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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2025-4366</article-id><article-id custom-type="edn" pub-id-type="custom">RBBWWW</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4366</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЩЕСТВЕННОЕ ЗДОРОВЬЕ, ОРГАНИЗАЦИЯ И СОЦИОЛОГИЯ ЗДРАВООХРАНЕНИЯ, МЕДИКО-СОЦИАЛЬНАЯ ЭКСПЕРТИЗА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PUBLIC HEALTH, ORGANIZATION AND SOCIOLOGY OF HEALTHCARE, MEDICAL AND SOCIAL EXPERTISE</subject></subj-group></article-categories><title-group><article-title>Региональная динамика и вариабельность коэффициентов смертности от хронической ишемической болезни сердца в Российской Федерации и ее субъектов в 2014-2023гг</article-title><trans-title-group xml:lang="en"><trans-title>Regional changes and variability of mortality rates from chronic ischemic heart disease in the Russian Federation in 2014-2023</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8984-9056</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шепель</surname><given-names>Р. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shepel</surname><given-names>R. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>К.м.н., зам. директора по перспективному развитию медицинской деятельности, в.н.с.</p><p>Москва, Петроверигский пер., 10-3, 101990</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">r.n.shepel@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9320-1503</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самородская</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Samorodskaya</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д.м.н., профессор, г.н.с.</p><p>Москва, Петроверигский пер., 10-3, 101990; Москва, ул. Щепкина, д. 61/2, г., 129110</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6033-5564</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Какорина</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kakorina</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д.м.н., профессор, зам. директора по науке, профессор.</p><p>Москва, ул. Щепкина, д. 61/2, г., 129110</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Д.м.н., профессор, академик РАН, директор.</p><p>Москва, Петроверигский пер., 10-3, 101990</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России; ГБУЗ МО "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского"</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine; Vladimirsky Moscow Regional Research Clinical Institute</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ МО "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского"</institution></aff><aff xml:lang="en"><institution>Vladimirsky Moscow Regional Research Clinical Institute</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>16</day><month>05</month><year>2025</year></pub-date><volume>24</volume><issue>4</issue><fpage>4366</fpage><lpage>4366</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шепель Р.Н., Самородская И.В., Какорина Е.П., Драпкина О.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Шепель Р.Н., Самородская И.В., Какорина Е.П., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Shepel R.N., Samorodskaya I.V., Kakorina E.P., Drapkina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4366">https://cardiovascular.elpub.ru/jour/article/view/4366</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценить динамику и вариабельность стандартизованных коэффициентов смертности (СКС) от различных форм хронической ишемической болезни сердца (ХИБС) в Российской Федерации и ее субъектах в 2014-2023гг.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведен анализ данных Росстата о числе умерших от ХИБС и отдельных ее форм за 2014-2023гг в соответствии с Краткой номенклатурой причин смерти Росстата. Расчеты выполнены с использованием программы ЭВМ "Расчёт и анализ показателей смертности и потерянных лет жизни в результате преждевременной смертности в субъектах Российской Федерации". Для расчетов СКС использовали Европейский стандарт Всемирной организации здравоохранения, 1976. Расчет среднерегиональных СКС и их сравнение выполнены с помощью программы SPSS 26.0.</p></sec><sec><title>Результаты</title><p>Результаты. Среднерегиональное значение СКС от ХИБС за 2014-2023гг снизилось с 205,93±67,93 до 175,81±62,36 на 100 тыс. населения. Региональная вариабельность СКС от ХИБС в целом не претерпела значительных изменений: в 2014г максимальное значение СКС превышало минимальное значение в 8,5 раз; в 2023г — в 8 раз. Количество регионов, в которых значение СКС от I25.0 и I25.9 равно нулю, за анализируемый период увеличилось с 8 до 19. Коэффициент вариации региональных СКС от ХИБС в 2023г выше, чем в 2014г. Ни по одной из форм ХИБС не зарегистрировано единых для всех регионов тенденций изменения показателя СКС.