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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2024-4019</article-id><article-id custom-type="edn" pub-id-type="custom">MXTTFT</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4019</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Повторный инфаркт миокарда — нерешённая проблема доказательной медицины</article-title><trans-title-group xml:lang="en"><trans-title>Recurrent myocardial infarction as an unsolved problem of evidence-based medicine</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7717-4362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марцевич</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Martsevich</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марцевич Сергей Юрьевич — д.м.н., профессор, руководитель отдела профилактической фармакотерапии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">sergeymartsevich@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>29</day><month>05</month><year>2024</year></pub-date><volume>23</volume><issue>6</issue><fpage>4019</fpage><lpage>4019</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Марцевич С.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Марцевич С.Ю.</copyright-holder><copyright-holder xml:lang="en">Martsevich S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4019">https://cardiovascular.elpub.ru/jour/article/view/4019</self-uri><abstract><p>Автор высказывает свое мнение о прогностической роли повторного инфаркта миокарда (ИМ) в настоящее время. В течение многих лет повторный ИМ считался одним из наиболее тяжелых осложнений первичного ИМ. Рассматриваются различия в официальном и научном определении повторного ИМ. Отмечается, что эти различия являются причиной неоднозначной оценки распространенности и прогностической роли повторного ИМ. Анализ литературных данных позволяет заключить, что повторный ИМ и в настоящее время сопровождается существенно более высокими показателями смертности, как в острой фазе, так и в отдаленные сроки по сравнению с первичным ИМ. Анализируются основные факторы, определяющие неблагоприятный прогноз жизни после повторного ИМ. Отмечается, что в современных клинических рекомендациях отсутствуют данные о специфике лечения повторного ИМ. Делается вывод о необходимости разработки специфических методов лечения повторного ИМ.</p></abstract><trans-abstract xml:lang="en"><p>The author brings out opinion on the prognostic role of recurrent myo­cardial infarction (MI) at the present time. For many years, recurrent MI was considered one of the most severe complications of primary MI. Differences in the official and scientific definition of recurrent MI are examined. These differences are the reason for the ambiguous assessment of the prevalence and prognostic role of recurrent MI. Ana­lysis of the literature data makes it possible to conclude that recurrent MI is still accompanied by significantly higher mortality rates, both in the acute phase and in the long term, compared to primary MI. The main factors determining the unfavorable prognosis of life after recurrent MI are analyzed. It is noted that modern clinical guidelines do not contain data on the specifics of treatment for recurrent MI. Specific methods for the treatment of recurrent myocardial infarction should be developed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый инфаркт миокарда</kwd><kwd>повторный инфаркт миокарда</kwd><kwd>официальная и научная терминология</kwd><kwd>ближайшие и отдаленные исходы</kwd><kwd>клинические рекомендации</kwd><kwd>особенности лечения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute myocardial infarction</kwd><kwd>recurrent myocardial infarc­tion</kwd><kwd>official and scientific terminology</kwd><kwd>immediate and long-term out­comes</kwd><kwd>clinical guidelines</kwd><kwd>treatment specifics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Obrastzov WP, Strazhesko ND. Zur Kenntnis der Thrombose der Koronararterien des Herzens. Z Klin Med. 1910;71:116-32.