cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2016-1-16-19cardiovascular-315Research ArticleХРОНИЧЕСКАЯ СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬCHRONIC HEART FAILUREВзаимосвязь процессов ремоделирования сердца с дисфункцией эндотелия у больных с хронической сердечной недостаточностьюRelation of the heart remodeling and endothelial dysfunction in chronic heart failure patientsАбдуллаеваЧ. А.AbdullaevaCh. A.charos27_81@mail.ruКамиловаУ. К.KamilovaU. K.

1.Tashkent Medical Academy. Tashkent; 2.Republic Specialized Scientific-Practical Medical Center for Internal Medicine and Medical Rehabilitation. Tashkent

umida_kamilova@mail.ruТашкентская медицинская академия. ТашкентTashkent Medical Academy. TashkentТашкентская медицинская академия. Ташкент; Республиканский специализиpованный научно-практический медицинский центp теpапии и медицинской реабилитации. ТашкентUzbekistan2016200220161511619Copyright © Абдуллаева Ч.А., Камилова У.К., 20162016Абдуллаева Ч.А., Камилова У.К.Abdullaeva C.A., Kamilova U.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/315Цель

Цель. Изучить взаимосвязь между процессами ремоделирования сердца и дисфункцией эндотелия у больных с хронической сердечной недостаточностью (ХСН).

Материал и методы

Материал и методы. Обследованы 103 больных с постинфарктным кардиосклерозом (ПИКС). Все больные были разделены на 3 группы по функциональному классу (ФК) ХСН: I группу составили 28 больных c ХСН I ФК, II группу – 46 больных II ФК и III группу – 29 больных с III ФК по классификации NYHA. Всем больным проводили эхокардиографию, допплерографию плечевой аpтеpии.

Результаты

Результаты. Постинфарктное ремоделирование левого желудочка (ЛЖ) приводило не только к структурной перестройке ЛЖ, сопровождаемой дилатацией полости, истончением стенок полости, снижением сократительной способности миокарда, но и к изменению геометрической формы ЛЖ. Снижение сократительной способности миокарда ЛЖ сопровождалось нарушением эндотелий-зависимой вазодилатации сосудов, характеризующихся увеличением пульсативного и резистивного индексов, снижением чувствительности плечевой артерии к напряжению сдвига.

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The authors declare that there are no conflicts of interest present.