<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2021-2953</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-2953</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>COVID-19 и сердечно-сосудистая коморбидность: поиск новых подходов к снижению смертности</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19 and cardiovascular comorbidity: novel approaches to reduce mortality</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8430-6215</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бунова</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bunova</surname><given-names>S. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Сергеевна Бунова — доктор медицинских наук, профессор кафедры семейной медицины</p></bio><bio xml:lang="en"><p>Bunova Svetlana Sergeevna - Doctor of Medical Sciences, Professor, Professor at the Department of Family Medicine</p></bio><email xlink:type="simple">ssbunova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5330-4783</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Охотникова</surname><given-names>П. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Okhotnikova</surname><given-names>P. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полина Игоревна Охотникова — ординатор кафедры факультетской терапии и гастроэнтерологии</p></bio><bio xml:lang="en"><p>Okhotnikova Polynya Igorevna - Resident in cardiology of the Department of Faculty Therapy and Gastroenterology</p></bio><email xlink:type="simple">PolyaZ-13_17@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6225-2444</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скирденко</surname><given-names>Ю. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Skirdenko</surname><given-names>Yu. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Петровна Скирденко — кандидат медицинских наук, доцент кафедры факультетской терапии и гастроэнтерологии</p></bio><bio xml:lang="en"><p>Skirdenko Yuliya Petrovna - Candidate of Medical Sciences, Associate Professor at the Department of Faculty Therapy and Gastroenterology</p></bio><email xlink:type="simple">julija-loseva1@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3758-4930</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николай Анатольевич Николаев — доктор медицинских наук, доцент, профессор кафедры факультетской терапии и гастроэнтерологии</p></bio><bio xml:lang="en"><p>Nikolaev Nikolay Anatol'evich - Doctor of Medical Sciences, Docent, Professor at the Department of Faculty Therapy and Gastroenterology. </p></bio><email xlink:type="simple">niknik.67@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7321-6529</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осипова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Osipova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Александровна Осипова — доктор медицинских наук, профессор кафедры госпитальной терапии Медицинского института</p></bio><bio xml:lang="en"><p>Osipova Olga Aleksandrovna - Department of  Hospital Therapy, Doctor of Medical Sciences, Professor</p></bio><email xlink:type="simple">osipova@bsu.edu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7648-0774</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жернакова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhernakova</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нина Ивановна Жернакова — доктор медицинских наук, профессор, зав. кафедрой семейной медицины.</p><p>Тел.: +7 (915) 560-59-90</p></bio><bio xml:lang="en"><p>Zhernakova Nina Ivanovna - Doctor of Medical Sciences, Professor, Head of the Department of Family Medicine</p></bio><email xlink:type="simple">Zhernakova@bsu.edu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Белгородский национальный исследовательский университет</institution></aff><aff xml:lang="en"><institution>Belgorod State University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО Омский государственный медицинский университет Минздрава России</institution></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО Омский государственный медицинский университет Минздрава России</institution></aff><aff xml:lang="en"><institution>Omsk State Medical University Omsk</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>07</month><year>2021</year></pub-date><volume>20</volume><issue>4</issue><fpage>2953</fpage><lpage>2953</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бунова С.С., Охотникова П.И., Скирденко Ю.П., Николаев Н.А., Осипова О.