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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2022-3164</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3164</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЦИФРОВЫЕ ТЕХНОЛОГИИ И ТЕЛЕМЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DIGITAL TECHNOLOGIES AND TELEMEDICINE</subject></subj-group></article-categories><title-group><article-title>Телемедицинские консультации в кардиоонкологии</article-title><trans-title-group xml:lang="en"><trans-title>Telehealth consultations in cardio-oncology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2459-7273</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потиевская</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Potievskaya</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Потиевская Вера Исааковна — доктор медицинских наук, главный научный сотрудник, заведующий отделением кардиологии и медицинской реабилитации</p><p>Москва</p><p>SPIN 3675-6880</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">vera.pot@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3970-7498</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кононова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kononova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кононова Елена Владиславовна — врач отделения кардиологии и медицинской реабилитации</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">elena24936@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6898-9589</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шапутько</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shaputko</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шапутько Надежда Викторовна — врач-кардиолог общеклинического отдела Московский научно-исследовательский онкологический институт им. П.А. Герцена — филиал ФГБУ “НМИЦ радиологии” Минздрава России, заочный аспирант кафедры кардиологии ФГАОУ ВО “Первый Московский государственный медицинский университет им. И.М. Сеченова” Минздрава России (Сеченовский Университет)</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">nadyashaputko@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8294-3042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Раушкин</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Raushkin</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Раушкин Дмитрий Андреевич  — врач-кардиолог поликлиники</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dima.raushkin@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8509-4338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гамеева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gameeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гамеева Елена Владимировна  — кандидат медицинских наук, заместитель директора по лечебной работе</p><p>Москва</p><p> </p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">gameeva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8204-9032</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Г. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>G. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексеева Галина Сергеевна  — доктор медицинских наук, заместитель директора по лечебной работе</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">gs.alekseeva@nmirc.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8784-8415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каприн Андрей Дмитриевич — академик РАН, доктор медицинских наук, профессор, генеральный директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">kaprin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.А.Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России</institution></aff><aff xml:lang="en"><institution>P. A. Herzen Moscow Oncology Research Institute — branch of the National Medical Research Center of Radiology</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский научно-исследовательский онкологический институт им. П.А. Герцена — филиал ФГБУ “НМИЦ радиологии” Минздрава России;&#13;
ФГАОУ ВО “Первый Московский государственный медицинский университет им. И.М. Сеченова” Минздрава России (Сеченовский Университет)</institution></aff><aff xml:lang="en"><institution>P. A. Herzen Moscow Oncology Research Institute — branch of the National Medical Research Center of Radiology;&#13;