</mixed-citation><mixed-citation xml:lang="en">Obrastzov WP, Strazhesko ND. Zur Kenntnis der Thrombose der Koronararterien des Herzens. Z Klin Med. 1910;71:116-32.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Nabel EG, Braunwald E. A tale of coronary artery disease and myocardial infarction. N Engl J Med. 2012;366(1):54-63. doi:10.1056/NEJMra1112570. Erratum in: N Engl J Med. 2012;366(10):970. doi:10.1056/NEJMra1112570.</mixed-citation><mixed-citation xml:lang="en">Nabel EG, Braunwald E. A tale of coronary artery disease and myocardial infarction. N Engl J Med. 2012;366(1):54-63. doi:10.1056/NEJMra1112570. Erratum in: N Engl J Med. 2012;366(10):970. doi:10.1056/NEJMra1112570.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gálvez-Montón C, Ordoñez-Llanos J, de Luna AB, et al. One hundred years of myocardial infarction. Eur Heart J. 2012;33(23): 2888-91. doi:10.1093/eurheartj/ehs364.</mixed-citation><mixed-citation xml:lang="en">Gálvez-Montón C, Ordoñez-Llanos J, de Luna AB, et al. One hundred years of myocardial infarction. Eur Heart J. 2012;33(23): 2888-91. doi:10.1093/eurheartj/ehs364.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Herrick JB. Clinical features of sudden obstruction of the coronary arteries. JAMA. 1912;250:1757-65.</mixed-citation><mixed-citation xml:lang="en">Herrick JB. Clinical features of sudden obstruction of the coronary arteries. JAMA. 1912;250:1757-65.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Руководство по внутренним болезням. Под редакцией А. Л. Мясникова. М., 1957, 482 с.</mixed-citation><mixed-citation xml:lang="en">Guide to Internal Medicine. Edited by A. L. Myasnikov. M., 1957, 482 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Norris RM, Bensley KE, Caughey DE, et al. Hospital mortality in acute myocardial infarction. Br Med J. 1968;3(5611):143-6. doi: 10.1136/bmj.3.5611.143.</mixed-citation><mixed-citation xml:lang="en">Norris RM, Bensley KE, Caughey DE, et al. Hospital mortality in acute myocardial infarction. Br Med J. 1968;3(5611):143-6. doi: 10.1136/bmj.3.5611.143.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Руда М. Я., Зыско А. П. Инфаркт миокарда. М., Медицина, 1977, 247 с.</mixed-citation><mixed-citation xml:lang="en">Ruda MYa, Zysko AP. Myocardial infarction. M., Medicine, 1977, 247 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Weinblatt E, Shapiro S, Frank CW, et al. Prognosis of men after first myocardial infarction: mortality and first recurrence in relation to selected parameters. Am J Public Health Nations Health. 1968;58(8):1329-47. doi:10.2105/ajph.58.8.1329.</mixed-citation><mixed-citation xml:lang="en">Weinblatt E, Shapiro S, Frank CW, et al. Prognosis of men after first myocardial infarction: mortality and first recurrence in relation to selected parameters. Am J Public Health Nations Health. 1968;58(8):1329-47. doi:10.2105/ajph.58.8.1329.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kitchin AH, Pocock SJ. Prognosis of patients with acute myocardial infarction admitted to a coronary care unit. II. Survival after hospi­tal discharge. Br Heart J. 1977;39(11):1167-71. doi:10.1136/hrt.39.11.1167.</mixed-citation><mixed-citation xml:lang="en">Kitchin AH, Pocock SJ. Prognosis of patients with acute myocardial infarction admitted to a coronary care unit. II. Survival after hospi­tal discharge. Br Heart J. 1977;39(11):1167-71. doi:10.1136/hrt.39.11.1167.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">National Clinical Coding Standards ICD-10 5th Edition (2023). Leeds, UK: NHS England; 2023, 274 p.</mixed-citation><mixed-citation xml:lang="en">National Clinical Coding Standards ICD-10 5th Edition (2023). Leeds, UK: NHS England; 2023, 274 p.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А., Самородская И. В., Га­лявич А. С. и др. Статистическая, клиническая и морфологическая классификации ишемической болезни сердца — есть ли возможность объединения? Российский кардиологический журнал. 2017;(3):63-71. doi:10.15829/1560-4071-2017-3-63-71.