cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2020-2647cardiovascular-2647Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESПрофилактика сердечно-сосудистых заболеваний на протяжении жизни. Часть 1: преконцепционный, пренатальный и грудной периодыLifelong prevention of cardiovascular disease. Part I: preconceptional, prenatal and infant periods of lifehttps://orcid.org/0000-0001-5397-5387КопыловаО. В.KopylovaO. V.

Оксана Викторовна Копылова —научный сотрудник лаборатории клиномики

Москва

osivakova@gnicpm.ruhttps://orcid.org/0000-0001-7989-0760ЕршоваА. И.ErshovaA. I.

Александра Игоревна Ершова. — кандидат медицинских наук, руководитель лаборатории клиномики

Москва

alersh@mail.ruhttps://orcid.org/0000-0001-5989-6233МешковА. Н.MeshkovA. N.

Алексей Николаевич Мешков — кандидат медицинских наук, руководитель лаборатории молекулярной генетики

Москва

meshkov@lipidclinic.ruhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Оксана Михайловна Драпкина — lоктор медицинских наук, профессор, член-корр. РАН, директор

Москва

drapkina@bk.ruФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины” Минздрава РоссииNational Research Center for Therapy and Preventive Medicine20202810202019626472647Copyright © Копылова О.В., Ершова А.И., Мешков А.Н., Драпкина О.М., 20202020Копылова О.В., Ершова А.И., Мешков А.Н., Драпкина О.М.Kopylova O.V., Ershova A.I., Meshkov A.N., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2647

Известные на данный момент профилактические вмешательства позволяют предотвратить или значимо отсрочить бóльшую часть сердечно-сосудистых заболеваний (ССЗ). Разнообразные факторы – внутренние биологические, психологические, влияние внешней окружающей среды – взаимосвязаны между собой и воздействуют на человека на протяжении всей его жизни, определяя вероятность развития ССЗ.  Это свидетельствует о необходимости профилактических мер на всех жизненных этапах и даже  до рождения. Положительные эффекты профилактики реализуются посредством различных молекулярных механизмов на генетическом, эпигенетическом и метаболическом уровнях. В связи с тем, что многие факторы риска ССЗ имеют накопительный эффект, внедрение превентивных мер, начиная с самых ранних этапов развития человека, будет иметь наибольшую эффективность. В статье рассмотрены различные аспекты профилактики ССЗ в преконцепционном, пренатальном и грудном периодах.

Current prophylactic actions prevent or significantly delay the majority of cardiovascular diseases (CVD). Various factors are interconnected and affect a person throughout his life, determining the risk of CVD. This indicates the need for preventive measures at all stages of life and even before birth. The beneficial effects of CVD prevention are realized through various genetic, epigenetic and metabolic mechanisms. Due to the fact that many risk factors for CVD have a cumulative effect, the introduction of preventive measures from the earliest life stages will be most effective. The purpose of the article is to consider various aspects of CVD prevention in the preconceptional, prenatal and infant periods.

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The authors declare that there are no conflicts of interest present.