I. M. Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>26</day><month>01</month><year>2022</year></pub-date><volume>21</volume><issue>2</issue><fpage>3164</fpage><lpage>3164</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Потиевская В.И., Кононова Е.В., Шапутько Н.В., Раушкин Д.А., Гамеева Е.В., Алексеева Г.С., Каприн А.Д., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Потиевская В.И., Кононова Е.В., Шапутько Н.В., Раушкин Д.А., Гамеева Е.В., Алексеева Г.С., Каприн А.Д.</copyright-holder><copyright-holder xml:lang="en">Potievskaya V.I., Kononova E.V., Shaputko N.V., Raushkin D.A., Gameeva E.V., Alekseeva G.S., Kaprin A.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3164">https://cardiovascular.elpub.ru/jour/article/view/3164</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценка роли кардиолога в  телемедицинском консультировании онкологических пациентов на базе федерального онкологического центра.</p></sec><sec><title>Материал и  методы</title><p>Материал и  методы. Проведено ретроспективное исследование по материалам 215 телемедицинских запросов на консультации по кардиоонкологии, выполненных в период с января 2019 по сентябрь 2021гг. Проанализированы данные направлений на консультацию кардиолога (кардиоонколога) из различных регионов России и  ответы консультантов с  учетом следующих данных: регион, пол, возраст пациента, вид злокачественного новообразования, стадия, участие других консультантов, тип сердечно-сосудистого заболевания, необходимость в  запросе дополнительной информации и особенности лечения пациента — хирургическое лечение, химиотерапия, лучевая терапия. Выполнялась оценка стратификации риска на основании чек-листа с  включением основных факторов риска кардиотоксичности. Был проведен анализ рекомендаций консультантов по мониторингу пациентов, а также назначений медикаментозной терапии.</p></sec><sec><title>Результаты</title><p>Результаты. Наиболее частыми локализациями злокачественного новообразования у  пациентов, направляемых на телемедицинские консультации по кардиоонкологии, были легкие, гортань и трахея, ободочная и прямая кишка, почки и мочевой пузырь, яичники и  матка, желудок. Консультации кардиологов проводились совместно с  консультациями онкологов  — хирургов, химиотерапевтов, а  также анестезиологов и  лучевых терапевтов. Наиболее распространенными сердечно-сосудистыми заболеваниями оказались артериальная гипертензия  — до 80,9% пациентов, хроническая сердечная недостаточность — до 60%, аритмии — до 41,6% и ишемическая болезнь сердца — до 37,7%. От 71 до 80,3% пациентов имели сохраненную фракцию выброса левого желудочка, 15,6-21% — умеренно сниженную и 3,9-7,8% — сниженную фракцию выброса левого желудочка. В 47,6-66,7% случаев консультантам потребовался запрос дополнительной информации. По результатам стратификации риска кардиотоксичности противоопухолевого лечения к категории высокого и очень высокого риска были отнесены 118 (81,9%) пациентов из 144. Большинству пациентов была рекомендована кардиопротекторная терапия, которая наиболее часто включала ингибиторы ангиотензинпревращающего фермента/блокаторы рецепторов ангиотензина — 43,1-53,1%, бета-адреноблокаторы  — 44,8-58,6%, статины  — 22,4-38,3%. Разработан алгоритм формирования информационного запроса на кардиоонкологическую телемедицинскую консультацию.</p></sec><sec><title>Заключение</title><p>Заключение. Продемонстрирована важная роль телемедицинских кардиоонкологических консультаций в  работе федерального онкологического центра. Кардиологи-консультанты являются частью единой мультидисциплинарной команды специалистов и  должны действовать с учетом особенностей онкологического заболевания и противоопухолевого лечения, назначаемого онкологами.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To evaluate the role of a cardiologist in telehealth counseling of cancer patients at the federal oncology center.</p></sec><sec><title>Material and methods</title><p>Material and methods. This retrospective study was conducted based on the materials of 215 telehealth consultations on cardiooncology, performed in the period from January 2019 to September 2021. Data on referrals to a cardiologist (cardio-oncologist) from various Russian regions and consultants’ answers were analyzed, taking into account the following data: region, sex, age of a patient, cancer type, stage, participation of other consultants, type of cardiovascular disease, the need for additional information and features of treatment  — surgery, chemotherapy, radiation therapy. Risk was stratified based on a checklist including the main risk factors for cardiotoxicity. The recommendations of consultants for monitoring patients, as well as drug therapy prescriptions, were analyzed.