А., Жернакова Н.И., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Бунова С.С., Охотникова П.И., Скирденко Ю.П., Николаев Н.А., Осипова О.А., Жернакова Н.И.</copyright-holder><copyright-holder xml:lang="en">Bunova S.S., Okhotnikova P.I., Skirdenko Y.P., Nikolaev N.A., Osipova O.A., zhernakova N.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/2953">https://cardiovascular.elpub.ru/jour/article/view/2953</self-uri><abstract><p>Сердечно-сосудистые заболевания (ССЗ) остаются ведущей причиной смерти во всем мире и оказывают значимое влияние на качество жизни пациентов и социально-экономические аспекты. Многочисленные отчеты неизменно демонстрируют, что болезни системы кровообращения являются одним из основных факторов риска увеличения тяжести новой коронавирусной инфекции (COVID-19, CoronaVIrus Disease 2019), включая более высокие риски госпитализаций и внутрибольничной смертности. В условиях текущей пандемии сопровождение пациентов с кардиоваскулярной патологией требует особо пристального внимания врачей. В настоящее время появляется все больше сообщений о долгосрочных эффектах COVID-19. Отдаленные последствия заболевания для здоровья сердечно-сосудистой системы миллионов людей, переживших инфекцию, в настоящий момент неизвестны. Цель обзора — систематизация накопленных знаний о взаимном влиянии COVID-19 и ССЗ. Рассматриваются особенности воздействия ССЗ на течение и исходы COVID-19, причины ухудшения течения кардиоваскулярной патологии у больных коронавирусной инфекцией. Обсуждается влияние перераспределения ресурсов здравоохранения и масштабных мер изоляции на курацию пациентов с ССЗ. Также в обзоре представлены наиболее актуальные данные о постковидном синдроме. Выделены предикторы затяжного течения заболевания для стратификации риска с целью своевременной реализации профилактических мер и разработки индивидуализированного лечения. Авторы были сосредоточены на поиске новых подходов к снижению смертности от ССЗ в условиях пандемии.</p></abstract><trans-abstract xml:lang="en"><p>Cardiovascular diseases (CVDs) remain the leading cause of death worldwide and significantly affect patient quality of life and socioeconomic status. Numerous reports consistently demonstrate that CVDs are a major risk factor for severe course of coronavirus disease 2019 (COVID-19), including higher risks of hospitalizations and inpatient mortality. In the context of the current pandemic, managing patients with CVDs requires special attention from doctors. There are now more and more reports of the long-term effects of COVID-19. The long-term effects on cardiovascular system of millions of COVID-19 survivors are currently unknown. The aim of the review was to systematize the accumulated knowledge about the mutual influence of COVID-19 and CVDs. The features of CVD impact on the course and outcomes of COVID-19, as well as the reasons for the worsening of CVD course in patients with COVID-19 are considered. The impact of redistribution of health care resources and large-scale isolation measures on the management of patients with CVDs is discussed. The review also presents the most relevant data on long COVID. Predictors of a long-term disease course were identified for risk stratification in order to timely implement preventive measures and develop an individualized treatment. The authors focused on finding novel approaches to reduce CVD mortality during a pandemic.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>коронавирусная инфекция</kwd><kwd>COVID-19</kwd><kwd>SARSCoV-2</kwd><kwd>постковидный синдром</kwd><kwd>коморбидность</kwd><kwd>заболевания сердечно-сосудистой системы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronavirus infection</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>long COVID</kwd><kwd>comorbidity</kwd><kwd>cardiovascular diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">JHU. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. https://coronavirus.jhu.edu/map.html (11 June 2021).</mixed-citation><mixed-citation xml:lang="en">JHU. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. https://coronavirus.jhu.edu/map.html (11 June 2021).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Министерство здравоохранения Российской Федерации. Карта распространения коронавируса в стране. https://covid19.rosminzdrav.ru (11 июня 2021).