</mixed-citation><mixed-citation xml:lang="en">Boytsov SA, Samorodskaya IV, Galyavich AS, et al. Statistical, cli­nical and morphological classifications of coronary heart di­sease — possible to unite? Russian Journal of Cardiology. 2017;(3):63-71. (In Russ.) doi:10.15829/1560-4071-2017-3-63-71.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Эрлих А. Д., Грацианский Н. А. от имени участников регистра РЕКОРД-3. Российский регистр острого коронарного синдрома "РЕКОРД-3". Характеристика пациентов и лечение до выписки из стационара. Кардиология. 2016;56(4):16-24. doi:10.18565/cardio.2016.4.16-24.</mixed-citation><mixed-citation xml:lang="en">Erlikh AD, Gratsiansky NA, on behalf of participants RECORD-3 registers. Registry of acute coronary syndromes "RECORD-3". Characteristics of patients and treatment until discharge during initial hospitalization. Kardiologiia. 2016;56(4):16-24. (In Russ.) doi:10.18565/cardio.2016.4.16-24.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gridnev VI, Kiselev AR, Posnenkova OM, et al.; Russian Registry of Acute Coronary Syndrome Investigators. Objectives and Design of the Russian Acute Coronary Syndrome Registry (RusACSR). Clin Cardiol. 2016;39(1):1-8. doi:10.1002/clc.22495.</mixed-citation><mixed-citation xml:lang="en">Gridnev VI, Kiselev AR, Posnenkova OM, et al.; Russian Registry of Acute Coronary Syndrome Investigators. Objectives and Design of the Russian Acute Coronary Syndrome Registry (RusACSR). Clin Cardiol. 2016;39(1):1-8. doi:10.1002/clc.22495.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Мясников А. Л. О некрозах миокарда. Кардиология. 1962;1:3-8.</mixed-citation><mixed-citation xml:lang="en">Myasnikov AL. About myocardial necrosis. Cardiology. 1962;1:3-8. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Самородская И. В., Бойцов С. А. Повторный инфаркт миокарда: оценка, риски, профилактика. Российский кардиологический журнал. 2017; (6):139-45. doi:10.15829/1560-4071-2017-6-139-145.</mixed-citation><mixed-citation xml:lang="en">Samorodskaya IV, Boytsov SA. Subsequent myocardial in­farction: risk assessment and prevention. Russian Journal of Cardiology. 2017;(6):139-45. (In Russ.) doi:10.15829/1560-4071-2017-6-139-145.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Демографический ежегодник России. Статистический сборник. М., Росстат. М., 2023. 256 с.</mixed-citation><mixed-citation xml:lang="en">The Demographic Yearbook of Russia. Statistical handbook. Moscow, Rosstat. 2023. 256 p. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ощепкова Е. В., Ефремова Ю. Е., Карпов Ю. А. Заболеваемость и смертность от инфаркта миокарда в Российской Федерации в 2000-2011гг. Терапевтический архив. 2013;85(4):4-10.</mixed-citation><mixed-citation xml:lang="en">Oshchepkova EV, Efremova IuE, Karpov YuA. Myocardial infarction morbidity and mortality in the Russian Federation in 2000-2011. Ter Arkh. 2013;85(4):4-10. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Thygesen K, Alpert JS, Jaffe AS, et al. Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72(18):2231-64. doi:10.1016/j.jacc.2018.08.1038.</mixed-citation><mixed-citation xml:lang="en">Thygesen K, Alpert JS, Jaffe AS, et al. Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72(18):2231-64. doi:10.1016/j.jacc.2018.08.1038.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lee SH, Jeong MH, Ahn JH, et al. KAMIR (Korea Acute Myocardial Infarction Registry)-NIH Investigators. Predictors of recurrent acute myocardial infarction despite successful percutaneous coronary intervention. Korean J Intern Med. 2022;37(4):777-85. doi:10.3904/kjim.2021.427.</mixed-citation><mixed-citation xml:lang="en">Lee SH, Jeong MH, Ahn JH, et al. KAMIR (Korea Acute Myocardial Infarction Registry)-NIH Investigators. Predictors of recurrent acute myocardial infarction despite successful percutaneous coronary intervention. Korean J Intern Med. 2022;37(4):777-85. doi:10.3904/kjim.2021.427.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Nair R, Johnson M, Kravitz K, et al. Characteristics and Outcomes of Early Recurrent Myocardial Infarction After Acute Myocardial Infarction. J Am Heart Assoc. 2021;10(16):e019270. doi:10.1161/JAHA.120.019270.