<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2025-4197</article-id><article-id custom-type="edn" pub-id-type="custom">VTIHDC</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4197</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>О практике быстрого снижения артериального давления пероральными препаратами. Научное мнение</article-title><trans-title-group xml:lang="en"><trans-title>On the practice of rapid blood pressure reduction with oral medications. A scientific view</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0607-2673</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эрлих</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Erlikh</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эрлих Алексей Дмитриевич — д.м.н., зав. отделением кардиологииКрасногорск, Москва</p></bio><bio xml:lang="en"><p>Krasnogorsk, Moscow</p></bio><email xlink:type="simple">alexeyerlikh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1565-5440</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Родионов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rodionov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Родионов Антон Владимирович — к.м.н., доцент кафедры факультетской терапии № 1Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">rodionov_a_v_1@staff.sechenov.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2816-1183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Явелов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yavelov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Явелов Игорь Семёнович — д.м.н., доцент, руководитель отдела фундаментальных и клинических проблем тромбоза при неинфекционных заболеванияхМосква</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">yavelov@yahoo.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8209-2791</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щекочихин</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchekochikhin</surname><given-names>D. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щекочихин Дмитрий Юрьевич — к.м.н., доцент кафедры кардиологии, функциональной и ультразвуковой диагностикиКрасногорск, Москва</p></bio><bio xml:lang="en"><p>Krasnogorsk, Moscow</p></bio><email xlink:type="simple">d.shchekochikhin@ihospital.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3729-616X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кашталап</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashtalap</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кашталап Василий Васильевич — д.м.н., доцент, зав. отделом клинической кардиологииКемерово</p></bio><bio xml:lang="en"><p>Kemerovo</p></bio><email xlink:type="simple">v_kash@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7717-4362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марцевич</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Martsevich</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марцевич Сергей Юрьевич — д.м.н., профессор, руководитель отдела профилактической фармакотерапииМосква</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">sergeymartsevich@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5670-167X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мацкеплишвили</surname><given-names>С. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Matskeplishvili</surname><given-names>S. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мацкеплишвили Симон Теймуразович — д.м.н., профессор, зам. директора по научной работе обособленного подразделения Медицинский научно-­образовательный институтМосква</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">simonmats@yahoo.com</email><xref ref-type="aff" rid="aff-6"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>АО "Ильинская больница";&#13;
ФГАОУ ВО "Российский национальный исследовательский медицинский университет им. Н. И. Пирогова" Минздрава России</institution></aff><aff xml:lang="en"><institution>AO Ilyinskaya Hospital;&#13;
Pirogov Russian National Research Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО "Первый МГМУ им. И. М. Сеченова" Минздрава России (Сеченовский Университет)</institution></aff><aff xml:lang="en"><institution>Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>АО "Ильинская больница";&#13;
ФГАОУ ВО "Первый МГМУ им. И. М. Сеченова" Минздрава России (Сеченовский Университет)</institution></aff><aff xml:lang="en"><institution>AO Ilyinskaya Hospital;&#13;
