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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2023-3657</article-id><article-id custom-type="edn" pub-id-type="custom">FMHVVK</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3657</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Половые и гендерные различия в здоровье и болезни. Часть I. Эволюционная</article-title><trans-title-group xml:lang="en"><trans-title>Sex and gender differences in health and disease. Part I. Evolutionary</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Драпкина Оксана Михайловна — доктор медицинских наук, профессор, академик РАН, директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ODrapkina@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0332-7696</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ким</surname><given-names>О. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>O. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ким Ольга Трофимовна — младший научный сотрудник отдела фундаментальных и прикладных аспектов ожирения</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">olgakimt06@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный научно-­исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2023</year></pub-date><volume>22</volume><issue>8</issue><fpage>3657</fpage><lpage>3657</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Драпкина О.М., Ким О.Т., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Драпкина О.М., Ким О.Т.</copyright-holder><copyright-holder xml:lang="en">Drapkina O.M., Kim O.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3657">https://cardiovascular.elpub.ru/jour/article/view/3657</self-uri><abstract><p>Пол влияет на многие аспекты существования человека, в т.ч. и на его здоровье. Продолжительность жизни — один из самых показательных примеров различий между полами. Установлено, что практически во всем мире женщины живут дольше мужчин, но разрыв в продолжительности жизни значительно варьирует от страны к стране. В обзоре обсуждаются эволюционные механизмы, обуславливающие эту разницу и потенциальные стратегии увеличения продолжительности жизни мужчин. Также рассматриваются вероятные процессы, приводящие к специфичной для пола заболеваемости.</p></abstract><trans-abstract xml:lang="en"><p>Sex affects many aspects of a person's existence, including health. Life expectancy is one of the most telling examples of differences between the sexes. Almost all over the world, women have been found to live longer than men, but the gap in life expectancy varies considerably from country to country. The review discusses the evolutionary mechanisms behind this difference and potential strategies for increasing male life expectancy. Likely processes leading to sex-specific morbidity are also considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пол</kwd><kwd>гендер</kwd><kwd>продолжительность жизни</kwd><kwd>эволюция</kwd><kwd>генетика</kwd><kwd>половые хромосомы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>sex</kwd><kwd>gender</kwd><kwd>lifespan</kwd><kwd>evolution</kwd><kwd>genetics</kwd><kwd>sex chromosomes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Baggio G, Corsini A, Floreani A, et al. Gender medicine: a task for the third millennium. Clin Chem Lab Med. 2013;51(4):713-27. doi:10.1515/cclm-2012-0849.</mixed-citation><mixed-citation xml:lang="en">Baggio G, Corsini A, Floreani A, et al. Gender medicine: a task for the third millennium. 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