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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2025-4415</article-id><article-id custom-type="edn" pub-id-type="custom">UAHOKY</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4415</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА И ИНФАРКТ МИОКАРДА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ISCHEMIC HEART DESEASE AND MYOCARDIAL INFARCTION</subject></subj-group></article-categories><title-group><article-title>Оценка вероятности наличия обструктивной коронарной болезни сердца у больных с приступообразной одышкой на фоне ишемии миокарда</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of the probability of obstructive coronary artery disease in patients with paroxysmal dyspnea due to myocardial ischemia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9102-175X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ярмедова</surname><given-names>С. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Yarmedova</surname><given-names>S. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Севиндж Фаледдиновна Ярмедова — аспирант.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">gottagetaway@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2816-1183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Явелов</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yavelov</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Игорь Семёнович Явелов — д.м.н., доцент, руководитель отдела фундаментальных и клинических проблем тромбоза при неинфекционных заболеваниях.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">IYavelov@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оксана Михайловна Драпкина — д.м.н., профессор, академик РАН, директор.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">drapkina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ "Национальный медицинский исследовательский центр терапии и профилактической медицины" Минздрава России</institution></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>11</day><month>08</month><year>2025</year></pub-date><volume>24</volume><issue>6</issue><fpage>4415</fpage><lpage>4415</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ярмедова С.Ф., Явелов И.С., Драпкина О.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Ярмедова С.Ф., Явелов И.С., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Yarmedova S.F., Yavelov I.S., Drapkina O.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4415">https://cardiovascular.elpub.ru/jour/article/view/4415</self-uri><abstract><sec><title>Цель</title><p>Цель. Охарактеризовать возможности оценки вероятности наличия обструктивного коронарного атеросклероза у больных со стабильной ишемической болезнью сердца и приступообразной одышкой на фоне ишемии миокарда.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В одномоментном исследовании у 36 стабильных больных с ишемической болезнью сердца, жалобами на приступообразную одышку во время стресс-эхокардиографии обнаружена преходящая ишемия миокарда. По данным коронарной ангиографии стенозы коронарных артерий ≥50% выявлены у 30 (83,3%) из них: ≥70% — у 25 (69,4%), ≥90% — у 18 (50,0%) пациентов.</p></sec><sec><title>Результаты</title><p>Результаты. Независимыми показателями, связанными с наличием стенозов ≥50%, являлись меньшая сумма баллов по шкале тревоги-депрессии, наличие патологических зубцов Q на электрокардиограмме и более высокое e'латеральное (ранняя диастолическая скорость движения фиброзного кольца митрального клапана по боковой стенке левого желудочка); для ≥70% — отсутствие бендопноэ, бóльшие длительность и тяжесть одышки, коронарное стентирование в анамнезе, отсутствие приступообразной фибрилляции предсердий в анамнезе и бóльшее e'латеральное; для стенозов ≥90% — бóльшая тяжесть одышки, меньшие баллы по зрительноаналоговой шкале депрессии и бóльшее e'латеральное. Площадь под характеристической кривой при прогнозировании стенозов ≥50% составляла 0,81 для регрессионного уравнения и 0,68 для балльной шкалы, ≥70% — 0,91 и 0,71, ≥90% — 0,82 и 0,75.</p></sec><sec><title>Заключение</title><p>Заключение. Наиболее информативными показателями, указывающими на обструктивную коронарную болезнь сердца у изученных больных, являлись бóльшая продолжительность и тяжесть одышки, невысокая сумма баллов по шкалам тревоги-депрессии, а также отсутствие диастолической дисфункции левого желудочка.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To characterize the potential of assessing the probability of obstructive coronary atherosclerosis in patients with stable coronary artery disease (CAD) and paroxysmal dyspnea due to myocardial ischemia.