cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2024-3993RKEDKScardiovascular-3993Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESАртериальная гипертензия и снижение минеральной плотности костей: неожиданные патогенетические механизмыHypertension and reduced bone mineral density: unexpected pathogenetic mechanismshttps://orcid.org/0000-0001-7230-0780ШептулинаА. Ф.SheptulinaA. F.

Шептулина Анна Фароковна — к.м.н., в.н.с., руководитель лаборатории профилактической и экспериментальной гастроэнтерологии отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

ASheptulina@gnicpm.ruhttps://orcid.org/0000-0003-1363-1891ГолубеваЮ. А.GolubevaYu. A.

Голубева Юлия Андреевна — м.н.с. лаборатории профилактической и экспериментальной гастроэнтерологии отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

yu_golubeva@mail.ruhttps://orcid.org/0000-0003-3002-1067ЯфароваА. А.YafarovaA. A.

Яфарова Адель Айратовна — м.н.с. лаборатории профилактической и экспериментальной гастроэнтерологии отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

adeleyafaroff@gmail.comhttps://orcid.org/0000-0001-9074-2291ЦориевТ. Т.TsorievT. T.

Цориев Тимур Тамерланович — к.м.н., н.с. отдела профилактика остеопороза и коморбидных состояний.

Москва

Moscow

TTsoriev@gnicpm.ruhttps://orcid.org/0000-0003-3967-3950КиселевА. Р.KiselevA. R.

Киселев Антон Робертович — д.м.н., доцент, руководитель центра координации фундаментальной научной деятельности.

Москва

Moscow

antonkis@list.tuhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Драпкина Оксана Михайловна — д.м.н., профессор, академик РАН, директор.

Москва

Moscow

drapkina@bk.ruФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава РоссииNational Medical Research Center for Therapy and Preventive Medicine20242604202423539933993Copyright © Шептулина А.Ф., Голубева Ю.А., Яфарова А.А., Цориев Т.Т., Киселев А.Р., Драпкина О.М., 20242024Шептулина А.Ф., Голубева Ю.А., Яфарова А.А., Цориев Т.Т., Киселев А.Р., Драпкина О.М.Sheptulina A.F., Golubeva Y.A., Yafarova A.A., Tsoriev T.T., Kiselev A.R., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/3993

Артериальная гипертензия (АГ) и остеопороз относятся к основным возраст-ассоциированным состояниям, каждое из которых является причиной значительной заболеваемости и смертности. На сегодняшний день накоплены данные о связи между АГ, маркерами формирования костного матрикса и резорбции костной ткани. В настоящей обзорной статье обсуждается взаимосвязь между АГ и снижением минеральной плотности костной ткани, а также ранее неизвестные патогенетические механизмы, лежащие в ее основе.

Hypertension (HTN) and osteoporosis are major age-related conditions, each of which causes significant morbidity and mortality. To date, data have been accumulated on the relationship between hypertension, markers of bone matrix formation and bone resorption. This review article discusses the relationship between hypertension and reduced bone mineral density, as well as previously unknown pathogenetic mechanisms underlying it.

