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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2024-3983</article-id><article-id custom-type="edn" pub-id-type="custom">JFCZDD</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-3983</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОСТРЫЙ КОРОНАРНЫЙ СИНДРОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACUTE CORONARY SYNDROME</subject></subj-group></article-categories><title-group><article-title>Особенности ведения пациентов пожилого и старческого возраста с острым коронарным синдромом без подъема сегмента ST в реальной клинической практике</article-title><trans-title-group xml:lang="en"><trans-title>Management features of elderly and senile patients with non-ST elevation acute coronary syndrome in clinical practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4918-3795</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Константинова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Konstantinova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Константинова Екатерина Владимировна — д.м.н., доцент кафедры факультетской терапии им. акад. А.И. Нестерова лечебного факультета, профессор кафедры интервенционной кардиологии и кардиореабилитации факультета дополнительного профессионального образования института непрерывного профессионального образования и профессионального развития, врач-кардиолог.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">katekons@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-5782-1064</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>С. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>S. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Денисова Светлана Олеговна — студентка 5 курса лечебного факультета.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">svetok301@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8089-2553</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербацевич</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Shcherbatsevich</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щербацевич Александра Дмитриевна — студентка 5 курса лечебного факультета.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">alexandra.scherbatsevich@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9597-6716</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калинина</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalinina</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Калинина Маргарита Игоревна — аспирант 1 года кафедры госпитальной терапии № 1 Института клинической медицины им. Н.В. Склифосовского.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dr.kalinina.margarita@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-0492-9878</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черников</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernikov</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черников Артём Олегович — старший лаборант кафедры интервенционной кардиологии и кардиореабилитации факультета дополнительного профессионального образования института непрерывного профессионального образования и профессионального развития, врач-кардиолог отделения реанимации и интенсивной терапии для больных с острым инфарктом миокарда.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">chernikovtema@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5664-8766</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахими</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rahimi</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рахими Навид А. — аспирант кафедры интервенционной кардиологии и кардиореабилитации факультета дополнительного профессионального образования института непрерывного профессионального образования и профессионального развития.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">abobakar.safi@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3655-1586</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Великоцкий</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Velikotsky</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Великоцкий Антон Александрович — врач — рентгенхирург.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">vel_aa@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-4694-6140</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Площенков</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ploshchenkov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Площенков Евгений Валерьевич — зав. отделением ренгенхирургических методов диагностики и лечения.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Jenya-09@inbox.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Минздрава России; ГБУЗ "ГКБ № 1 им. Н.И. Пирогова" ДЗМ</institution></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University; Pirogov City Clinical Hospital № 1</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО "Российский национальный исследовательский медицинский университет им. Н.И. Пирогова" Минздрава России</institution></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО "Первый Московский государственный медицинский университет им. И.М. Сеченова" Минздрава России (Сеченовский Университет)</institution></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ "ГКБ № 1 им. Н.И. Пирогова" ДЗМ</institution></aff><aff xml:lang="en"><institution>Pirogov City Clinical Hospital № 1</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>05</month><year>2024</year></pub-date><volume>23</volume><issue>7</issue><fpage>3983</fpage><lpage>3983</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Константинова Е.В., Денисова С.О., Щербацевич А.Д., Калинина М.И., Черников А.О., Рахими Н.А., Великоцкий А.А., Площенков Е.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Константинова Е.В., Денисова С.О., Щербацевич А.Д., Калинина М.И., Черников А.О., Рахими Н.А., Великоцкий А.А., Площенков Е.В.