</mixed-citation><mixed-citation xml:lang="en">Ministry of Health of the Russian Federation. Map of the spread of coronavirus in the country. (In Russ.) Министерство здравоохранения Российской Федерации. Карта распространения коронавируса в стране. https://covid19.rosminzdrav.ru (11 июня 2021).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мамедов М. Н., Родионова Ю.В., Явелов И.С. и др. Коронавирусная инфекция с точки зрения междисциплинарного подхода. Круглый стол. Кардиоваскулярная терапия и профилактика. 2021;20(3):2849. doi:10.15829/1728-8800-2021-2849.</mixed-citation><mixed-citation xml:lang="en">Mamedov MN, Rodionova YuV, Yavelov IS, et al. COVID-19 from the interdisciplinary standpoint. Round table. Cardiovascular Therapy and Prevention. 2021;20(3):2849. (In Russ.) doi:10.15829/1728-8800-2021-2849.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О. М., Карпов О. Э., Лукьянов М. М. и др. Проспективный госпитальный регистр больных с предполагаемыми или подтвержденными коронавирусной инфекцией COVID-19 и внебольничной пневмонией (ТАРГЕТ-ВИП): характеристика включенных больных и оценка исходов стационарного этапа лечения. Кардиоваскулярная терапия и профилактика. 2020;19(6):2727. doi:10.15829/1728-8800-2020-2727.</mixed-citation><mixed-citation xml:lang="en">Drapkina OM, Karpov OE, Lukyanov MM, et al. Prospective inhospital registry of patients with suspected or documented COVID-19 infection and community-acquired pneumonia (TARGET-VIP): characteristics of patients and assessment of in-hospital outcomes. Cardiovascular Therapy and Prevention. 2020;19(6):2727. (In Russ.) doi:10.15829/1728-8800-2020-2727.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pranata R, Huang I, Lim MA, et al. Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression. J Stroke Cerebrovasc Dis. 2020;29(8):104949. doi:10.1016/j.jstrokecerebrovasdis.2020.104949.</mixed-citation><mixed-citation xml:lang="en">Pranata R, Huang I, Lim MA, et al. Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression. J Stroke Cerebrovasc Dis. 2020;29(8):104949. doi:10.1016/j.jstrokecerebrovasdis.2020.104949.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Noor FM, Islam MM. Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis. J Community Health. 2020;45(6):1270-82. doi:10.1007/s10900-020-00920-x.</mixed-citation><mixed-citation xml:lang="en">Noor FM, Islam MM. Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis. J Community Health. 2020;45(6):1270-82. doi:10.1007/s10900-020-00920-x.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Liu PP, Blet A, Smyth D, Li H. The Science Underlying COVID-19. Circulation. 2020;142(1):68-78. doi:10.1161/CIRCULATIONAHA.120.047549.</mixed-citation><mixed-citation xml:lang="en">Liu PP, Blet A, Smyth D, Li H. The Science Underlying COVID-19. Circulation. 2020;142(1):68-78. doi:10.1161/CIRCULATIONAHA.120.047549.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральная служба государственной статистики. Оперативные демографические показатели за январь-октябрь 2020 г. https://rosstat.gov.ru/folder/12781</mixed-citation><mixed-citation xml:lang="en">Federal state statistics service. Operational demographic indicators for January — October 2020. (11 June 2021). (In Russ.) https://rosstat.gov.ru/folder/12781</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Woolley I. Coronavirus disease 2019 (COVID-19): not one epidemic but four. Intern Med J. 2020;50(6):657-8. doi:10.1111/imj.14866.</mixed-citation><mixed-citation xml:lang="en">Woolley I. Coronavirus disease 2019 (COVID-19): not one epidemic but four. Intern Med J. 2020;50(6):657-8. doi:10.1111/imj.14866.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Butt JH, Fosbøl EL, Gerds T, et al. All-cause mortality and location of death in patients with established cardiovascular disease before, during, and after the COVID-19 lockdown: a Danish Nationwide Cohort Study. Eur Heart J. 2021;ehab028. doi:10.1093/eurheartj/ehab028.</mixed-citation><mixed-citation xml:lang="en">Butt JH, Fosbøl EL, Gerds T, et al. All-cause mortality and location of death in patients with established cardiovascular disease before, during, and after the COVID-19 lockdown: a Danish Nationwide Cohort Study. Eur Heart J. 2021;ehab028. doi:10.1093/eurheartj/ehab028.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Halpin SJ, McIvor C, Whyatt G, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021;93(2):1013-22. doi:10.1002/jmv.26368.</mixed-citation><mixed-citation xml:lang="en">Halpin SJ, McIvor C, Whyatt G, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2021;93(2):1013-22. doi:10.1002/jmv.26368.