cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2022-2909cardiovascular-2909Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESВозможности оптической когерентной томографии и внутрисосудистого ультразвука в выявлении нестабильных бляшек в коронарных артерияхPotential of optical coherence tomography and intravascular ultrasound in the detection of vulnerable plaques in coronary arterieshttps://orcid.org/0000-0002-1534-264XКочергинН. А.KocherginN. A.

Никита Александрович Кочергин — кандидат медицинских наук, научный сотрудник

Кемерово. Тел.: +7 (908) 952-32-35

Kemerovo

nikotwin@mail.ruhttps://orcid.org/0000-0003-3998-7028КочергинаА. М.KocherginaA. M.

Анастасия Михайловна Кочергина — кандидат медицинских наук, научный сотрудник.

Кемерово

Kemerovo

noony88@mail.ruФГБНУ Научный исследовательский институт комплексных проблем сердечно-сосудистых заболеванийResearch Institute of Complex Issues of Cardiovascular Diseases20222801202221129092909Copyright © Кочергин Н.А., Кочергина А.М., 20222022Кочергин Н.А., Кочергина А.М.Kochergin N.A., Kochergina A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/2909

Внутрисосудистая визуализация нестабильных бляшек in vivo имеет большой потенциал для прогнозирования коронарных событий. В настоящее время существует несколько методов внутрисосудистой визуализации, которые позволяют верифицировать компоненты бляшки и, соответственно, ее уязвимость. Наиболее распространенными являются виртуальная гистология внутрисосудистого ультразвукового исследования и оптическая когерентная томография. В ряде исследований доказано, что с помощью этих методов визуализации возможна стратификация риска неблагоприятных сердечно-сосудистых событий, а также оценка эффективности медикаментозной терапии. В настоящей статье описаны преимущества и недостатки внутрисосудистого ультразвука и оптической когерентной томографии в выявлении уязвимых поражений коронарных артерий.

Intravascular imaging of vulnerable plaques in vivo has great potential for predicting coronary events. Currently, there are several methods of intravascular imaging, which make it possible to verify the components of the plaque and, accordingly, its vulnerability. The most common are virtual-histology intravascular ultrasound and optical coherence tomography. Several studies have shown that these imaging techniques can stratify the risk of adverse cardiovascular events, as well as assess the effectiveness of drug therapy. This article will describe the advantages and disadvantages of intravascular ultrasound and optical coherence tomography in identifying vulnerable coronary lesions.