</p></sec><sec><title>Заключение</title><p>Заключение. Регистрируется значительная и нарастающая региональная вариабельность СКС от отдельных форм ХИБС. Отсутствие стандартизации клинических, морфологических и статистических принципов кодирования отдельных форм ХИБС в качестве первоначальной причины смерти препятствует оценке и анализу динамики показателей смертности, и, следовательно, разработке мер по достоверному и эффективному их снижению. Типизация подходов кодирования будет служить повышению качества анализа данных статистики смертности от ХИБС и последующего принятия таргетных управленческих решений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the changes and variability of standardized mortality rates (SMR) from various types of chronic ischemic heart disease (CIHD) in the Russian Federation and its regions in 2014-2023.</p></sec><sec><title>Material and methods</title><p>Material and methods. The Rosstat data analysis of CIHD mortality for 2014-2023 was carried out in accordance with the Rosstat Brief No­menclature of Death Causes. The calculations were performed using the computer program "Calculation and Analysis of Mortality Rates and Years of Life Lost due to Premature Mortality in the Subjects of the Rus­sian Federation". The European standard of the World Health Orga­nization (1976) was used to calculate the SMR. The calculation of mean regional SMRs and their comparison were performed using the SPSS 26.0 program.</p></sec><sec><title>Results</title><p>Results. The mean regional SMR from CIHD for 2014-2023 decreased from 205,93±67,93 to 175,81±62,36 per 100 thousand population. Regional variability of SMR from CIHD as a whole did not undergo significant changes as follows: in 2014, the maximum SMR exceeded the minimum by 8,5 times; in 2023 — 8 times. The number of regions with I25.0-I25.9 SMR of 0 increased from 8 to 19 during the analyzed period. The coefficient of variation of regional SMRs from CIHD in 2023 is higher than in 2014. No uniform trends in the SMR for all regions were recorded for any CIHD types.</p></sec><sec><title>Conclusion</title><p>Conclusion. Significant and increasing regional variability of SMR from certain CIHD types is recorded. No standardization of clinical, morphological and statistical principles for coding certain CIHD types as the underlying cause of death hinders the assessment and analysis of mortality changes. Consequently, this inhibits the development of measures to reduce them reliably and effectively. Typification of coding approaches will serve to improve the quality of analysis of CIHD mortality statistics and the subsequent adoption of targeted management decisions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая ишемическая болезнь сердца</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>регистры</kwd><kwd>первоначальная причина смерти</kwd><kwd>смертность</kwd><kwd>международная классификация болезней</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic ischemic heart disease</kwd><kwd>ischemic heart disease</kwd><kwd>registries</kwd><kwd>underlying cause of death</kwd><kwd>mortality</kwd><kwd>international classi­fi­ca­tion of diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Khan MA, Hashim MJ, Mustafa H, et al. Global epidemiology of ischemic heart disease: results from the global burden of disease study. Cureus. 2020;12(7):e9349. doi:10.7759/cureus.9349.</mixed-citation><mixed-citation xml:lang="en">Khan MA, Hashim MJ, Mustafa H, et al. Global epidemiology of ischemic heart disease: results from the global burden of disease study. Cureus. 2020;12(7):e9349. doi:10.7759/cureus.9349.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Шепель Р. Н., Самородская И. В., Какорина Е. П. и др. Смертность от хронических форм ишемической болезни сердца в Российской Федерации: достаточно ли данных для анализа и принятия управленческих решений? Кардиоваскулярная терапия и профилактика. 2024;23(12):4293. doi:10.15829/1728-8800-2024-4293.</mixed-citation><mixed-citation xml:lang="en">Shepel RN, Samorodskaya IV, Kakorina EP, et al. Mortality from chronic ischaemic heart disease in the Russian Federation: are there enough data for analysis and decision-making? Cardiovascular Therapy and Prevention. 