cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2024-4225VFFOUAcardiovascular-4225Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESМикроРНК как биомаркеры ишемической болезни сердца для использования в клинической практикеMicroRNA as biomarkers of coronary artery disease in real-world practicehttps://orcid.org/0000-0002-5375-7328МихайлинаВ. И.MikhailinaV. I.

м.н.с. отдела персонализированной диагностики, терапии и профилактики атеросклеротических сердечно-сосудистых заболеваний.

Москва

Moscow

spandex2007@mail.ruhttps://orcid.org/0000-0001-5989-6233МешковА. Н.MeshkovA. N.

д.м.н., руководитель Института персонализированной терапии и профилактики.

Москва

Moscow

meshkov@lipidclinic.ruhttps://orcid.org/0000-0003-4765-8021КиселеваА. В.KiselevaA. N.

к.б.н., руководитель лаборатории молекулярной генетики, в.н.с.

Москва

Moscow

sanyutabe@gmail.comhttps://orcid.org/0000-0001-7989-0760ЕршоваА. И.ErshovaA. I.

д.м.н., руководитель лаборатории клиномики, зам. директора по фундаментальной науке.

Москва

Moscow

alersh@mail.ruhttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

д.м.н., профессор, академик РАН, директор.

Москва

Moscow

odrapkina@gnicpm.ruФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава РоссииNational Medical Research Center for Therapy and Preventive Medicine202413022025231242254225Copyright © Михайлина В.И., Мешков А.Н., Киселева А.В., Ершова А.И., Драпкина О.М., 20252025Михайлина В.И., Мешков А.Н., Киселева А.В., Ершова А.И., Драпкина О.М.Mikhailina V.I., Meshkov A.N., Kiseleva A.N., Ershova A.I., Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/4225

Обзор литературы посвящен свободно циркулирующим микроРНК (малым некодирующим молекулам рибонуклеиновой кислоты) плазмы и сыворотки крови, возможности их применения в качестве новых биомаркеров ишемической болезни сердца (ИБС) на различных этапах развития заболевания. Результаты исследований демонстрируют отличающиеся уровни экспрессии микроРНК в плазме и сыворотке крови у больных ИБС и без нее. В связи с этим представляется перспективным применение определения уровня экспрессии микроРНК для малоинвазивной диагностики ИБС, а также дальнейшего прогноза прогрессирования заболевания. В результате проведения обзора литературы сформирован список микроРНК — потенциальных биомаркеров ИБС.

The literature review is devoted to circulating microRNA (small noncoding ribonucleic acid molecules) of blood plasma and serum, and potential of their use as new biomarkers of coronary artery disease (CAD) at various stages. The study results demonstrate different levels of plasma and serum microRNA expression in patients with and without CAD. In this regard, determination of microRNA expression level for minimally invasive diagnosis of CAD seems promising, as well as further prognosis of disease progression. A list of microRNAs as potential biomarkers of CAD has been compiled.

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The authors declare that there are no conflicts of interest present.