cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2022-3464cardiovascular-3464Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESОценка полигенного риска артериальной гипертензииAssessment of polygenic risk of hypertensionhttps://orcid.org/0000-0003-1500-3696ЛимоноваА. С.LimonovaA. S.

Алена Сергеевна Лимонова — младший научный сотрудник лаборатории клиномики.

Москва

Moscow

limonova-alena@yandex.ruhttps://orcid.org/0000-0001-7989-0760ЕршоваА. И.ErshovaA. I.

Александра Игоревна Ершова — доктор медицинских наук, заместитель директора по фундаментальной науке, руководитель лаборатории клиномики.

Москва

Moscow

alersh@mail.ruhttps://orcid.org/0000-0003-4765-8021КиселеваА. В.KiselevaA. V.

Анна Витальевна Киселева — кандидат биологических наук, ведущий научный сотрудник лаборатории молекулярной генетики.

Москва

Moscow

sanyutabe@gmail.comhttps://orcid.org/0000-0001-7867-9509РаменскийВ. Е.RamenskyV. E.

Василий Евгеньевич Раменский — кандидат физико-математических наук, руководитель лаборатории геномной и медицинской биоинформатики, доцент факультета биоинженерии и биоинформатики.

Москва

Moscow

ramensky@gmail.comhttps://orcid.org/0000-0002-9056-8796ВяткинЮ. В.VyatkinYu. V.

Юрий Викторович Вяткин — программист лаборатории геномной и медицинской биоинформати ки, старший преподаватель факультета естественных наук.

Москва, Новосибирск

Moscow, Novosibirsk

vyatkin@gmail.comhttps://orcid.org/0000-0001-9844-3122КуценкоВ. А.KutsenkoV. A.

Владимир Александрович Куценко — старший научный сотрудник лаборатории биостатистики отдела эпидемиологии ХНИЗ, аспирант кафедры теории вероятностей.

Москва

Moscow

vlakutsenko@ya.ruhttps://orcid.org/0000-0001-5989-6233МешковА. Н.MeshkovA. N.

Алексей Николаевич Мешков — доктор медицинских наук, руководитель лаборатории молекулярной генетики, доцент.

Москва

Moscow

meshkov@lipidclinic.ruhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Оксана Михайловна Драпкина — доктор медицинских наук, профессор, академик РАН, директор.

Москва

Moscow

drapkina@bk.ruФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины, Минздрав РоссииNational Medical Research Center for Therapy and Preventive MedicineФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины, Минздрав России; ФГБОУ ВО Московский государственный университет им. М.В. ЛомоносоваNational Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State UniversityФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины, Минздрав России; ФГБОУ ВО Новосибирский национальный исследовательский государственный университетNational Medical Research Center for Therapy and Preventive Medicine; Novosibirsk National Research State UniversityФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины, Минздрав России; ФГБОУ ВО Московский государственный университет им. М.В. ЛомоносоваNational Medical Research Center for Therapy and Preventive Medicine; Faculty of Mechanics and Mathematics, Lomonosov Moscow State UniversityФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины, Минздрав России; ФГАОУ ВО Российский национальный исследовательский медицинский университет им. Н.И. Пирогова, Минздрав РоссииNational Medical Research Center for Therapy and Preventive Medicine; Pirogov Russian National Research Medical University202219012023211234643464Copyright © Лимонова А.С., Ершова А.И., Киселева А.В., Раменский В.Е., Вяткин Ю.В., Куценко В.А., Мешков А.Н., Драпкина О.М., 20232023Лимонова А.С., Ершова А.И., Киселева А.В., Раменский В.Е., Вяткин Ю.В., Куценко В.А., Мешков А.Н., Драпкина О.М.Limonova A.S., Ershova A.I., Kiseleva A.V., Ramensky V.E., Vyatkin Y.V., Kutsenko V.A., Meshkov A.N., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/3464

Артериальная гипертензия (АГ) является ведущим фактором риска развития сердечно-сосудистых заболеваний. В последние десятилетия стремительное развитие генетических исследований, в частности полногеномного поиска ассоциаций (GWAS), позволило выявить сотни вариантов нуклеотидной последовательности, ассоциированных с развитием АГ. Одним из подходов к повышению предсказательной способности генетического тестирования является объединение информации о многих вариантах нуклеотидной последовательности в единую систему оценки риска, часто называемую шкалой генетического риска. В рамках настоящего обзора будут рассмотрены наиболее значимые публикации по изучению шкалы генетического риска АГ, обсуждены особенности их разработки и применения.

Hypertension (HTN) is a leading risk factor for the development of cardiovascular diseases. In recent decades, the rapid development of genetic tests, in particular genome-wide association study (GWAS), has made it possible to identify hundreds of nucleotide sequence variants associated with the development of HTN. One approach to improve the predictive power of genetic testing is to combine information about many nucleotide sequence variants into a single risk assessment system, often referred to as a genetic risk score. Within the framework of this review, the most significant publications on the study of the genetic risk score for HTN will be considered, and the features of their development and application will be discussed.

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The authors declare that there are no conflicts of interest present.