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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2023-3338</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CORONARY HEART DISEASE</subject></subj-group></article-categories><title-group><article-title>Комплексный анализ клинико-инструментальных параметров коронарного кровотока у больных острыми формами ишемической болезни сердца на фоне сахарного диабета 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Comprehensive analysis of clinical and paraclinical parameters of coronary blood flow in patients with acute types of coronary artery disease and type 2 diabetes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2211-8160</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кокожева</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kokozheva</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кокожева Мадина Алиевна — аспирант.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">kokozheva@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9844-3122</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куценко</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kutsenko</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куценко Владимир Александрович — младший научный сотрудник лаборатории биостатистики отдела эпидемиологии хронических неинфекционных заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">vlakutsenko@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8820-9436</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марданов</surname><given-names>Б. У.</given-names></name><name name-style="western" xml:lang="en"><surname>Mardanov</surname><given-names>B. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марданов Баходир Умаркулович — кандидат медицинских наук, старший научный сотрудник отдела вторичной профилактики хронических неинфекционных заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mb_sky@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6707-5128</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахундова</surname><given-names>Х. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhundova</surname><given-names>H. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахундова Хумра Рамизовна — соискатель отдела вторичной профилактики хронических неинфекционных заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">xumra_akhundova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7131-8049</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамедов</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamedov</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мамедов Мехман Ниязи оглы — доктор медицинских наук, профессор, руководитель отдела вторичной профилактики хронических неинфекционных заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mmamedov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>21</day><month>06</month><year>2023</year></pub-date><volume>22</volume><issue>5</issue><fpage>3338</fpage><lpage>3338</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кокожева М.А., Куценко В.А., Марданов Б.У., Ахундова Х.Р., Мамедов М.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Кокожева М.А., Куценко В.А., Марданов Б.У., Ахундова Х.Р., Мамедов М.Н.</copyright-holder><copyright-holder xml:lang="en">Kokozheva M.A., Kutsenko V.A., Mardanov B.U., Akhundova H.R., Mamedov M.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3338">https://cardiovascular.elpub.ru/jour/article/view/3338</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить особенности клинико-инструментальных параметров и поражения коронарного русла у больных с острыми формами ишемической болезни сердца (ИБС) на фоне сахарного диабета (CД) 2 типа.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 102 больных обоих полов с острыми формами ИБС. Больные анализировались в двух группах: первую (средний возраст 56,6±0,96 лет, мужчин/женщин 34/16) составили 50 пациентов с острым коронарным синдромом (ОКС) и СД 2 типа, вторую (средний возраст 58,7±1,01 лет, мужчины/женщины 37/15) — 52 пациента без СД. Наряду с оценкой поведенческих и биологических факторов риска ССЗ анализировались клинико-гемодинамические показатели, результаты коронароангиографии.</p></sec><sec><title>Результаты</title><p>Результаты. В группе лиц с ОКС и СД продолжительность СД составила 5,6±3,7 лет. Коморбидность соматических заболеваний была зарегистрирована у 74% в первой группе, и у 53,8% во второй. По данным эхокардиографии в группе лиц с ОКС и СД фракция выброса левого желудочка оказалась ниже, а среднее давление в легочной артерии выше по сравнению с группой без СД. Стенозы дистальной трети коронарной артерии у пациентов с СД встречались в 78% случаев, а у пациентов без СД — в 42%, различия оказались статистически значимы (р&lt;0,001). Диффузное поражение коронарных артерий также преобладало в первой группе и составляло 58%, а во второй — 27%. Расчет суммарного риска по анатомической шкале SYNTAX Score продемонстрировал более высокое значение у больных СД по сравнению с группой лиц без СД — 29,2 и 22%, соответственно (p&lt;0,001).</p></sec><sec><title>Заключение</title><p>Заключение. У пациентов с ОКС и СД выявлено превалирование случаев легочной гипертензии и систолической дисфункции миокарда левого желудочка. Особенностями коронарного русла у больных СД с ОКС явились преимущественно дистальный тип поражения, а также повышение риска осложнений процедур ангиопластики, оцениваемой с помощью шкалы SYNTAX Score.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study clinical and paraclinical parameters and lesions of the coronary bed in patients with acute types of coronary artery disease (CAD) and type 2 diabetes (T2D).</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 102 patients of both sexes with acute CAD. Patients were analyzed in two following groups: the first (mean age, 56,6±0,96 years, men/women 34/16) consisted of 50 patients with acute coronary syndrome (ACS) and type 2 diabetes, the second (mean age, 58,7±1,01 years, men/women 37/15) — 52 patients without T2D. Along with the assessment of behavioral and biological risk factors for CVD, clinical and hemodynamic parameters and the results of coronary angiography were analyzed.</p></sec><sec><title>Results</title><p>Results. In patients with ACS and T2D, the duration of T2D was 5,6±3,7 years. Somatic comorbidities were registered in 74% in the first group, and in 53,8% in the second. According to echocardiography, in the group of people with ACS and T2D, the left ventricular ejection fraction was lower, and the mean pulmonary artery pressure was higher compared to the group without T2D. Stenosis of the distal coronary artery third in patients with T2D occurred in 78% of cases, and in patients without T2D — in 42%; the differences were significant (p&lt;0,001). Diffuse CAD also prevailed in the first group and amounted to 58%, and in the second — 27%. The SYNTAX score was higher in patients with T2D compared with the group of people without T2D — 29,2 and 22%, respectively (p&lt;0,001).</p></sec><sec><title>Conclusion</title><p>Conclusion. In patients with ACS and T2D, the prevalence of pulmonary hypertension and left ventricular systolic dysfunction was revealed. The features of the coronary flow in patients with T2D with ACS were predominantly the distal type of lesion, as well as an increased risk of angioplasty complications, assessed using the SYNTAX score.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>сахарный диабет</kwd><kwd>острый коронарный синдром</kwd><kwd>атеросклероз коронарных артерий</kwd><kwd>стенозы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary artery disease</kwd><kwd>diabetes</kwd><kwd>acute coronary synd­rome</kwd><kwd>coronary atherosclerosis</kwd><kwd>stenosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О. М., Концевая А. В., Калинина А. М. и др. Профилактика хронических неинфекционных заболеваний в Российской Федерации. Национальное руководство 2022. 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