</copyright-holder><copyright-holder xml:lang="en">Konstantinova E.V., Denisova S.O., Shcherbatsevich A.D., Kalinina M.I., Chernikov A.O., Rahimi N.A., Velikotsky A.A., Ploshchenkov E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/3983">https://cardiovascular.elpub.ru/jour/article/view/3983</self-uri><abstract><sec><title>Цель</title><p>Цель. Сравнительный анализ двух групп пациентов с острым коронарным синдромом без подъёма сегмента ST (ОКСбпST) в возрастных подгруппах 60 лет-74 года (пожилого возраста) и в возрасте ≥75 лет (старческого возраста); сопоставление частоты выполнения коронароангиографии (КАГ) с намерением выполнить чрескожное коронарное вмешательство (ЧКВ) и времени до выполнения вмешательства, оценка коморбидных состояний, ассоциированных с непроведением ЧКВ в реальной клинической практике в выделенных подгруппах пациентов.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 580 пациентов в возрасте ≥60 лет: 60-74 лет (пожилого возраста) и ≥75 лет (старческого возраста), — последовательно госпитализированных в региональный сосудистый центр городской клинической больницы г. Москвы за период с 01.01.2021 по 31.12.2022 с диагнозом ОКСбпST. Решение о выполнении КАГ с возможным ЧКВ принимали врачи стационара в рабочем порядке ежедневной клинической практики. Статистическая обработка данных выполнялась в программе Microsoft Excel 19.0.</p></sec><sec><title>Результаты</title><p>Результаты. В группе пациентов старческого возраста выявлен сравнительно бóльшая доля женщин, пациентов с окончательным диагнозом инфаркт миокарда, частота выявления анемии, хронической и острой сердечной недостаточности ≥II класса по Killip, фибрилляции предсердий и хронической болезни почек стадии ≥3. КАГ/ЧКВ была выполнена в группе пациентов пожилого возраста в 91,5% случаев, что оказалось более частым в сравнении с пациентами старческого возраста, у которых вмешательство было выполнено в 85% случаев (p=0,015). КАГ/ЧКВ в обеих группах выполнялись преимущественно в первые сутки от поступления в стационар. В группах с консервативной стратегией у пациентов 60-74 лет достоверно чаще наблюдалась анемия, в возрасте ≥75 лет — аортальный стеноз, в любом возрасте в группе с непроведением КАГ/ЧКВ значимо чаще отмечался летальный исход заболевания в стационаре.</p></sec><sec><title>Заключение</title><p>Заключение. Пациенты с ОКСбпST пожилого и старческого возраста, включённые в исследование, подвергались преимущественно инвазивному лечению в первые сутки от момента госпитализации. Группы пациентов пожилого и старческого возраста различались по частоте реваскуляризации, коморбидной патологии и исходам заболевания в стационаре, но не различалась по времени и тактике лечения. В подгруппах с интервенционным лечением чаще наблюдался благоприятный исход заболевания в стационаре.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Comparative analysis of two groups of patients with non-ST elevation acute coronary syndrome (NSTE-ACS) in age subgroups 60-74 years (elderly patients) and 75 years and older (senile patients); comparison of the coronary angiography (CAG) performance rate with percutaneous coronary intervention (PCI) consideration and time to intervention; evaluation of comorbidities associated with PCI non-performance in clinical practice in the selected subgroups of patients.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 580 patients aged 60 years and older (60-74 years (elderly patient group) and 75 years and older (senile patient group)), hospitalized at the regional vascular center of City Clinical Hospital in Moscow during the period from January 01, 2021 to December 31, 2022 with the diagnosis of NSTE-ACS. The decision to perform CAG with possible PCI was made by hospital physicians in the routine order of daily clinical practice. Statistical analysis was performed in Microsoft Excel 19.</p></sec><sec><title>Results</title><p>Results. In the group of senile patients, there was a comparatively higher percentage of women, patients with a final diagnosis of myocardial infarction, prevalence of anemia, chronic and Killip class ≥II acute heart failure, atrial fibrillation, and stage ≥3 chronic kidney disease. CAG/PCI was performed in the elderly patient group in 91,5% of cases, which was more frequent compared to the senile patient group, where the intervention was performed in 85% of cases (p=0,015). Mostly, CAG/PCI in both groups was performed within the first day of hospital admission. Anemia was significantly more common in patients aged 60-74 years in the conservative strategy groups, and aortic stenosis was more common in those aged 75 years and older. In any age group with non-performance of CAG/PCI, a significant frequency of in-hospital mortality was observed.</p></sec><sec><title>Conclusion</title><p>Conclusion. Patients with NSTE-ACS of elderly and senile age included in the study predominantly underwent invasive treatment within the first day of hospitalization. The elderly and senile age patient groups differed in the prevalence of revascularization, comorbidities and in-hospital outcomes, and did not differ in the time and treatment strategy. The subgroups with interventional treatment more often had a favorable in-hospital outcome.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром без подъёма сегмента ST</kwd><kwd>пациенты пожилого возраста</kwd><kwd>пациенты старческого возраста</kwd><kwd>чрескожное коронарное вмешательство</kwd><kwd>коморбидная патология</kwd><kwd>реальная клиническая практика</kwd><kwd>время до реваскуляризации</kwd><kwd>инвазивная стратегия</kwd><kwd>консервативная стратегия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>non-ST elevation acute coronary syndrome</kwd><kwd>elderly patients</kwd><kwd>senile patients</kwd><kwd>percutaneous coronary intervention</kwd><kwd>comorbid pathology</kwd><kwd>clinical practice</kwd><kwd>time to revascularization</kwd><kwd>invasive strategy</kwd><kwd>conservative strategy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Damluji AA, Forman DE, Wang TY, et al. 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