</mixed-citation><mixed-citation xml:lang="en">Nair R, Johnson M, Kravitz K, et al. Characteristics and Outcomes of Early Recurrent Myocardial Infarction After Acute Myocardial Infarction. J Am Heart Assoc. 2021;10(16):e019270. doi:10.1161/JAHA.120.019270.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Buch P, Rasmussen S, Gislason GH, et al. Temporal decline in the prognostic impact of a recurrent acute myocardial infarction 1985 to 2002. Heart. 2007;93(2):210-5. doi:10.1136/hrt.2006.092213.</mixed-citation><mixed-citation xml:lang="en">Buch P, Rasmussen S, Gislason GH, et al. Temporal decline in the prognostic impact of a recurrent acute myocardial infarction 1985 to 2002. Heart. 2007;93(2):210-5. doi:10.1136/hrt.2006.092213.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gauthier V, Lafrance M, Barthoulot M, et al. Long-term follow-up of survivors of a first acute coronary syndrome: Results from the French MONICA registries from 2009 to 2017. Int J Cardiol. 2023;378:138-43. doi:10.1016/j.ijcard.2023.02.035.</mixed-citation><mixed-citation xml:lang="en">Gauthier V, Lafrance M, Barthoulot M, et al. Long-term follow-up of survivors of a first acute coronary syndrome: Results from the French MONICA registries from 2009 to 2017. Int J Cardiol. 2023;378:138-43. doi:10.1016/j.ijcard.2023.02.035.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y, Leifheit E, Normand ST, et al. Association Between Subsequent Hospitalizations and Recurrent Acute Myocardial Infarction Within 1 Year After Acute Myocardial Infarction. J Am Heart Assoc. 2020;9(6):e014907. doi:10.1161/JAHA.119.014907.</mixed-citation><mixed-citation xml:lang="en">Wang Y, Leifheit E, Normand ST, et al. Association Between Subsequent Hospitalizations and Recurrent Acute Myocardial Infarction Within 1 Year After Acute Myocardial Infarction. J Am Heart Assoc. 2020;9(6):e014907. doi:10.1161/JAHA.119.014907.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lee CY, Liu KT, Lu HT, et al. Sex and gender differences in pre­sentation, treatment and outcomes in acute coronary syndrome, a 10 year study from a multi-ethnic Asian population: The Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome (NCVD-ACS) registry. PLoS One. 2021;16(2):e0246474. doi:10.1371/journal.pone.0246474.</mixed-citation><mixed-citation xml:lang="en">Lee CY, Liu KT, Lu HT, et al. Sex and gender differences in pre­sentation, treatment and outcomes in acute coronary syndrome, a 10 year study from a multi-ethnic Asian population: The Malaysian National Cardiovascular Disease Database-Acute Coronary Syndrome (NCVD-ACS) registry. PLoS One. 2021;16(2):e0246474. doi:10.1371/journal.pone.0246474.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Smolina K, Wright FL, Rayner M, et al. Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study. Eur J Public Health. 2012;22(6):848-53. doi:10.1093/eurpub/ckr196.</mixed-citation><mixed-citation xml:lang="en">Smolina K, Wright FL, Rayner M, et al. Incidence and 30-day case fatality for acute myocardial infarction in England in 2010: national-linked database study. Eur J Public Health. 2012;22(6):848-53. doi:10.1093/eurpub/ckr196.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Holzmann MJ, Andersson T, Doemland ML, et al. Recurrent myo­cardial infarction and emergency department visits: a retro­spective study on the Stockholm Area Chest Pain Cohort. Open Heart. 2023;10(1):e002206. doi:10.1136/openhrt-2022-002206.</mixed-citation><mixed-citation xml:lang="en">Holzmann MJ, Andersson T, Doemland ML, et al. Recurrent myo­cardial infarction and emergency department visits: a retro­spective study on the Stockholm Area Chest Pain Cohort. Open Heart. 2023;10(1):e002206. doi:10.1136/openhrt-2022-002206.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Seo Y, Moon J, Lee HH, et al. Incidence and case fatality of acute myocardial infarction in Korea, 2011-2020. Epidemiol Health. 2024;46:e2024002. doi:10.4178/epih.e2024002.