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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2021-2648</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2648</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>Роль глифлозинов в терапии синдрома висцерального ожирения</article-title><trans-title-group xml:lang="en"><trans-title>Role of SGLT2 inhibitors in the treatment of visceral obesity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3147-9056</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дружилов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Druzhilov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марк Андреевич Дружилов — кандидат медицинских наук, доцент центра постдипломного образования медицинских работников медицинского института.</p><p>Петрозаводск, Тел.: +7 (911) 403-19-48, +7 (8142) 738-848</p></bio><bio xml:lang="en"><p>Petrozavodsk</p></bio><email xlink:type="simple">drmark1982@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6654-1382</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузнецова</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuznetsova</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Татьяна Юрьевна Кузнецова — заведующий кафедрой факультетской терапии, фтизиатрии, инфекционных болезней и эпидемиологии медицинского института, доктор медицинских наук.</p><p>Петрозаводск</p></bio><bio xml:lang="en"><p>Petrozavodsk</p></bio><email xlink:type="simple">eme@karelia.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Петрозаводский государственный университет</institution></aff><aff xml:lang="en"><institution>Petrozavodsk State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>19</day><month>02</month><year>2021</year></pub-date><volume>20</volume><issue>1</issue><fpage>2648</fpage><lpage>2648</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дружилов М.А., Кузнецова Т.Ю., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Дружилов М.А., Кузнецова Т.Ю.</copyright-holder><copyright-holder xml:lang="en">Druzhilov M.A., Kuznetsova T.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2648">https://cardiovascular.elpub.ru/jour/article/view/2648</self-uri><abstract><p>Увеличивающаяся распространенность ожирения ограничивает успехи профилактической медицины в отношении предупреждения развития и прогрессирования хронических неинфекционных заболеваний. Основными методами коррекции риска, ассоциированного с ожирением, являются мероприятия по изменению образа жизни и назначение при соответствующих показаниях лекарственных препаратов, зарегистрированных для лечения ожирения. Ингибиторы натрий-глюкозного ко-транспортера 2 типа, или глифлозины, позиционируемые в клинической практике для фармакотерапии сахарного диабета второго типа, в многочисленных исследованиях продемонстрировали дополнительные положительные эффекты на суррогатные и твердые конечные точки. Это стало основанием для детального изучения механизмов их кардиоваскулонефропротективных свойств и проведения исследований с препаратами данной группы в других когортах пациентов. В настоящем обзоре приведены результаты исследований, в которых изучалось влияние глифлозинов на вес тела у лиц с избыточным весом и ожирением, количественные характеристики и функциональную активность висцеральной жировой ткани, а также другие составляющие синдрома висцерального ожирения, обсуждается возможность применения этих препаратов при ведении таких пациентов.</p></abstract><trans-abstract xml:lang="en"><p>The increasing prevalence of obesity limits the prevention of the development and progression of chronic non-communicable diseases. The central methods of risk correction associated with obesity are lifestyle changes and prescribing medications for obesity. Sodium-glucose co-transporter type-2 (SGLT2) inhibitors, also called gliflozins, which are used for type 2 diabetes, have shown additional positive effects on surrogate and hard endpoints in numerous studies. This became the basis for a detailed study of their cardio- and neuroprotective effects and for conducting studies with such drugs in other cohorts of patients. This review presents the results of studies that examined the effect of SGLT2 inhibitors on body weight in overweight and obese individuals, the quantitative characteristics and functional activity of visceral adipose tissue, as well as other components of visceral obesity, and discusses the potential of using these drugs in the management of such patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>висцеральное ожирение</kwd><kwd>ингибиторы натрий-глюкозного ко-транспортера второго типа</kwd><kwd>глифлозины</kwd><kwd>кардиоренометаболический риск</kwd></kwd-group><kwd-group xml:lang="en"><kwd>visceral obesity</kwd><kwd>sodium-glucose co-transporter type-2</kwd><kwd>gliflozins</kwd><kwd>cardio-renal-metabolic risk</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Obesity and overweight fact sheet. 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