<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2022-3460</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3460</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕГИСТРЫ И ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>STUDIES AND REGISTERS</subject></subj-group></article-categories><title-group><article-title>Показатели мужской и женской смертности от острых форм ишемической болезни сердца в пятилетних возрастных группах в Российской Федерации: о чем говорят цифры?</article-title><trans-title-group xml:lang="en"><trans-title>Male and female mortality rates due to acute types of coronary artery disease in five-year age groups in the Russian Federation: what do the numbers mean?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9320-1503</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самородская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Samorodskaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ирина Владимировна Самородская — доктор медицинских наук, профессор, главный научный сотрудник.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">samor2000@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2250-5942</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бубнова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bubnova</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марина Геннадьевна Бубнова — доктор медицинских наук, профессор, руководитель отдела реабилитации и вторичной профилактики сердечно-сосудистых заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mbubnova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4302-258X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акулова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akulova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, врач-кардиолог.</p><p>Курган</p></bio><bio xml:lang="en"><p>Kurgan</p></bio><email xlink:type="simple">mbubnova@gnicpm.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, академик РАН, директор.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mbubnova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУ «Курганский областной кардиологический диспансер»</institution></aff><aff xml:lang="en"><institution>Kurgan Regional Cardiology Dispensary</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>01</month><year>2023</year></pub-date><volume>21</volume><issue>12</issue><fpage>3460</fpage><lpage>3460</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Самородская И.В., Бубнова М.Г., Акулова О.А., Драпкина О.М., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Самородская И.В., Бубнова М.Г., Акулова О.А., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Samorodskaya I.V., Bubnova M.G., Akulova O.A., Drapkina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3460">https://cardiovascular.elpub.ru/jour/article/view/3460</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценка показателей смертности (ПС) от острых форм (ОФ) ишемической болезни сердца (ИБС) в пятилетних возрастных группах (ПВГ) (20-85+ лет) и вклада в смертность от всех причин в 2019-2020гг.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Из данных Центра демографических исследований Российской экономической школы отобраны ПС от всех причин, смертности от ОФ ИБС (коды I21.0-9; I22.0-9; I20, I24.1-9) в ПВГ (от 2024 лет до группы 85+ включительно) мужчин и женщин в соответствии с "Краткой номенклатурой причин смерти Росстата" (КНПСР) из расчета на 1 млн населения в 2019 и 2020гг. Определен вклад (в %) ОФ ИБС в смертность от всех причин, вклад каждой из ОФ ИБС в смертность от ОФ ИБС, отношение показателей смертности мужчин/женщин.</p></sec><sec><title>Результаты</title><p>Результаты. Вклад всех ОФ ИБС в смертность от всех причин среди мужчин разных ПВГ составляет от 1,2 до 7,9% (50-54 лет), среди женщин от 0,9 до 5,5% (65-69 лет) и имеет характер параболической зависимости от возраста. В каждой последующей ПВГ ПС от всех ОФ ИБС выше по сравнению с предыдущей, однако, в ПВГ до 60 лет преобладает доля "другие формы острой ИБС" (от 51% до 100%), а после 60 лет — инфаркт миокарда (ИМ) (от 56% до 78%). По всем ОФ ИБС в 2019-2020гг. ПС среди мужчин выше ПС среди женщин: максимум в 25 раз от повторного ИМ в ПВГ 40-44 лет в 2020г; в 7 раз от острого ИМ в ПВГ 40-44 года в 2019г; и в 4,5 раза от "других форм острой ИБС" в ПВГ 50-54 лет в 2019г. В 2020г по сравнению с 2019г отмечен рост ПС от всех ОФ ИБС, за исключением ПВГ 25-29 лет среди женщин и ПВГ мужчин с 20 до 34 лет.</p></sec><sec><title>Заключение</title><p>Заключение. Выявленные структурные половозрастные особенности ПС от ОФ ИБС могут быть обусловлены подходами к диагностике и установлению в качестве причины смерти разных ОФ ИБС и требуют создания в Российской Федерации методологического протокола или алгоритма установления в качестве причины смерти разных ОФ ИБС.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess mortality rates due to acute types of coronary artery disease (CAD) in five-year age groups (20-85+ years) and the contribution to all-cause mortality in 2019-2020.