</mixed-citation><mixed-citation xml:lang="en">Seo Y, Moon J, Lee HH, et al. Incidence and case fatality of acute myocardial infarction in Korea, 2011-2020. Epidemiol Health. 2024;46:e2024002. doi:10.4178/epih.e2024002.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С. Ю., Лукина Ю. В., Кутишенко Н. П. и др. Медицинские регистры. Роль в доказательной медицине. Рекомендации по созданию. Методические рекомендации. М.: ООО "Силицея-Полиграф". 2023. 44 с. ISBN: 978-5-6049087-8-5. doi:10.15829/ROPNIZ-m1-2023. EDN OCKJVC.</mixed-citation><mixed-citation xml:lang="en">Martsevich SYu, Lukina YuV, Kutishenko NP, et al. Medical registers. Role in evidence-based medicine. Guidelines for creation. Methodological guidelines. M.: ROPNIZ, Silicea-Poligraf. 2023. 44 p. (In Russ.) ISBN: 978-5-6049087-8-5. doi:10.15829/ROPNIZ-m1-2023. EDN OCKJVC.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С. Ю., Кутишенко Н. П., Гинзбург М. Л. и др. Исследование ЛИС (Люберецкое исследование смертности больных, перенесших острый инфаркт миокарда): портрет заболевшего. Кардиоваскулярная терапия и профилактика. 2011;10(6):89-93. doi:10.15829/1728-8800- 2011-6-89-93.</mixed-citation><mixed-citation xml:lang="en">Martsevich SY, Kutishenko NP, Ginzburg ML, et al. LIS Study (Lyubertsy Study of mortality in patients after acute myocardial infarction): the patients’ portrait. Cardiovascular Therapy and Pre­vention. 2011;10(6):89-93. (In Russ.) doi:10.15829/1728-8800- 2011-6-89-93.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Сагайдак О. В., Ощепкова Е. В., Попова Ю. В. и др. Анализ оказания медицинской помощи больным с острым коронарным синдромом в 2019 году (по данным федерального регистра острого коронарного синдрома). Кардиологический вестник. 2020;3:37-45.</mixed-citation><mixed-citation xml:lang="en">Sagaydak OV, Oshchepkova EV, Popova YuV, et al. Treatment of patients with acute coronary syndrome in 2019 (data from federal registry of acute coronary syndrome). Russian Cardiology Bul­letin=Kardiologicheskii Vestnik. 2020;3:37-45. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Al Saleh AS, Alhabib KF, Alsheik-Ali AA, et al. Predictors and Impact of In-Hospital Recurrent Myocardial Infarction in Patients with Acute Coronary Syndrome: Findings From Gulf RACE-2. Angiology. 2017;68(6):508-12. doi:10.1177/0003319716674855.</mixed-citation><mixed-citation xml:lang="en">Al Saleh AS, Alhabib KF, Alsheik-Ali AA, et al. Predictors and Impact of In-Hospital Recurrent Myocardial Infarction in Patients with Acute Coronary Syndrome: Findings From Gulf RACE-2. Angiology. 2017;68(6):508-12. doi:10.1177/0003319716674855.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Nedkoff L, Briffa T, Murray K, et al. Risk of early recurrence and mortality in high-risk myocardial infarction patients: A population-based linked data study. Int J Cardiol Cardiovasc Risk Prev. 2023;17:200185. doi:10.1016/j.ijcrp.2023.200185.</mixed-citation><mixed-citation xml:lang="en">Nedkoff L, Briffa T, Murray K, et al. Risk of early recurrence and mortality in high-risk myocardial infarction patients: A population-based linked data study. Int J Cardiol Cardiovasc Risk Prev. 2023;17:200185. doi:10.1016/j.ijcrp.2023.200185.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Svendsen K, Krogh HW, Igland J, et al. 2.5-fold increased risk of recurrent acute myocardial infarction with familial hyper­cholesterolemia. Atherosclerosis. 2021;319:28-34. doi:10.1016/j.atherosclerosis.2020.12.019.</mixed-citation><mixed-citation xml:lang="en">Svendsen K, Krogh HW, Igland J, et al. 2.5-fold increased risk of recurrent acute myocardial infarction with familial hyper­cholesterolemia. Atherosclerosis. 2021;319:28-34. doi:10.1016/j.atherosclerosis.2020.12.019.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Radovanovic D, Maurer L, Bertel O, et al. Treatment and out­comes of patients with recurrent myocardial infarction: A prospective observational cohort study. J Cardiol. 2016;68(6): 498-503. doi:10.1016/j.jjcc.2015.11.013.</mixed-citation><mixed-citation xml:lang="en">Radovanovic D, Maurer L, Bertel O, et al. Treatment and out­comes of patients with recurrent myocardial infarction: A prospective observational cohort study. J Cardiol. 