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052. doi:10.1001/jama.2020.6775.</mixed-citation><mixed-citation xml:lang="en">Richardson S, Hirsch JS, Narasimhan M, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020;323(20):2052. doi:10.1001/jama.2020.6775.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">O’Hearn M, Liu J, Cudhea F, et al. Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis. J Am Heart Assoc. 2021;10(5). doi:10.1161/JAHA.120.019259.</mixed-citation><mixed-citation xml:lang="en">O’Hearn M, Liu J, Cudhea F, et al. Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis. J Am Heart Assoc. 2021;10(5). doi:10.1161/JAHA.120.019259.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Арутюнов Г. П., Тарловская Е. И., Арутюнов А. Г. и др. Международный регистр “Анализ динамики Коморбидных заболеваний у пациентов, перенесшИхинфицироВание SARS-CoV-2” (AКТИВ SARS-CoV-2): анализ предикторов неблагоприятных исходов острой стадии новой коронавирусной инфекции. Российский кардиологический журнал. 2021;26(4):4470. doi:10.15829/1560-4071-2021-4470.</mixed-citation><mixed-citation xml:lang="en">Arutyunov GP, Tarlovskaya EI, Arutyunov AG, et al. International register “Dynamics analysis of comorbidities in SARS-CoV-2 survivors” (AKTIV SARS-CoV-2): analysis of predictors of short-term adverse outcomes in COVID-19. Russ J Cardiol. 2021;26(4):4470. (In Russ.) doi:10.15829/1560-4071-2021-4470.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802. doi:10.1001/jamacardio.2020.0950.</mixed-citation><mixed-citation xml:lang="en">Shi S, Qin M, Shen B, et al. Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802. doi:10.1001/jamacardio.2020.0950.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, et al. Clinical characteristics of patients hospitalized with COVID-19 in Spain: results from the SEMI-COVID-19 Registry. Rev Clínica Española (English Ed). 2020;220(8):480-94. doi:10.1016/j.rceng.2020.07.003.</mixed-citation><mixed-citation xml:lang="en">Casas-Rojo JM, Antón-Santos JM, Millán-Núñez-Cortés J, et al. Clinical characteristics of patients hospitalized with COVID-19 in Spain: results from the SEMI-COVID-19 Registry. Rev Clínica Española (English Ed). 2020;220(8):480-94. doi:10.1016/j.rceng.2020.07.003.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hessami A, Shamshirian A, Heydari K, et al. Cardiovascular diseases burden in COVID-19: Systematic review and metaanalysis. Am J Emerg Med. 2020. doi:10.1016/j.ajem.2020.10.022.</mixed-citation><mixed-citation xml:lang="en">Hessami A, Shamshirian A, Heydari K, et al. Cardiovascular diseases burden in COVID-19: Systematic review and metaanalysis. Am J Emerg Med. 2020. doi:10.1016/j.ajem.2020.10.022.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gu T, Chu Q, Yu Z, et al. History of coronary heart disease increased the mortality rate of patients with COVID-19: a nested case-control study. BMJ Open. 2020;10(9):e038976. doi:10.1136/bmjopen-2020-038976.</mixed-citation><mixed-citation xml:lang="en">Gu T, Chu Q, Yu Z, et al. History of coronary heart disease increased the mortality rate of patients with COVID-19: a nested case-control study. BMJ Open. 2020;10(9):e038976. doi:10.1136/bmjopen-2020-038976.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Yang H, Liang X, Xu J, et al. Meta-Analysis of Atrial Fibrillation in Patients With COVID-19. Am J Cardiol. 2021;144:152-6. doi:10.1016/j.amjcard.2021.01.010.</mixed-citation><mixed-citation xml:lang="en">Yang H, Liang X, Xu J, et al. Meta-Analysis of Atrial Fibrillation in Patients With COVID-19. Am J Cardiol. 2021;144:152-6. doi:10.1016/j.amjcard.2021.01.010.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kytömaa S, Hegde S, Claggett B, et al. Association of Influenzalike Illness Activity With Hospitalizations for Heart Failure. JAMA Cardiol. 2019;4(4):363. doi:10.1001/jamacardio.2019.0549.</mixed-citation><mixed-citation xml:lang="en">Kytömaa S, Hegde S, Claggett B, et al. Association of Influenzalike Illness Activity With Hospitalizations for Heart Failure. JAMA Cardiol. 2019;4(4):363. doi:10.1001/jamacardio.2019.0549.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Yonas E, Alwi I, Pranata R, et al. Effect of heart failure on the outcome of COVID-19 — A meta-analysis and systematic review. Am J Emerg Med. 2020;S0735-6757(20)30602-1. doi:10.1016/j.ajem.2020.07.009.