</p></sec><sec><title>Material and methods</title><p>Material and methods. From the Center for Demographic Research of the Russian Economic School, data on all-cause and acute CAD mortality rates were selected (codes: I21.0-9; I22.0-9; I20, I24.1-9) in five-year age groups (from 20-24 years to the group 85+ inclusive) of men and women per 1 million population in 2019 and 2020. The contribution (in %) of acute types of CAD to all-cause mortality, the contribution of each disease to mortality, and the ratio of male/female mortality rates were determined.</p></sec><sec><title>Results</title><p>Results. The contribution of all acute types of CAD to all-cause mortality among men of different 5-year age groups ranges from 1,2 to 7,9% (50-54 years), among women from 0,9 to 5,5% (65-69 years) and has the character parabolic dependence on age. In each subsequent 5-year age groups, mortality rates due to acute CAD is higher compared to the previous one. However, in age groups up to 60 years, the share of "other forms of acute CAD" prevails (from 51% to 100%), and after 60 years — myocardial infarction (MI) (from 56% to 78%). For all acute types of CAD in 2019-2020, mortality rate among men is higher than among women: a maximum of 25 times from recurrent MI in age group of 40-44 years in 2020; 7 times — from acute MI in age group of 40-44 years in 2019; and 4,5 times from "other forms of acute CAD" in age group of 50-54 years in 2019. In 2020, compared to 2019, there was an increase in mortality from all acute CAD, with the exception of age group of 25-29 years among women and 20-34 years among men.</p></sec><sec><title>Conclusion</title><p>Conclusion. The identified structural age-sex features of mortality from acute CAD may be due to approaches to diagnosis and identification of various CAD forms as the cause of death and require the creation in the Russian Federation of a methodological protocol or algorithm for determining the cause of death of various acute types of CAD.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>инфаркт миокарда</kwd><kwd>пятилетние возрастные группы</kwd><kwd>смертность</kwd><kwd>острый коронарный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary artery disease</kwd><kwd>myocardial infarction</kwd><kwd>five-year age groups</kwd><kwd>mortality</kwd><kwd>acute coronary syndrome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">нет</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchis-Gomar F, Perez-Quilis C, Leischik R, et al. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256. doi:10.21037/atm.2016.06.33.</mixed-citation><mixed-citation xml:lang="en">Sanchis-Gomar F, Perez-Quilis C, Leischik R, et al. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 2016;4(13):256. doi:10.21037/atm.2016.06.33.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lunova T, Komorovsky R, Klishch I. Gender Differences in Treatment Delays, Management and Mortality among Patients with Acute Coronary Syndrome: A Systematic Review and Meta-Analysis. CurrCardiol Rev. 2022. doi:10.2174/1573403X18666220630120259.</mixed-citation><mixed-citation xml:lang="en">Lunova T, Komorovsky R, Klishch I. Gender Differences in Treatment Delays, Management and Mortality among Patients with Acute Coronary Syndrome: A Systematic Review and Meta-Analysis. CurrCardiol Rev. 2022. doi:10.2174/1573403X18666220630120259.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Manzo-Silberman S, Couturaud F, Charpentier S, et al. Influence of gender on delays and early mortality in ST-segment elevation myocardial infarction: Insight from the first French Metaregistry, 2005-2012 patient-level pooled analysis. Int J Cardiol. 2018;262:1-8. doi:10.1016/j.ijcard.2018.02.044.</mixed-citation><mixed-citation xml:lang="en">Manzo-Silberman S, Couturaud F, Charpentier S, et al. Influence of gender on delays and early mortality in ST-segment elevation myocardial infarction: Insight from the first French Metaregistry, 2005-2012 patient-level pooled analysis. Int J Cardiol. 2018;262:1-8. doi:10.1016/j.ijcard.2018.02.044.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cook NL. Bridging the Sex Gap in Early Myocardial Infarction Mortality: Why It Matters. Circ Cardiovasc Qual Outcomes. 2017;10(12):e004334. doi:10.1161/CIRCOUTCOMES.117.004334.</mixed-citation><mixed-citation xml:lang="en">Cook NL. Bridging the Sex Gap in Early Myocardial Infarction Mortality: Why It Matters. Circ Cardiovasc Qual Outcomes. 2017;10(12):e004334. doi:10.1161/CIRCOUTCOMES.117.004334.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Smilowitz NR, Mahajan AM, Roe MT, et al. Mortality of Myocardial Infarction by Sex, Age, and Obstructive Coronary Artery Disease Status in the ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network RegistryGet with the Guidelines). Circ Cardiovasc Qual Outcomes. 2017;10(12):e003443. doi:10.1161/CIRCOUTCOMES.116.003443.