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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2024-3874</article-id><article-id custom-type="edn" pub-id-type="custom">NQABHL</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3874</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CORONARY HEART DISEASE</subject></subj-group></article-categories><title-group><article-title>Повлиял ли COVID-19 на региональную смертность от острых форм ишемической болезни сердца? (сравнение двух периодов 2017-2019гг и 2020-2022гг)</article-title><trans-title-group xml:lang="en"><trans-title>Has COVID-19 affected regional mortality from acute coronary artery disease? (comparison of two periods of 2017-2019 and 2020-2022)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9320-1503</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самородская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Samorodskaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самородская Ирина Владимировна — д.м.н., профессор, г.н.с.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">samor2000@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2250-5942</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бубнова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bubnova</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бубнова Марина Геннадьевна — д.м.н., профессор, руководитель отдела реабилитации и вторичной профилактики сердечно- сосудистых заболеваний.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mbubnova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4302-258X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Акулова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akulova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Акулова Оксана Александровна — к.м.н., врач-кардиолог.</p><p>Курган</p></bio><bio xml:lang="en"><p>Kurgan</p></bio><email xlink:type="simple">akulaox@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУ "Курганский областной кардиологический диспансер"</institution></aff><aff xml:lang="en"><institution>Kurgan Regional Cardiology Dispensary</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>01</month><year>2024</year></pub-date><volume>23</volume><issue>1</issue><fpage>3874</fpage><lpage>3874</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Самородская И.В., Бубнова М.Г., Акулова О.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Самородская И.В., Бубнова М.Г., Акулова О.А.</copyright-holder><copyright-holder xml:lang="en">Samorodskaya I.V., Bubnova M.G., Akulova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3874">https://cardiovascular.elpub.ru/jour/article/view/3874</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценка динамики смертности от острых форм (ОФ) ишемической болезни сердца (ИБС) в регионах Российской Федерации во время периода пандемии (ПП) COVID-19 (COrona VIrus Disease 2019) в 2020-2022гг и ее сравнение с 2017-2019гг — допандемическим периодом (ДПП).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Использованы данные Росстата о среднегодовой численности населения и числе умерших в однолетних возрастных группах по 82 регионам Российской Федерации. В Краткой номенклатуре причин смерти Росстата (КНПСР) коды Международной классификации болезней, травм и причин смерти 10-го пересмотра (МКБ-10) сгруппированы следующим образом: I21.0-9 (острый первичный) инфаркт миокарда (ИМ), I22.0-9 (повторный ИМ), I20, I24.1-9 (другие формы острой ИБС), U07.1 и U07.2 (коронавирусная инфекция COVID-19). Вычислены среднерегиональные стандартизованные показатели смертности (СПС; M±SD) с использованием Европейского стандарта населения методом прямой стандартизации на 100 тыс. населения. Сравнение проводилось с помощью непараметрического t-критерия Вилкоксона (значимыми считались различия при р&lt;0,05).