артериальная гипертензияостеопенияостеопорозминеральная плотность костной тканиhypertensionosteopeniaosteoporosisbone mineral densityРабота выполнена в рамках гранта РНФ-БРФФИ: "Распространенность и факторы, ассоциированные с нарушениями костно-мышечного статуса, у пациентов молодого и среднего возраста с артериальной гипертензией и неалкогольной жировой болезнью печени в российской и белорусской популяциях" (Проект № 23-45-10030; 2023-2025гг).The work was carried out within the framework of the RNF-BRFFI grant: "Prevalence and factors associated with disorders of musculoskeletal status in young and middle-aged patients with arterial hypertension and non-alcoholic fatty liver disease in Russian and Belarusian populations" (Project № 23-45-10030; 2023-2025).ReferencesБелая Ж. Е., Белова К. Ю., Бирюкова Е. В. и др. Федеральные клинические рекомендации по диагностике, лечению и профилактике остеопороза. Остеопороз и остеопатии. 2021;24(2):4-47. doi:10.14341/osteo12930.Belaya ZhE, Belova KYu, Biryukova EV, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4-47. (In Russ.) doi:10.14341/osteo12930.Михайлов Е. Е., Беневоленская Л.И. Руководство по остеопорозу. М.: БИНОМ. Лаборатория знаний; 2003.Mikhailov EE, Benevolenskaya LI. Rukovodstvo po osteoporozu. Moscow: BINOM. Laboratoriya znaniy; 2003. (In Russ.)Лесняк О. М., Ершова О.Б. Аудит состояния проблемы остеопороза в странах Восточной Европы и Центральной Азии 2010. Naturaprint: International Osteoporosis Foundation (CH); 2011;14(2):3-6. doi:10.14341/osteo201123-6.Lesnyak OM, Ershova OB. Audit sostoyaniya problemy osteoporoza v stranakh Vostochnoy Evropy i Tsentral'noy Azii 2010. Naturaprint: International Osteoporosis Foundation (CH). 2011;14(2):3-6. (In Russ.) doi:10.14341/osteo201123-6.Varacallo MA, Fox EJ, Paul EM, et al. Patients' response toward an automated orthopedic osteoporosis intervention program. Geriatr Orthop Surg Rehabil. 2013;4(3):89-98. doi:10.1177/2151458513502039.Varacallo MA, Fox EJ, Paul EM, et al. Patients' response toward an automated orthopedic osteoporosis intervention program. Geriatr Orthop Surg Rehabil. 2013;4(3):89-98. doi:10.1177/2151458513502039.Aldukhayel A. Prevalence and patterns of bone mineral density disorders among women in Buraidah, KSA. J Taibah Univ Med Sci. 2022;18(2):348-55. doi:10.1016/j.jtumed.2022.09.014.Aldukhayel A. Prevalence and patterns of bone mineral density disorders among women in Buraidah, KSA. J Taibah Univ Med Sci. 2022;18(2):348-55. doi:10.1016/j.jtumed.2022.09.014.Sarafrazi N, Wambogo EA, Shepherd JA. Osteoporosis or Low Bone Mass in Older Adults: United States, 2017-2018. NCHS Data Brief. 2021;(405):1-8.Sarafrazi N, Wambogo EA, Shepherd JA. Osteoporosis or Low Bone Mass in Older Adults: United States, 2017-2018. NCHS Data Brief. 2021;(405):1-8.Shatrugna V, Kulkarni B, Kumar PA, et al. Bone status of Indian women from a low-income group and its relationship to the nutritional status. Osteoporos Int. 2005;16(12):1827-35. doi:10.1007/s00198-005-1933-1.Shatrugna V, Kulkarni B, Kumar PA, et al. Bone status of Indian women from a low-income group and its relationship to the nutritional status. Osteoporos Int. 2005;16(12):1827-35. doi:10.1007/s00198-005-1933-1.Panahi N, Saeedi Moghaddam S, et al. Trend in global burden attributable to low bone mineral density in different WHO regions: 2000 and beyond, results from the Global Burden of Disease (GBD) study 2019. Endocr Connect. 2023;12(10):e230160. doi:10.1530/EC-23-0160.Panahi N, Saeedi Moghaddam S, et al. Trend in global burden attributable to low bone mineral density in different WHO regions: 2000 and beyond, results from the Global Burden of Disease (GBD) study 2019. Endocr Connect. 2023;12(10):e230160. doi:10.1530/EC-23-0160.Хозяинова Н.Ю., Царева В.М., Курбасова Ю.В. и др. Снижение минеральной плотности костной ткани — маркер сердечно-сосудистого ремоделирования. Тихоокеанский медицинский журнал. 