2016;68(6): 498-503. doi:10.1016/j.jjcc.2015.11.013.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Smolina K, Wright FL, Rayner M, et al. Long-term survival and recurrence after acute myocardial infarction in England, 2004 to 2010. Circ Cardiovasc Qual Outcomes. 2012;5(4):532-40. doi:10.1161/CIRCOUTCOMES.111.964700.</mixed-citation><mixed-citation xml:lang="en">Smolina K, Wright FL, Rayner M, et al. Long-term survival and recurrence after acute myocardial infarction in England, 2004 to 2010. Circ Cardiovasc Qual Outcomes. 2012;5(4):532-40. doi:10.1161/CIRCOUTCOMES.111.964700.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Motivala AA, Tamhane U, Ramanath VS, et al. A prior myocardial infarction: how does it affect management and outcomes in recurrent acute coronary syndromes? Clin Cardiol. 2008;31(12): 590-6. doi:10.1002/clc.20356.</mixed-citation><mixed-citation xml:lang="en">Motivala AA, Tamhane U, Ramanath VS, et al. A prior myocardial infarction: how does it affect management and outcomes in recurrent acute coronary syndromes? Clin Cardiol. 2008;31(12): 590-6. doi:10.1002/clc.20356.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Lim S, Choo EH, Choi IJ, et al. Risks of Recurrent Cardiovascular Events and Mortality in 1-Year Survivors of Acute Myocardial Infarction Implanted with Newer-Generation Drug-Eluting Stents. J Clin Med. 2021;10(16):3642. doi:10.3390/jcm10163642.</mixed-citation><mixed-citation xml:lang="en">Lim S, Choo EH, Choi IJ, et al. Risks of Recurrent Cardiovascular Events and Mortality in 1-Year Survivors of Acute Myocardial Infarction Implanted with Newer-Generation Drug-Eluting Stents. J Clin Med. 2021;10(16):3642. doi:10.3390/jcm10163642.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">De Luca L, Paolucci L, Nusca A, et al. Current management and prognosis of patients with recurrent myocardial infarction. Rev Cardiovasc Med. 2021;22(3):731-40. doi:10.31083/j.rcm2203080.</mixed-citation><mixed-citation xml:lang="en">De Luca L, Paolucci L, Nusca A, et al. Current management and prognosis of patients with recurrent myocardial infarction. Rev Cardiovasc Med. 2021;22(3):731-40. doi:10.31083/j.rcm2203080.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Song J, Murugiah K, Hu S, et al; China PEACE Collabortive Group. Incidence, predictors, and prognostic impact of recurrent acute myocardial infarction in China. Heart. 2020;107(4):313-8. doi:10.1136/heartjnl-2020-317165.</mixed-citation><mixed-citation xml:lang="en">Song J, Murugiah K, Hu S, et al; China PEACE Collabortive Group. Incidence, predictors, and prognostic impact of recurrent acute myocardial infarction in China. Heart. 2020;107(4):313-8. doi:10.1136/heartjnl-2020-317165.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С. Ю., Загребельный А. В., Афонина О. С. и др. Изучение особенностей течения повторного инфаркта миокарда в острой стадии в рамках госпитального регистра. Рациональная Фармакотерапия в Кардиологии. 2024;20(1):46-51. doi:10.20996/1819-6446-2024-3008. EDN MYLWJX.</mixed-citation><mixed-citation xml:lang="en">Martsevich SYu, Zagrebelnyy AV, Afonina OS, et al. Study of the course of recurrent myocardial infarction in the acute stage within the framework the hospital registry. Rational Pharmacotherapy in Cardiology. 2024;20(1):46-51. (In Russ.) doi:10.20996/1819-6446-2024-3008. EDN MYLWJX.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart Journal. 2023;44:3720-826. doi:10.1093/eurheartj/ehad191.</mixed-citation><mixed-citation xml:lang="en">2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart Journal. 2023;44:3720-826. doi:10.1093/eurheartj/ehad191.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Российское кардиологическое общество (РКО). Острый инфаркт миокарда с подъемом сегмента ST электрокардиограммы. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(11):4103. doi:10.15829/29/1560-4071-2020-4103.</mixed-citation><mixed-citation xml:lang="en">Russian Society of Cardiology. 