оптическая когерентная томографиявнутрисосудистый ультразвукнестабильная бляшкафиброатерома с тонкой капсулойoptical coherence tomographyintravascular ultrasoundvulnerable plaquethin-cap fibroatheromaСтатья подготовлена при поддержке гранта Президента Российской Федерации МК-1673.2020.7The article was supported by the grant of the President of the Russian Federation MK-1673.2020.7ReferencesMuller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989;79:733-43. doi:10.1161/01.cir.79.4.733.Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989;79:733-43. doi:10.1161/01.cir.79.4.733.Johnson TW, Raber L, di Mario C, et al. Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J. 2019;40:2566-84. doi: 10.1093/eurheartj/ehz332.Johnson TW, Raber L, di Mario C, et al. Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J. 2019;40:2566-84. doi: 10.1093/eurheartj/ehz332.Mintz GS, Nissen SE, Anderson WD, et al. American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2001;37:1478-92. doi:10.1016/s0735-1097(01)01175-5.Mintz GS, Nissen SE, Anderson WD, et al. American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2001;37:1478-92. doi:10.1016/s0735-1097(01)01175-5.Nakano M, Yahagi K, Yamamoto H, et al. Additive Value of Integrated Backscatter IVUS for Detection of Vulnerable Plaque by Optical Frequency Domain Imaging: An Ex Vivo Autopsy Study of Human Coronary Arteries. JACC Cardiovasc Imaging. 2016;9:163-72. doi:10.1016/j.jcmg.2015.07.011.Nakano M, Yahagi K, Yamamoto H, et al. Additive Value of Integrated Backscatter IVUS for Detection of Vulnerable Plaque by Optical Frequency Domain Imaging: An Ex Vivo Autopsy Study of Human Coronary Arteries. JACC Cardiovasc Imaging. 2016;9:163-72. doi:10.1016/j.jcmg.2015.07.011.Brown AJ, Obaid DR, Costopoulos C, et al. Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma. Circ Cardiovasc Imaging. 2015;8:e003487. doi:10.1161/CIRCIMAGING.115.003487.Brown AJ, Obaid DR, Costopoulos C, et al. Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma. Circ Cardiovasc Imaging. 2015;8:e003487. doi:10.1161/CIRCIMAGING.115.003487.Fujii K, Hao H, Shibuya M, et al. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA: An Ex Vivo Validation Study. JACC Cardiovasc Imaging. 2015;8:451-60. doi:10.1016/j.jcmg.2014.10.015.Fujii K, Hao H, Shibuya M, et al. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA: An Ex Vivo Validation Study. JACC Cardiovasc Imaging. 2015;8:451-60. doi:10.1016/j.jcmg.2014.10.015.Stone GW, Maehara A, Lansky AJ, et al; PROSPECT Investigators. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226-35. doi:10.1056/NEJMoa1002358.Stone GW, Maehara A, Lansky AJ, et al; PROSPECT Investigators. A prospective natural-history study of coronary atherosclerosis. N Engl J Med. 2011;364:226-35. doi:10.1056/NEJMoa1002358.Calvert PA, Obaid DR, O’Sullivan M, et al. Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in Vulnerable Atherosclerosis) Study. JACC Cardiovasc Imaging. 2011;4:894-901. doi:10.1016/j.jcmg.2011.05.005.Calvert PA, Obaid DR, O’Sullivan M, et al. Association between IVUS findings and adverse outcomes in patients with coronary artery disease: the VIVA (VH-IVUS in Vulnerable Atherosclerosis) Study. JACC Cardiovasc Imaging. 2011;4:894-901. doi:10.1016/j.jcmg.2011.05.005.Cheng JM, Garcia-Garcia HM, de Boer SP, et al. In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Eur Heart J. 2014;35:639-47. doi:10.1093/eurheartj/eht484.Cheng JM, Garcia-Garcia HM, de Boer SP, et al. In vivo detection of high-risk coronary plaques by radiofrequency intravascular ultrasound and cardiovascular outcome: results of the ATHEROREMO-IVUS study. Eur Heart J. 2014;35:639-47. doi:10.1093/eurheartj/eht484.Stone GW, Maehara A, Ali ZA, et al., for the PROSPECT ABSORB Investigators. Percutaneous Coronary Intervention for Vulnerable Coronary Atherosclerotic Plaque. J Am Coll Cardiol. 2020;76(20):2289-301. doi:10.1016/j.jacc.2020.09.547.Stone GW, Maehara A, Ali ZA, et al., for the PROSPECT ABSORB Investigators. Percutaneous Coronary Intervention for Vulnerable Coronary Atherosclerotic Plaque. J Am Coll Cardiol. 2020;76(20):2289-301. doi:10.1016/j.jacc.2020.09.547.Kubo T, Maehara A, Mintz GS, et al. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. J Am Coll Cardiol. 2010;55:1590-7 doi:10.1016/j.jacc.2009.07078.Kubo T, Maehara A, Mintz GS, et al. The dynamic nature of coronary artery lesion morphology assessed by serial virtual histology intravascular ultrasound tissue characterization. J Am Coll Cardiol. 2010;55:1590-7 doi:10.1016/j.jacc.2009.07078.Кочергин Н. А., Кочергина А. М., Хорлампенко А. А. и др. Нестабильные атеросклеротические бляшки коронарных артерий при стабильной ишемической болезни сердца: 12-месячное наблюдение. Кардиология. 2020;60(2):1-6. doi:10.18087/cardio.2020.2.n467Kochergin NA, Kochergina AM, Khorlampenko AA, et al. Vulnerable atherosclerotic plaques of coronary arteries in patients with stable coronary artery disease: 12-months followup. Kardiologiia. 2020;60(2):1-6. (In Russ.) doi:10.18087/cardio.2020.2.n467Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA. 2016;316:2373-84. doi:10.1001/jama.2016.16951.Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA. 2016;316:2373-84. doi:10.1001/jama.2016.16951.Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Coronary Plaque Composition. J Am Coll Cardiol. 2018;72:2012-21. doi:10.1016/j.jacc.2018.06.078.Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Coronary Plaque Composition. J Am Coll Cardiol. 2018;72:2012-21. doi:10.1016/j.jacc.2018.06.078.Räber L, Taniwaki M, Zaugg S, et al. IBIS 4 (Integrated Biomarkers and Imaging Study-4) Trial Investigators (NCT00962416). Effect of high-intensity statin therapy on atherosclerosis in noninfarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study. Eur Heart J. 2015;36:490-500. doi:10.1093/eurheartj/ehu373.Räber L, Taniwaki M, Zaugg S, et al. IBIS 4 (Integrated Biomarkers and Imaging Study-4) Trial Investigators (NCT00962416). Effect of high-intensity statin therapy on atherosclerosis in noninfarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study. Eur Heart J. 2015;36:490-500. doi:10.1093/eurheartj/ehu373.Räber L, Mintz GS, Koskinas KC, et al. ESC Scientific Document Group. Clinical use of intracoronary imaging. Part 1: guidance and optimization of coronary interventions. An expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J. 2018;39:3281-300. doi:10.1093/eurheartj/ehy285.Räber L, Mintz GS, Koskinas KC, et al. ESC Scientific Document Group. Clinical use of intracoronary imaging. Part 1: guidance and optimization of coronary interventions. An expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. Eur Heart J. 2018;39:3281-300. doi:10.1093/eurheartj/ehy285.Kataoka Y, Hammadah M, Puri R, et al. Plaque microstructures in patients with coronary artery disease who achieved very low low-density lipoprotein cholesterol levels. Atherosclerosis. 2015;242:490-5. doi:10.1016/j.atherosclerosis.2015.08.005.17 Kataoka Y, Hammadah M, Puri R, et al. Plaque microstructures in patients with coronary artery disease who achieved very low low-density lipoprotein cholesterol levels. Atherosclerosis. 2015;242:490-5. doi:10.1016/j.atherosclerosis.2015.08.005.Kitabata H, Tanaka A, Kubo T, et al. Relation of microchannel structure identified by optical coherence tomography to plaque vulnerability in patients with coronary artery disease. Am J 31. Cardiol. 2010;105:1673-8. doi:10.1016/j.amjcard.2010.01.346.Kitabata H, Tanaka A, Kubo T, et al. Relation of microchannel structure identified by optical coherence tomography to plaque vulnerability in patients with coronary artery disease. Am J 31. Cardiol. 2010;105:1673-8. doi:10.1016/j.amjcard.2010.01.346.Kitahara S, Kataoka Y, Otsuka F, et al. Plaque erosion or coronary artery embolism? Findings from clinical presentation, optical coherence tomographic and histopathological analysis in a case with acute coronary syndrome. Int J Cardiovasc Imaging. 2019;35:1791-2. doi:10.1007/s10554-019-01641-6.Kitahara S, Kataoka Y, Otsuka F, et al. Plaque erosion or coronary artery embolism? Findings from clinical presentation, optical coherence tomographic and histopathological analysis in a case with acute coronary syndrome. Int J Cardiovasc Imaging. 2019;35:1791-2. doi:10.1007/s10554-019-01641-6.Yabushita H, Bouma BE, Houser SL, et al. Characterization of human atherosclerosis by optical coherence tomography. Circulation. 