2011;(4):58-61.Khoziainova NYu, Tsareva VM, Kurbasova YuV, et al. Reduction of mineral density of bone tissue as cardiovascular remodelling marker. Pacific Medical Journal. 2011;(4):58-61. (In Russ.)McCloskey E, Rathi J, Heijmans S, et al. Prevalence of FRAX risk factors and the osteoporosis treatment gap among women >70 years of age in routine primary care across 8 countries in Europe. Arch Osteoporos. 2022;17(1):20. doi:10.1007/s11657-021-01048-8.McCloskey E, Rathi J, Heijmans S, et al. Prevalence of FRAX risk factors and the osteoporosis treatment gap among women >70 years of age in routine primary care across 8 countries in Europe. Arch Osteoporos. 2022;17(1):20. doi:10.1007/s11657-021-01048-8.Asaba Y, Ito M, Fumoto T, et al. Activation of renin-angiotensin system induces osteoporosis independently of hypertension. J Bone Miner Res. 2009;24(2):241-50. doi:10.1359/jbmr.081006.Asaba Y, Ito M, Fumoto T, et al. Activation of renin-angiotensin system induces osteoporosis independently of hypertension. J Bone Miner Res. 2009;24(2):241-50. doi:10.1359/jbmr.081006.Yang S, Nguyen ND, Center JR, et al. Association between hypertension and fragility fracture: a longitudinal study. Osteoporos Int. 2014;25(1):97-103. doi:10.1007/s00198-013-2457-8.Yang S, Nguyen ND, Center JR, et al. Association between hypertension and fragility fracture: a longitudinal study. Osteoporos Int. 2014;25(1):97-103. doi:10.1007/s00198-013-2457-8.Cappuccio FP, Meilahn E, Zmuda JM, et al. High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet. 1999;354(9183):971-5.Cappuccio FP, Meilahn E, Zmuda JM, et al. High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet. 1999;354(9183):971-5.Tsuda K, Nishio I, Masuyama Y. Bone mineral density in women with essential hypertension. Am J Hypertens. 2001; 14(7 Pt 1):704-7. doi:10.1016/s0895-7061(01)01303-6.Tsuda K, Nishio I, Masuyama Y. Bone mineral density in women with essential hypertension. Am J Hypertens. 2001; 14(7 Pt 1):704-7. doi:10.1016/s0895-7061(01)01303-6.Al-Hariri M, Aldhafery B. Association of Hypertension and Lipid Profile with Osteoporosis. Scientifica (Cairo). 2020; 2020: 7075815. doi:10.1155/2020/7075815.Al-Hariri M, Aldhafery B. Association of Hypertension and Lipid Profile with Osteoporosis. Scientifica (Cairo). 2020; 2020: 7075815. doi:10.1155/2020/7075815.Mussolino ME, Gillum RF. Bone mineral density and hypertension prevalence in postmenopausal women: results from the Third National Health and Nutrition Examination Survey. Ann Epidemiol. 2006;16:395-9. doi:10.1016/j.annepidem.2005.06.051.Mussolino ME, Gillum RF. Bone mineral density and hypertension prevalence in postmenopausal women: results from the Third National Health and Nutrition Examination Survey. Ann Epidemiol. 2006;16:395-9. doi:10.1016/j.annepidem.2005.06.051.Javed F, Khan SA, Ayers EW, et al. Association of hypertension and bone mineral density in an elderly African American female population. J Natl Med Assoc. 2012;104(3-4):172-8. doi:10.1016/s0027-9684(15)30140-1.Javed F, Khan SA, Ayers EW, et al. Association of hypertension and bone mineral density in an elderly African American female population. J Natl Med Assoc. 2012;104(3-4):172-8. doi:10.1016/s0027-9684(15)30140-1.Woo J, Kwok T, Leung J, et al. Dietary intake, blood pressure and osteoporosis. J Hum Hypertens. 2009;23(7):451-5. doi:10.1038/jhh.2008.156.Woo J, Kwok T, Leung J, et al. Dietary intake, blood pressure and osteoporosis. J Hum Hypertens. 2009;23(7):451-5. doi:10.1038/jhh.2008.156.Hanley DA, Brown JP, Tenenhouse A, et al. Associations among disease conditions, bone mineral density, and prevalent vertebral deformities in men and women 50 years of age and older: crosssectional results from the Canadian Multicentre Osteoporosis Study. J Bone Miner Res. 2003;18:784-90. doi:10.1359/jbmr.2003.18.4.784.Hanley DA, Brown JP, Tenenhouse A, et al. Associations among disease conditions, bone mineral density, and prevalent vertebral deformities in men and women 50 years of age and older: crosssectional results from the Canadian Multicentre Osteoporosis Study. J Bone Miner Res. 2003;18:784-90. doi:10.1359/jbmr.2003.18.4.784.He B, Yin L, Zhang M, et al. Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study. Front Endocrinol (Lausanne). 2021;12:716681. doi:10.3389/fendo.2021.716681.He B, Yin L, Zhang M, et al. Causal Effect of Blood Pressure on Bone Mineral Density and Fracture: A Mendelian Randomization Study. Front Endocrinol (Lausanne). 2021;12:716681. doi:10.3389/fendo.2021.716681.Yazici S, Yazici M, Korkmaz U, et al. Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women. Arch Med Sci. 2011;7(2):264-70. doi:10.5114/aoms.2011.22077.Yazici S, Yazici M, Korkmaz U, et al. Relationship between blood pressure levels and bone mineral density in postmenopausal Turkish women. Arch Med Sci. 2011;7(2):264-70. doi:10.5114/aoms.2011.22077.Lidfeldt J, Holmdahl L, Samsioe G, et al. The influence of hormonal status and features of the metabolic syndrome on bone density: a population-based study of Swedish women aged 50 to 59 years. The women's health in the Lund area study. Metabolism. 2002;51(2):267-70. doi:10.1053/meta.2002.300001.Lidfeldt J, Holmdahl L, Samsioe G, et al. The influence of hormonal status and features of the metabolic syndrome on bone density: a population-based study of Swedish women aged 50 to 59 years. The women's health in the Lund area study. Metabolism. 2002;51(2):267-70. doi:10.1053/meta.2002.300001.Mani K, Mani A. The significance of plasma collagen degradation products as biomarkers for advanced hypertensive heart disease. J Clin Hypertens (Greenwich). 2021;23(5):1017-9. doi:10.1111/jch.14205.Mani K, Mani A. The significance of plasma collagen degradation products as biomarkers for advanced hypertensive heart disease. J Clin Hypertens (Greenwich). 2021;23(5):1017-9. doi:10.1111/jch.14205.Querejeta R, Lopez B, Gonzalez A, et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation. 2OO4;110(10):1263-8.Querejeta R, Lopez B, Gonzalez A, et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation. 2OO4;110(10):1263-8.Hassager C, Jensen L, Johansen J, et al. The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism. 1991;40:205-8. doi:10.1016/0026-0495(91)90176-W.Hassager C, Jensen L, Johansen J, et al. The carboxy-terminal propeptide of type I procollagen in serum as a marker of bone formation: the effect of nandrolone decanoate and female sex hormones. Metabolism. 1991;40:205-8. doi:10.1016/0026-0495(91)90176-W.Eriksen EF, Charles P, Melsen F, et al. Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res. 1993;8:127-32. doi:10.1002/jbmr.5650080202.Eriksen EF, Charles P, Melsen F, et al. Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res. 1993;8:127-32. doi:10.1002/jbmr.5650080202.Park SY, Ahn SH, Yoo JI, et al. Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment. J Bone Metab. 2019;26(4):213-24. doi:10.11005/jbm.2019.26.4.213.Park SY, Ahn SH, Yoo JI, et al. Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment. J Bone Metab. 2019;26(4):213-24. doi:10.11005/jbm.2019.26.4.213.Feldbrin Z, Shargorodsky M. Bone remodelling markers in hypertensive patients with and without diabetes mellitus: link between bone and glucose metabolism. Diabetes Metab Res Rev. 2015; 31(7):752-7. doi:10.1002/dmrr.2668.Feldbrin Z, Shargorodsky M. Bone remodelling markers in hypertensive patients with and without diabetes mellitus: link between bone and glucose metabolism. Diabetes Metab Res Rev. 2015; 31(7):752-7. doi:10.1002/dmrr.2668.Fink HA, Litwack-Harrison S, Taylor BC, et al. Clinical utility of routine laboratory testing to identify possible secondary causes in older men with osteoporosis: the osteoporotic fractures in men (MrOS) study. Osteoporos Int. 2016;27:331-8.Fink HA, Litwack-Harrison S, Taylor BC, et al. Clinical utility of routine laboratory testing to identify possible secondary causes in older men with osteoporosis: the osteoporotic fractures in men (MrOS) study. Osteoporos Int. 2016;27:331-8.Shimizu Y, Nakazato M, Sekita T, et al. Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study. J Physiol Anthropol. 2013;32(1):10. doi:10.1186/1880-6805-32-10.Shimizu Y, Nakazato M, Sekita T, et al. Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study. J Physiol Anthropol. 2013;32(1):10. doi:10.1186/1880-6805-32-10.Webber M, Krishnan A, Thomas NG, et al. Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 20052006. Clin Chem Lab Med. 2010;48(2):167-73. doi:10.1515/CCLM.2010.052.Webber M, Krishnan A, Thomas NG, et al. Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 20052006. Clin Chem Lab Med. 2010;48(2):167-73. doi:10.1515/CCLM.2010.052.Schutte R, Huisman HW, Malan L, et al. Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study. Int J Cardiol. 2013;167(5):1995-2001. doi:10.1016/j.ijcard.2012.05.035.Schutte R, Huisman HW, Malan L, et al. Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study. Int J Cardiol. 2013;167(5):1995-2001. doi:10.1016/j.ijcard.2012.05.035.Lee JH, Lee JW, Lee YJ. The Relationship between Serum Alkaline Phosphatase and Arterial Stiffness in Korean Adults. J Atheroscler Thromb. 2019;26(12):1084-91. doi:10.5551/jat.48942.Lee JH, Lee JW, Lee YJ. The Relationship between Serum Alkaline Phosphatase and Arterial Stiffness in Korean Adults. J Atheroscler Thromb. 2019;26(12):1084-91. doi:10.5551/jat.48942.Zhang Y, Li H, Xie D, et al. Positive Association Between Serum Alkaline Phosphatase and First Stroke in Hypertensive Adults. Front Cardiovasc Med. 2021;8:749196. doi:10.3389/fcvm.2021.749196.Zhang Y, Li H, Xie D, et al. Positive Association Between Serum Alkaline Phosphatase and First Stroke in Hypertensive Adults. Front Cardiovasc Med. 2021;8:749196. doi:10.3389/fcvm.2021.749196.Kunutsor SK, Apekey TA, Khan H.Liver enzymes and risk of cardiovascular disease in the general population: a meta-analysis of prospective cohort studies. Atherosclerosis. 2014;236(1):7-17. doi:10.1016/j.atherosclerosis.2014.06.006.Kunutsor SK, Apekey TA, Khan H.Liver enzymes and risk of cardiovascular disease in the general population: a meta-analysis of prospective cohort studies. Atherosclerosis. 2014;236(1):7-17. doi:10.1016/j.atherosclerosis.2014.06.006.Hu Z, Yang K, Hu Z, et al. Determining the association between hypertension and bone metabolism markers in osteoporotic patients. Medicine (Baltimore). 2021;100(24):e26276. doi:10.1097/MD.0000000000026276.Hu Z, Yang K, Hu Z, et al. Determining the association between hypertension and bone metabolism markers in osteoporotic patients. Medicine (Baltimore). 2021;100(24):e26276. doi:10.1097/MD.0000000000026276.Bezerra dos Santos Magalhaes K, Magalhaes MM, Diniz ET, et al. Metabolic syndrome and central fat distribution are related to lower serum osteocalcin concentrations. Ann Nutr Metab. 2013;62(3):183-8. doi:10.1159/000342561.37 Bezerra dos Santos Magalhaes K, Magalhaes MM, Diniz ET, et al. Metabolic syndrome and central fat distribution are related to lower serum osteocalcin concentrations. Ann Nutr Metab. 2013;62(3):183-8. doi:10.1159/000342561.Choi BH, Joo NS, Kim MJ, et al. Coronary artery calcification is associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men. Clin Endocrinol (Oxf). 2015;83(3):320-6. doi:10.1111/cen.12792.Choi BH, Joo NS, Kim MJ, et al. Coronary artery calcification is associated with high serum concentration of undercarboxylated osteocalcin in asymptomatic Korean men. Clin Endocrinol (Oxf). 2015;83(3):320-6. doi:10.1111/cen.12792.Chen YN, Wei P, Yu Bs J. Higher concentration of serum C-terminal cross-linking telopeptide of type I collagen is positively related with inflammatory factors in postmenopausal women with H-type hypertension and osteoporosis. Orthop Surg. 2019; 11(6):1135-41. doi:10.1111/os.12567.Chen YN, Wei P, Yu Bs J. Higher concentration of serum C-terminal cross-linking telopeptide of type I collagen is positively related with inflammatory factors in postmenopausal women with H-type hypertension and osteoporosis. Orthop Surg. 2019; 11(6):1135-41. doi:10.1111/os.12567.