cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2024-4064cardiovascular-4064Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESМаммографическая плотность молочной железы и сердечно-сосудистые заболевания у женщин. Обзор литературыMammographic breast density and cardiovascular disease in women. A literature reviewhttps://orcid.org/0000-0003-0836-7539БочкареваЕ. В.BochkarevaE. V.

Бочкарева Елена Викторовна — д.м.н., руководитель лаборатории медикаментозной профилактики в первичном звене здравоохранения

Moscow

Moscow

ebochkareva@gnicpm.ruhttps://orcid.org/0000-0003-0920-1549РожковаН. И.RozhkovaN. I.

Рожкова Надежда Ивановна — д.м.н., профессор, зав. Национальным центром онкологии репродуктивных органов, профессор кафедры клинической маммологии, лучевой диагностики, лучевой терапии

Moscow

Moscow

nrozhkova2013@yandex.ruhttps://orcid.org/0000-0003-2960-7044БутинаЕ. К.Butina E. KE. K.

Бутина Екатерина Кронидовна — к.м.н., с.н.с. лаборатории медикаментозной профилактики в первичном звене здравоохранения

Moscow

Moscow

ebutina@gnicpm.ruhttps://orcid.org/0000-0001-5122-4723КимИ. В.KimI. V.

Ким Ирина Витальевна — к.м.н., н.с. лаборатории медикаментозной профилактики в первичном звене здравоохранения

Moscow

Moscow

ivkimivkim@gmail.comhttps://orcid.org/0000-0003-3623-5752МолчановаО. В.MolchanovaO. V.

Молчанова Ольга Викторовна — к.м.н., в.н.с. лаборатории медикаментозной профилактики в первичном звене здравоохранения

Moscow

Moscow

OMolchanova@gnicpm.ruhttps://orcid.org/0000-0002-3495-4895МикушинС. Ю.MikushinS. Yu.

Микушин Сергей Юрьевич — к.м.н., н.с. отделения комплексной диагностики и интервенционной радиологии в маммологии, доцент кафедры клинической маммологии, лучевой диагностики и лучевой терапии

Moscow

Moscow

mikushinsergey@gmail.comhttps://orcid.org/0000-0001-7724-6429ИпатовП. В.IpatovP. V.

Д.м.н., профессор, г.н.с., в.н.с. научно-организационного отдела

Moscow

Moscow

https://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Драпкина Оксана Михайловна — д.м.н., профессор, академик РАН, директор

Moscow

Moscow

odrapkina@gnicpm.ruФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава РоссииРоссияNational Medical Research Center for Therapy and Preventive MedicineRussian FederationМНИОИ им. П. А. Герцена — филиал ФГБУ "НМИЦ радиологии" Минздрава России; ФГАОУ ВО "Российский университет дружбы народов им. Патриса Лумумбы"РоссияHerzen Moscow Oncology Research Institute — branch of the National Medical Research Center of Radiology; Peoples' Friendship University of RussiaRussian Federation20241109202423840644064Copyright © Бочкарева Е.В., Рожкова Н.И., Бутина Е.К., Ким И.В., Молчанова О.В., Микушин С.Ю., Ипатов П.В., Драпкина О.М., 20242024Бочкарева Е.В., Рожкова Н.И., Бутина Е.К., Ким И.В., Молчанова О.В., Микушин С.Ю., Ипатов П.В., Драпкина О.М.Bochkareva E.V., Rozhkova N.I., Butina E. K E.K., Kim I.V., Molchanova O.V., Mikushin S.Y., Ipatov P.V., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/4064

В мире ведется поиск новых простых и экономически доступных гендер-специфических маркеров для улучшения стратификации сердечно-сосудистого риска у женщин. Целью настоящего обзора является анализ связи маммографической плотности (МП) с сердечнососудистыми заболеваниями (ССЗ). Показано, что при низкой МП, т.е. высоком относительном содержании жира в молочной железе, наблюдается более высокая частота основных факторов риска ССЗ: артериальной гипертонии, гиперлипидемии, гипергликемии, избыточной массы тела, а также увеличение объема жировых депо, висцерального и эктопического жира. Низкая МП связана с более высоким 10-летним риском таких неблагоприятных сердечно-сосудистых событий, как ишемическая болезнь сердца, инсульт, заболевания периферических артерий, реваскуляризация, сердечная недостаточность, и может служить предиктором их развития. Включение МП в модель оценки риска ССЗ Framingham Risk Score повышает ее точность. Выявление низкой МП, как маркера высокого сердечно-сосудистого риска, позволяет использовать маммографию для раннего выявления и профилактики двух наиболее опасных заболеваний среди женского населения — рака молочной железы и ССЗ.

The world is searching for new simple and economically available gender-specific markers to improve cardiovascular risk stratification in women. The aim of this review was to analyze the association of mammographic density (MD) with cardiovascular disease (CVD). In low MD, i.e., high relative mammary gland fat content, there is a higher incidence of the main risk factors for CVD: hypertension, hyperlipidemia, hyperglycemia, excess body weight, as well as an increase in the volume of fat depots, visceral and ectopic fat. Low MD is associated with a higher 10-year risk of adverse cardiovascular events such as coronary artery disease, stroke, peripheral arterial disease, revascularization, and heart failure, and may serve as a predictor of their development. Including MD in the Framingham Risk Score model improves its accuracy. Identification of low MD, as a marker of high cardiovascular risk, allows the use of mammography for early detection and prevention of the two most dangerous diseases among the female population — breast cancer and CVD. 

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The authors declare that there are no conflicts of interest present.