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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2025-4296</article-id><article-id custom-type="edn" pub-id-type="custom">NPRPHJ</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4296</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЕРДЕЧНАЯ НЕДОСТАТОЧНОСТЬ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>HEART FAILURE</subject></subj-group></article-categories><title-group><article-title>Возможности кардиопульмонального тестирования и диастолического стресс-теста в диагностике сердечной недостаточности с сохраненной фракцией выброса у больных артериальной гипертонией и ожирением</article-title><trans-title-group xml:lang="en"><trans-title>Potential of cardiopulmonary exercise testing and diastolic stress test in diagnosis of heart failure with preserved ejection fraction in patients with hypertension and obesity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6188-4610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шупенина</surname><given-names>Е Ю</given-names></name><name name-style="western" xml:lang="en"><surname>Shupenina</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>К.м.н., профессор кафедры госпитальной терапии № 1</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">eshupenina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4870-0252</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафарова</surname><given-names>Г А</given-names></name><name name-style="western" xml:lang="en"><surname>Safarova</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ассистент кафедры госпитальной терапии №1</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">m-medik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2913-9797</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васюк</surname><given-names>Ю А</given-names></name><name name-style="western" xml:lang="en"><surname>Vasyuk</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д.м.н., профессор, зав. кафедрой госпитальной терапии № 1</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">yvasyuk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО "Российский университет медицины" Минздрава РФ</institution></aff><aff xml:lang="en"><institution>Russian University of Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2025</year></pub-date><volume>24</volume><issue>8</issue><fpage>4296</fpage><lpage>4296</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шупенина Е.Ю., Сафарова Г.А., Васюк Ю.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шупенина Е.Ю., Сафарова Г.А., Васюк Ю.А.</copyright-holder><copyright-holder xml:lang="en">Shupenina E.Y., Safarova G.A., Vasyuk Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4296">https://cardiovascular.elpub.ru/jour/article/view/4296</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить возможности кардиопульмонального тестирования в сочетании со стресс-эхокардиографией с дозированной физической нагрузкой (ФН) в выявлении хронической сердечной недостаточности (СН) с сохраненной фракцией выброса (СНсФВ) левого желудочка (ЛЖ) у пациентов с артериальной гипертонией и ожирением.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В обсервационное исследование были включены 150 больных с АГ, из которых 35 — без ожирения и не имели признаков СН, 35 — с ожирением и без признаков СН, 80 — с признаками СНсФВ и ожирением. Артериальная гипертония считалась выявленной, если офисное артериальное давление ≥140/90 мм рт.ст., ожирение диагностировалось при индексе массы тела ≥30 кг/м2. Пациентам выполнялись эхокардиография (ЭхоКГ) в покое и на фоне дозированной ФН, анализировались параметры систолической и диастолической функции ЛЖ. При проведении диастолического стресс-теста оценка диастолической функции ЛЖ проводилась на уровне 50 Вт, при достижении анаэробного порога (АП), субмаксимальной частоты сердечных сокращений, а также в период восстановления.</p></sec><sec><title>Результаты</title><p>Результаты. Средний возраст пациентов составил 58,2±10,8 лет. Динамика показателей тканевой допплерографии у больных с признаками СНсФВ показала достоверно более низкие значения скорости движения септальной (e’ септ.) и латеральной (e’ лат.) части фиброзного кольца митрального клапана на всех этапах ФН, по сравнению с другими группами. При этом e’ септ. и e’ лат. увеличивались по мере достижения АП, а дальнейшее увеличение ФН не сопровождалось повышением данных показателей и на уровне субмаксимальной частоты сердечных сокращений.</p></sec><sec><title>Заключение</title><p>Заключение. Сочетание диастолического стресс-теста с кардиопульмональным тестированием позволило выявить снижение систолической функции ЛЖ на фоне увеличения нагрузки выше АП у больных СНсФВ, тогда как в других группах эти параметры продолжали расти. Данные показатели могут быть использованы в диагностике СНсФВ при неубедительном приросте соотношения максимальной скорости раннего диастолического трансмитрального кровотока и диастолического подъема основания ЛЖ в раннюю диастолу (E/e’) при небольшом уровне ФН.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To evaluate the potential of cardiopulmonary exercise testing in combination with exercise stress echocardiography in detection of heart failure (HF) with preserved ejection fraction (HFpEF) in patients with hypertension (HTN) and obesity.</p></sec><sec><title>Material and methods</title><p>Material and methods. The observational study included 150 patients with HTN, of which 35 were without obesity and had no signs of HF, 35 — with obesity and without signs of HF, while 80 had signs of HFpEF and obesity. Hypertension was considered detected with office blood pressure ≥140/90 mm Hg, while obesity — with a body mass index ≥30 kg/m2. Patients underwent resting and exercise echocardiography, and the parameters of systolic and diastolic left ventricular (LV) function were analyzed. During the diastolic stress test, LV diastolic function was assessed at 50 W, upon reaching the anaerobic threshold (AT), submaximal heart rate, and during the recovery period.</p></sec><sec><title>Results</title><p>Results. The mean age of patients was 58,2±10,8 years. Changes of tissue Doppler parameters in patients with HFpEF showed significantly lower septal and lateral mitral annulus velocity (e’) at all exercise stages, compared with other groups. At the same time, septal and lateral e' increased as AT was reached, and a further exercise increase was not accompanied by an increase in these parameters at the level of submaximal heart rate.</p></sec><sec><title>Conclusion</title><p>Conclusion. The combination of diastolic stress test with cardiopulmonary testing made it possible to identify a decrease in LV systolic function with a load increase above AT in patients with HFpEF, while in other groups these parameters continued to grow. These parameters can be used in the diagnosis of HFpEF with an inconclusive increase in the ratio of the peak velocity of early diastolic transmitral flow to early diastolic rise of LV base (E/e’) at a low exercise level.</p></sec><sec><title> </title><p> </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечная недостаточность с сохраненной фракцией выброса левого желудочка</kwd><kwd>диастолическая дисфункция левого желудочка</kwd><kwd>диастолический стресс-тест</kwd><kwd>кардиопульмональное нагрузочное тестирование</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>heart failure with preserved left ventricular ejection fraction</kwd><kwd>left ventricular diastolic dysfunction</kwd><kwd>diastolic stress test</kwd><kwd>cardiopulmonary exercise testing</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Галявич А. 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