</mixed-citation><mixed-citation xml:lang="en">Yonas E, Alwi I, Pranata R, et al. Effect of heart failure on the outcome of COVID-19 — A meta-analysis and systematic review. Am J Emerg Med. 2020;S0735-6757(20)30602-1. doi:10.1016/j.ajem.2020.07.009.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ayoubkhani D, Khunti K, Nafilyan V, et al. Epidemiology of postCOVID syndrome following hospitalisation with coronavirus: a retrospective cohort study. MedRxiv. 2021. doi:10.1101/2021.01.15.21249885.</mixed-citation><mixed-citation xml:lang="en">Ayoubkhani D, Khunti K, Nafilyan V, et al. Epidemiology of postCOVID syndrome following hospitalisation with coronavirus: a retrospective cohort study. MedRxiv. 2021. doi:10.1101/2021.01.15.21249885.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lindner D, Fitzek A, Bräuninger H, et al. Association of Cardiac Infection with SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol. 2020;5(11):1281-5. doi:10.1001/jamacardio.2020.3551.</mixed-citation><mixed-citation xml:lang="en">Lindner D, Fitzek A, Bräuninger H, et al. Association of Cardiac Infection with SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases. JAMA Cardiol. 2020;5(11):1281-5. doi:10.1001/jamacardio.2020.3551.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Chung MK, Zidar DA, Bristow MR, et al. COVID-19 and Cardiovascular Disease. Circ Res. 2021;128(8):1214-36. doi:10.1161/CIRCRESAHA.121.317997.</mixed-citation><mixed-citation xml:lang="en">Chung MK, Zidar DA, Bristow MR, et al. COVID-19 and Cardiovascular Disease. Circ Res. 2021;128(8):1214-36. doi:10.1161/CIRCRESAHA.121.317997.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5.</mixed-citation><mixed-citation xml:lang="en">Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Yokota S, Kuroiwa Y, Nishioka K Novel coronavirus disease (COVID-19) and cytokine storms. For more effective treatments from the viewpoints of an inflammatory pathophysiology perspective. Infect Dis News, Opin Train. 2020;9(4):13-25. doi:10.33029/2305-3496-2020-9-4-13-25.</mixed-citation><mixed-citation xml:lang="en">Yokota S, Kuroiwa Y, Nishioka K Novel coronavirus disease (COVID-19) and cytokine storms. For more effective treatments from the viewpoints of an inflammatory pathophysiology perspective. Infect Dis News, Opin Train. 2020;9(4):13-25. doi:10.33029/2305-3496-2020-9-4-13-25.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ. Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19). Mayo Clin Proc. 2020;95(6):1213-21. doi:10.1016/j.mayocp.2020.03.024.</mixed-citation><mixed-citation xml:lang="en">Giudicessi JR, Noseworthy PA, Friedman PA, Ackerman MJ. Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19). Mayo Clin Proc. 2020;95(6):1213-21. doi:10.1016/j.mayocp.2020.03.024.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sardu C, Gambardella J, Morelli MB, et al. Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence. J Clin Med. 2020;9(5):1417. doi:10.3390/jcm9051417.</mixed-citation><mixed-citation xml:lang="en">Sardu C, Gambardella J, Morelli MB, et al. Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence. J Clin Med. 2020;9(5):1417. doi:10.3390/jcm9051417.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Siripanthong B, Nazarian S, Muser D, et al. Recognizing COVID-19 — related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Hear Rhythm. 2020;17(9):1463-71. doi:10.1016/j.hrthm.2020.05.001.</mixed-citation><mixed-citation xml:lang="en">Siripanthong B, Nazarian S, Muser D, et al. Recognizing COVID-19 — related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Hear Rhythm. 2020;17(9):1463-71. doi:10.1016/j.hrthm.2020.05.001.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Puntmann VO, Carerj ML, Wieters I, et al. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020;5(11):1265. doi:10.1001/jamacardio.2020.3557.</mixed-citation><mixed-citation xml:lang="en">Puntmann VO, Carerj ML, Wieters I, et al. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020;5(11):1265. doi:10.1001/jamacardio.2020.3557.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Кактурский Л. В., Михалева Л. М., Мишнев О. Д. и др. Синдром Такоцубо (стресс-индуцированная кардиомиопатия). Архив патологии. 2021;83(1):5-11. doi:10.17116/patol2021830115.</mixed-citation><mixed-citation xml:lang="en">Kakturskiy LV, Mikhaleva LM, Mishnev OD, et al. Takotsubo syndrome (stress-induced cardiomyopathy). Arkh Patol. 2021;83(1):5. (In Russ.) doi:10.17116/patol2021830115.