<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2023-3405</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3405</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Отрыв хорд митрального клапана на фоне воспалительного поражения сердца, ассоциированного с инфекцией SARS-CoV-2. Серия клинических случаев</article-title><trans-title-group xml:lang="en"><trans-title>Mitral valve chordal rupture against the background of cardiac SARS-CoV-2 infection. Cases series</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7858-7820</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сукмарова</surname><given-names>З. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukmarova</surname><given-names>Z. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сукмарова Зульфия Наилевна — кандидат медицинских наук, научный сотрудник лаборатории системной красной волчанки</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Suzulfia@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1999-3949</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мацкевич</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Matskevich</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мацкевич Людмила Алексеевна — заведующая отделением функциональной диагностики</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">LMatskevich@gnicpm.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1843-087X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчинников</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovchinnikov</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овчинников Юрий Викторович — доктор медицинских наук, профессор кафедры терапии неотложных состояний</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">suzulfia@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1518-2807</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голощапов</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Goloshchapov</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голощапов Олег Игоревич — врач-кардиолог, анестезиолог-реаниматолог отделения неотложной кардиологии</p><p>Гатчина, Ленинградская область</p></bio><bio xml:lang="en"><p>Gatchina, Leningrad region</p></bio><email xlink:type="simple">suzulfia@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лила Александр Михайлович — доктор медицинских наук, профессор, член-корреспондент РАН, директор, заведующий кафедрой ревматологии, Главный внештатный специалист-ревматолог МЗ РФ, заслуженный врач России</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">suzulfia@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ "Научно-исследовательский институт ревматологии им. В. А. Насоновой"</institution></aff><aff xml:lang="en"><institution>V. A. Nasonova Research Institute of Rheumatology</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Филиал ФГБВОУ ВО "Военно- медицинская академия им. С. М. Кирова" МО РФ</institution></aff><aff xml:lang="en"><institution>Branch of the S. M. Kirov Military Medical Academy</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ ЛО Гатчинская Клиническая Межрайонная больница</institution></aff><aff xml:lang="en"><institution>Gatchina Clinical Interdistrict Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБНУ "Научно-исследовательский институт ревматологии им. В. А. Насоновой";&#13;
ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России</institution></aff><aff xml:lang="en"><institution>V. A. Nasonova Research Institute of Rheumatology;&#13;
Medical Academy of Continuous Professional Education</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>06</day><month>01</month><year>2023</year></pub-date><volume>22</volume><issue>2</issue><fpage>3405</fpage><lpage>3405</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сукмарова З.Н., Мацкевич Л.А., Овчинников Ю.В., Голощапов О.И., Лила А.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Сукмарова З.Н., Мацкевич Л.А., Овчинников Ю.В., Голощапов О.И., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Sukmarova Z.N., Matskevich L.A., Ovchinnikov Y.V., Goloshchapov O.I., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3405">https://cardiovascular.elpub.ru/jour/article/view/3405</self-uri><abstract><p>В постоянно меняющемся потоке информации о пандемии новой коронавирусной инфекции 2019г (COVID-19 — COrona VIrus Disease 2019) мы приводим описание серии случаев отрыва хорд митрального клапана (ОХМК) у некоморбидных мужчин среднего возраста, произошедших в течение от 3 до 5 нед. после заражения вирусом SARS- CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2). На фоне значительных успехов в профилактике острой ревматической лихорадки, лечении бактериального эндокардита и острого коронарного синдрома "острая митральная недостаточность" стала относительно редким диагнозом. В период пандемии наметился всплеск встречаемости спонтанного ОХМК, и накапливаются новые данные о проблеме, вероятно, обусловленные кардиотропностью нового коронавируса. Представленные наблюдения объединены тем, что симптомы инфекции были легкими, в последующем прослеживались признаки вероятного эндомиокардита, нераспознанные вовремя, а острая недостаточность митрального клапана развилась на фоне физической провокации (нагрузки и кашель). У двух пациентов ранее был диагностирован пролапс митрального клапана (миксоматозная дегенерация и синдром дисплазии соединительной ткани). Два пациента были успешно прооперированы в различных клиниках. Описанные истории болезни подчеркивают, что последствия персистенции воспаления могут быть тяжелее первичного вирусного повреждения, что обуславливает важность всестороннего обследования и долговременного наблюдения. На сегодняшний день в дифференциальный диагноз пациентов с внезапно развившейся одышкой и болью в груди, ассоциированными с инфекционным процессом, следует включать ОХМК. </p></abstract><trans-abstract xml:lang="en"><p>In an ever-changing information flow on coronavirus disease 2019 (COVID-19) pandemic, we describe a case series of mitral valve chordal rupture (MVCR) in non-comorbid middle-aged men that occurred over a period of 3 to 5 weeks after Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection. With significant advances in the prevention of acute rheumatic fever, the treatment of bacterial endocarditis and acute coronary syndrome, acute mitral regurgitation has become a relatively rare diagnosis. During the pandemic, there has been a surge in the incidence of spontaneous MVCR, and new data on the problem are accumulating. The presented case series are united by the fact that the infection symptoms were mild, followed by signs of probable endomyocarditis, unrecognized in time, and acute mitral valve regurgitation developed against the background of physical provocation (exercise and cough). Two patients had previously been diagnosed with mitral valve prolapse (myxomatous degeneration and connective tissue disease). Two patients were successfully operated on in different clinics. The described cases emphasize that the consequences of inflammation persistence may be more severe than the primary viral damage, which determines the importance of a comprehensive examination and long-term follow-up. To date, the differential diagnosis of patients with sudden onset of dyspnea and chest pain associated with an infectious process should include MVCR.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>миокардит</kwd><kwd>отрыв хорд митрального клапана</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>myocarditis</kwd><kwd>mitral valve chordal rupture</kwd><kwd>case series</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">нет</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сукмарова З. Н., Овчинников Ю.В., Ларина О.М. и др. Отрыв хорд митрального клапана у высокотренированных мужчин в ранние сроки после COVID-19. Серия клинических случаев. Спортивная медицина: наука и практика. 2022;12(1):77-85. doi:10.47529/22232524.2022.1.2.</mixed-citation><mixed-citation xml:lang="en">Sukmarova ZN, Ovchinnikov YuV, Larina OM, et al. Acute mitral chodae rupture in the early postcovid in heavy physical active men. Case series. Sports medicine: research and practice. 2022;12(1):77-85. (In Russ.) doi:10.47529/22232524.2022.1.2.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Gabbay U, Yosefy C. The underlying causes of chordae tendinae rupture: a systematic review. Int J Cardiol. 2010;143(2):113-8. doi:10.1016/j.ijcard.2010.02.011.</mixed-citation><mixed-citation xml:lang="en">Gabbay U, Yosefy C. The underlying causes of chordae tendinae rupture: a systematic review. Int J Cardiol. 2010;143(2):113-8. doi:10.1016/j.ijcard.2010.02.011.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Elbadawi A, Elgendy IY, Mahmoud K. Temporal trends and outcomes of mechanical complications in patients with acute myocardial infarction. J Am Coll Cardiol Intv. 2019;12:1825-36. doi:10.1016/j.jcin.2019.04.039.