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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2022-3228</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3228</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW ARTICLES</subject></subj-group></article-categories><title-group><article-title>Новый штамм SARS-CoV-2 Омикрон — клиника, лечение, профилактика (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>New SARS-CoV-2 Omicron variant — clinical picture, treatment, prevention (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3568-5065</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вечорко</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Vechorko</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Валерий Иванович Вечорко — кандидат медицинских наук, доцент, главный врач.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">emma.makoeva123@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3010-755X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аверков</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Averkov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олег Валерьевич Аверков — доктор медицинских наук, профессор, зам. главного врача по лечебной работе.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">oleg.averkov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9226-2870</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зимин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zimin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Алексеевич Зимин — кандидат педагогических наук, аналитик, научный сотрудник.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">leha-zimin@inbox.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ Городская клиническая больница № 15 Департамента здравоохранения Москвы</institution></aff><aff xml:lang="en"><institution>City Clinical Hospital № 15</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ Городская клиническая больница № 15 Департамента здравоохранения Москвы; ФГБНУ Научный центр  неврологии</institution></aff><aff xml:lang="en"><institution>City Clinical Hospital № 15; Research Center of Neurology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>07</day><month>07</month><year>2022</year></pub-date><volume>21</volume><issue>6</issue><fpage>3228</fpage><lpage>3228</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вечорко В.И., Аверков О.В., Зимин А.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Вечорко В.И., Аверков О.В., Зимин А.А.</copyright-holder><copyright-holder xml:lang="en">Vechorko V.I., Averkov O.V., Zimin A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3228">https://cardiovascular.elpub.ru/jour/article/view/3228</self-uri><abstract><p>Несмотря на снижение уровня заболеваемости, на сегодняшний день проблема новой коронавирусной инфекции (COVID-19, COronaVIrus Disease 2019) в глобальном масштабе остается актуальной. Среди вариантов вируса SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2) на сегодняшний день штамм Омикрон является доминирующим. Отличительными свойствами нового штамма являются более короткий инкубационный период (1-5 сут.), высокая контагиозность, относительно легкое течение заболевания, что связано с наибольшим среди всех вариантов вируса SARS-CoV-2 числом мутаций в геноме. Для нового штамма характерны симптомы поражения верхних дыхательных путей: насморк, выраженная боль в горле, чихание, реже — кашель, головная боль, слабость. Пероральные противовирусные препараты Паксловид и Молнупиравир эффективны для лечения при легкой и среднетяжелой формах COVID-19, в т.ч. на амбулаторном этапе медицинской помощи. При лечении пациентов со среднетяжелыми и тяжелыми случаями COVID-19 по-прежнему эффективны кортикостероиды и блокаторы рецепторов интерлейкина-6, эффективность анти-SARS-CoV-2 моноклональных антител на сегодняшний день полностью не доказана. Вакцинация, особенно с применением бустерных доз, против SARS-CoV-2 является наиболее эффективным методом предотвращения и ликвидации COVID-19. Цель обзора — анализ литературы для определения ключевых аспектов профилактики, клиники и лечения нового варианта вируса SARSCoV-2 Омикрон. В работе использованы источники из научных баз PubMed, eLibrary, MedRxiv, Google Scholar, опубликованных за период с ноября 2021 по 25 февраля 2022гг, посвященных профилактике, диагностике и лечению COVID-19, вызываемой штаммом вируса SARS-CoV-2 Омикрон. В качестве ключевых слов использованы: “Омикрон/Omicron”, “SARS-CoV-2”, “COVID-19”, “Omicron treatment”. На основании анализа можно сделать вывод, что COVID-19, вызванная штаммом Омикрон, характеризуется относительно легким течением, однако из-за его высокой контагиозности данный штамм представляет существенную проблему вследствие избыточной нагрузки на амбулаторное и на стационарное звено здравоохранения, включая отделения реанимации и интенсивной терапии.</p></abstract><trans-abstract xml:lang="en"><p>Despite the decrease in the incidence rate, today the problem of a coronavirus disease 2019 (COVID-19) remains relevant on a global scale. Among the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) variants, the Omicron is currently dominant. The differentiating properties of the Omicron variant are a shorter incubation period (1-5 days), high contagiousness, and a relatively mild course of the disease, which is associated with the highest number of genome mutations among all SARS-CoV-2 variants. The new variant is characterized by upper respiratory tract symptoms: rhinorrhea, severe sore throat, sneezing, less commonly cough, headache, and weakness. Oral antiviral drugs Paxlovid and Molnupiravir are effective for treating mild to moderate COVID-19, including in outpatients. While corticosteroids and interleukin-6 receptor antagonists are still effective in treating patients with moderate to severe COVID-19, the effectiveness of anti-SARS-CoV-2 monoclonal antibodies has not yet been fully proven. Vaccination, especially booster doses, against SARS-CoV-2 is the most effective method of preventing COVID-19. The review purpose was to analyze the literature to determine the key aspects of prevention, clinical picture and treatment of a new SARSCoV-2 Omicron variant. The work used publications for the period from November 2021 to February 25, 2022, dedicated to the prevention, diagnosis and treatment of COVID-19 caused by the Omicron variant from the following databases: PubMed, eLibrary, MedRxiv, Google Scholar. The following key words were used: “Omicron”, “SARS CoV-2”, “COVID-19”, “Omicron treatment”. The analysis showed that COVID-19 caused by the Omicron variant is characterized by a relatively mild course. However, due to high contagiousness, this variant poses a significant problem due to the excessive load on outpatient and inpatient healthcare, including intensive care units.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Омикрон</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Omicron</kwd><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">НамазоваБаранова Л.С., Садеки Н., Эфендиева К. Е. Новые данные по эволюции пандемии COVID-19: обзор литературы. Педиатрическая фармакология. 2021;18:314-9. doi:10.15690/pf.v18i4.2299.</mixed-citation><mixed-citation xml:lang="en">Namazova-Baranova LS, Sadeki N, Efendieva KE. New Evidence on the Evolution of the COVID-19 Pandemic: A Literature Review. Pediatric pharmacology. 2021;18:314-9. 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