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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2025-4328</article-id><article-id custom-type="edn" pub-id-type="custom">RDLIHV</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4328</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИБРИЛЛЯЦИЯ ПРЕДСЕРДИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ATRIAL FIBRILLATION</subject></subj-group></article-categories><title-group><article-title>Церебральные микрокровоизлияния у гериатрических пациентов с неклапанной фибрилляцией предсердий</article-title><trans-title-group xml:lang="en"><trans-title>Cerebral microbleeds in geriatric patients with non-valvular atrial fibrillation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3091-7904</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черняева</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyaeva</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черняева Марина Сергеевна — к.м.н., доцент кафедры клинической фармакологии и терапии им. акад. Б. Е. Вотчала, ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России; доцент кафедры внутренних болезней и профилактической медицины, ФГБУ ДПО "Центральная государственная медицинская академия" Управления делами Президента Российской Федерации; зав. отделением гериатрии, главный внештатный специалист по гериатрии ГБУЗ "Госпиталь для ветеранов войн № 2 Департамента здравоохранения города Москвы"</p><p>Москва</p><p> </p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">doctor@cherniaeva.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-2933-637X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Погодина</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pogodina</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Погодина Анастасия Алексеевна — студент 6 курса</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">anastasiz_alma@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9788-5666</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прохорова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokhorova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Прохорова Екатерина Алексеевна — к.м.н., с.н.с. отдела клинической физиологии, инструментальной и лучевой диагностики, врач-рентгенолог отделения рентгендиагностики и компьютерной томографии Научно-клинического центра</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">katrinpr@list.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5050-4220</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Моисеева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Moiseeva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Моисеева Екатерина Александровна — врач-терапевт консультативного отделения </p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ka2sha.moiseeva@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-9329-7477</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рожкова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rozhkova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рожкова Мария Александровна — врач-терапевт </p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mariavronskaya196@gmail.com</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5042-8288</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трифонов</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Trifonov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Трифонов Михаил Игоревич — врач гериатр, заведующий терапевтическим отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">the.trifon@gmail.com</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9777-3832</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Лариса Александровна — д.м.н., профессор кафедры внутренних болезней и профилактической медицины</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Egorova-ossn@yandex.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9599-7381</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Масленникова</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Maslennikova</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Масленникова Ольга Михайловна — д.м.н., заведующий кафедрой внутренних болезней и профилактической медицины</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">O.m.maslennikova@gmail.com</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8830-7231</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ломакин</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lomakin</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ломакин Никита Валерьевич — д.м.н., зав. кафедрой кардиологии, ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России; зав. кардиологическим отделением № 2, ФГБУ "Центральная клиническая больница с поликлиникой" Управления делами Президента Российской Федерации</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Lomakinnikita@gmail.com</email><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4496-3680</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sychev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сычев Дмитрий Алексеевич — д.м.н., профессор, профессор РАН, академик РАН, заслуженный деятель науки РФ, зав. кафедрой клинической фармакологии и терапии им. акад. Б. Е. Вотчала</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">dimasychev@mail.ru</email><xref ref-type="aff" rid="aff-9"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России;&#13;
ФГБУ ДПО "Центральная государственная медицинская академия" Управления делами Президента Российской Федерации;&#13;
ГБУЗ "Госпиталь для ветеранов войн № 2 Департамента здравоохранения города Москвы"</institution></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education;&#13;
Central State Medical Academy;&#13;
