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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2016-1-64-68</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-316</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Влияние анемии на течение сердечно-сосудистых заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>The influence of anemia on cardiovascular disease course</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будневский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budnevsky</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">budnev@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овсянников</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovsyannikov</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">ovses@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Редька</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Red`ka</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">ikdron2006@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Воронежский государственный медицинский университет им. Н. Н. Бурденко» Минздрава России. Воронеж</institution></aff><aff xml:lang="en"><institution>N. N. Burdenko Voronezh State Medical University. Voronezh, Russia</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2016</year></pub-date><volume>15</volume><issue>1</issue><fpage>64</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Будневский А.В., Овсянников Е.С., Редька А.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Будневский А.В., Овсянников Е.С., Редька А.В.</copyright-holder><copyright-holder xml:lang="en">Budnevsky A.V., Ovsyannikov E.S., Red`ka A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/316">https://cardiovascular.elpub.ru/jour/article/view/316</self-uri><abstract><p>Анемия, определяемая согласно рекомендациям Всемирной организации здравоохранения, как снижение уровня гемоглобина &lt;130 г/л у мужчин и 120 г/л у женщин, является независимым фактором риска сердечно-сосудистых заболеваний. Снижение уровня гемоглобина на 10 г/л увеличивает риск смертности от коронарной патологии. В обзоре описаны основные патофизиологические механизмы связи анемии и заболеваний сердечно-сосудистой системы, кратко приводятся результаты сравнительно недавних исследований в этой области, рассматривается их значение в клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>Anemia, defined by WHO guidelines as a decrease of hemoglobin level &lt;130 g/L in men and 120 g/L in women, is an independent risk factor for cardiovascular diseases. Hemoglobin level decrease by 10 g/L does increase risk of death from coronary pathology. The review focuses on the key pathophysiological mechanisms of anemia relation with cardiovascular diseases, the results briefly introduced, of comparably recent studies in this field, and their significance is treated for clinical practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>анемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>anemia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lipgic E, Asselbergs FW, van der Meer P, et al. Anaemia predicts cardiovascular events in patients with stable coronary artery disease. Netherlands Heart J 2005; 13: 254-8.</mixed-citation><mixed-citation xml:lang="en">Lipgic E, Asselbergs FW, van der Meer P, et al. Anaemia predicts cardiovascular events in patients with stable coronary artery disease. Netherlands Heart J 2005; 13: 254-8.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Naito Y, Tsujino T, Matsumoto M, et al. Adaptive response of the heart to long–term anemia induced by iron deficiency. Am J Physiol Heart Circ Physiol 2009; 296: 585-93.</mixed-citation><mixed-citation xml:lang="en">Naito Y, Tsujino T, Matsumoto M, et al. Adaptive response of the heart to long–term anemia induced by iron deficiency. Am J Physiol Heart Circ Physiol 2009; 296: 585-93.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson J, Glynn LG, Newell J, et al. The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study. BMC Cardiovascular Disorders 2009; 9: 51-8.</mixed-citation><mixed-citation xml:lang="en">Anderson J, Glynn LG, Newell J, et al. The impact of renal insufficiency and anaemia on survival in patients with cardiovascular disease: a cohort study. BMC Cardiovascular Disorders 2009; 9: 51-8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American college of cardiology foundation/american heart association task force on practice guidelines. JACC 2013; 62: 147-239.</mixed-citation><mixed-citation xml:lang="en">Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American college of cardiology foundation/american heart association task force on practice guidelines. JACC 2013; 62: 147-239.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Upadhya B, Ntim W, Brandon Stacey R, et al. Prolongation of QTc intervals and risk of death among patients with sickle cell disease. Eur J Haematol 2013; 91: 170-8.</mixed-citation><mixed-citation xml:lang="en">Upadhya B, Ntim W, Brandon Stacey R, et al. Prolongation of QTc intervals and risk of death among patients with sickle cell disease. Eur J Haematol 2013; 91: 170-8.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Anker SD, Voors A, Okonko D, et al. Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial. Eur Heart J 2009; 30: 1331-9.</mixed-citation><mixed-citation xml:lang="en">Anker SD, Voors A, Okonko D, et al. Prevalence, incidence, and prognostic value of anaemia in patients after an acute myocardial infarction: data from the OPTIMAAL trial. Eur Heart J 2009; 30: 1331-9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Young JB, Abraham WT, Albert NM, et al. Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry. Am J Cardiol 2008; 101: 223-30.</mixed-citation><mixed-citation xml:lang="en">Young JB, Abraham WT, Albert NM, et al. Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry. Am J Cardiol 2008; 101: 223-30.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Turner SJ, Ketch TR, Gandhi SK, et al. Routine hematologic clinical tests as prognosticmarkers in patients with acute coronary syndromes. Am Heart J 2008; 155: 806-16.</mixed-citation><mixed-citation xml:lang="en">Turner SJ, Ketch TR, Gandhi SK, et al. Routine hematologic clinical tests as prognosticmarkers in patients with acute coronary syndromes. Am Heart J 2008; 155: 806-16.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tang YD, Katz SD. Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options. Circulation 2006; 113: 2454-61.</mixed-citation><mixed-citation xml:lang="en">Tang YD, Katz SD. Anemia in chronic heart failure: prevalence, etiology, clinical correlates, and treatment options. Circulation 2006; 113: 2454-61.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Berry C, Hogg K, Norrie J, et al. Heart failure with preserved left ventricular systolic function: a hospital cohort study. Heart 2005; 91: 907-13.</mixed-citation><mixed-citation xml:lang="en">Berry C, Hogg K, Norrie J, et al. Heart failure with preserved left ventricular systolic function: a hospital cohort study. Heart 2005; 91: 907-13.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Detterich J, Noetzli L, Dorey F, et al. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol 2012; 87: 139-44.</mixed-citation><mixed-citation xml:lang="en">Detterich J, Noetzli L, Dorey F, et al. Electrocardiographic consequences of cardiac iron overload in thalassemia major. Am J Hematol 2012; 87: 139-44.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Westenbrink BD, Voors AA, de Boer RA, et al. Bone marrow dysfunction in chronic heart failure patients. Eur J Heart Failure 2010; 12: 676-84.</mixed-citation><mixed-citation xml:lang="en">Westenbrink BD, Voors AA, de Boer RA, et al. Bone marrow dysfunction in chronic heart failure patients. Eur J Heart Failure 2010; 12: 676-84.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Anand S. Anemia and chronic heart failure. JACC 2008; 52: 501-11.</mixed-citation><mixed-citation xml:lang="en">Anand S. Anemia and chronic heart failure. JACC 2008; 52: 501-11.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kazory Т, Ross EA. Anemia: the point of convergence or divergence for kidney disease and heart failure. JACC 2009; 53: 639-47.</mixed-citation><mixed-citation xml:lang="en">Kazory Т, Ross EA. Anemia: the point of convergence or divergence for kidney disease and heart failure. JACC 2009; 53: 639-47.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Jankowska EA, von Haehling S, Anker SD, et al. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J 2013; 34: 816-29.</mixed-citation><mixed-citation xml:lang="en">Jankowska EA, von Haehling S, Anker SD, et al. Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J 2013; 34: 816-29.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ruifrok WPT, Qian C, Sillj´e HH, et al. Heart failure associated anemia: bone marrow dysfunction and response to erythropoietin. J Molecul Med 2011; 89: 377-87.</mixed-citation><mixed-citation xml:lang="en">Ruifrok WPT, Qian C, Sillj´e HH, et al. Heart failure associated anemia: bone marrow dysfunction and response to erythropoietin. J Molecul Med 2011; 89: 377-87.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Pakbaz Z, Wun T. Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics. Hematol/Oncol Clin North Am 2014; 28: 355-74.</mixed-citation><mixed-citation xml:lang="en">Pakbaz Z, Wun T. Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics. Hematol/Oncol Clin North Am 2014; 28: 355-74.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Palazzuoli А, Silverberg D, Iovine F, et al. Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. Am Heart J 2006; 152: 9-15.</mixed-citation><mixed-citation xml:lang="en">Palazzuoli А, Silverberg D, Iovine F, et al. Erythropoietin improves anemia exercise tolerance and renal function and reduces B-type natriuretic peptide and hospitalization in patients with heart failure and anemia. Am Heart J 2006; 152: 9-15.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Zeng YJ, Liu GF, Liu LP, et al. Anemia on admission increases the risk of mortality at 6 months and 1 year in hemorrhagic stroke patients in China. J Stroke and Cerebrovasc Dis 2014; 23: 1500-05.</mixed-citation><mixed-citation xml:lang="en">Zeng YJ, Liu GF, Liu LP, et al. Anemia on admission increases the risk of mortality at 6 months and 1 year in hemorrhagic stroke patients in China. J Stroke and Cerebrovasc Dis 2014; 23: 1500-05.