</p></sec><sec><title>Results</title><p>Results. The most common cancer sites in patients referred for telehealth consultations on cardio-oncology were lungs, larynx and trachea, colon and rectum, kidneys and bladder, ovaries and uterus, and stomach. Cardiologists consulted together with oncologists  — surgeons, medical oncologists, as well as anesthesiologists and radiation oncologists. The most common cardiovascular diseases were hypertension  — 80,9% of patients, heart failure  — 60%, arrhythmias — 41,6% and coronary heart disease — 37,7%. From 71 to 80,3%, 15,6-21% and 3,9-7,8% of patients had preserved, mid-range and reduced left ventricular ejection fraction. In 47,6-66,7% of cases, consultants required additional information. Based on risk stratification of cardiotoxicity of anticancer treatment, 118 (81,9%) patients out of 144 were classified as high and very high risk. Most patients were recommended cardioprotective therapy, which most often included angiotensin-converting enzyme inhibitors/angiotensin receptor blockers  — 43,1-53,1%, beta-blockers  — 44,8-58,6%, and statins  — 22,4-38,3%. An algorithm for creating a request for a cardio-oncology telehealth consultation has been developed.</p></sec><sec><title>Conclusion</title><p>Conclusion. The important role of cardio-oncology telehealth consultations in the work of the federal oncology center is demonstrated. Consulting cardiologists are part of a single multidisciplinary team of specialists and must act taking into account the characteristics of cancer and antitumor therapy prescribed by oncologists.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиоонкология</kwd><kwd>телемедицина</kwd><kwd>мультидисциплинарный подход</kwd><kwd>дистанционное лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardio-oncology</kwd><kwd>telemedicine</kwd><kwd>multidisciplinary approach</kwd><kwd>remote treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Зволинская Е.Ю., Мамедов М.Н., Потиевская В.И. и др. Роль модифицируемых сердечно-сосудистых факторов риска в возникновении онкологических заболеваний. Кардиология. 2020;60(9):110-21. doi:10.18087/cardio.2020.9.n910.</mixed-citation><mixed-citation xml:lang="en">Zvolinskaya EYu, Mamedov MN, Potievskaya VI, et al. Role of modified cardiovascular risk factors in development of oncologic diseases. Kardiologiia. 2020;60(9):110-21. (In Russ.) doi:10.18087/cardio.2020.9.n910.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kwan JM, Henry ML, Christophers B, et al. The Role and Impact of Social Media in Cardio-oncology During the COVID-19 Pandemic. Curr Oncol Rep. 2021;23(8):99. doi:10.1007/s11912021-01081-3.</mixed-citation><mixed-citation xml:lang="en">Kwan JM, Henry ML, Christophers B, et al. The Role and Impact of Social Media in Cardio-oncology During the COVID-19 Pandemic. Curr Oncol Rep. 2021;23(8):99. doi:10.1007/s11912021-01081-3.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Brown SA, Zaharova S, Mason P, et al. Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology. Front Cardiovasc Med. 2020;7:568720. doi:10.3389/fcvm.2020.568720.</mixed-citation><mixed-citation xml:lang="en">Brown SA, Zaharova S, Mason P, et al. Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology. Front Cardiovasc Med. 2020;7:568720. doi:10.3389/fcvm.2020.568720.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brown SA, Rhee JW, Guha A, Rao VU. Innovation in Precision Cardio-Oncology During the Coronavirus Pandemic and Into a Post-pandemic World. Front Cardiovasc Med. 20207:145. doi:10.3389/fcvm.2020.00145.</mixed-citation><mixed-citation xml:lang="en">Brown SA, Rhee JW, Guha A, Rao VU. Innovation in Precision Cardio-Oncology During the Coronavirus Pandemic and Into a Post-pandemic World. Front Cardiovasc Med. 20207:145. doi:10.3389/fcvm.2020.00145.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Brown SA, Patel S, Rayan D, et al. A virtual-hybrid approach to launching a cardio-oncology clinic during a pandemic. Cardiooncology. 20217(1):2. doi:10.1186/s40959-020-00088-2.