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Jabri A, Kalra A, Kumar A, et al. Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic. JAMA Netw Open. 2020;3(7):e2014780. doi:10.1001/jamanetworkopen.2020.14780.</mixed-citation><mixed-citation xml:lang="en">Jabri A, Kalra A, Kumar A, et al. Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic. JAMA Netw Open. 2020;3(7):e2014780. doi:10.1001/jamanetworkopen.2020.14780.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kotecha T, Knight DS, Razvi Y, et al. Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance. Eur Heart J. 2021;42(19):1866-1878. doi:10.1093/eurheartj/ehab075.</mixed-citation><mixed-citation xml:lang="en">Kotecha T, Knight DS, Razvi Y, et al. Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance. Eur Heart J. 2021;42(19):1866-1878. doi:10.1093/eurheartj/ehab075.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Tersalvi G, Winterton D, Cioffi GM, et al. Telemedicine in Heart Failure During COVID-19: A Step Into the Future. Front Cardiovasc Med. 2020;7:612818. doi:10.3389/fcvm.2020.612818.</mixed-citation><mixed-citation xml:lang="en">Tersalvi G, Winterton D, Cioffi GM, et al. Telemedicine in Heart Failure During COVID-19: A Step Into the Future. Front Cardiovasc Med. 2020;7:612818. doi:10.3389/fcvm.2020.612818.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Einstein AJ, Shaw LJ, Hirschfeld C, et al. International Impact of COVID-19 on the Diagnosis of Heart Disease. J Am Coll Cardiol. 2021;77(2):173-85. doi:10.1016/j.jacc.2020.10.054.</mixed-citation><mixed-citation xml:lang="en">Einstein AJ, Shaw LJ, Hirschfeld C, et al. International Impact of COVID-19 on the Diagnosis of Heart Disease. J Am Coll Cardiol. 2021;77(2):173-85. doi:10.1016/j.jacc.2020.10.054.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">De Rosa S, Spaccarotella C, Basso C, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J. 2020;41(22):2083-8. doi:10.1093/eurheartj/ehaa409.</mixed-citation><mixed-citation xml:lang="en">De Rosa S, Spaccarotella C, Basso C, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J. 2020;41(22):2083-8. doi:10.1093/eurheartj/ehaa409.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Бунова С. С., Жернакова Н. И., Федорин М. М. и др. Эффективная антигипертензивная терапия: фокус на управление приверженностью. Кардиоваскулярная терапия и профилактика. 2020;19(5):2663. doi:10.15829/1728-8800-2020-2663.</mixed-citation><mixed-citation xml:lang="en">Bunova SS, Zhernakova NI, Fedorin MM, et al. Effective antihypertensive therapy: focus on adherence management. Cardiovascular Therapy and Prevention. 2020;19(5):2663. (In Russ.) doi:10.15829/1728-8800-2020-2663.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С. Ю., Кутишенко Н. П., Лукина Ю. В. и др. Самоконтроль и лечение хронических неинфекционных заболеваний в условиях пандемии COVID-19. Консенсус экспертов Национального общества доказательной фармакотерапии и Российского общества профилактики неинфекционных заболеваний. Кардиоваскулярная терапия и профилактика. 2020;19(3):2567. doi:10.15829/1728-8800-2020-2567.</mixed-citation><mixed-citation xml:lang="en">Martsevich SYu, Kutishenko NP, Lukina YuV, et al. Self-monitoring and treatment of chronic non-communicable diseases in the context of the COVID-19 pandemic. Consensus of experts of the National society of evidence-based pharmacotherapy and the Russian society of the prevention of non-communicable diseases. Cardiovascular Therapy and Prevention. 2020;19(3):2567. (In Russ.) doi:10.15829/1728-8800-2020-2567.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Vervoort D, Luc JGY, Percy E, et al. Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era. Ann Thorac Surg. 2020;110(3):757-60. doi:10.1016/j.athoracsur.2020.04.015.</mixed-citation><mixed-citation xml:lang="en">Vervoort D, Luc JGY, Percy E, et al. Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era. Ann Thorac Surg. 2020;110(3):757-60. doi:10.1016/j.athoracsur.2020.04.015.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">COVID-19 rapid guideline: managing the long-term effects of COVID-19. London: National Institute for Health and Care Excellence (UK). https://www.nice.org.uk/guidance/ng188 (11 June 2021).</mixed-citation><mixed-citation xml:lang="en">COVID-19 rapid guideline: managing the long-term effects of COVID-19. London: National Institute for Health and Care Excellence (UK). https://www.nice.org.uk/guidance/ng188 (11 June 2021).