</mixed-citation><mixed-citation xml:lang="en">Smilowitz NR, Mahajan AM, Roe MT, et al. Mortality of Myocardial Infarction by Sex, Age, and Obstructive Coronary Artery Disease Status in the ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network RegistryGet with the Guidelines). Circ Cardiovasc Qual Outcomes. 2017;10(12):e003443. doi:10.1161/CIRCOUTCOMES.116.003443.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cenko E, Yoon J, Kedev S, et al. Sex Differences in Outcomes After STEMI: Effect Modification by Treatment Strategy and Age. JAMA Intern Med. 2018;178(5):632-9. doi:10.1001/ jamainternmed.2018.0514.</mixed-citation><mixed-citation xml:lang="en">Cenko E, Yoon J, Kedev S, et al. Sex Differences in Outcomes After STEMI: Effect Modification by Treatment Strategy and Age. JAMA Intern Med. 2018;178(5):632-9. doi:10.1001/jamainternmed.2018.0514.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ten Haaf ME, Bax M, Ten Berg JM, et al. Sex differences in characteristics and outcome in acute coronary syndrome patients in the Netherlands. Neth Heart J. 2019;27(5):263-71. doi:10.1007/s12471-019-1271-0.</mixed-citation><mixed-citation xml:lang="en">Ten Haaf ME, Bax M, Ten Berg JM, et al. Sex differences in characteristics and outcome in acute coronary syndrome patients in the Netherlands. Neth Heart J. 2019;27(5):263-71. doi:10.1007/ s12471-019-1271-0.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bandyopadhyay D, Chakraborty S, Amgai B, et al. Acute myocardial infarction in the young — National Trend Analysis with gender-based difference in outcomes. Int J Cardiol. 2020;301:218. doi:10.1016/j.ijcard.2019.11.096.</mixed-citation><mixed-citation xml:lang="en">Bandyopadhyay D, Chakraborty S, Amgai B, et al. Acute myocardial infarction in the young — National Trend Analysis with gender-based difference in outcomes. Int J Cardiol. 2020;301:218. doi:10.1016/j.ijcard.2019.11.096.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Krämer C, Meisinger C, Kirchberger I, et al. Epidemiological trends in mortality, event rates and case fatality of acute myocardial infarction from 2004 to 2015: results from the KORA MI registry. Ann Med. 2021;53(1):2142-52. doi:10.1080/07853890.2021.2002926.</mixed-citation><mixed-citation xml:lang="en">Krämer C, Meisinger C, Kirchberger I, et al. Epidemiological trends in mortality, event rates and case fatality of acute myocardial infarction from 2004 to 2015: results from the KORA MI registry. Ann Med. 2021;53(1):2142-52. doi:10.1080/07853890.2021.2002926.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Самородская И. В., Бубнова М. Г., Акулова О. А., Матвеева И. Ф. Смертность от острых форм ишемической болезни сердца у мужчин и женщин в Российской Федерации в 2015 и 2019 годах. Кардиоваскулярная терапия и профилактика. 2022;21(6):3273. doi:10.15829/1728-8800-2022-3273.</mixed-citation><mixed-citation xml:lang="en">Samorodskaya IV, Bubnova MG, Akulova OA, Matveeva IF. Mortality from acute types of coronary artery disease in men and women in Russia in 2015 and 2019. Cardiovascular Therapy and Prevention. 2022;21(6):3273. (In Russ.) doi:10.15829/1728-8800-2022-3273.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Haider A, Bengs S, Luu J, et al. Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome. Eur Heart J. 2020;41:1328-36. doi:10.1093/eurheartj/ehz898.</mixed-citation><mixed-citation xml:lang="en">Haider A, Bengs S, Luu J, et al. Sex and gender in cardiovascular medicine: presentation and outcomes of acute coronary syndrome. Eur Heart J. 2020;41:1328-36. doi:10.1093/eurheartj/ehz898.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ostrominski JW, Amione-Guerra J, Hernandez B, et al. Coding Variation and Adherence to Methodological Standards in Cardiac Research Using the National Inpatient Sample. Front Cardiovasc Med. 2021;8:713695. doi:10.3389/fcvm.2021.713695.</mixed-citation><mixed-citation xml:lang="en">Ostrominski JW, Amione-Guerra J, Hernandez B, et al. Coding Variation and Adherence to Methodological Standards in Cardiac Research Using the National Inpatient Sample. Front Cardiovasc Med. 2021;8:713695. doi:10.3389/fcvm.2021.713695.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Davis LA, Mann A, Cannon GW, et al. Validation of Diagnostic and Procedural Codes for Identification of Acute Cardiovascular Events in US Veterans with Rheumatoid Arthritis. EGEMS (Wash DC). 2013;1(3):1023. doi:10.13063/2327-9214.1023.</mixed-citation><mixed-citation xml:lang="en">Davis LA, Mann A, Cannon GW, et al. Validation of Diagnostic and Procedural Codes for Identification of Acute Cardiovascular Events in US Veterans with Rheumatoid Arthritis. EGEMS (Wash DC). 2013;1(3):1023. doi:10.13063/2327-9214.1023.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;4(3):237-69. doi:10.1093/eurheartj/ehy462.</mixed-citation><mixed-citation xml:lang="en">Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;4(3):237-69. doi:10.1093/eurheartj/ehy462.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