2002;106:1640-5. doi: 10.1161/01.cir.0000029927.92825.f6.Yabushita H, Bouma BE, Houser SL, et al. Characterization of human atherosclerosis by optical coherence tomography. Circulation. 2002;106:1640-5. doi: 10.1161/01.cir.0000029927.92825.f6.Xing L, Higuma T, Wang Z, et al. Clinical Significance of LipidRich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol. 2017;69:2502-13. doi:10.1016/j.jacc.2017.03.556.Xing L, Higuma T, Wang Z, et al. Clinical Significance of LipidRich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study. J Am Coll Cardiol. 2017;69:2502-13. doi:10.1016/j.jacc.2017.03.556.Prati F, Romagnoli E, Gatto L, et al. Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study. Eur Heart J. 2020;41:383-91. doi:10.1093/eurheartj/ehz520.Prati F, Romagnoli E, Gatto L, et al. Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: the CLIMA study. Eur Heart J. 2020;41:383-91. doi:10.1093/eurheartj/ehz520.Kedhi E, Berta B, Roleder T, et al. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial. Eur Heart J. 2021 Dec 1;42(45):4671-4679. doi:10.1093/eurheartj/ehab433.Kedhi E, Berta B, Roleder T, et al. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve: the COMBINE OCT-FFR trial. Eur Heart J. 2021 Dec 1;42(45):4671-4679. doi:10.1093/eurheartj/ehab433.Tarkin JM, Dweck MR, Evans NR, et al. Imaging Atherosclerosis. Circ Res. 2016;118:750-69. doi: 10.1161/CIRCRESAHA.115.306247.Tarkin JM, Dweck MR, Evans NR, et al. Imaging Atherosclerosis. Circ Res. 2016;118:750-69. doi: 10.1161/CIRCRESAHA.115.306247.Sugane H, Kataoka Y, Otsuka F, Yasuda S. Cholesterol-crystalized coronary atheroma as a potential precursor lesion causing acute coronary syndrome: a case report. Eur Heart J Case Rep. 2019;3:ytz128. doi:10.1093/ehjcr/ytz128.Sugane H, Kataoka Y, Otsuka F, Yasuda S. Cholesterol-crystalized coronary atheroma as a potential precursor lesion causing acute coronary syndrome: a case report. Eur Heart J Case Rep. 2019;3:ytz128. doi:10.1093/ehjcr/ytz128.Kini AS, Vengrenyuk Y, Yoshimura T, et al. Fibrous Cap Thickness by Optical Coherence Tomography In Vivo. J Am Coll Cardiol. 2017;69:644-57 doi:10.1016/j.jacc.2016.10.028.Kini AS, Vengrenyuk Y, Yoshimura T, et al. Fibrous Cap Thickness by Optical Coherence Tomography In Vivo. J Am Coll Cardiol. 2017;69:644-57 doi:10.1016/j.jacc.2016.10.028.Jia H, Abtahian F, Aguirre AD, et al. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;62:1748-58. doi:10.1016/j.jacc.2013.05.071.27 Jia H, Abtahian F, Aguirre AD, et al. In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol. 2013;62:1748-58. doi:10.1016/j.jacc.2013.05.071.Okamura T, Onuma Y, Garcia-Garcia HM, et al. First-in-man evaluation of intravascular optical frequency domain imaging (OFDI) of Terumo: A comparison with intravascular ultrasound and quantitative coronary angiography. EuroIntervention. 2011;6:1037-45. doi:10.4244/EIJV6I9A182.Okamura T, Onuma Y, Garcia-Garcia HM, et al. First-in-man evaluation of intravascular optical frequency domain imaging (OFDI) of Terumo: A comparison with intravascular ultrasound and quantitative coronary angiography. EuroIntervention. 2011;6:1037-45. doi:10.4244/EIJV6I9A182.Кочергин Н.А., Кочергина А. М., Ганюков В. И., Барбараш О. Л. Нестабильные атеросклеротические бляшки коронарных артерий у пациентов со стабильной ишемической болезнью сердца. Комплексные проблемы сердечно-сосудистых заболеваний. 2018;7(3):65-71. doi: 10.17802/2306-1278-2018-7-3-65-71.Kochergin NA, Kochergina AM, Ganjukov VI, Barbarash OL. Vulnerable atherosclerotic plaques of coronary arteries in patients with stable coronary artery disease. Complex Issues of Cardiovascular Diseases. 2018;7(3):65-71. (In Russ.) doi: 10.17802/2306-1278-2018-7-3-65-71.Sawada T, Shite J, Garcia-Garcia HM, et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma. Eur Heart J. 2008;29:1136-46. doi:10.1093/eurheartj/ehn132.Sawada T, Shite J, Garcia-Garcia HM, et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma. Eur Heart J. 2008;29:1136-46. doi:10.1093/eurheartj/ehn132.

The authors declare that there are no conflicts of interest present.