Sechenov First Moscow State Medical University.</institution></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБУ "Научно-­исследовательский институт комплексных проблем сердечно-­сосудистых заболеваний" Минобрнауки России</institution></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ФГБОУ ВО "Московский государственный университет им. М. В. Ломоносова"</institution></aff><aff xml:lang="en"><institution>Lomonosov Moscow State University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>01</month><year>2025</year></pub-date><volume>24</volume><issue>1</issue><fpage>4197</fpage><lpage>4197</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Эрлих А.Д., Родионов А.В., Явелов И.С., Щекочихин Д.Ю., Кашталап В.В., Марцевич С.Ю., Мацкеплишвили С.Т., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Эрлих А.Д., Родионов А.В., Явелов И.С., Щекочихин Д.Ю., Кашталап В.В., Марцевич С.Ю., Мацкеплишвили С.Т.</copyright-holder><copyright-holder xml:lang="en">Erlikh A.D., Rodionov A.V., Yavelov I.S., Shchekochikhin D.Y., Kashtalap V.V., Martsevich S.Y., Matskeplishvili S.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4197">https://cardiovascular.elpub.ru/jour/article/view/4197</self-uri><abstract><p>Вопреки положениям современных руководств по лечению артериальной гипертонии в реальной клинической практике нередко применяются пероральные и сублингвальные гипотензивные препараты для быстрого снижения бессимптомного или малосимптомного повышения артериального давления (АД). Врачи и пациенты объясняют это необходимостью "купировать неосложненный гипертонический криз" ради профилактики сердечно-­сосудистых катастроф. Данные клинических исследований свидетельствуют о том, что подобный подход, как назначение короткодействующих препаратов на амбулаторном приёме или в стационаре, так и рекомендации по ситуационному самолечению АГ, не только не приносит пользу пациенту, но и, вероятно, сопряжён с повышением риска сердечно-­сосудистых осложнений. Смещение акцента в лечении АГ с улучшения прогноза в долгосрочной перспективе на сиюминутное снижение АД может повышать краткосрочную вариабельность АД, что является возможным механизмом развития осложнений при использовании быстродействующих пероральных гипотензивных препаратов. В статье обосновывается неприемлемость практики "неотложного" снижения АД пероральными и сублингвальными гипотензивными препаратами. Описаны рацио­нальные действия врача в случае выявления у пациента бессимптомного или малосимптомного повышения АД и представлены возможные подходы к домашнему самоконтролю АД в соответствии с современными клиническими руководствами. Также описана тактика лечения истинных гипертонических кризов (неотложных гипертонических состояний) в зависимости от характера поражения органов-­мишеней.</p></abstract><trans-abstract xml:lang="en"><p>Contrary to modern guidelines for the treatment of hypertension, oral and sublingual antihypertensive medications are often used in real-world practice to quickly reduce asymptomatic or low-symptom elevated blood pressure (BP). Doctors and patients explain this by the need to "stop an uncomplicated hypertensive crisis" for preventing cardiovascular events. Clinical trial data indicate that such an approach, both the prescription of short-­acting drugs at an outpatient or inpatient levels, and recommendations for self-treatment of hypertension, not only does not benefit the patient, but is also likely to be associated with an increased risk of cardiovascular events. Shifting the focus of hypertension treatment from improving the long-term prognosis to immediate BP reduction may increase short-term variability of BP, which is a possible mechanism for the development of complications when using fast-acting oral antihypertensives. The article substantiates the unacceptability of emergency BP reduction with oral and sublingual antihypertensive drugs. It describes rational actions of a physician in case of detection of asymptomatic or low-symptom BP increase in a patient and presents possible approaches to home BP self-monitoring in accordance with modern clinical guidelines. It also describes the management of true hypertensive crises depending on the characteristics of hypertension-­mediated organ damage.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>гипертонический криз</kwd><kwd>неотложное гипертоническое состояние</kwd><kwd>артериальное давление</kwd><kwd>быстрое снижение</kwd><kwd>измерение артериального давления</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>hypertensive crisis</kwd><kwd>hypertensive emergency</kwd><kwd>blood pressure</kwd><kwd>rapid reduction</kwd><kwd>blood pressure measurement</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension. 2020;75(2):285-92. doi:10.1161/HYPERTENSIONAHA.119.14240.</mixed-citation><mixed-citation xml:lang="en">Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension. 