</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220-32. doi:10.1016/S0140-6736(20)32656-8.</mixed-citation><mixed-citation xml:lang="en">Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220-32. doi:10.1016/S0140-6736(20)32656-8.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Tenforde MW, Kim SS, Lindsell CJ, et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020. MMWR Morb Mortal Wkly Rep. 2020;69(30):993-8. doi:10.15585/mmwr.mm6930e1.</mixed-citation><mixed-citation xml:lang="en">Tenforde MW, Kim SS, Lindsell CJ, et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020. MMWR Morb Mortal Wkly Rep. 2020;69(30):993-8. doi:10.15585/mmwr.mm6930e1.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Menni C, Valdes AM, Freidin MB, et al. Real-time tracking of selfreported symptoms to predict potential COVID-19. Nat Med. 2020;26(7):1037-40. doi:10.1038/s41591-020-0916-2.</mixed-citation><mixed-citation xml:lang="en">Menni C, Valdes AM, Freidin MB, et al. Real-time tracking of selfreported symptoms to predict potential COVID-19. Nat Med. 2020;26(7):1037-40. doi:10.1038/s41591-020-0916-2.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sudre CH, Murray B, Varsavsky T, et al. Attributes and predictors of long COVID. Nat Med. 2021;27(4):626-31. doi:10.1038/s41591-021-01292-y.</mixed-citation><mixed-citation xml:lang="en">Sudre CH, Murray B, Varsavsky T, et al. Attributes and predictors of long COVID. Nat Med. 2021;27(4):626-31. doi:10.1038/s41591-021-01292-y.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Carfì A, Bernabei R, Landi F. Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020;324(6):603. doi:10.1001/jama.2020.12603.</mixed-citation><mixed-citation xml:lang="en">Carfì A, Bernabei R, Landi F. Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020;324(6):603. doi:10.1001/jama.2020.12603.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Yancy CW, Fonarow GC. Coronavirus Disease 2019 (COVID-19) and the Heart — Is Heart Failure the Next Chapter? JAMA Cardiol. 2020;5(11):1216. doi:10.1001/jamacardio.2020.3575.</mixed-citation><mixed-citation xml:lang="en">Yancy CW, Fonarow GC. Coronavirus Disease 2019 (COVID-19) and the Heart — Is Heart Failure the Next Chapter? JAMA Cardiol. 2020;5(11):1216. doi:10.1001/jamacardio.2020.3575.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Starfield B, Shi L, Macinko J. Contribution of Primary Care to Health Systems and Health. Milbank Q. 2005;83(3):457-502. doi:10.1111/j.1468-0009.2005.00409.x.</mixed-citation><mixed-citation xml:lang="en">Starfield B, Shi L, Macinko J. Contribution of Primary Care to Health Systems and Health. Milbank Q. 2005;83(3):457-502. doi:10.1111/j.1468-0009.2005.00409.x.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Greenhalgh T, Knight M, A’Court C, et al. Management of postacute COVID-19 in primary care. BMJ. 2020:m3026. doi:10.1136/bmj.m3026.</mixed-citation><mixed-citation xml:lang="en">Greenhalgh T, Knight M, A’Court C, et al. Management of postacute COVID-19 in primary care. BMJ. 2020:m3026. doi:10.1136/bmj.m3026.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Needham DM, Davidson J, Cohen H, et al. Improving long-term outcomes after discharge from intensive care unit. Crit Care Med. 2012;40(2):502-9. doi:10.1097/CCM.0b013e318232da75.</mixed-citation><mixed-citation xml:lang="en">Needham DM, Davidson J, Cohen H, et al. Improving long-term outcomes after discharge from intensive care unit. Crit Care Med. 2012;40(2):502-9. doi:10.1097/CCM.0b013e318232da75.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kamdar BB, Suri R, Suchyta MR, et al. Return to work after critical illness: a systematic review and meta-analysis. Thorax. 2020;75(1):17-27. doi:10.1136/thoraxjnl-2019-213803.</mixed-citation><mixed-citation xml:lang="en">Kamdar BB, Suri R, Suchyta MR, et al. Return to work after critical illness: a systematic review and meta-analysis. Thorax. 2020;75(1):17-27. doi:10.1136/thoraxjnl-2019-213803.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Bhala N, Curry G, Martineau AR, et al. Sharpening the global focus on ethnicity and race in the time of COVID-19. Lancet. 2020;395(10238):1673-6. doi:10.1016/S0140-6736(20)31102-8.</mixed-citation><mixed-citation xml:lang="en">Bhala N, Curry G, Martineau AR, et al. Sharpening the global focus on ethnicity and race in the time of COVID-19. Lancet. 2020;395(10238):1673-6. doi:10.1016/S0140-6736(20)31102-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