War Veterans Hospital № 2</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО "Российский национальный исследовательский медицинский университет им. Н. И. Пирогова" Минздрава России (Пироговский Университет)</institution></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ "Российский научный центр хирургии им. акад. Б. В. Петровского"</institution></aff><aff xml:lang="en"><institution>Petrovsky Russian Research Center of Surgery</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ "Госпиталь для ветеранов войн № 2 Департамента здравоохранения города Москвы"</institution></aff><aff xml:lang="en"><institution>War Veterans Hospital № 2</institution></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБУ "Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства"</institution></aff><aff xml:lang="en"><institution>Federal Research and Clinical Center of Specialized Healthcare and Medical Technologies</institution></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>ООО "А Медклиник"</institution></aff><aff xml:lang="en"><institution>OOO A Medclinic</institution></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>ФГБУ ДПО "Центральная государственная медицинская академия" Управления делами Президента Российской Федерации</institution></aff><aff xml:lang="en"><institution>Central State Medical Academy</institution></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России;&#13;
ФГБУ "Центральная клиническая больница с поликлиникой" Управления делами Президента Российской Федерации</institution></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education;&#13;
Central Clinical Hospital with a Polyclinic</institution></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>ФГБОУ ДПО "Российская медицинская академия непрерывного профессионального образования" Минздрава России</institution></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>15</day><month>07</month><year>2025</year></pub-date><volume>24</volume><issue>5</issue><fpage>4328</fpage><lpage>4328</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черняева М.С., Погодина А.А., Прохорова Е.А., Моисеева Е.А., Рожкова М.А., Трифонов М.И., Егорова Л.А., Масленникова О.М., Ломакин Н.В., Сычев Д.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Черняева М.С., Погодина А.А., Прохорова Е.А., Моисеева Е.А., Рожкова М.А., Трифонов М.И., Егорова Л.А., Масленникова О.М., Ломакин Н.В., Сычев Д.А.</copyright-holder><copyright-holder xml:lang="en">Chernyaeva M.S., Pogodina A.A., Prokhorova E.A., Moiseeva E.A., Rozhkova M.A., Trifonov M.A., Egorova L.A., Maslennikova O.M., Lomakin N.V., Sychev D.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4328">https://cardiovascular.elpub.ru/jour/article/view/4328</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить частоту и структуру церебральных микрокровоизлияний (ЦМК) у пациентов ≥80 лет с неклапанной фибрилляцией предсердий в реальной клинической практике.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Обследовано 80 пациентов (медиана возраста 83 (81; 86) лет, 72,5% женщин). Всем пациентам была выполнена магнитно-резонансная томография головного мозга на аппарате MAGNETOM Skyra 3 Тесла (Siemens) при первичном обследовании и повторно, через год.</p></sec><sec><title>Результаты</title><p>Результаты. При первичном осмотре частота выявления ЦМК составила 48,8% и значимо не различалась в зависимости от принимаемого прямого орального антикоагулянта (p=0,738). Количество ЦМК составило 161 у 39 пациентов, в среднем на одного пациента — 4,1±3,6 ЦМК. При повторном обследовании новые ЦМК возникли у 21,6%. В структуре ЦМК при первичном осмотре преобладала смешанная локализация (43,6%), преимущественно в лобной доле (25,5%). При повторном осмотре — лобарная локализация (54,5%) и также преимущественно в лобной доле (43,5%).</p></sec><sec><title>Заключение</title><p>Заключение. Высокая частота выявления ЦМК у пациентов ≥80 лет с неклапанной фибрилляцией предсердий, как при первичном осмотре, так и через год, особенно в лобарной локализации, свидетельствует о высоком риске развития внутричерепного кровоизлияния, для профилактики которого необходим мультидисциплинарный подход к ведению таких пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To study the prevalence and structure of cerebral microbleeds (CMBs) in patients ≥80 years old with non-valvular atrial fibrillation in real-world practice.</p></sec><sec><title>Material and methods</title><p>Material and methods. Eighty patients were examined (median age 83 (81; 86) years, 72,5% women). All patients underwent brain magnetic resonance imaging using a MAGNETOM Skyra system 3 Tesla (Siemens) during the initial examination and again one year later.</p></sec><sec><title>Results</title><p>Results. During the initial examination, the detection rate of CMBs was 48,8% and did not differ significantly depending on the direct oral anticoagulant taken (p=0,738). There were 161 CMBs in 39 patients (an average of 4,1±3,6 CMBs per patient). During the repeated examination, newly detected CMBs were in 21,6% of patients. In the initial examination, mixed location of CMBs prevailed (43,6%), mainly in the frontal lobe (25,5%), while in reexamination, lobar location (54,5%) and also mainly in the frontal lobe (43,5%).</p></sec><sec><title>Conclusion</title><p>Conclusion. The high detection rate of CMBs in patients ≥80 years with non-valvular atrial fibrillation, both at the initial examination and after one year, especially in the lobar location, indicates a high risk of intracranial hemorrhage. Its prevention requires a multidisciplinary approach to the management of such patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>церебральное микрокровоизлияние</kwd><kwd>фибрилляция предсердий</kwd><kwd>прямые оральные антикоагулянты</kwd><kwd>пожилой пациент</kwd><kwd>профилактика кровотечения</kwd><kwd>внутричерепное кровоизлияние</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cerebral microbleeds</kwd><kwd>atrial fibrillation</kwd><kwd>direct oral anticoagulants</kwd><kwd>elderly patient</kwd><kwd>bleeding prevention</kwd><kwd>intracranial hemorrhage</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Van Gelder IC, Rienstra M, Bunting KV, et al. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). 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