2020 Clinical practice guidelines for Acute ST-segment elevation myocardial infarction. Russian Journal of Cardiology. 2020;25(11):4103. (In Russ.) doi:10.15829/29/1560-4071-2020-4103.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Eagle KA, Lim MJ, Dabbous OH, et al.; GRACE Investigators. A validated prediction model for all forms of acute coronary syn­drome: estimating the risk of 6-month postdischarge death in an international registry. JAMA. 2004;291(22):2727-33. doi:10.1001/jama.291.22.2727.</mixed-citation><mixed-citation xml:lang="en">Eagle KA, Lim MJ, Dabbous OH, et al.; GRACE Investigators. A validated prediction model for all forms of acute coronary syn­drome: estimating the risk of 6-month postdischarge death in an international registry. JAMA. 2004;291(22):2727-33. doi:10.1001/jama.291.22.2727.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Aragam KG, Tamhane UU, Kline-Rogers E, et al. Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores. PLoS One. 2009;4(11):e7947. doi:10.1371/journal.pone.0007947.</mixed-citation><mixed-citation xml:lang="en">Aragam KG, Tamhane UU, Kline-Rogers E, et al. Does simplicity compromise accuracy in ACS risk prediction? A retrospective analysis of the TIMI and GRACE risk scores. PLoS One. 2009;4(11):e7947. doi:10.1371/journal.pone.0007947.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Calabrò P, Gragnano F. Event recurrence after myocardial in­farction: Prediction is very difficult, especially about the future. Int J Cardiol. 2019;296:30-31. doi:10.1016/j.ijcard.2019.08.032.</mixed-citation><mixed-citation xml:lang="en">Calabrò P, Gragnano F. Event recurrence after myocardial in­farction: Prediction is very difficult, especially about the future. Int J Cardiol. 2019;296:30-31. doi:10.1016/j.ijcard.2019.08.032.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Granger CB, Pocock SJ, Gersh BJ. The need for new clinical trials of old cardiovascular drugs. Nat Rev Cardiol. 2023;20(2):71-2. doi:10.1038/s41569-022-00819-1.</mixed-citation><mixed-citation xml:lang="en">Granger CB, Pocock SJ, Gersh BJ. The need for new clinical trials of old cardiovascular drugs. Nat Rev Cardiol. 2023;20(2):71-2. doi:10.1038/s41569-022-00819-1.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Mehta SR, Wood DA, Storey RF, et al. Complete Revascularization with Multivessel PCI for Myocardial Infarction. N Engl J Med. 2019;381(15):1411-21. doi:10.1056/NEJMoa1907775.</mixed-citation><mixed-citation xml:lang="en">Mehta SR, Wood DA, Storey RF, et al. Complete Revascularization with Multivessel PCI for Myocardial Infarction. N Engl J Med. 2019;381(15):1411-21. doi:10.1056/NEJMoa1907775.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Böhm F, Mogensen B, Engstrøm T, et al. FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction. N Engl J Med. 2024;390(16):1481-92. doi:10.1056/NEJMoa2314149.</mixed-citation><mixed-citation xml:lang="en">Böhm F, Mogensen B, Engstrøm T, et al. FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction. N Engl J Med. 2024;390(16):1481-92. doi:10.1056/NEJMoa2314149.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki K, Oikawa T, Nochioka K, et al. Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment. Arterioscler Thromb Vasc Biol. 2019;39(5):934-44. doi:10.1161/ATVBAHA.119.312336.</mixed-citation><mixed-citation xml:lang="en">Suzuki K, Oikawa T, Nochioka K, et al. Elevated Serum Non-HDL (High-Density Lipoprotein) Cholesterol and Triglyceride Levels as Residual Risks for Myocardial Infarction Recurrence Under Statin Treatment. Arterioscler Thromb Vasc Biol. 2019;39(5):934-44. doi:10.1161/ATVBAHA.119.312336.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Wong MC, Liu J, Zhou S, et al. The association between multi­morbidity and poor adherence with cardiovascular medica­tions. Int J Cardiol. 2014;177(2):477-82. doi:10.1016/j.ijcard.2014.09.103.</mixed-citation><mixed-citation xml:lang="en">Wong MC, Liu J, Zhou S, et al. The association between multi­morbidity and poor adherence with cardiovascular medica­tions. Int J Cardiol. 