</mixed-citation><mixed-citation xml:lang="en">Brown SA, Patel S, Rayan D, et al. A virtual-hybrid approach to launching a cardio-oncology clinic during a pandemic. Cardiooncology. 20217(1):2. doi:10.1186/s40959-020-00088-2.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sadler D, DeCara JM, Herrmann J, et al; Cardio-Oncology International Collaborative Network. Perspectives on the COVID-19 pandemic impact on cardio-oncology: results from the COVID-19 International Collaborative Network survey. Cardiooncology. 2020;6(1):28. doi:10.1186/s40959-020-00085-5.</mixed-citation><mixed-citation xml:lang="en">Sadler D, DeCara JM, Herrmann J, et al; Cardio-Oncology International Collaborative Network. Perspectives on the COVID-19 pandemic impact on cardio-oncology: results from the COVID-19 International Collaborative Network survey. Cardiooncology. 2020;6(1):28. doi:10.1186/s40959-020-00085-5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lyon AR, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020;22(11):1945-60. doi:10.1002/ejhf.1920.</mixed-citation><mixed-citation xml:lang="en">Lyon AR, Dent S, Stanway S, et al. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society. Eur J Heart Fail. 2020;22(11):1945-60. doi:10.1002/ejhf.1920.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Curigliano G, Lenihan D, Fradley M, et al; ESMO Guidelines Committee. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31(2):171-90. doi:10.1016/j.annonc.2019.10.023.</mixed-citation><mixed-citation xml:lang="en">Curigliano G, Lenihan D, Fradley M, et al; ESMO Guidelines Committee. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020;31(2):171-90. doi:10.1016/j.annonc.2019.10.023.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Taskforce of the Hellenic Heart Failure Clinics Network. Distribution, infrastructure, and expertise of heart failure and cardio-oncology clinics in a developing network: temporal evolution and challenges during the coronavirus disease 2019 pandemic. ESC Heart Fail. 2020;7(6):3408-13. doi:10.1002/ehf2.12870.</mixed-citation><mixed-citation xml:lang="en">Taskforce of the Hellenic Heart Failure Clinics Network. Distribution, infrastructure, and expertise of heart failure and cardio-oncology clinics in a developing network: temporal evolution and challenges during the coronavirus disease 2019 pandemic. ESC Heart Fail. 2020;7(6):3408-13. doi:10.1002/ehf2.12870.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Шляхто Е. В., Конради А. О., Арутюнов Г. П. и др. Руководство по диагностике и лечению болезней системы кровообращения в контексте пандемии COVID-19. Российский кардиологический журнал. 2020;25(3):3801. doi:10.15829/1560-4071-2020-3-3801.</mixed-citation><mixed-citation xml:lang="en">Shlyakhto EV, Konradi AO, Arutyunov GP, et al. Guidelines for the diagnosis and treatment of circulatory diseases in the context of the COVID-19 pandemic. Russian Journal of Cardiology. 2020;25(3):3801. (In Russ.) doi:10.15829/1560-4071-2020-3-3801.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bisceglia I, Gabrielli D, Canale ML, et al. ANMCO POSITION PAPER: cardio-oncology in the COVID era (CO and CO). Eur Heart J Suppl. 2021;23(Suppl C):C128-53. doi:10.1093/eurheartj/suab067.</mixed-citation><mixed-citation xml:lang="en">Bisceglia I, Gabrielli D, Canale ML, et al. ANMCO POSITION PAPER: cardio-oncology in the COVID era (CO and CO). Eur Heart J Suppl. 2021;23(Suppl C):C128-53. doi:10.1093/eurheartj/suab067.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Dutkowska AE, Antczak A. Comorbidities in lung cancer. Pneumonol Alergol Pol. 2016;84(3):186-92. doi:10.5603/PiAP.2016.0022.</mixed-citation><mixed-citation xml:lang="en">Dutkowska AE, Antczak A. Comorbidities in lung cancer. Pneumonol Alergol Pol. 2016;84(3):186-92. doi:10.5603/PiAP.2016.0022.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kenzik KM, Balentine C, Richman J, et al. New-Onset Cardiovascular Morbidity in Older Adults with Stage I to III Colorectal Cancer. J Clin Oncol. 2018;36(6):609-16. doi:10.1200/JCO.2017.74.9739.</mixed-citation><mixed-citation xml:lang="en">Kenzik KM, Balentine C, Richman J, et al. New-Onset Cardiovascular Morbidity in Older Adults with Stage I to III Colorectal Cancer. J Clin Oncol. 2018;36(6):609-16. doi:10.1200/JCO.2017.74.9739.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wilk M, Waśko-Grabowska A, Szmit S. Cardiovascular Complications of Prostate Cancer Treatment. Front Pharmacol. 