cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2014-2-46-50cardiovascular-29Research ArticleХРОНИЧЕСКАЯ СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬCHRONIC HEART FAILUREОЦЕНКА ЭФФЕКТИВНОСТИ КАРВЕДИЛОЛА И ЭПРОСАРТАНА У БОЛЬНЫХ С МЕТАБОЛИЧЕСКИМ СИНДРОМОМ И ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮTHE EFFECTIVENESS OF CARVEDILOL AND EPROSARTAN IN PATIENTS WITH METABOLIC SYNDROME AND CHRONIC HEART FAILUREДашдамировР. Л.DashnamirovR. L.

к. м.н., с. н.с. отделения сердечной недостаточности, заместитель директора по научной работе

rafaelmed@mail.ruНаучно-исследовательский институт кардиологии им. академика Дж. Абдуллаева Министерства здравоохранения Азербайджанской Республики, БакуAzerbaijan2014200420141324650Copyright © Дашдамиров Р.Л., 20142014Дашдамиров Р.Л.Dashnamirov R.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/29Цель

Цель. Оценить эффективность добавления карведилола и эпросартана к традиционному лечению больных метаболическим синдромом и хронической сердечной недостаточностью (ХСН).

Материал и методы

Материал и методы. 57 больных представляли группу контроля, которая получала традиционное лечение (нитросорбид — 30 мг/сут. + дигоксин — 0,25 мг/сут. + тромбоАСС — 100 мг/сут. + аторвастатин — 20 мг/сут. + фуросемид — 40 мг/сут. + верошпирон — 50 мг/сут. + атенолол — 12,5–25 мг/сут.). 91 больному, основная группа дополнительно были назначены эпросартан в дозе 300

Аim

Аim. of the study was to assess the effectiveness of carvedilol and eprosartan in addition to the traditional treatment (Nitrosorbid 30mg/day + Digoxin 0.25mg/day + TromboASS 100mg/day + Atorvastatin 20mg/day + Furosemid 40mg/day + Verospiron 50mg/day + Atenolol 12.5–25 mg/day) in patients with metabolic syndrome and chronic heart failure.

Materials and methods

Materials and methods. 91 patients with MS and CHF included sharing mentioned criteria. Carvedilol in doses of 6,25 ÷ 25 mg/day and eprosartan in doses of 300 ÷ 600 mg/day were administered in addition to the traditional treatment.

Results

Results. After 12 months of treatment systolic BP decreased by 23.6% and diastolic by 17.2%. Heart rate decreased by 23.1%, and exercise tolerance increased by 22.3%. Dynamics of the presented indicators are statistically significant.

Conclusion

Conclusion. Administration of an alpha-beta blocker carvedilol and angiotensin II receptor blocker eprosartan in the above dosages promote the longest remission of heart failure, improvement in functional class and regression of pathological remodeling.

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The authors declare that there are no conflicts of interest present.