2014;177(2):477-82. doi:10.1016/j.ijcard.2014.09.103.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Skou ST, Mair FS, Fortin M, et al. Multimorbidity. Nat Rev Dis Primers. 2022;8(1):48. doi:10.1038/s41572-022-00376-4.</mixed-citation><mixed-citation xml:lang="en">Skou ST, Mair FS, Fortin M, et al. Multimorbidity. Nat Rev Dis Primers. 2022;8(1):48. doi:10.1038/s41572-022-00376-4.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Эрлих А. Д., Грацианский Н. А. от имени участников регистра РЕКОРД. Регистр острый коронарных синдромов РЕКОРД. Характеристика больных и лечение до выписки из стационара. Кардиология. 2009;49(7-8):4-12.</mixed-citation><mixed-citation xml:lang="en">Erlikh AD, Gratsiansky NA. and participants of the RECORD registry. Registry of acute coronary syndromes RECORD. Characteristics of patients and results of inhospital treatment. Kardiologiia. 2009;49(7-8):4-12. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Малай Л. Н., Солохина Л. В., Бухонкина Ю. М. и др. Характеристика больных и госпитальные исходы у пациентов с острым инфарктом миокарда: данные регистра (г. Хабаровск). Часть 1. Рациональная фармакотерапия в кардиологии. 2016;12(1):56-62.</mixed-citation><mixed-citation xml:lang="en">Malay LN, Solokhina LV, Bukhonkina YM, et al. Characteristic features, treatment and hospital outcomes in patients with acute myocardial infarction: Khabarovsk Register data. Part I. Rational Pharmacotherapy in Cardiology. 2016;12(1):56-62. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А., Шахнович Р. М., Эрлих А. Д. и др. Регистр острого инфаркта миокарда. РЕГИОН-ИМ — Российский рЕГИстр Острого иНфаркта миокарда. Кардиология. 2021;61(6):41-51. doi:10.18087/cardio.2021.6.n1595.</mixed-citation><mixed-citation xml:lang="en">Boytsov SA, Shakhnovich RM, Erlikh AD, et al. Registry of Acute Myocardial Infarction. REGION-MI — Russian Registry of Acute Myocardial Infarction. Kardiologiia. 2021;61(6):41-51. (In Russ.) doi:10.18087/cardio.2021.6.n1595.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С. Ю., Загребельный А. В., Золотарева Н. П. и др. Регистр острого коронарного синдрома ЛИС-3: динамика клинико-демографических характеристик и тактика догоспитального и госпитального лечения выживших пациентов, перенесших острый коронарный синдром, за 4-летний период. Рациональная Фармакотерапия в Кардиологии. 2020;16(2):266-72. doi:10.20996/1819-6446-2020-04-15.</mixed-citation><mixed-citation xml:lang="en">Martsevich SY, Zagrebelnyy AV, Zolotareva NP, et al. LIS-3 Acute Coronary Syndrome Registry: Changes in Clinical and Demographic Characteristics and Tactics of Prehospital and Hospital Treatment of Surviving Patients After Acute Coronary Syndrome Over a 4-Year Period. Rational Pharmacotherapy in Cardiology. 2020;16(2):266-72. (In Russ.) doi:10.20996/1819-6446-2020-04-15.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С. Ю., Кутишенко Н. П., Сичинава Д. П. и др. Проспективный амбулаторный регистр больных, перенесших острый инфаркт миокарда (ПРОФИЛЬ-ИМ): дизайн исследования и первые результаты. Кардио­васкулярная терапия и профилактика. 2018;17(1):81-6. doi:10.15829/1728-8800-2018-1-81-86.</mixed-citation><mixed-citation xml:lang="en">Martsevich SYu, Kutishenko NP, Sichinava DP, et al. Prospective outpatient registry of myocardial infarction patients (PROFILE-MI): study design and first results. Cardiovascular Therapy and Prevention. 2018;17(1):81-6. (In Russ.) doi:10.15829/1728-8800-2018-1-81-86.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Кинаш В. И., Воробьев А. С., Урванцева И. А. и др. Особенности клинико-анамнестических характеристик и структуры госпитальных осложнений у пациентов с различными типами инфаркта миокарда. РМЖ. 2022;9:2-6.</mixed-citation><mixed-citation xml:lang="en">Kinash VI, Vorobiev AS, Urvantseva IA, et al. Characteristics of clinical presentation, medical history and structure of hospital acquired complications in patients with various types of myocardial infarction. RMJ. 2022;9:2-6. (In Russ.)</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