2024;23(12):4293. (In Russ.) doi:10.15829/1728-8800-2024-4293.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шепель Р. Н., Самородская И. В., Какорина Е. П. и др. Динамика и структура смертности от хронической ишемической болезни сердца среди мужчин и женщин в Российской Федерации в 2014-2023гг. Российский кардиологический журнал. 2024; 29(12S):6198. doi:10.15829/1560-4071-2024-6198.</mixed-citation><mixed-citation xml:lang="en">Shepel RN, Samorodskaya IV, Kakorina EP, et al. Dynamics and structure of mortality from chronic coronary artery disease among men and women in the Russian Federation in 2014-2023. Russian Journal of Cardiology. 2024;29(12S):6198. (In Russ.) doi:10.15829/1560-4071-2024-6198.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А., Самородская И. В., Галявич А. С. и др. Статистическая, клиническая и морфологическая классификация ишемической болезни сердца — есть ли возможность объединения? Российский кардиологический журнал. 2017;(3):63-71. doi:10.15829/1560-4071-2017-3-63-71.</mixed-citation><mixed-citation xml:lang="en">Boytsov SA, Samorodskaya IV, Galyavich AS, et al. Statistical, cli­nical and morphological classifications of coronary heart disease — possible to unite? Russian Journal of Cardiology. 2017; (3):63-71. (In Russ.) doi:10.15829/1560-4071-2017-3-63-71.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Stolpe S, Stang A. Noninformative coding of causes of death in cardiovascular deaths: effects on the mortality rate for ischemic heart disease. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019;62(12):1458-67. doi:10.1007/s00103-019-03050-5.</mixed-citation><mixed-citation xml:lang="en">Stolpe S, Stang A. Noninformative coding of causes of death in cardiovascular deaths: effects on the mortality rate for ischemic heart disease. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019;62(12):1458-67. doi:10.1007/s00103-019-03050-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Virani SS, Newby LK, Arnold SV, et al. Peer Review Committee Members. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disea­se: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023;148(9):e9-e119. doi:10.1161/CIR.0000000000001168.</mixed-citation><mixed-citation xml:lang="en">Virani SS, Newby LK, Arnold SV, et al. Peer Review Committee Members. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disea­se: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. Circulation. 2023;148(9):e9-e119. doi:10.1161/CIR.0000000000001168.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Vrints C, Andreotti F, Koskinas KC, et al. ESC scientific document group. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-537. doi:10.1093/eurheartj/ehae177.</mixed-citation><mixed-citation xml:lang="en">Vrints C, Andreotti F, Koskinas KC, et al. ESC scientific document group. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-537. doi:10.1093/eurheartj/ehae177.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nakano S, Kohsaka S, Chikamori T, et al. JCS joint working group. JCS 2022 Guideline focused update on diagnosis and treat­ment in patients with stable coronary artery disease. Circ J. 2022; 86(5):882-915. doi:10.1253/circj.CJ-21-1041.</mixed-citation><mixed-citation xml:lang="en">Nakano S, Kohsaka S, Chikamori T, et al. JCS joint working group. JCS 2022 Guideline focused update on diagnosis and treat­ment in patients with stable coronary artery disease. Circ J. 2022; 86(5):882-915. doi:10.1253/circj.CJ-21-1041.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Самородская И. В., Шепель Р. Н., Какорина Е. П. и др. Хронические формы ишемической болезни сердца: особенности учета и кодирования в клинической практике (результаты анкетирования врачей). Кардиоваскулярная терапия и профилактика. 2024;23(5):4027. doi:10.15829/1728-8800-2024-4027.</mixed-citation><mixed-citation xml:lang="en">Samorodskaya IV, Shepel RN, Kakorina EP, et al. Chronic co­ro­nary artery disease: aspects of recording and coding in clinical practice (results of a survey of physicians). Cardiovascular Therapy and Prevention.2024;23(5):4027. (In Russ.) doi:10.15829/1728-8800-2024-4027.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Vähätalo J, Holmström L, Pakanen L, et al. Coronary artery di­sease as the cause of sudden cardiac death among victims &lt; 50 years of age. Am J Cardiol. 2021;147:33-8. doi:10.1016/j.amjcard.2021.02.012.</mixed-citation><mixed-citation xml:lang="en">Vähätalo J, Holmström L, Pakanen L, et al. Coronary artery di­sease as the cause of sudden cardiac death among victims &lt; 50 years of age. Am J Cardiol. 