Костина Д. А., Успенский В. Е., Семенова Д. С. и др. Молекулярные механизмы сосудистой кальцификации. Трансляционная медицина. 2020;7(1):6-21. doi:10.18705/2311-4495-2020-7-1-6-21.Kostina DA, Uspensky VE, Semenova DS, et al. Role of calcification in aortic degeneration. Translational Medicine. 2020; 7(1):6-21. (In Russ.) doi:10.18705/2311-4495-2020-7-1-6-21.Caesar C, Lyle AN, Joseph G, et al. Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta. Cell Mol Bioeng. 2017;10(2):144-52. doi:10.1007/s12195-016-0475-2.Caesar C, Lyle AN, Joseph G, et al. Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta. Cell Mol Bioeng. 2017;10(2):144-52. doi:10.1007/s12195-016-0475-2.Lorenzen JM, Neunhoffer H, David S, et al. Angiotensin II receptor blocker and statins lower elevated levels of osteo-pontin in essential hypertension-results from the EUTOPIA trial. Atherosclerosis. 2010;209:184-8. doi:10.1016/j.atherosclerosis.2009.09.009.Lorenzen JM, Neunhoffer H, David S, et al. Angiotensin II receptor blocker and statins lower elevated levels of osteo-pontin in essential hypertension-results from the EUTOPIA trial. Atherosclerosis. 2010;209:184-8. doi:10.1016/j.atherosclerosis.2009.09.009.Omland T, Drazner MH, Ueland T, et al. Plasma osteoprote-gerin levels in the general population: relation to indices of left ventricular structure and function. Hypertension. 2007;49(6):1392-8. doi:10.1161/HYPERTENSIONAHA.107.087742.Omland T, Drazner MH, Ueland T, et al. Plasma osteoprotegerin levels in the general population: relation to indices of left ventricular structure and function. Hypertension. 2007;49(6):1392-8. doi:10.1161/HYPERTENSIONAHA.107.087742.Kuipers AL, Kammerer CM, Pratt JH, et al. Association of Circulating Renin and Aldosterone With Osteocalcin and Bone Mineral Density in African Ancestry Families. Hypertension. 2016;67(5):977-82. doi:10.1161/HYPERTENSIONAHA.115.06837.Kuipers AL, Kammerer CM, Pratt JH, et al. Association of Circulating Renin and Aldosterone With Osteocalcin and Bone Mineral Density in African Ancestry Families. Hypertension. 2016;67(5):977-82. doi:10.1161/HYPERTENSIONAHA.115.06837.Cakmak T, Kadife i, Ayhan E, et al. The relationship between osteoporosis and non-dipper hypertension in postmenopausal women. J Health Sci Med. 2023;6(5):898-904.Cakmak T, Kadife i, Ayhan E, et al. The relationship between osteoporosis and non-dipper hypertension in postmenopausal women. J Health Sci Med. 2023;6(5):898-904.Нуруллина Г. М., Ахмадуллина Г. И., Маслова И.С. Функциональный гипопаратиреоз: причины, патогенез, клиническое значение в патологии костной ткани. Остеопороз и остеопатии. 2018;21(2):30-5. doi:10.14341/osteo9962.Nurullina GM, Akhmadullina GI, Maslova IS. Functional hypoparathyroidism: causes, pathogenesis, clinical significance in Bone tissue pathology. Osteoporosis and Bone Diseases. 2018;21(2):30-5. (In Russ.) doi:10.14341/osteo9962.Liu J, Huang F, He HW. Melatonin effects on hard tissues: bone and tooth. Int J Mol Sci. 2013;14(5):10063-74. doi:10.3390/ijms140510063.Liu J, Huang F, He HW. Melatonin effects on hard tissues: bone and tooth. Int J Mol Sci. 2013;14(5):10063-74. doi:10.3390/ijms140510063.Costa JL, Naot D, Lin JM, et al. Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro. Int J Pept. 2011;2011:605193. doi:10.1155/2011/605193.Costa JL, Naot D, Lin JM, et al. Ghrelin is an Osteoblast Mitogen and Increases Osteoclastic Bone Resorption In Vitro. Int J Pept. 2011;2011:605193. doi:10.1155/2011/605193.Tosun A, Dogru MT, Aydin G, et al. Does autonomic dysfunction exist in postmenopausal osteoporosis? Am J Phys Med Rehabil. 2011;90(12):1012-9. doi:10.1097/PHM.0b013e31822dea1a.Tosun A, Dogru MT, Aydin G, et al. Does autonomic dysfunction exist in postmenopausal osteoporosis? Am J Phys Med Rehabil. 2011;90(12):1012-9. doi:10.1097/PHM.0b013e31822dea1a.

The authors declare that there are no conflicts of interest present.