</p></sec><sec><title>Результаты</title><p>Результаты. Выявлено снижение среднерегионального СПС (на 100 тыс. населения) в ПП по сравнению с ДПП: от суммы всех ОФ ИБС — с 51,24±31,98 до 50,21±33,38 и от повторного ИМ — с 7,65±5,42 до 4,80±4,84; повышение СПС от острого ИМ — с 24,00±10,1 до 25,57±11,55, от других ОФ ИБС — с 19,58±25,23 до 19,83±26,21. Отмечена значительная региональная вариабельность как динамики СПС от трех ОФ ИБС, так и минимальных и максимальных СПС. Только в 2-х регионах в ПП отмечено увеличение СПС от каждой из трех ОФ ИБС в ПП по сравнению с ДПП; в 18-и отмечалось снижение СПС от каждой из трех форм, а в остальных отмечена разнонаправленная динамика. Корреляционной взаимосвязи между СПС от COVID-19 и СПС от ОФ ИБС не выявлено (r=0,034; р=0,76).</p></sec><sec><title>Заключение</title><p>Заключение. Пандемия COVID-19 не оказала значимого влияния на среднерегиональные СПС от ОФ ИБС. Статистически значимое снижение СПС от повторного ИМ, вероятно, обусловлено особенностями выбора первоначальной причины смерти.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the changes of mortality from acute coronary artery disease (CAD) in the Russian regions during the coronavirus disease 2019 (COVID-19) pandemic in 2020-2022 in comparison with the prepandemic period (2017-2019).</p></sec><sec><title>Material and methods</title><p>Material and methods. Rosstat data on the average annual population and mortality rate in one-year age groups for 82 regions Russian were used. In the brief Nomenclature of Causes of Death of Rosstat, the codes of the International Classification of Diseases, 10th revision (ICD-10) are grouped as follows: I21.0-9 (acute primary) myocardial infarction (MI), I22.0-9 (recurrent MI), I20, I24.1-9 (other types of acute coronary artery disease), U07.1 and U07.2 (coronavirus disease 2019 (COVID-19)). The regional average standardized mortality rates (SMR; M±SD) were calculated using the European population standard using the direct standardization method per 100 thousand population. Comparisons were made using the nonparametric Wilcoxon t-test (differences were considered significant at p&lt;0,05).</p></sec><sec><title>Results</title><p>Results. A decrease in the regional average SMR (per 100 thousand population) in the pandemic compared to the pre-pandemic period was revealed: from the sum of all acute CAD types — from 51,24±31,98 to 50,21±33,38 and from repeated MI — from 7,65±5,42 to 4,80±4,84; increase in SMR from acute MI — from 24,00±10,1 to 25,57±11,55, from other acute CAD types — from 19,58±25,23 to 19,83±26,21. Significant regional variability was noted in both the dynamics of the SMR from three acute CAD types, as well as the minimum and maximum SMR. Only in 2 regions in the pandemic period there was an increase in SMR from each of the three acute CAD types compared to the pre-pandemic period. In 18 regions, there was a decrease in SMR from each of the three forms, and in the rest, multidirectional changes were noted. There was no correlation between SMR for COVID-19 and SMR for acute CAD (r=0,034; p=0,76).</p></sec><sec><title>Conclusion</title><p>Conclusion. The COVID-19 pandemic did not have a significant impact on the regional average SMR from acute CAD. The significant decrease in SMR from recurrent MI is likely due to choice of the initial cause of death.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>прогнозирование смертности</kwd><kwd>стандартизованный показатель смертности</kwd><kwd>острые формы ишемической болезни сердца</kwd><kwd>первоначальная причина смерти</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary artery disease</kwd><kwd>mortality prediction</kwd><kwd>standardized mortality rate</kwd><kwd>acute types of coronary artery disease</kwd><kwd>primary cause of death</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kole C, Stefanou E, Karvelas N, et al. Acute and Post-Acute COVID-19 Cardiovascular Complications: A Comprehensive Review. Cardiovasc Drugs Ther. 2023;20:1-16. doi:10.1007/s10557-023-07465-w.</mixed-citation><mixed-citation xml:lang="en">Kole C, Stefanou E, Karvelas N, et al. Acute and Post-Acute COVID-19 Cardiovascular Complications: A Comprehensive Review. Cardiovasc Drugs Ther. 2023;20:1-16. doi:10.1007/s10557-023-07465-w.