2021;147:33-8. doi:10.1016/j.amjcard.2021.02.012.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tseng ZH, Moffatt E, Kim A, et al. Sudden cardiac death and myocardial fibrosis, determined by autopsy, in persons with HIV. N Engl J Med. 2021;384(24):2306-16. doi:10.1056/NEJMoa1914279.</mixed-citation><mixed-citation xml:lang="en">Tseng ZH, Moffatt E, Kim A, et al. Sudden cardiac death and myocardial fibrosis, determined by autopsy, in persons with HIV. N Engl J Med. 2021;384(24):2306-16. doi:10.1056/NEJMoa1914279.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Milroy CM. Coronary artery disease, sudden death and implica­tions for forensic pathology practice. Diagnostic Histopathology. 2017;23(3):479-85. doi:10.1016/j.mpdhp.2017.09.007.</mixed-citation><mixed-citation xml:lang="en">Milroy CM. Coronary artery disease, sudden death and implica­tions for forensic pathology practice. Diagnostic Histopathology. 2017;23(3):479-85. doi:10.1016/j.mpdhp.2017.09.007.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hookana E, Junttila MJ, Puurunen VP, et al. Causes of non­ischemic sudden cardiac death in the current era. Heart Rhythm. 2011;8(10):1570-5. doi:10.1016/j.hrthm.2011.06.031.</mixed-citation><mixed-citation xml:lang="en">Hookana E, Junttila MJ, Puurunen VP, et al. Causes of non­ischemic sudden cardiac death in the current era. Heart Rhythm. 2011;8(10):1570-5. doi:10.1016/j.hrthm.2011.06.031.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Basso C, Aguilera B, Banner J, et al. Association for European Car­diovascular Pathology. Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology. Virchows Arch. 2017; 471(6):691-705. doi:10.1007/s00428-017-2221-0.</mixed-citation><mixed-citation xml:lang="en">Basso C, Aguilera B, Banner J, et al. Association for European Car­diovascular Pathology. Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology. Virchows Arch. 2017; 471(6):691-705. doi:10.1007/s00428-017-2221-0.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Yazdanfard PD, Christensen AH, Tfelt-Hansen J, et al. Non-diagnostic autopsy findings in sudden unexplained death victims. BMC Cardiovasc Disord. 2020;20:58. doi:10.1186/s12872-020-01361-z.</mixed-citation><mixed-citation xml:lang="en">Yazdanfard PD, Christensen AH, Tfelt-Hansen J, et al. Non-diagnostic autopsy findings in sudden unexplained death victims. BMC Cardiovasc Disord. 2020;20:58. doi:10.1186/s12872-020-01361-z.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Yao Y, Xue J, Li B. Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention. Front Cell Dev Biol. 2022;10:1044923. doi:10.3389/fcell.2022.1044923.</mixed-citation><mixed-citation xml:lang="en">Yao Y, Xue J, Li B. Obesity and sudden cardiac death: Prevalence, pathogenesis, prevention and intervention. Front Cell Dev Biol. 2022;10:1044923. doi:10.3389/fcell.2022.1044923.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Holmstrom L, Junttila J, Chugh S. Sudden death in obesity: mechanisms and management. JACC. 2024;84(23):2308-24. doi:10.1016/j.jacc.2024.09.016.</mixed-citation><mixed-citation xml:lang="en">Holmstrom L, Junttila J, Chugh S. Sudden death in obesity: mechanisms and management. JACC. 2024;84(23):2308-24. doi:10.1016/j.jacc.2024.09.016.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Henson KE, McGale P, Darby SC, et al. Cardiac mortality after radiotherapy, chemotherapy and endocrine therapy for breast cancer: Cohort study of 2 million women from 57 cancer registries in 22 countries. Int J Cancer. 2020;47(5):1437-49. doi:10.1002/ijc.32908.</mixed-citation><mixed-citation xml:lang="en">Henson KE, McGale P, Darby SC, et al. Cardiac mortality after radiotherapy, chemotherapy and endocrine therapy for breast cancer: Cohort study of 2 million women from 57 cancer registries in 22 countries. Int J Cancer. 2020;47(5):1437-49. doi:10.1002/ijc.32908.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Liu S, Horowitz JD, Koczwara B, et al. Cardiac events among a cohort of 17,389 patients receiving cancer chemotherapy: short and long-term implications. Cardio-Oncology. 2024;10:72. doi:10.1186/s40959-024-00269-3.</mixed-citation><mixed-citation xml:lang="en">Liu S, Horowitz JD, Koczwara B, et al. Cardiac events among a cohort of 17,389 patients receiving cancer chemotherapy: short and long-term implications. Cardio-Oncology. 2024;10:72. doi:10.1186/s40959-024-00269-3.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
