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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2021-2634</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2634</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АРТЕРИАЛЬНАЯ ГИПЕРТОНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ARTERIAL HYPERTENSION</subject></subj-group></article-categories><title-group><article-title>Функция щитовидной железы, биоэлектрическая активность головного мозга и вариабельность ритма сердца у больных артериальной гипертонией</article-title><trans-title-group xml:lang="en"><trans-title>Thyroid function, brain bioelectrical activity and heart rate variability in patients with hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6966-8522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курданова</surname><given-names>М. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurdanova</surname><given-names>M. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, ведущий научный сотрудник отдела клинической медицины и физиологии.</p><p>Нальчик</p></bio><bio xml:lang="en"><p>Nalchik</p></bio><email xlink:type="simple">maryamk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7294-6968</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бесланеев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Beslaneev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, ведущий научный сотрудник отдела физиологии и патологии высокогорья.</p><p>Нальчик, Тел.: 8 (622) 44-23-90, тел./факс: 8 (622) 44-31-55</p></bio><bio xml:lang="en"><p>Nalchik</p></bio><email xlink:type="simple">ibisl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2592-8270</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курданова</surname><given-names>Мд. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurdanova</surname><given-names>Md. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, старший научный сотрудник отдела клинической медицины и физиологии.</p><p>Нальчик</p></bio><bio xml:lang="en"><p>Nalchik</p></bio><email xlink:type="simple">kurdanovamh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0340-7565</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батырбекова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Batyrbekova</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, старший научный сотрудник отдела клинической медицины и физиологии.</p><p>Нальчик</p></bio><bio xml:lang="en"><p>Nalchik</p></bio><email xlink:type="simple">batyrbekova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9240-0292</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курданов</surname><given-names>Х. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurdanov</surname><given-names>Kh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, директор, ORCID: 0000-0002-9240-0292</p><p>Нальчик</p></bio><bio xml:lang="en"><p>Nalchik</p></bio><email xlink:type="simple">kurdanov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Центр медико-экологических исследований — ФГБУН Государственный научный центр Российской Федерации — Института медико-биологических проблем, Российская академия наук</institution></aff><aff xml:lang="en"><institution>Institute of Biomedical Problems, Russian Academy of Sciences</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2021</year></pub-date><volume>20</volume><issue>2</issue><fpage>2634</fpage><lpage>2634</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Курданова М.Х., Бесланеев И.А., Курданова М.Х., Батырбекова Л.М., Курданов Х.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Курданова М.Х., Бесланеев И.А., Курданова М.Х., Батырбекова Л.М., Курданов Х.А.</copyright-holder><copyright-holder xml:lang="en">Kurdanova M.K., Beslaneev I.A., Kurdanova M.K., Batyrbekova L.M., Kurdanov K.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2634">https://cardiovascular.elpub.ru/jour/article/view/2634</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить содержание тиреотропного гормона (ТТГ) и тиреоидных гомонов (ТГ), частотно-амплитудные показатели альфа-ритма головного мозга, параметры вариабельности ритма сердца, гемодинамики и их взаимосвязи у больных артериальной гипертонией (АГ) и здоровых лиц.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Клинически обследовано 75 больных АГ 2 ст. и 70 здоровых лиц. Всем пациентам проведено электроэнцефалографическое исследование, суточное мониторирование артериального давления и расчет средневзвешенной вариабельности ритма (СВВР); определение в плазме крови уровней ТТГ, ТГ. Статистическая обработка полученных данных, множественный регрессионный и корреляционный анализ проведены с помощью пакета программы “Statistics v. 10.0.1”, StatSoft Inc.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что у больных АГ ТТГ на 50% и ТГ на 38% ниже, чем в контрольной группе; ниже на 40% оказался и а-индекс. Больные АГ характеризовались более низкими спектральными показателями: амплитуда была ниже, чем в контроле на 35%, частота и мощность а-ритма на 13-35%, СВВР — на 30%. Скорость распространения пульсовой волны у больных АГ превышала контрольную величину на 18%, а системная динамическая реакция — в 2,2 раза. Группы различались по характеру взаимосвязей а-ритма между долями и полушариями головного мозга с ТТГ, ТГ, показателями СВВР и гемодинамики.</p></sec><sec><title>Заключение</title><p>Заключение. Концентрация ТТГ и ТГ взаимосвязана с амплитудно-частотными показателями а-ритма головного мозга, изменениями СВВР и показателями гемодинамики у больных АГ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the levels of thyroid-stimulating hormone (TSH) and thyroid hormones (TH), frequency and amplitude parameters of alpha wave, parameters of heart rate variability, hemodynamics and their relationship in patients with hypertension (HTN) and healthy individuals.</p></sec><sec><title>Material and methods</title><p>Material and methods. We studied 75 patients with stage 2 HTN and 70 healthy individuals. All patients underwent an electroencephalography, 24-hour blood pressure monitoring. Weighted average heart rate variability was calculated. We determined blood plasma levels of TSH and TH. Statistical processing, multiple regression and correlation analysis were carried out using the Statistica v. 10.0.1 software package (StatSoft Inc).</p></sec><sec><title>Results</title><p>Results. In patients with HTN, TSH and TH were lower than in the control group by 50% and 38%, respectively. The а-index was also 40% lower. Patients with HTN were characterized by lower amplitude, frequency and power of а-wave, and weighted average heart rate variability by 35%, 13-35%, and 30%, respectively. Pulse wave velocity in patients with HTN exceeded the control group by 18%, and the systemic dynamic response was 2,2 times higher. The groups differed in the characteristics of the relationship of а-wave between the brain lobes and hemispheres with TSH, TH, heart rate variability and hemodynamics.</p></sec><sec><title>Conclusion</title><p>Conclusion. The concentration of TSH and TH is interrelated with the frequency and amplitude parameters of alpha wave, heart rate variability and hemodynamic parameters in hypertensive patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ттиреотропный гормон</kwd><kwd>тиреоидные гормоны</kwd><kwd>амплитудно-частотные показатели альфа-ритма</kwd><kwd>вариабельность ритма сердца</kwd><kwd>артериальная гипертония</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thyroid-stimulating hormone</kwd><kwd>thyroid hormones</kwd><kwd>frequency and amplitude parameters of а-wave</kwd><kwd>heart rate variability</kwd><kwd>hypertension</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена по теме 64.3 в рамках программы фундаментальных исследований РАН</funding-statement><funding-statement xml:lang="en">The work was performed on the topic 64.3 in the framework of the program of fundamental research of the RAS</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. 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