2020;75(2):285-92. doi:10.1161/HYPERTENSIONAHA.119.14240.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bundy JD, Li C, Stuchlik P, et al. Systolic blood pressure reduction and risk of cardiovascular disease and mortality: a systematic review and network meta-analysis. JAMA Cardiol. 2017;2:775-81. doi:10.1001/jamacardio.2017.1421.</mixed-citation><mixed-citation xml:lang="en">Bundy JD, Li C, Stuchlik P, et al. Systolic blood pressure reduction and risk of cardiovascular disease and mortality: a systematic review and network meta-analysis. JAMA Cardiol. 2017;2:775-81. doi:10.1001/jamacardio.2017.1421.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Prabhakaran D, Anand S, Watkins D, et al. Cardiovascular, respiratory, and related disorders: key messages from Disease Control Priorities. 3rd ed. Lancet. 2018;391:1224-36. doi:10.1016/S0140-6736(17)32471-6.</mixed-citation><mixed-citation xml:lang="en">Prabhakaran D, Anand S, Watkins D, et al. Cardiovascular, respiratory, and related disorders: key messages from Disease Control Priorities. 3rd ed. Lancet. 2018;391:1224-36. doi:10.1016/S0140-6736(17)32471-6.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G, Kreutz R, Brunström M, et al. 2023 ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension. Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41:1874-2071. doi:10.1097/HJH.0000000000003480.</mixed-citation><mixed-citation xml:lang="en">Mancia G, Kreutz R, Brunström M, et al. 2023 ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Hypertension. Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023;41:1874-2071. doi:10.1097/HJH.0000000000003480.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">McEvoy JW, McCarthy CP, Bruno RM, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension Developed by the task force on the management of elevated blood pressure and hypertension of the European Society of Cardiology (ESC) and endorsed by the European Society of Endocrinology (ESE) and the European Stroke Organization (ESO). Eur Heart J. 2024;45(38):3912-4018. doi:10.1093/eurheartj/ehae178.</mixed-citation><mixed-citation xml:lang="en">McEvoy JW, McCarthy CP, Bruno RM, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension Developed by the task force on the management of elevated blood pressure and hypertension of the European Society of Cardiology (ESC) and endorsed by the European Society of Endocrinology (ESE) and the European Stroke Organization (ESO). Eur Heart J. 2024;45(38):3912-4018. doi:10.1093/eurheartj/ehae178.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kallioinen N, Hill A, Horswill MS, et al. Sources of inaccuracy in the measurement of adult patients’ resting blood pressure in clinical settings: a systematic review. J Hypertens. 2017;35:421-41. doi:10.1097/HJH.0000000000001197.</mixed-citation><mixed-citation xml:lang="en">Kallioinen N, Hill A, Horswill MS, et al. Sources of inaccuracy in the measurement of adult patients’ resting blood pressure in clinical settings: a systematic review. J Hypertens. 2017;35:421-41. doi:10.1097/HJH.0000000000001197.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418. doi:10.1161/STR.0000000000000211.</mixed-citation><mixed-citation xml:lang="en">Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418. doi:10.1161/STR.0000000000000211.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Janeway TC. A clinical study of hypertensive cardiovascular disease. JAMA Intern Med. 1913;755-98. doi:10.1001/archinte.1913.00070060147012.</mixed-citation><mixed-citation xml:lang="en">Janeway TC. A clinical study of hypertensive cardiovascular disease. JAMA Intern Med. 1913;755-98. doi:10.1001/archinte.1913.00070060147012.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. doi:10.1177/0333102417738202.</mixed-citation><mixed-citation xml:lang="en">Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. doi:10.1177/0333102417738202.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Born B-J, Lip GYH, Brguljan-Hitij J, et al. ESC Council on Hypertension position document on the management of hypertensive emergencies. Eur Heart J Cardiovasc Pharmacother. 2019;5;1:37-46. doi:10.1093/ehjcvp/pvy032.</mixed-citation><mixed-citation xml:lang="en">Van der Born B-J, Lip GYH, Brguljan-Hitij J, et al. ESC Council on Hypertension position document on the management of hypertensive emergencies. Eur Heart J Cardiovasc Pharmacother. 2019;5;1:37-46. doi:10.1093/ehjcvp/pvy032.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж. Д., Конради А. О., Недогода С.В. и др. Артериальная гипертензия у взрослых. Клинические рекомендации 2020. Российский кардиологический журнал. 