</mixed-citation><mixed-citation xml:lang="en">Elbadawi A, Elgendy IY, Mahmoud K. Temporal trends and outcomes of mechanical complications in patients with acute myocardial infarction. J Am Coll Cardiol Intv. 2019;12:1825-36. doi:10.1016/j.jcin.2019.04.039.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Fox T, Akhtar H, Blocher N, et al. Mitral valve chord rupture in a pregnant patient with uncontrolled hyperthyroidism. Endocrinology Diabetes and Metabolism Case Reports 2022;1:22-0298. doi:10.1530/EDM-22-0298.</mixed-citation><mixed-citation xml:lang="en">Fox T, Akhtar H, Blocher N, et al. Mitral valve chord rupture in a pregnant patient with uncontrolled hyperthyroidism. Endocrinology Diabetes and Metabolism Case Reports 2022;1:22-0298. doi:10.1530/EDM-22-0298.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chiu FH, Yang CJ, Huang CK, et al. Spontaneous chordae tendineae rupture during peripartum. Am J Emerg Med. 2018;36(6):1127.e1-1127.e3. doi:10.1016/j.ajem.2018.03.038.</mixed-citation><mixed-citation xml:lang="en">Chiu FH, Yang CJ, Huang CK, et al. Spontaneous chordae tendineae rupture during peripartum. Am J Emerg Med. 2018;36(6):1127.e1-1127.e3. doi:10.1016/j.ajem.2018.03.038.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Zwane NL, Ponnusamy S, Naidoo DP. The spectrum of rheumatic mitral valve regurgitation presenting to Inkosi Albert Luthuli Central Hospital, KwaZulu-Natal, over a 10-year period. Cardiovasc J Afr. 2021;230;32(2):62-9. doi:10.5830/CVJA2020-029.</mixed-citation><mixed-citation xml:lang="en">Zwane NL, Ponnusamy S, Naidoo DP. The spectrum of rheumatic mitral valve regurgitation presenting to Inkosi Albert Luthuli Central Hospital, KwaZulu-Natal, over a 10-year period. Cardiovasc J Afr. 2021;230;32(2):62-9. doi:10.5830/CVJA2020-029.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Juang JJ, Ke SR, Lin JL, et al. Rupture of mitral chordae tendineae: adding to the list of hypertension complications. Heart. 2009;95(12):976-9. doi:10.1136/hrt.2008.159848.</mixed-citation><mixed-citation xml:lang="en">Juang JJ, Ke SR, Lin JL, et al. Rupture of mitral chordae tendineae: adding to the list of hypertension complications. Heart. 2009;95(12):976-9. doi:10.1136/hrt.2008.159848.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Luo XL, Qiao SB, Yuan JS, et al. Clinical and echocardiographic characteristics of mitral chordal rupture from 292 hospitalized patients. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37(3):253-6.</mixed-citation><mixed-citation xml:lang="en">Luo XL, Qiao SB, Yuan JS, et al. Clinical and echocardiographic characteristics of mitral chordal rupture from 292 hospitalized patients. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37(3):253-6.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов Е. Л., Лила А. М., Мазуров В. И. и др. Коронавирусная болезнь 2019 (COVID-19) и иммуновоспалительные ревматические заболевания. Рекомендации Общероссийской общественной организации "Ассоциация ревматологов России". Научно-практическая ревматология. 2021;59(3):239-54. doi:10.47360/1995-4484-2021-239-254.</mixed-citation><mixed-citation xml:lang="en">Nasonov EL, Lila AM, Mazurov VI, et al. Coronavirus Disease 2019 (COVID-19) and Immune-mediated Rheumatic Diseases. Recommendations of the Association of Rheumatologists of Russia. Rheumatology Science and Practice. 2021;59(3):23954. (In Russ.) doi:10.47360/1995-4484-2021-239-254.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan M, Yavuz F, Davutoğlu V, et al. The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress. Eur J Ther. 2020;26:117-21. doi:10.5152/EurJTher.2019.19063.</mixed-citation><mixed-citation xml:lang="en">Kaplan M, Yavuz F, Davutoğlu V, et al. The Relationship between Mitral Chordae Rupture and Inflammation Level and Oxidative Stress. Eur J Ther. 2020;26:117-21. doi:10.5152/EurJTher.2019.19063.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Puntmann VO, Martin, S, Shchendrygina A, et al. Long-term cardiac pathology in individuals with mild initial COVID-19 illness. Nat Med. 2022;28(10):2117-23. doi:10.1038/s41591-02202000-0.</mixed-citation><mixed-citation xml:lang="en">Puntmann VO, Martin, S, Shchendrygina A, et al. Long-term cardiac pathology in individuals with mild initial COVID-19 illness. Nat Med. 2022;28(10):2117-23. doi:10.1038/s41591-02202000-0.