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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2025-4103</article-id><article-id custom-type="edn" pub-id-type="custom">ZKQUXH</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4103</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОЖИРЕНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBESITY</subject></subj-group></article-categories><title-group><article-title>Коморбидные ожирению заболевания и полипатии у лиц молодого и среднего возраста</article-title><trans-title-group xml:lang="en"><trans-title>Comorbid obesity diseases and polypathies in young and middle-aged individuals</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7951-0040</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синеглазова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sineglazova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>=</p><p>Альбина Владимировна Синеглазова — д.м.н., профессор, зав. кафедрой поликлинической терапии и общей врачебной практики.</p><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><email xlink:type="simple">sineglazovaav@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7518-0964</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуриева</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Nurieva</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Альбина Рашидовна Нуриева — к.м.н., ассистент кафедры поликлинической терапии и общей врачебной практики.</p><p>Казань</p></bio><bio xml:lang="en"><p>Kazan</p></bio><email xlink:type="simple">albina-rashidovna@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО "Казанский государственный медицинский университет" Минздрава России</institution></aff><aff xml:lang="en"><institution>Kazan State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>11</day><month>08</month><year>2025</year></pub-date><volume>24</volume><issue>6</issue><fpage>4103</fpage><lpage>4103</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Синеглазова А.В., Нуриева А.Р., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Синеглазова А.В., Нуриева А.Р.</copyright-holder><copyright-holder xml:lang="en">Sineglazova A.V., Nurieva A.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4103">https://cardiovascular.elpub.ru/jour/article/view/4103</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить особенности коморбидных ожирению заболеваний и полипатий у лиц молодого и среднего возраста с учетом фенотипа ожирения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Методом когортного одномоментного исследования обследован 201 пациент с индексом массы тела (ИМТ) ≥25 кг/м2 и/или абдоминальным ожирением (АО), медиана возраста 39 [33-47] лет. Проведена антропометрия, измерен уровень висцерального жира (ВЖ) биоимпедансным методом. Проведено обследование на наличие коморбидных ожирению заболеваний/состояний: артериальной гипертензии (АГ), дислипидемии, предиабета, остеоартрита, гастроэзофагеальной рефлюксной болезни, неалкогольной жировой болезни печени (НАЖБП), стеатоза поджелудочной железы (ПЖ), синдрома обструктивного апноэ сна (СОАС).</p></sec><sec><title>Результаты</title><p>Результаты. Более, чем в четверти случаев, установлены дислипидемия (77,6%), АГ (32,3%), предиабет (25,4%), реже — остеоартрит (21,9%), стеатоз ПЖ (19,9%), НАЖБП (16,9%), СОАС (10,4%), гастроэзофагеальная рефлюксная болезнь (9,0%). Преобладала коморбидная ожирению полипатия (83,1%), представленная комбинациями АГ с предиабетом, НАЖБП, стеатозом ПЖ; АГ с предиабетом, СОАС. На основании "Дерева решений" наиболее часто полипатия встречалась среди лиц в возрасте ≥32 лет при уровне ВЖ ≥7 Ед. Эти данные послужили основанием для разработки алгоритма приоритизации проведения обследования на коморбидную ожирению полипатию.</p></sec><sec><title>Заключение</title><p>Заключение. При фенотипе, характеризующимся сочетанием ИМТ ≥25 кг/м2, АО и повышенным уровнем ВЖ, установлен более высокий шанс наличия АГ, НАЖБП, стеатоза ПЖ. У каждого восьмого пациента диагностирована коморбидная ожирению полипатия. Наиболее высокую вероятность наличия ≥3 коморбидных ожирению заболеваний имели лица с ИМТ ≥25 кг/м2 и/или АО в возрасте ≥32 лет и уровнем ВЖ ≥7 Ед.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the characteristics of comorbid obesity diseases and polypathies in young and middle-aged individuals taking into account the obesity phenotype.</p></sec><sec><title>Material and methods</title><p>Material and methods. This cohort cross-sectional study was used to examine 201 patients with a body mass index (BMI) ≥25 kg/m2 and/or abdominal obesity (AO) (median age 39 [33-47] years). Anthropometry was performed. Visceral fat (VF) level was measured using the bioelectrical impedance analysis. We analyzed participants for the following diseases/conditions comorbid with obesity: hypertension (HTN), dyslipidemia, prediabetes, osteoarthritis, gastroesophageal reflux disease, non-alcoholic fatty liver disease (NAFLD), pancreatic steatosis, obstructive sleep apnea (OSA).</p></sec><sec><title>Results</title><p>Results. Dyslipidemia (77,6%), HTN (32,3%), prediabetes (25,4%), less often — osteoarthritis (21,9%), pancreatic steatosis (19,9%), NAFLD (16,9%), OSA (10,4%), gastroesophageal reflux disease (9,0%) were established in more than a quarter of cases. Obesity multi­mor­bi­dity prevailed (83,1%), represented by combinations of HTN with prediabetes, NAFLD, pancreatic steatosis; HTN with prediabetes, OSA. Based on the decision tree, multimorbidity was most common among individuals aged ≥32 years with a VF ≥7 units. Therefore, an algorithm was developed to prioritise screening for polypathy of obesity related comorbidity.</p></sec><sec><title>Conclusion</title><p>Conclusion. With a phenotype of BMI ≥25 kg/m2, AO and an increased VF level, there is a high probability of HTN, NAFLD, and pancreatic steatosis. Obesity multimorbidity was diagnosed in every eighth patient. The highest probability of ≥3 comorbid obesity diseases was observed in individuals with a BMI ≥25 kg/m2 and/or AO at the age of ≥32 years and VF ≥7 units.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коморбидность</kwd><kwd>полипатия</kwd><kwd>ожирение</kwd><kwd>висцеральный жир</kwd><kwd>молодой и средний возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>comorbidity</kwd><kwd>polypathy</kwd><kwd>obesity</kwd><kwd>visceral fat</kwd><kwd>young and middle age</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Драпкина О. М., Концевая А. В., Калинина А. М. и др. Коморбидность пациентов с хроническими неинфекционными заболеваниями в практике врача-терапевта. 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