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Singh K, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. New Engl J Med 2006; 355: 2085-98.</mixed-citation><mixed-citation xml:lang="en">Singh K, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. New Engl J Med 2006; 355: 2085-98.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Drueke TB, Locatelli F, Clyne N, et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. New Engl J Med 2006; 355: 2071-84.</mixed-citation><mixed-citation xml:lang="en">Drueke TB, Locatelli F, Clyne N, et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. New Engl J Med 2006; 355: 2071-84.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Jie KE, Verhaar MC, Cramer MJM, et al. Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectors. Am J Physiol 2006; 291: 932-44.</mixed-citation><mixed-citation xml:lang="en">Jie KE, Verhaar MC, Cramer MJM, et al. Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectors. Am J Physiol 2006; 291: 932-44.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Toblli JE, Lombrana A, Duarte P, et al. Intravenous iron reduces NT-Pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. JACC 2007; 50: 1657-65.</mixed-citation><mixed-citation xml:lang="en">Toblli JE, Lombrana A, Duarte P, et al. Intravenous iron reduces NT-Pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency. JACC 2007; 50: 1657-65.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Usmanov RI, Zueva EB, Silverberg DS, et al. Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. J Nephrol 2008; 21: 236-42.</mixed-citation><mixed-citation xml:lang="en">Usmanov RI, Zueva EB, Silverberg DS, et al. Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency. J Nephrol 2008; 21: 236-42.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Jankowska EA, Kasztura M. Sokolski M, et al. Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. Eur Heart J 2014; 35: 2468-76.</mixed-citation><mixed-citation xml:lang="en">Jankowska EA, Kasztura M. Sokolski M, et al. Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure. Eur Heart J 2014; 35: 2468-76.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Locatelli F, Pozzoni P, del Vecchio L, et al. Effect of anemia on left ventricular hypertrophy in end-stage renal disease. Eur J Heart Failure Supplements 2006; 2: 207-12.</mixed-citation><mixed-citation xml:lang="en">Locatelli F, Pozzoni P, del Vecchio L, et al. Effect of anemia on left ventricular hypertrophy in end-stage renal disease. Eur J Heart Failure Supplements 2006; 2: 207-12.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Crary SE, Troendle S, Ahmad N, et al. Traditional laboratory measures of cardiovascular risk in hereditary spherocytosis. Pediatric Blood and Cancer 2010; 55: 684-9.</mixed-citation><mixed-citation xml:lang="en">Crary SE, Troendle S, Ahmad N, et al. Traditional laboratory measures of cardiovascular risk in hereditary spherocytosis. Pediatric Blood and Cancer 2010; 55: 684-9.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bindra K, Berry C, Rogers J, et al. Abnormal haemoglobin levels in acute coronary syndromes. QJM 2006; 99: 851-62.</mixed-citation><mixed-citation xml:lang="en">Bindra K, Berry C, Rogers J, et al. Abnormal haemoglobin levels in acute coronary syndromes. QJM 2006; 99: 851-62.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Gonz´alez-Ferrer JJ, Garc´ıa-Rubira JC, Balcones DV, et al. Influence of hemoglobin level on in-hospital prognosis in patients with acute coronary syndrome. Revista Esp de Card 2008; 61: 945-52.</mixed-citation><mixed-citation xml:lang="en">Gonz´alez-Ferrer JJ, Garc´ıa-Rubira JC, Balcones DV, et al. Influence of hemoglobin level on in-hospital prognosis in patients with acute coronary syndrome. Revista Esp de Card 2008; 61: 945-52.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kurek T, Lenarczyk R, Kowalczyk J, et al. Effect of anemia in high-risk groups of patients with acute myocardial infarction treated with percutaneous coronary intervention. Am J Cardiol 2010; 105: 611-8.</mixed-citation><mixed-citation xml:lang="en">Kurek T, Lenarczyk R, Kowalczyk J, et al. Effect of anemia in high-risk groups of patients with acute myocardial infarction treated with percutaneous coronary intervention. Am J Cardiol 2010; 105: 611-8.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bassand JP, Afzal R, Eikelboom J, et al. Relationship between baseline haemoglobin and major bleeding complications in acute coronary syndromes. Eur Heart J 2010; 31: 50-8.</mixed-citation><mixed-citation xml:lang="en">Bassand JP, Afzal R, Eikelboom J, et al. Relationship between baseline haemoglobin and major bleeding complications in acute coronary syndromes. Eur Heart J 2010; 31: 50-8.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Steinvil M, Banai S, Leshem-Rubinow E, et al. The development of anemia of inflammation during acute myocardial infarction. International J Cardiol 2012; 156: 160-4.</mixed-citation><mixed-citation xml:lang="en">Steinvil M, Banai S, Leshem-Rubinow E, et al. The development of anemia of inflammation during acute myocardial infarction. International J Cardiol 2012; 156: 160-4.