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Yu HT, Moon J, Yang WI, et al. High prevalence of unrecognized chordae tendineae rupture in mitral valve prolapse patients undergoing valve replacement surgery. Can J Cardiol. 2013;29(12):1643-8. doi:10.1016/j.cjca.2013.09.002.</mixed-citation><mixed-citation xml:lang="en">Yu HT, Moon J, Yang WI, et al. High prevalence of unrecognized chordae tendineae rupture in mitral valve prolapse patients undergoing valve replacement surgery. Can J Cardiol. 2013;29(12):1643-8. doi:10.1016/j.cjca.2013.09.002.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Vahanian A, Beyersdorf F, Praz F, et al; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022; 43(7):561-632. doi:10.1093/eurheartj/ehab395.</mixed-citation><mixed-citation xml:lang="en">Vahanian A, Beyersdorf F, Praz F, et al; ESC/EACTS Scientific Document Group. 2021 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022; 43(7):561-632. doi:10.1093/eurheartj/ehab395.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nalliah CJ, Mahajan R, Elliott AD, et al. Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis. Heart. 2019;105(2):144-51. doi:10.1136/heartjnl-2017-312932.</mixed-citation><mixed-citation xml:lang="en">Nalliah CJ, Mahajan R, Elliott AD, et al. Mitral valve prolapse and sudden cardiac death: a systematic review and meta-analysis. Heart. 2019;105(2):144-51. doi:10.1136/heartjnl-2017-312932.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Khanduri A, Anand U, Doss M, et al. Severe acute mitral valve regurgitation in a COVID-19-infected patient. BMJ Case Rep. 2021;14(1):e239782. doi:10.1136/bcr-2020-239782.</mixed-citation><mixed-citation xml:lang="en">Khanduri A, Anand U, Doss M, et al. Severe acute mitral valve regurgitation in a COVID-19-infected patient. BMJ Case Rep. 2021;14(1):e239782. doi:10.1136/bcr-2020-239782.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Alizadehasl A, Salehi P, Roudbari S, et al. Complicated AMI in a COVID-19 Patient; Chordal Rupture and Flail of Mitral Valve. Multidiscip Cardio Annal. 2020;11(2):e106953. doi:10.5812/mca.106953.</mixed-citation><mixed-citation xml:lang="en">Alizadehasl A, Salehi P, Roudbari S, et al. Complicated AMI in a COVID-19 Patient; Chordal Rupture and Flail of Mitral Valve. Multidiscip Cardio Annal. 2020;11(2):e106953. doi:10.5812/mca.106953.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Alizadehasl A, Salehi P, Roudbari S, et al. Infectious endocarditis of the prosthetic mitral valve after COVID-19 infection. Eur Heart J. 2020;41(48):4604. doi:10.1093/eurheartj/ehaa852.</mixed-citation><mixed-citation xml:lang="en">Alizadehasl A, Salehi P, Roudbari S, et al. Infectious endocarditis of the prosthetic mitral valve after COVID-19 infection. Eur Heart J. 2020;41(48):4604. doi:10.1093/eurheartj/ehaa852.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Llopis Gisbert G, Vidal Urrutia V, Moruno Benita MA, et al. Bioprosthetic Valve Thrombosis and Obstruction Secondary to COVID-19. Can J Cardiol. 2021;37(6):938.e3-938.e6. doi:10.1016/j.cjca.2020.10.008.</mixed-citation><mixed-citation xml:lang="en">Llopis Gisbert G, Vidal Urrutia V, Moruno Benita MA, et al. Bioprosthetic Valve Thrombosis and Obstruction Secondary to COVID-19. Can J Cardiol. 2021;37(6):938.e3-938.e6. doi:10.1016/j.cjca.2020.10.008.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jeckelmann C, Djokic B, Duchatelle V, Girod G. Case report: Mechanical mitral prosthetic valve thrombosis in the context of COVID-19 despite effective anticoagulation. Eur Heart J Case Rep. 2022;6(2):ytac006. doi:10.1093/ehjcr/ytac006.</mixed-citation><mixed-citation xml:lang="en">Jeckelmann C, Djokic B, Duchatelle V, Girod G. Case report: Mechanical mitral prosthetic valve thrombosis in the context of COVID-19 despite effective anticoagulation. Eur Heart J Case Rep. 2022;6(2):ytac006. doi:10.1093/ehjcr/ytac006.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Бубнова М. Г., Шляхто Е. В., Аронов Д. М. и др. Новая коронавирусная инфекционная болезнь COVID-19: особенности комплексной кардиологической и респираторной реабилитации. Российский кардиологический журнал. 2021;26(5):4487. doi:10.15829/1560-4071-2021-4487.</mixed-citation><mixed-citation xml:lang="en">Bubnova MG, Shlyakhto EV, Aronov DM, et al. Coronavirus disease 2019: features of comprehensive cardiac and pulmonary rehabilitation. Russian Journal of Cardiology. 2021;26(5):4487. (In Russ.) doi:10.15829/1560-4071-2021-4487.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
