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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2016-1-69-72</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-309</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Микробиота кишечника и факторы кардиоваскулярного риска. Часть IV. Артериальная гипертония, курение и микробиота кишечника</article-title><trans-title-group xml:lang="en"><trans-title>Gut microbiota and cardiovascular risk factors. Part IV. Arterial hypertension, smoking and the gut microbiota</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каштанова</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashtanova</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">dr.kashtanova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">tkacheva@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бойцов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Boytsov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">prof-boytsov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Государственный научно-исследовательский центр профилактической медицины» Минздрава России. Москва</institution></aff><aff xml:lang="en"><institution>National Research Center for Preventive Medicine of the Ministry of Health. Moscow, Russia</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2016</year></pub-date><volume>15</volume><issue>1</issue><fpage>69</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каштанова Д.А., Ткачева О.Н., Бойцов С.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Каштанова Д.А., Ткачева О.Н., Бойцов С.А.</copyright-holder><copyright-holder xml:lang="en">Kashtanova D.A., Tkacheva O.N., Boytsov S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/309">https://cardiovascular.elpub.ru/jour/article/view/309</self-uri><abstract><p>Накопленный опыт в исследовании влияния на человека его кишечной микробиоты открывает новые горизонты для дальнейшего изучения и трансляции в практическую медицину новых методов воздействия на организм в целом и на отдельные системы в частности посредством коррекции состояния кишечной микробиоты. В предыдущих обзорах цикла были представлены новые сведения о взаимосвязи микробиоты кишечника с основными факторами сердечно-сосудистого риска. Заключительная статья в цикле «Микробиота кишечника и факторы кардиоваскулярного риска» посвящена современным представлениям о взаимосвязи состояния микробиоты кишечника и артериальной гипертонии, а также о влиянии курения на микробиоту кишечника. В статье описаны результаты работ по влиянию молочнокислых бактерий и короткоцепочечных жирных кислот на артериальное давление, а также по воздействию курения на микробиоту кишечника.</p></abstract><trans-abstract xml:lang="en"><p>The collected data on the interaction of human-as-host and their gut microbiota reveals new opportunities for further investigation and translation to practice the novel methods of the body influence in whole and on separate systems, particularly via correction of gut microbiota condition. Previous reviews focused on recent data on the interaction of gut microbiota with the main cariovascular risk factors. Last article in this sequel focuses on the recent data on hypertension and condition of the gut microbiota, as on the influence of smoking on the gut microbiota. The article presents the results of investigations on the influence of short-chain fatty acids on arterial pressure, and on smoking impact on the gut microbiota.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>микробиота кишечника</kwd><kwd>артериальная гипертония</kwd><kwd>факторы риска сердечно-сосудистых заболеваний</kwd><kwd>курение</kwd><kwd>короткоцепочечные жирные кислоты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gut microbiota</kwd><kwd>arterial hypertension</kwd><kwd>cardiovascular risk factors</kwd><kwd>smoking</kwd><kwd>short-chain fatty acids</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gelfer M, Drouin D, Dawes M, et al. World Health Day: focusing on hypertension in 2013. Can Fam Physician 2013; 59(4): 341-2.</mixed-citation><mixed-citation xml:lang="en">Gelfer M, Drouin D, Dawes M, et al. World Health Day: focusing on hypertension in 2013. Can Fam Physician 2013; 59(4): 341-2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. WHO global report on mortality attributable to tobacco. 2012, Geneva: World Health Organization. 392 p.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. WHO global report on mortality attributable to tobacco. 2012, Geneva: World Health Organization. 392 p.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Y, Liu W, Xue J, et al., Angiotensin-converting enzyme inhibitory activity of Lactobacillus helveticus strains from traditional fermented dairy foods and antihypertensive effect of fermented milk of strain H9. J Dairy Sci 2014; 97(11): 6680-92.</mixed-citation><mixed-citation xml:lang="en">Chen Y, Liu W, Xue J, et al., Angiotensin-converting enzyme inhibitory activity of Lactobacillus helveticus strains from traditional fermented dairy foods and antihypertensive effect of fermented milk of strain H9. J Dairy Sci 2014; 97(11): 6680-92.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Qian B, Xing M, Cui L, et al. Antioxidant, antihypertensive, and immunomodulatory activities of peptide fractions from fermented skim milk with Lactobacillus delbrueckii ssp. bulgaricus LB340. J Dairy Res 2011; 78(1): 72-9.</mixed-citation><mixed-citation xml:lang="en">Qian B, Xing M, Cui L, et al. Antioxidant, antihypertensive, and immunomodulatory activities of peptide fractions from fermented skim milk with Lactobacillus delbrueckii ssp. bulgaricus LB340. J Dairy Res 2011; 78(1): 72-9.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jauhiainen T, Vapaatalo H, Poussa T, et al. Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement. Am J Hypertens 2005; 18(12 Pt 1): 1600-5.</mixed-citation><mixed-citation xml:lang="en">Jauhiainen T, Vapaatalo H, Poussa T, et al. Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement. Am J Hypertens 2005; 18(12 Pt 1): 1600-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jauhiainen T, Korpela R, Roennback M, et al. New use of therapeutically useful peptides. 2007, Patents WO2007132054 A1.</mixed-citation><mixed-citation xml:lang="en">Jauhiainen T, Korpela R, Roennback M, et al. New use of therapeutically useful peptides. 2007, Patents WO2007132054 A1.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cho YR, Chang JY, Chang HC. Production of gamma-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J Microbiol Biotechnol 2007; 17(1): 104-9.</mixed-citation><mixed-citation xml:lang="en">Cho YR, Chang JY, Chang HC. Production of gamma-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J Microbiol Biotechnol 2007; 17(1): 104-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mazzoli R, Pessione E, Dufour M, et al. Glutamate-induced metabolic changes in Lactococcus lactis NCDO 2118 during GABA production: combined transcriptomic and proteomic analysis. Amino Acids 2010; 39(3): 727-37.</mixed-citation><mixed-citation xml:lang="en">Mazzoli R, Pessione E, Dufour M, et al. Glutamate-induced metabolic changes in Lactococcus lactis NCDO 2118 during GABA production: combined transcriptomic and proteomic analysis. Amino Acids 2010; 39(3): 727-37.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003; 57(3): 490-5.</mixed-citation><mixed-citation xml:lang="en">Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003; 57(3): 490-5.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Penas E, Diana M, Frias J, et al. A multistrategic approach in the development of sourdough bread targeted towards blood pressure reduction. Plant Foods Hum Nutr 2015; 70(1): 97-103.</mixed-citation><mixed-citation xml:lang="en">Penas E, Diana M, Frias J, et al. A multistrategic approach in the development of sourdough bread targeted towards blood pressure reduction. Plant Foods Hum Nutr 2015; 70(1): 97-103.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ringel-Kulka T, Goldsmith JR, Carroll IM, et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther 2014; 40(2): 200-7.</mixed-citation><mixed-citation xml:lang="en">Ringel-Kulka T, Goldsmith JR, Carroll IM, et al. Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study. Aliment Pharmacol Ther 2014; 40(2): 200-7.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rousseaux C, Thuru X, Gelot A, et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat Med 2007; 13(1): 35-7.</mixed-citation><mixed-citation xml:lang="en">Rousseaux C, Thuru X, Gelot A, et al. Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors. Nat Med 2007; 13(1): 35-7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ebner J, Asci Arslan A, Fedorova M, et al. Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains. J Proteomics 2015; 117: 41-57.</mixed-citation><mixed-citation xml:lang="en">Ebner J, Asci Arslan A, Fedorova M, et al. Peptide profiling of bovine kefir reveals 236 unique peptides released from caseins during its production by starter culture or kefir grains. J Proteomics 2015; 117: 41-57.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Pluznick JL, Protzko RJ, Gevorgyan H, et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A 2013; 110(11): 4410-5.</mixed-citation><mixed-citation xml:lang="en">Pluznick JL, Protzko RJ, Gevorgyan H, et al. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci U S A 2013; 110(11): 4410-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pluznick J. A novel SCFA receptor, the microbiota, and blood pressure regulation. Gut Microbes 2014; 5(2): 202-7.</mixed-citation><mixed-citation xml:lang="en">Pluznick J. A novel SCFA receptor, the microbiota, and blood pressure regulation. Gut Microbes 2014; 5(2): 202-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res 2012; 91(2): 142-9.</mixed-citation><mixed-citation xml:lang="en">Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res 2012; 91(2): 142-9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H, Zhao JX, Hu N, et al. Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins. World J Gastroenterol 2012; 18(18): 2180-7.</mixed-citation><mixed-citation xml:lang="en">Wang H, Zhao JX, Hu N, et al. Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins. World J Gastroenterol 2012; 18(18): 2180-7.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Biedermann L, Zeitz J, Mwinyi J, et al. Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans. PLoS One 2013; 8(3): e59260.</mixed-citation><mixed-citation xml:lang="en">Biedermann L, Zeitz J, Mwinyi J, et al. Smoking cessation induces profound changes in the composition of the intestinal microbiota in humans. PLoS One 2013; 8(3): e59260.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Parkes GC, Whelan K, Lindsay JO. Smoking in inflammatory bowel disease: impact on disease course and insights into the aetiology of its effect. J Crohns Colitis 2014; 8(8): 717-25.</mixed-citation><mixed-citation xml:lang="en">Parkes GC, Whelan K, Lindsay JO. Smoking in inflammatory bowel disease: impact on disease course and insights into the aetiology of its effect. J Crohns Colitis 2014; 8(8): 717-25.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Derkinderen P, Shannon K.M, Brundin P. Gut feelings about smoking and coffee in Parkinson's disease. Mov Disord 2014; 29(8): 976-9.</mixed-citation><mixed-citation xml:lang="en">Derkinderen P, Shannon K.M, Brundin P. Gut feelings about smoking and coffee in Parkinson's disease. Mov Disord 2014; 29(8): 976-9.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