2020;25(3):3786. doi:10.15829/1560-4071-2020-3-3786.</mixed-citation><mixed-citation xml:lang="en">Kobalava ZhD, Konradi AO, Nedogoda SV, et al. Arterial hypertension in adults. Clinical guidelines 2020. Russian Journal of Cardiology. 2020;25(3):3786. (In Russ.) doi:10.15829/1560-4071-2020-3-3786.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Rossi GP, Rossitto G, Maifredini C, et al. Management of hypertensive emergencies: a practical approach. Blood Press. 2021; 30(4):208-19. doi:10.1080/08037051.2021.1917983.</mixed-citation><mixed-citation xml:lang="en">Rossi GP, Rossitto G, Maifredini C, et al. Management of hypertensive emergencies: a practical approach. Blood Press. 2021; 30(4):208-19. doi:10.1080/08037051.2021.1917983.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dela U, Rido M, Monica T.Sublingual versus oral captopril for blood pressure reduction in hypertension urgency: a systematic review and meta-analysis. J Hypertens. 2021;39:e13. doi:10.1097/01.hjh.0000752556.41180.65.</mixed-citation><mixed-citation xml:lang="en">Dela U, Rido M, Monica T.Sublingual versus oral captopril for blood pressure reduction in hypertension urgency: a systematic review and meta-analysis. J Hypertens. 2021;39:e13. doi:10.1097/01.hjh.0000752556.41180.65.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Grassi D, O’Flaherty M, Pellizzari M, et al. Hypertensive urgencies in the emergency department: evaluating blood pressure response to rest and to antihypertensive drugs with different profiles. J Clin Hypertens (Greenwich). 2008;10:662-7. doi:10.1111/j.1751-7176.2008.00001.x.</mixed-citation><mixed-citation xml:lang="en">Grassi D, O’Flaherty M, Pellizzari M, et al. Hypertensive urgencies in the emergency department: evaluating blood pressure response to rest and to antihypertensive drugs with different profiles. J Clin Hypertens (Greenwich). 2008;10:662-7. doi:10.1111/j.1751-7176.2008.00001.x.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Levy PD, Mahn JJ, Miller J, et al. Blood pressure treatment and outcomes in hypertensive patients without acute target organ damage: a retrospective cohort. Am J Emerg Med. 2015;33:1219-24. doi:10.1016/j.ajem.2015.05.036.</mixed-citation><mixed-citation xml:lang="en">Levy PD, Mahn JJ, Miller J, et al. Blood pressure treatment and outcomes in hypertensive patients without acute target organ damage: a retrospective cohort. Am J Emerg Med. 2015;33:1219-24. doi:10.1016/j.ajem.2015.05.036.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sricharoen P, Poungnil A, Yuksen C.Immediate Prescription of Oral Antihypertensive Agents in Hypertensive Urgency Patients and the Risk of Revisits with Elevated Blood Pressure. Open Access Emerg Med. 2020;12:333-40. doi:10.2147/OAEM.S275799.</mixed-citation><mixed-citation xml:lang="en">Sricharoen P, Poungnil A, Yuksen C.Immediate Prescription of Oral Antihypertensive Agents in Hypertensive Urgency Patients and the Risk of Revisits with Elevated Blood Pressure. Open Access Emerg Med. 2020;12:333-40. doi:10.2147/OAEM.S275799.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Park SK, Lee DY, Kim WJ, et al. Comparing the clinical efficacy of resting and antihypertensive medication in patients of hypertensive urgency: a randomized, control trial. J Hypertens. 2017;35(7):1474-80. doi:10.1097/HJH.0000000000001340.</mixed-citation><mixed-citation xml:lang="en">Park SK, Lee DY, Kim WJ, et al. Comparing the clinical efficacy of resting and antihypertensive medication in patients of hypertensive urgency: a randomized, control trial. J Hypertens. 2017;35(7):1474-80. doi:10.1097/HJH.0000000000001340.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hsu C-Y, Huang L-Y, Saver JL, et al. Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study. Hypertens Res. 2019;42(11):1794-800. doi:10.1038/s41440-019-0300-0.</mixed-citation><mixed-citation xml:lang="en">Hsu C-Y, Huang L-Y, Saver JL, et al. Oral short-acting antihypertensive medications and the occurrence of stroke: a nationwide case-crossover study. Hypertens Res. 2019;42(11):1794-800. doi:10.1038/s41440-019-0300-0.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mohandas R, Chamarthi G, Bozorgmehri S, et al. PRN Antihypertensive Medications and Adverse Outcomes in Hospitalized Patients: A Propensity Matched Cohort Study. Hypertension. 2021;78(2):516-24. doi:10.1161/HYPERTENSIONAHA.121.17279.</mixed-citation><mixed-citation xml:lang="en">Mohandas R, Chamarthi G, Bozorgmehri S, et al. PRN Antihypertensive Medications and Adverse Outcomes in Hospitalized Patients: A Propensity Matched Cohort Study. Hypertension. 