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Canalella A, Vitale E, Vella F, et al. How the Heart Was Involved in COVID-19 during the First Pandemic Phase: A Review. Epidemio-logia (Basel). 2021;22;2(1):124-39. doi:10.3390/epidemiologia2010011.</mixed-citation><mixed-citation xml:lang="en">Canalella A, Vitale E, Vella F, et al. How the Heart Was Involved in COVID-19 during the First Pandemic Phase: A Review. Epidemio-logia (Basel). 2021;22;2(1):124-39. doi:10.3390/epidemiologia2010011.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Roth G, Vaduganathan M, Mensah G, et al. Impact of the COVID-19 Pandemic on Cardiovascular Health in 2020. J Am Coll Cardiol. 2022;80(6)631-40. doi:10.1016/j.jacc.2022.06.008.</mixed-citation><mixed-citation xml:lang="en">Roth G, Vaduganathan M, Mensah G, et al. Impact of the COVID-19 Pandemic on Cardiovascular Health in 2020. J Am Coll Cardiol. 2022;80(6)631-40. doi:10.1016/j.jacc.2022.06.008.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Guo H, Shen Y, Wu N, et al. Myocardial injury in severe and critical coronavirus disease 2019 patients. J Card Surg. 2021;36(1):82-8. doi:10.1111/jocs.15164.</mixed-citation><mixed-citation xml:lang="en">Guo H, Shen Y, Wu N, et al. Myocardial injury in severe and critical coronavirus disease 2019 patients. J Card Surg. 2021;36(1):82-8. doi:10.1111/jocs.15164.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506. doi:10.1016/S0140-6736(20)30183-5.</mixed-citation><mixed-citation xml:lang="en">Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506. doi:10.1016/S0140-6736(20)30183-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109:531-38. doi:10.1007/s00392-020-01626-9.</mixed-citation><mixed-citation xml:lang="en">Li B, Yang J, Zhao F, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109:531-38. doi:10.1007/s00392-020-01626-9.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Liu PP, Blet A, Smyth D, et al. The Science Underlying COVID-19: Implications for the Cardiovascular System. Circulation. 2020;142(1):68-78. doi:10.1161/CIRCULATIONAHA.120.047549.</mixed-citation><mixed-citation xml:lang="en">Liu PP, Blet A, Smyth D, et al. The Science Underlying COVID-19: Implications for the Cardiovascular System. Circulation. 2020;142(1):68-78. doi:10.1161/CIRCULATIONAHA.120.047549.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Z, Tang M, Luan X, et al. Editorial: What do we know about COVID-19 implications for cardiovascular disease? Front Cardiovasc Med. 2023;10:1125655. doi:10.3389/fcvm.2023.1125655.</mixed-citation><mixed-citation xml:lang="en">Wang Z, Tang M, Luan X, et al. Editorial: What do we know about COVID-19 implications for cardiovascular disease? Front Cardiovasc Med. 2023;10:1125655. doi:10.3389/fcvm.2023.1125655.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bonow RO, Fonarow GC, O'Gara PT, et al. Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality. JAMA Cardiol. 2020;5(7):751-3. doi:10.1001/jamacardio.2020.1105.</mixed-citation><mixed-citation xml:lang="en">Bonow RO, Fonarow GC, O'Gara PT, et al. Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality. JAMA Cardiol. 2020;5(7):751-3. doi:10.1001/jamacardio.2020.1105.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Xiong TY, Redwood S, Prendergast B, et al. Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J. 2020;41(19):1798-800. doi:10.1093/eurheartj/ehaa231.</mixed-citation><mixed-citation xml:lang="en">Xiong TY, Redwood S, Prendergast B, et al. Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J. 2020;41(19):1798-800. doi:10.1093/eurheartj/ehaa231.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Liang C, Zhang W, Li S, et al. Coronary heart disease and COVID-19: A meta-analysis. Med Clin (Barc). 2021;156(11):547-54. doi:10.1016/j.medcli.2020.12.017.</mixed-citation><mixed-citation xml:lang="en">Liang C, Zhang W, Li S, et al. Coronary heart disease and COVID-19: A meta-analysis. Med Clin (Barc). 2021;156(11):547-54. doi:10.1016/j.medcli.2020.12.017.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wadhera RK, Shen C, Gondi S, et al. Cardiovascular deaths during the COVID-19 pandemic in the United States. J Am Coll Cardiol. 