cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2024-4133MNBJJEcardiovascular-4133Research ArticleАРТЕРИАЛЬНАЯ ГИПЕРТОНИЯARTERIAL HYPERTENSIONСтруктурно-функциональное состояние микроциркуляторного русла кожи у мужчин с различными фенотипами артериальной гипертензии низкого и умеренного сердечно-сосудистого рискаStructural and functional state of the skin microcirculation in men with different phenotypes of hypertension of low and moderate cardiovascular riskhttps://orcid.org/0000-0001-9830-8959КоролевА. И.KorolevA. I.

Королев Андрей Игоревич — к.м.н., м.н.с. лаборатории микроциркуляции и регионарного кровообращения отдела фундаментальных и прикладных аспектов ожирения, врач-кардиолог.

Москва

Moscow

dr.korolev.andrei@gmail.comhttps://orcid.org/0009-0005-9678-1378ОсосковВ. С.OsoskovV. S.

М.н.с.

Москва

Moscow

https://orcid.org/0000-0001-5140-568XФедоровичА. А.FedorovichA. A.

Федорович Андрей Александрович — к.м.н., с.н.с лаборатории микроциркуляции и регионарного кровообращения отдела фундаментальных и прикладных аспектов ожирения ФГБУ «НМИЦ ТПМ» Минздрава России; с.н.с. лаборатории вегетативной регуляции сердечно-сосудистой системы.

Москва

Moscow

faa-micro@yandex.ruhttps://orcid.org/0000-0001-6292-3837ЧащинМ. Г.ChashchinM. G.

Чащин Михаил Георгиевич — к.м.н., руководитель липидной клиники КДЦ.

Москва

Moscow

dr.chaschin@gmail.comhttps://orcid.org/0000-0002-0348-4480ДадаеваВ. А.DadaevaV. A.

Дадаева Валида Арсланалиевна — к.м.н., н.с. отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

dr.dadaeva@mail.ruhttps://orcid.org/0000-0003-4789-1640СтрелковаА. В.StrelkovaA. V.

Стрелкова Анна Владиславовна — м.н.с. лаборатории микроциркуляции и регионарного кровообращения отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

strelkovaanya@mail.ruhttps://orcid.org/0000-0002-7948-4866ОмельяненкоК. В.OmelyanenkoK. V.

Омельяненко Ксения Витальевна — лаборант-исследователь отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

kseniya.cardio@yandex.ruhttps://orcid.org/0000-0001-8089-8970МихайловаМ. А.MikhailovaM. A.

Михайлова Мария Александровна — н.с. отдела фундаментальных и прикладных аспектов ожирения.

Москва

Moscow

marya.filina-2015@yandex.ruhttps://orcid.org/0000-0002-1423-214XГоршковА. Ю.GorshkovA. Y.

Горшков Александр Юрьевич — к.м.н., зав. лабораторией микроциркуляции и регионарного кровообращения отдела фундаментальных и прикладных аспектов ожирения, зам. директора по научной и амбулаторно-поликлинической работе.

Москва

Moscow

aygorshkov@gmail.comhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

Драпкина Оксана Михайловна — д.м.н., профессор, академик РАН, директор.

Москва

Moscow

drapkina@bk.ruФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава РоссииNational Medical Research Center for Therapy and Preventive MedicineФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России; ФГБУ ГНЦ РФ "Институт медико-биологических проблем" РАНNational Medical Research Center for Therapy and Preventive Medicine; Institute of Biomedical Problems202418092024231041334133Copyright © Королев А.И., Ососков В.С., Федорович А.А., Чащин М.Г., Дадаева В.А., Стрелкова А.В., Омельяненко К.В., Михайлова М.А., Горшков А.Ю., Драпкина О.М., 20242024Королев А.И., Ососков В.С., Федорович А.А., Чащин М.Г., Дадаева В.А., Стрелкова А.В., Омельяненко К.В., Михайлова М.А., Горшков А.Ю., Драпкина О.М.Korolev A.I., Ososkov V.S., Fedorovich A.A., Chashchin M.G., Dadaeva V.A., Strelkova A.V., Omelyanenko K.V., Mikhailova M.A., Gorshkov A.Y., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/4133Цель

Цель. Изучить структурно-функциональное состояние микрососудов кожи у мужчин трудоспособного возраста с различными фенотипами артериальной гипертензии (АГ) низкого/умеренного сердечно-сосудистого риска.