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Madjid M, Fatemi O. Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update. Texas Heart Institute J 2013; 40: 17-29.</mixed-citation><mixed-citation xml:lang="en">Madjid M, Fatemi O. Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update. Texas Heart Institute J 2013; 40: 17-29.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Archbold RA, Balami D, Hajiri AA, et al. Hemoglobin concentration is an independent determinant of heart failure in acute coronary syndromes: cohort analysis of 2310 patients. Am Heart J 2006; 152: 1091-5.</mixed-citation><mixed-citation xml:lang="en">Archbold RA, Balami D, Hajiri AA, et al. Hemoglobin concentration is an independent determinant of heart failure in acute coronary syndromes: cohort analysis of 2310 patients. Am Heart J 2006; 152: 1091-5.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Osadnik T, Strzelczyk J, Hawranek M, et al. Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease. BMC Cardiovascular Disorders 2013; 13: 113-8.</mixed-citation><mixed-citation xml:lang="en">Osadnik T, Strzelczyk J, Hawranek M, et al. Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease. BMC Cardiovascular Disorders 2013; 13: 113-8.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117: 163-8.</mixed-citation><mixed-citation xml:lang="en">Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008; 117: 163-8.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurolog Scien 2009; 277: 103-8.</mixed-citation><mixed-citation xml:lang="en">Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurolog Scien 2009; 277: 103-8.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Arant CB, Wessel TR, Olsonet MB, et al. Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute women’s ischemia syndrome evaluation study. JACC 2005; 43: 2009-14.</mixed-citation><mixed-citation xml:lang="en">Arant CB, Wessel TR, Olsonet MB, et al. Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing evaluation for chest pain: results from the National Heart, Lung, and Blood Institute women’s ischemia syndrome evaluation study. JACC 2005; 43: 2009-14.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Schilling RF, Gangnon RE, Traver MI. Delayed adverse vascular events after splenectomy in hereditary spherocytosis. J Thrombosis and Haemost 2008; 6: 1289-95.</mixed-citation><mixed-citation xml:lang="en">Schilling RF, Gangnon RE, Traver MI. Delayed adverse vascular events after splenectomy in hereditary spherocytosis. J Thrombosis and Haemost 2008; 6: 1289-95.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Sabatine MS, Morrow DA, Giugliano RP, et al. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation 2005; 111: 2042-9.</mixed-citation><mixed-citation xml:lang="en">Sabatine MS, Morrow DA, Giugliano RP, et al. Association of hemoglobin levels with clinical outcomes in acute coronary syndromes. Circulation 2005; 111: 2042-9.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Wilfred NC, Woodman R, DePasquale C. Prevalence and correlates of anaemia in essential hypertension. Clin Experim Pharmacol Physiol 2008; 35: 1461-4.</mixed-citation><mixed-citation xml:lang="en">Wilfred NC, Woodman R, DePasquale C. Prevalence and correlates of anaemia in essential hypertension. Clin Experim Pharmacol Physiol 2008; 35: 1461-4.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Freudenberger RS, Carson JL. Is there an optimal hemoglobin value in the cardiac intensive care unit? Curr Opin Critic Care 2005; 9: 356-61.</mixed-citation><mixed-citation xml:lang="en">Freudenberger RS, Carson JL. Is there an optimal hemoglobin value in the cardiac intensive care unit? Curr Opin Critic Care 2005; 9: 356-61.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Marketou M, Patrianakos A, Parthenakis F, et al. Systemic blood pressure profile in hypertensive patients with low hemoglobin concentrations. International J Cardiol 2010; 142: 95-6.</mixed-citation><mixed-citation xml:lang="en">Marketou M, Patrianakos A, Parthenakis F, et al. Systemic blood pressure profile in hypertensive patients with low hemoglobin concentrations. International J Cardiol 2010; 142: 95-6.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Bindra K, Berry C, Rogers J, et al. Abnormal haemoglobin levels in acute coronary syndromes. QJM 2006; 851-62.</mixed-citation><mixed-citation xml:lang="en">Bindra K, Berry C, Rogers J, et al. Abnormal haemoglobin levels in acute coronary syndromes. QJM 2006; 851-62.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Diamond PT, Gale SD, Evans BA. Relationship of initial hematocrit level to discharge estination and resource utilization after ischemic stroke: a pilot study. Archiv Physical Medicine and Rehabilitation 2005; 84: 964-7.</mixed-citation><mixed-citation xml:lang="en">Diamond PT, Gale SD, Evans BA. Relationship of initial hematocrit level to discharge estination and resource utilization after ischemic stroke: a pilot study. Archiv Physical Medicine and Rehabilitation 2005; 84: 964-7.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