2021;77:2:159-69. doi:10.1016/j.jacc.2020.10.055.</mixed-citation><mixed-citation xml:lang="en">Wadhera RK, Shen C, Gondi S, et al. Cardiovascular deaths during the COVID-19 pandemic in the United States. J Am Coll Cardiol. 2021;77:2:159-69. doi:10.1016/j.jacc.2020.10.055.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">De Rosa S, Spaccarotella C, Basso C, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J. 2020;41(22):2083-8. doi:10.1093/eurheartj/ehaa409.</mixed-citation><mixed-citation xml:lang="en">De Rosa S, Spaccarotella C, Basso C, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J. 2020;41(22):2083-8. doi:10.1093/eurheartj/ehaa409.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Altobelli E, Angeletti PM, Marzi F, et al. Impact of SARS-CoV-2 Outbreak on Emergency Department Presentation and Prognosis of Patients with Acute Myocardial Infarction: A Systematic Review and Updated Meta-Analysis. J Clin Med. 2022;11(9):2323. doi:10.3390/jcm11092323.</mixed-citation><mixed-citation xml:lang="en">Altobelli E, Angeletti PM, Marzi F, et al. Impact of SARS-CoV-2 Outbreak on Emergency Department Presentation and Prognosis of Patients with Acute Myocardial Infarction: A Systematic Review and Updated Meta-Analysis. J Clin Med. 2022;11(9):2323. doi:10.3390/jcm11092323.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Данилова И.А. Заболеваемость и смертность от COVID-19. Проблема сопоставимости данных. Демографическое обозрение. 2020;7(1):6-26. doi:10.17323/demreview.v7i1.10818.</mixed-citation><mixed-citation xml:lang="en">Danilova IA. Morbidity and mortality from COVID-19. Data comparability issue. Demographic review. 2020;7(1):6-26. (In Russ.) doi:10.17323/demreview.v7i1.10818.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lindahl B, Mills NL. A new clinical classification of acute myocardial infarction. Nat Med. 2023;29(9):2200-5. doi:10.1038/s41591-023-02513-2.</mixed-citation><mixed-citation xml:lang="en">Lindahl B, Mills NL. A new clinical classification of acute myocardial infarction. Nat Med. 2023;29(9):2200-5. doi:10.1038/s41591-023-02513-2.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hart JD, Sorchik R, Bo KS, et al. Improving medical certification of cause of death: effective strategies and approaches based on experiences from the Data for Health Initiative. BMC Med. 2020;18(1):74. doi:10.1186/s12916-020-01519-8.</mixed-citation><mixed-citation xml:lang="en">Hart JD, Sorchik R, Bo KS, et al. Improving medical certification of cause of death: effective strategies and approaches based on experiences from the Data for Health Initiative. BMC Med. 2020;18(1):74. doi:10.1186/s12916-020-01519-8.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Romaguera R, Ribera A, Guell-Viaplana F, et al. Decrease in ST-segment elevation myocardial infarction admissions in Catalonia during the COVID-19 pandemic. Rev Esp Cardiol (Engl Ed). 2020; 73(9):778-80. doi:10.1016/j.rec.2020.06.001.</mixed-citation><mixed-citation xml:lang="en">Romaguera R, Ribera A, Guell-Viaplana F, et al. Decrease in ST-segment elevation myocardial infarction admissions in Catalonia during the COVID-19 pandemic. Rev Esp Cardiol (Engl Ed). 2020; 73(9):778-80. doi:10.1016/j.rec.2020.06.001.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Самородская И. В., Бубнова М.Г., Акулова О.А. и др. Показатели мужской и женской смертности от острых форм ишемической болезни сердца в пятилетних возрастных группах в Российской Федерации: о чем говорят цифры? Кардиоваскулярная терапия и профилактика. 2022;21(12):3460. doi:10.15829/1728-8800-2022-3460.</mixed-citation><mixed-citation xml:lang="en">Samorodskaya IV, Bubnova MG, Akulova OA, et al. Indicators of male and female mortality from acute forms of coronary heart disease in five-year age groups in the Russian Federation: what do the figures say? Cardiovascular Therapy and Prevention. 2022;21(12):3460. (In Russ.) doi:10.15829/1728-8800-2022-3460.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