Материал и методы

Материал и методы. 218 "условно" здоровым мужчинам выполнено обследование "от капилляров до сердца": клинический и биохимический анализ крови, объемная сфигмография, видеокапилляроскопия, лазерная допплеровская флоуметрия в покое и с констрикторной и дилататорной пробами, фотоплетизмография, поток-зависимая вазодилатация плечевой артерии, ультразвуковое исследование сердца и магистральных артерий, суточное мониторирование артериального давления (АД). По результатам суточного мониторирования АД сформировано три группы: группа нормального АД (НАД) — 72 мужчины, группа изолированной диастолической АГ (ИДГ) — 70, группа систолодиастолической АГ (СДГ) — 76.

Результаты

Результаты. По данным видеокапилляроскопии и лазерной допплеровской флоуметрии достоверных межгрупповых различий на уровне капилляров и прекапиллярных артериол не получено. По данным фотоплетизмографии мужчины с СДГ относительно группы НАД имели бóльший Alp75 (индекс аугментации, нормированный на частоту сердечных сокращений 75 уд./мин) (7,35 vs -5,4%; p<0,001), VA (сосудистый возраст) (49 vs 43 года; p<0,001) и RI (индекс отражения) (38 vs 29,1%; p<0,001), а пациенты с ИДГ — бóльший RI (35,3 vs 29,1%; p<0,001), соответственно.

Заключение

Заключение. У мужчин с ИДГ и СДГ разрежения капиллярного русла, изменения тонуса, констрикторной и дилататорной активности прекапиллярных артериол в коже нет. Мужчины с ИДГ и СДГ характеризуются бóльшим тонусом гладкомышечных клеток терминальных мышечных артерий и распределительных артериол, а мужчины с СДГ также имеют бóльшую артериальную жесткость.

Aim

Aim. To study the structural and functional state of skin microcirculation in working-age men with different phenotypes of hypertension (HTN) of low/moderate cardiovascular risk.

Material and methods

Material and methods. A total of 218 healthy men underwent total blood count and biochemical blood tests, volumetric sphygmography, videocapillaroscopy, laser Doppler flowmetry at rest and with const­rictor and dilator tests, photoplethysmography, flow-mediated vasodilation of the brachial artery, cardiac and main artery ultrasound, 24-hour blood pressure (BP) monitoring. Based on the 24-hour BP monitoring, three following groups were formed: normal BP (NBP) group — 72 men, isolated diastolic hypertension (IDH) group — 70, systolic-diastolic hypertension (SDH) group — 76.

Results

Results. According to videocapillaroscopy and laser Doppler flow­metry, no reliable intergroup differences were found at the level of capillaries and precapillary arterioles. According to photoplethymography, men with SDH compared to the NBP group had higher AIp75 (augmentation index normalized to 75 bpm) (7,35 vs -5,4%; p<0,001), vascular age (VA) (49 vs 43 years; p<0,001) and reflection index (RI) (38 vs 29,1%; p<0,001), while patients with IDH had higher RI (35,3 vs 29,1%; p<0,001), respectively.

Conclusion

Conclusion. Men with IDH and SDH do not have capillary rarefaction, tone changes, or constrictor and dilator activity of skin precapillary arterioles. Men with IDH and SDH are characterized by a higher tone of smooth muscle cells of terminal muscular arteries and distributing arterioles, and men with SDH also have higher arterial stiffness.

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The authors declare that there are no conflicts of interest present.