2020;11:555475. doi:10.3389/fphar.2020.555475.</mixed-citation><mixed-citation xml:lang="en">Wilk M, Waśko-Grabowska A, Szmit S. Cardiovascular Complications of Prostate Cancer Treatment. Front Pharmacol. 2020;11:555475. doi:10.3389/fphar.2020.555475.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sturgeon KM, Deng L, Bluethmann SM, et al. A populationbased study of cardiovascular disease mortality risk in US cancer patients. Eur. Heart J. 2019;40:3889-97. doi:10.1093/eurheartj/ehz766.</mixed-citation><mixed-citation xml:lang="en">Sturgeon KM, Deng L, Bluethmann SM, et al. A populationbased study of cardiovascular disease mortality risk in US cancer patients. Eur. Heart J. 2019;40:3889-97. doi:10.1093/eurheartj/ehz766.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ha TK, Seo YK, Kang BK, Shin J, Ha E. Cardiovascular Risk Factors in Gastric Cancer Patients Decrease 1 Year After Gastrectomy. Obes Surg. 2016;26(10):2340-7. doi:10.1007/s11695-016-2085-4.</mixed-citation><mixed-citation xml:lang="en">Ha TK, Seo YK, Kang BK, Shin J, Ha E. Cardiovascular Risk Factors in Gastric Cancer Patients Decrease 1 Year After Gastrectomy. Obes Surg. 2016;26(10):2340-7. doi:10.1007/s11695-016-2085-4.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jin X, Bai Y, Gao L, Wu S. Incidence of and risk factors for cardiotoxicity after fluorouracil-based chemotherapy in locally advanced or metastatic gastric cancer patients. Cancer Chemother Pharmacol. 2019;84(3):599-607. doi:10.1007/s00280-019-03888-1.</mixed-citation><mixed-citation xml:lang="en">Jin X, Bai Y, Gao L, Wu S. Incidence of and risk factors for cardiotoxicity after fluorouracil-based chemotherapy in locally advanced or metastatic gastric cancer patients. Cancer Chemother Pharmacol. 2019;84(3):599-607. doi:10.1007/s00280-019-03888-1.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Perez RV. e-Health and COVID-19: time for telecardiology. E-Journal of Cardiology Practice. 2021;21(6).</mixed-citation><mixed-citation xml:lang="en">Perez RV. e-Health and COVID-19: time for telecardiology. E-Journal of Cardiology Practice. 2021;21(6).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Eid BG, El-Shitany NAE, Neamatallah T. Trimetazidine improved adriamycin-induced cardiomyopathy by downregulating TNF-α, BAX, and VEGF immunoexpression via an antioxidant mechanism. Environ Toxicol. 2021;36(6):1217-25. doi:10.1002/tox.23120.</mixed-citation><mixed-citation xml:lang="en">Eid BG, El-Shitany NAE, Neamatallah T. Trimetazidine improved adriamycin-induced cardiomyopathy by downregulating TNF-α, BAX, and VEGF immunoexpression via an antioxidant mechanism. Environ Toxicol. 2021;36(6):1217-25. doi:10.1002/tox.23120.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wang W. Cardioprotective effects of creatine phosphate sodium in elderly breast cancer patients under epirubicin adjuvant chemotherapy. Int J Clin Exp Med. 2019;12(10):12418-25.</mixed-citation><mixed-citation xml:lang="en">Wang W. Cardioprotective effects of creatine phosphate sodium in elderly breast cancer patients under epirubicin adjuvant chemotherapy. Int J Clin Exp Med. 2019;12(10):12418-25.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Дербугов В. Н., Потапов А. Л., Потиевская В. И., Хмелевский Я. М. Применение экзогенного фосфокреатина у пациентов пожилого и старческого возраста, оперируемых по поводу колоректального рака. Общая реаниматология. 2017;13(4):38-45. doi:10.15360/1813-97792017-4-38-45.</mixed-citation><mixed-citation xml:lang="en">Derbugov VN, Potapov AL, Potievskaya VI, Khmelevski YaM. Exogenous Phosphocreatine Application in Elderly and Senile Patients Operated for Colorectal Cancer. General Reanimatology. 2017;13(4):38-45. (In Russ.) doi:10.15360/1813-97792017-4-38-45.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Мамедов М.Н., Родионова Ю.В., Явелов И.С. и др. Коронавирусная инфекция с точки зрения междисциплинарного подхода. Круглый стол. Кардиоваскулярная терапия и профилактика. 2021;20(3):2849. doi:10.15829/1728-8800-2021-2849.</mixed-citation><mixed-citation xml:lang="en">Mamedov MN, Rodionova YuV, Yavelov IS, et al. COVID-19 from the interdisciplinary standpoint. Round table. Cardiovascular Therapy and Prevention. 2021;20(3):2849. (In Russ.) doi:10.15829/1728-8800-2021-2849.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
