cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2015-6-87-92cardiovascular-289Research ArticleОБЗОРЫREVIEWSЭНДОТЕЛИАЛЬНЫЙ ГЛИКОКАЛИКС — ПОТЕНЦИАЛЬНЫЙ СОСУДИСТЫЙ БИОМАРКЕР: ДИАГНОСТИЧЕСКАЯ И ТЕРАПЕВТИЧЕСКАЯ МИШЕНЬ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙENDOTHELIAL GLYCOCALYX — POTENTIAL VASCULAR BIOMARKER: DIAGNOSTIC AND THERAPEUTIC TARGET IN CARDIOVASCULAR DISEASESГоршковА. Ю.GorshkovA. Yu.

аспирант

Тел.: +7 (916) 310-91-84

AGorshkov@gnicpm.ruБойцовС. А.BoytsovS. A.

д.м.н., профессор, директор

ФГБУ “Государственный научно-исследовательский центр профилактической медицины” Минздрава России, МоскваNational Research Center for Preventive Medicine of the Ministry of Health, Moscow2015201220151468792Copyright © Горшков А.Ю., Бойцов С.А., 20152015Горшков А.Ю., Бойцов С.А.Gorshkov A.Y., Boytsov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/289

Эндотелиальный гликокаликс (ЭГК) представляет собой высокоорганизованную протективную структуру сосудистого русла. Повреждение ЭГК является одним из первых патогенетических механизмов развития различных патологий, и в первую очередь сердечно-сосудистых заболеваний. В настоящей статье представлены данные о строении, функционировании ЭГК в норме и патологии, а также о возможности использования ЭГК в качестве потенциального сосудистого биомаркера, терапевтической мишени.

Endothelium glycocalyx (EG) is a highly organized protecting complex of the vessels. Damage of EG is one of the first pathogenetic mechanisms of a range of pathologies onset, and primarily cardiovascular diseases. Current paper focuses on the structure, functioning of EG normally and in pathology, and on the possibility to apply EG as potential vascular biomarker, target for therapy. 

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The authors declare that there are no conflicts of interest present.