2021;78(2):516-24. doi:10.1161/HYPERTENSIONAHA.121.17279.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rastogi R, Sheehan MM, Hu B, et al. Treatment and Outcomes of Inpatient Hypertension Among Adults With Noncardiac Admissions. JAMA Intern Med. 2021;181(3):345-52. doi:10.1001/jamainternmed.2020.7501.</mixed-citation><mixed-citation xml:lang="en">Rastogi R, Sheehan MM, Hu B, et al. Treatment and Outcomes of Inpatient Hypertension Among Adults With Noncardiac Admissions. JAMA Intern Med. 2021;181(3):345-52. doi:10.1001/jamainternmed.2020.7501.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">San Jose-Saras D, Vicente-Guijarro J, Sousa P, et al. Inappropriate hospital admission as a risk factor for the subsequent development of adverse events: a cross-sectional study. BMC Med. 2023;21(1):312-24. doi:10.1186/s12916-023-03024-0.</mixed-citation><mixed-citation xml:lang="en">San Jose-Saras D, Vicente-Guijarro J, Sousa P, et al. Inappropriate hospital admission as a risk factor for the subsequent development of adverse events: a cross-sectional study. BMC Med. 2023;21(1):312-24. doi:10.1186/s12916-023-03024-0.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Остроумова О.Д., Борисова Е.В., Остроумова Т.М. и др. Вариабельность артериального давления в течение суток: прогностическое значение, методы оценки и влияние антигипертензивной терапии. Кардиология. 2017;57(12):62-72. doi:10.18087/cardio.2017.12.10068.</mixed-citation><mixed-citation xml:lang="en">Ostroumova OD, Borisova EV, Ostroumova TM, et al. 24-Hour Arterial Pressure Variability: Prognostic Significance, Methods of Evaluation, Effect of Antihypertensive Therapy. Kardiologiia. 2017;57(12):62-72. (In Russ.) doi:10.18087/cardio.2017.12.10068.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Parati G, Stergiou GS, Dolan E, et al. Blood pressure variability: clinical relevance and application. J Clin Hypertens (Greenwich). 2018;20(7):1133-7. doi:10.1111/jch.13304.</mixed-citation><mixed-citation xml:lang="en">Parati G, Stergiou GS, Dolan E, et al. Blood pressure variability: clinical relevance and application. J Clin Hypertens (Greenwich). 2018;20(7):1133-7. doi:10.1111/jch.13304.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Stevens SL, Wood S, Koshiaris C, et al. Blood pressure variability and cardiovascular disease: systematic review and metaanalysis. BMJ. 2016;354:i4098. doi:10.1136/bmj.i4098.</mixed-citation><mixed-citation xml:lang="en">Stevens SL, Wood S, Koshiaris C, et al. Blood pressure variability and cardiovascular disease: systematic review and metaanalysis. BMJ. 2016;354:i4098. doi:10.1136/bmj.i4098.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Родионов А.В. Неосложнённый гипертонический криз или высокая вариабельность артериального давления? Терапевтический архив. 2017;89(3):108-11. doi:10.17116/terarkh2017893108-111.</mixed-citation><mixed-citation xml:lang="en">Rodionov AV. Uncomplicated hypertensive crisis or high blood pressure variability? Therapeutic Archive. 2017;89(3):108-11. (In Russ.) doi:10.17116/terarkh2017893108-111.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bress AP, Anderson TS, Flack JM, et al. on behalf of the American Heart Association Council on Hypertension; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association. Hypertension. 2024;81:e01-e13. doi:10.1161/HYP.0000000000000238.</mixed-citation><mixed-citation xml:lang="en">Bress AP, Anderson TS, Flack JM, et al. on behalf of the American Heart Association Council on Hypertension; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. The Management of Elevated Blood Pressure in the Acute Care Setting: A Scientific Statement From the American Heart Association. Hypertension. 2024;81:e01-e13. doi:10.1161/HYP.0000000000000238.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Осипова В.В., Табеева Г.Р., Тринитатский Ю.В. и др. Первичные головные боли: клиника, диагностика, терапия. Информационное письмо (для неврологов, терапевтов, врачей общей практики). Ростов-на-Дону: "Антей", 2011. ISBN: 978-5-91365-157-0.</mixed-citation><mixed-citation xml:lang="en">Osipova VV, Tabeeva GR, Trinitatskiy YuV, et al. Primary headaches: clinical presentation, diagnostics, therapy. Information letter (for neurologists, therapists, general practitioners). Rostovon-Don: "Antey", 2011. (In Russ.) ISBN: 978-5-91365-157-0.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227-3337. doi:10.1093/eurheartj/ehab484.</mixed-citation><mixed-citation xml:lang="en">Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227-3337. doi:10.1093/eurheartj/ehab484.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
