haemost. 2020. doi:10.1111/JTH.14844.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Carsana L, Sonzogni A, Nasr A. Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy. doi:10.1101/2020.04.19.20054262 https://www.medrxiv.org/content/10.1101/2020.04.19.20054262v1.</mixed-citation><mixed-citation xml:lang="en">Carsana L, Sonzogni A, Nasr A. Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy. doi:10.1101/2020.04.19.20054262 https://www.medrxiv.org/content/10.1101/2020.04.19.20054262v1.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Thachil J, Tang N, Gando S, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID‐19. J Thromb Haemost. 2020. doi:10.1111/jth.14810.</mixed-citation><mixed-citation xml:lang="en">Thachil J, Tang N, Gando S, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID‐19. J Thromb Haemost. 2020. doi:10.1111/jth.14810.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A metaanalysis. Clin Chim Acta. 2020. doi:10.1016/j.cca.2020.03.022.</mixed-citation><mixed-citation xml:lang="en">Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A metaanalysis. Clin Chim Acta. 2020. doi:10.1016/j.cca.2020.03.022.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Xiao M, Zhang S. Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020. doi:10.1056/NEJMc2007575.</mixed-citation><mixed-citation xml:lang="en">Zhang Y, Xiao M, Zhang S. Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020. doi:10.1056/NEJMc2007575.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ciceri F, Beretta L, Scandroglio AM, et al. Microvascular COVID19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc. 2020. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Ciceri F, Beretta L, Scandroglio AM, et al. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc. 2020. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18:844-7. doi:10.1111/jth.14768.</mixed-citation><mixed-citation xml:lang="en">Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18:844-7. doi:10.1111/jth.14768.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tang N, Bai H, Chen X, et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020. doi:10.1111/JTH.14817.</mixed-citation><mixed-citation xml:lang="en">Tang N, Bai H, Chen X, et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020. doi:10.1111/JTH.14817.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-62. doi:10.1016/S0140-6736(20)30566-3.</mixed-citation><mixed-citation xml:lang="en">Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054-62. doi:10.1016/S0140-6736(20)30566-3.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospitalization and critical illness among 4,103 patients with Covid-19 disease in New York City. doi:10.1101/2020.04.08.20057794. https://www.medrxiv.org/content/10.1101/2020.04.08.20057794v1.</mixed-citation><mixed-citation xml:lang="en">Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospitalization and critical illness among 4,103 patients with Covid-19 disease in New York City. doi:10.1101/2020.04.08.20057794. https://www.medrxiv.org/content/10.1101/2020.04.08.20057794v1.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Massachusetts General Hospital. Hematology Issues during COVID-19. Version 7.0, 4/14/2020. https://www.massgeneral.org/assets/MGH/pdf/news/coronavirus/guidance-from-massgeneral-hematology.pdf.</mixed-citation><mixed-citation xml:lang="en">Massachusetts General Hospital. Hematology Issues during COVID-19. Version 7.0, 4/14/2020. https://www.massgeneral.org/assets/MGH/pdf/news/coronavirus/guidance-from-massgeneral-hematology.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Iba T, Levy JH, Warkentin TE, et al. the Scientific and Standardization Committee on DIC, and the Scientific and Standardization Committee on Perioperative and Critical Care of the International Society on Thrombosis and Haemostasis. Diagnosis and ma - nagement of sepsis‐induced coagulopathy and disseminated intravascular coagulation. J Thromb Haemost. 2019;17:1989-94. doi:10.1111/jth.14578.</mixed-citation><mixed-citation xml:lang="en">Iba T, Levy JH, Warkentin TE, et al. the Scientific and Standardization Committee on DIC, and the Scientific and Standardization Committee on Perioperative and Critical Care of the International Society on Thrombosis and Haemostasis. Diagnosis and management of sepsis‐induced coagulopathy and disseminated intravascular coagulation. J Thromb Haemost. 2019;17:1989-94. doi:10.1111/jth.14578.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Samama MM, Cohen AT, Darmon JY, et al. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. N Engl J Med. 1999;341:793-800.</mixed-citation><mixed-citation xml:lang="en">Samama MM, Cohen AT, Darmon JY, et al. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. N Engl J Med. 1999;341:793-800.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen AT, Davidson BL, Gallus AS, et al. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomized placebo-controlled trial. BMJ. 2006;332:325-9. doi:10.1136/bmj.38733.466748.7C.</mixed-citation><mixed-citation xml:lang="en">Cohen AT, Davidson BL, Gallus AS, et al. Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomized placebo-controlled trial. BMJ. 2006;332:325-9. doi:10.1136/bmj.38733.466748.7C.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Leizorovicz A, Cohen AT, Turpie AG, et al. Randomized, placebocontrolled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients. Circulation. 2004;110:874-9. doi:10.1161/01.CIR.0000138928.83266.24.</mixed-citation><mixed-citation xml:lang="en">Leizorovicz A, Cohen AT, Turpie AG, et al. Randomized, placebocontrolled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients. Circulation. 2004;110:874-9. doi:10.1161/01.CIR.0000138928.83266.24.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of Venous Thromboembolism. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:381S-453S. doi:10.1378/chest.08-0656.</mixed-citation><mixed-citation xml:lang="en">Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of Venous Thromboembolism. American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:381S-453S. doi:10.1378/chest.08-0656.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in Nonsurgical Patients. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(suppl):e195Se226S. doi:10.1378/chest.11-2296.</mixed-citation><mixed-citation xml:lang="en">Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in Nonsurgical Patients. Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(suppl):e195Se226S. doi:10.1378/chest.11-2296.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Barbar S, Noventa F, Rossetto V, et al. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. J Thromb Haemost. 2010;8:2450-7. doi:10.1111/j.1538-7836.2010.04044.x.</mixed-citation><mixed-citation xml:lang="en">Barbar S, Noventa F, Rossetto V, et al. A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score. J Thromb Haemost. 2010;8:2450-7. doi:10.1111/j.1538-7836.2010.04044.x.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Spyropoulos AC, Anderson FA, FitzGerald G, et al., for the IMPROVE Investigators. Predictive and Associative Models to Identify Hospitalized Medical Patients at Risk for VTE. Chest. 2011;140:706-14. doi:10.1378/chest.10-1944.</mixed-citation><mixed-citation xml:lang="en">Spyropoulos AC, Anderson FA, FitzGerald G, et al., for the IMPROVE Investigators. Predictive and Associative Models to Identify Hospitalized Medical Patients at Risk for VTE. Chest. 2011;140:706-14. doi:10.1378/chest.10-1944.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen AT, Harrington RA, Goldhaber SZ, et al., for the APEX Investigators. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016;375:534-44. doi:10.1056/NEJMoa1601747.</mixed-citation><mixed-citation xml:lang="en">Cohen AT, Harrington RA, Goldhaber SZ, et al., for the APEX Investigators. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016;375:534-44. doi:10.1056/NEJMoa1601747.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gibson CM, Spyropoulos AC, Cohen AT, et al. The IMPROVEDD VTE Risk Score: Incorporation of D-Dimer into the IMPROVE Score to Improve Venous Thromboembolism Risk Stratification. TH Open. 2017;1:e56-e65. doi:10.1055/s-0037-1603929.</mixed-citation><mixed-citation xml:lang="en">Gibson CM, Spyropoulos AC, Cohen AT, et al. The IMPROVEDD VTE Risk Score: Incorporation of D-Dimer into the IMPROVE Score to Improve Venous Thromboembolism Risk Stratification. TH Open. 2017;1:e56-e65. doi:10.1055/s-0037-1603929.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Thachil J. The versatile heparin in COVID-19. J Thromb Haemost. 2020. doi:10.1111/JTH.14821.</mixed-citation><mixed-citation xml:lang="en">Thachil J. The versatile heparin in COVID-19. J Thromb Haemost. 2020. doi:10.1111/JTH.14821.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hull RD, Schellong SM, Tapson VF, et al., for the EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study. ExtendedDuration Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients With Recently Reduced Mobility. A Randomized Trial. Ann Intern Med. 2010;153:8-18. doi:10.7326/0003-4819-153-1-201007060-00004.</mixed-citation><mixed-citation xml:lang="en">Hull RD, Schellong SM, Tapson VF, et al., for the EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study. Extended-Duration Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients With Recently Reduced Mobility. A Randomized Trial. Ann Intern Med. 2010;153:8-18. doi:10.7326/0003-4819-153-1-201007060-00004.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Spyropoulos AC, Ageno W, Albers GW, et al., for the MARINER Investigators. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. Engl J Med. 2018;379:1118-27. doi:10.1056/NEJMoa1805090.</mixed-citation><mixed-citation xml:lang="en">Spyropoulos AC, Ageno W, Albers GW, et al., for the MARINER Investigators. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. Engl J Med. 2018;379:1118-27. doi:10.1056/NEJMoa1805090.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Moore HB, Barrett CD, Moore EE, et al. Is There a Role for Tissue Plasminogen Activator (tPA) as a Novel Treatment for Refractory COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)? J Trauma and Acute Care Surgery. 2020. doi:10.1097/TA.0000000000002694.</mixed-citation><mixed-citation xml:lang="en">Moore HB, Barrett CD, Moore EE, et al. Is There a Role for Tissue Plasminogen Activator (tPA) as a Novel Treatment for Refractory COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)? J Trauma and Acute Care Surgery. 2020. doi:10.1097/TA.0000000000002694.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Wang J, Hajizadeh N, Moore EE, et al. Tissue Plasminogen Activator (tPA) Treatment for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): A Case Series. J Thromb Haemost. 2020. doi:10.1111/JTH.14828.</mixed-citation><mixed-citation xml:lang="en">Wang J, Hajizadeh N, Moore EE, et al. Tissue Plasminogen Activator (tPA) Treatment for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): A Case Series. J Thromb Haemost. 2020. doi:10.1111/JTH.14828.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Li J, Li Y, Yang B, et al. Low-molecular-weight heparin treatment for acute lung injury/acute respiratory distress syndrome: a metaanalysis of randomized controlled trials. Int J Clin Exp Med. 2018;11:414-22.</mixed-citation><mixed-citation xml:lang="en">Li J, Li Y, Yang B, et al. Low-molecular-weight heparin treatment for acute lung injury/acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. Int J Clin Exp Med. 2018;11:414-22.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Liverpool Drug Interaction Group. Interactions with Experimental COVID-19 Therapies. https://www.covid19-druginteractions.org.</mixed-citation><mixed-citation xml:lang="en">Liverpool Drug Interaction Group. Interactions with Experimental COVID-19 Therapies. https://www.covid19-druginteractions.org.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. Last updated on 21 April 2020. https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance.</mixed-citation><mixed-citation xml:lang="en">ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. Last updated on 21 April 2020. https://www.escardio.org/Education/COVID-19-and-Cardiology/ESC-COVID-19-Guidance.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