</p></sec><sec><title>Material and methods</title><p>Material and methods. In a cross-sectional study of 36 stable patients with CAD, complaining of paroxysmal dyspnea during stress echocardiography, transient myocardial ischemia was detected. According to coronary angiography data, coronary artery stenosis ≥50% was detected in 30 (83,3%) of them: ≥70% — in 25 (69,4%), ≥90% — in 18 (50,0%) patients.</p></sec><sec><title>Results</title><p>Results. Independent parameters associated with stenosis ≥50% were a lower anxiety-depression scale score, the presence of pathological Q waves and higher e'lateral (early diastolic mitral annular velocity along the left ventricular lateral wall); for ≥70% — no bendopnea, greater duration and severity of dyspnea, a history of coronary stenting, no prior paroxysmal atrial fibrillation and a higher e'lateral; for stenosis ≥90% — greater severity of dyspnea, lower scores on the visual analogue scale of depression and greater e'lateral. The area under the characteristic curve when predicting stenosis ≥50% was 0,81 for the regression equation and 0,68 for the point scale, while ≥70% — 0,91 and 0,71, ≥90% — 0,82 and 0,75, respectively.</p></sec><sec><title>Conclusion</title><p>Conclusion. The most informative indicators of obstructive CAD in the studied patients were a longer duration and severity of dyspnea, a low anxiety-depression scale score, as well as the absence of left ventricular diastolic dysfunction.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>одышка</kwd><kwd>ишемия миокарда</kwd><kwd>стресс-эхокардиография</kwd><kwd>обструктивная коронарная болезнь сердца</kwd><kwd>прогностические модели</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dyspnea</kwd><kwd>myocardial ischemia</kwd><kwd>stress echocardiography</kwd><kwd>obstructive coronary artery disease</kwd><kwd>prognostic models</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">ФГБУ “Национальный медицинский исследовательский центр терапии и профилактической медицины”</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Douglas PS, Nanna MG, Kelsey MD, et al. Comparison of an Ini­tial Risk-­Based Testing Strategy vs Usual Testing in Stable Symp­tomatic Patients With Suspected Coronary Artery Di­sease: The PRECISE Randomized Clinical Trial. JAMA Cardiol. 2023; 8(10):904-14. doi:10.1001/jamacardio.2023.2595.</mixed-citation><mixed-citation xml:lang="en">Douglas PS, Nanna MG, Kelsey MD, et al. Comparison of an Ini­tial Risk-­Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial. JAMA Cardiol. 2023; 8(10):904-14. doi:10.1001/jamacardio.2023.2595.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Douglas PS, Hoffmann U, Patel MR, et al. Outcomes of ana­to­mical versus functional testing for coronary artery disease. N Engl J Med. 2015;372(14):1291-300. doi:10.1056/NEJMoa1415516.</mixed-citation><mixed-citation xml:lang="en">Douglas PS, Hoffmann U, Patel MR, et al. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015;372(14):1291-300. doi:10.1056/NEJMoa1415516.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Navarese EP, Lansky AJ, Kereiakes DJ, et al. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis. Eur Heart J. 2021;42:4638-51. doi:10.1093/eurheartj/ehab246.</mixed-citation><mixed-citation xml:lang="en">Navarese EP, Lansky AJ, Kereiakes DJ, et al. Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and metaanalysis. Eur Heart J. 2021;42:4638-51. doi:10.1093/eurheartj/ehab246.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes: Developed by the task force for the management of chronic coronary syndromes of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;00:1-123. doi:10.1093/eurheartj/ehae177.</mixed-citation><mixed-citation xml:lang="en">Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes: Developed by the task force for the management of chronic coronary syn­dromes of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-­Thoracic Surgery (EACTS). Eur Heart J. 2024;00:1-123. doi:10.1093/eurheartj/ehae177.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Virani SS, Newby LK, Arnold SV, et al. Peer Review Committee Members. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disea­se: A Report of the American Heart Association/American College of Cardiolo­gy Joint Committee on Clinical Practice Guide­lines. Circulation. 2023;148(9):e9-e119. doi:10.1161/CIR.0000000000001168.</mixed-citation><mixed-citation xml:lang="en">Virani SS, Newby LK, Arnold SV, et al. Peer Review Committee Members. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disea­se: A Report of the American Heart Association/American Colle­ge of Cardiology Joint Committee on Clinical Practice Guide­lines. Circulation. 2023;148(9):e9-e119. doi:10.1161/CIR.0000000000001168.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hoorweg BB, Willemsen RT, Cleef LE, et al. Frequency of chest pain in primary care, diagnostic tests performed and final diagnoses. Heart (British Cardiac Society). 2017;103(21):1727-32. doi:10.1136/heartjnl-2016-310905.</mixed-citation><mixed-citation xml:lang="en">Hoorweg BB, Willemsen RT, Cleef LE, et al. Frequency of chest pain in primary care, diagnostic tests performed and final diagnoses. Heart (British Cardiac Society). 2017;103(21):1727-32. doi:10.1136/heartjnl-2016-310905.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Winther S, Schmidt SE, Rasmussen LD, et al. Validation of the Euro­pean Society of Cardiology pretest probability model for obstructive coronary artery disease. Eur Heart J. 2021;42(14): 1401-11. doi:10.1093/eurheartj/ehaa755.</mixed-citation><mixed-citation xml:lang="en">Winther S, Schmidt SE, Rasmussen LD, et al. Validation of the Euro­pean Society of Cardiology pre-test probability model for obstructive coronary artery disease. Eur Heart J. 2021;42(14): 1401-11. doi:10.1093/eurheartj/ehaa755.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ярмедова С. Ф., Явелов И. С., Драпкина О. М. Причины приступообразной одышки у больных со стабильной ишемической болезнью сердца. Рациональная Фармакотерапия в Кардиологии. 2024;20(2):212-20. doi:10.20996/1819-6446-2024-3023.</mixed-citation><mixed-citation xml:lang="en">Yarmedova SF, Yavelov IS, Drapkina OM. Causes of paroxysmal dysp­nea in patients with stable coronary artery disease. Rational Pharmacotherapy in Cardiology. 2024;20(2):212-20. (In Russ.) doi:10.20996/1819-6446-2024-3023.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Ярмедова С. Ф., Явелов И. С., Драпкина О. М. Ишемия миокарда как причина приступообразной одышки у больных со стабильной ишемической ­болезнью сердца. Кардиоваскулярная терапия и профилактика. 2024; 23(12):4267. doi:10.15829/1728-8800-2024-4267. EDN: ZDOXKH.</mixed-citation><mixed-citation xml:lang="en">Yarmedova SF, Yavelov IS, Drapkina OM. Myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable coronary artery disease. Cardiovascular Therapy and Prevention. 2024; 23(12):4267. (In Russ.) doi:10.15829/1728-8800-2024-4267. EDN: ZDOXKH.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Параева О. С., Мартыненко Т. И., Черногорюк Г. Э. и др. Прогностическая модель диагноза у больных с одышкой предположительно легочного или сердечного происхождения. Вестник современной клинической медицины. 2019;12(6):48-53. doi:10.20969/VSKM.2019.12(6).48-53.</mixed-citation><mixed-citation xml:lang="en">Paraeva OS, Martynenko TI, Chernogoryuk GE, et al. Prognostic model of the diagnosis in patients with shortness of breath presumably pulmonary or cardiac origin. The Bulletin of Contemporary Clinical Medicine. 2019;12(6):48-53. (In Russ.) doi:10.20969/VSKM.2019.12(6).48-53.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas M, Jones PG, Arnold SV, et al. Interpretation of the Seattle Angina Questionnaire as an Outcome Measure in Clinical Trials and Clinical Care: A Review. JAMA Cardiol. 2021;6(5):593-9. doi:10.1001/jamacardio.2020.7478.</mixed-citation><mixed-citation xml:lang="en">Thomas M, Jones PG, Arnold SV, et al. Interpretation of the Seattle Angina Questionnaire as an Outcome Measure in Clinical Trials and Clinical Care: A Review. JAMA Cardiol. 2021;6(5):593-9. doi:10.1001/jamacardio.2020.7478.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Сумин А. Н. Место клинической оценки в выявлении обструктивных поражений коронарных артерий при стабильной ишемической болезни сердца. Часть II. Российский кардиологический журнал. 2019;(8):111-5. doi:10.15829/1560-4071-2019-8-111-115.</mixed-citation><mixed-citation xml:lang="en">Sumin AN. Place of clinical evaluation in the identification of obstructive coronary arteries lesions in patients with stable coronary artery disease: Part II. Russian Journal of Cardiology. 2019; (8):111-5. (In Russ.) doi:10.15829/1560-4071-2019-8-111-115.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rio P, Ramos R, Pereirada-Silva T, et al. Yield of contemporary clinical strategies to detect patients with obstructive coronary artery disease. Heart Int. 2016;10(1):e12-e19. doi:10.5301/heartint.5000224.</mixed-citation><mixed-citation xml:lang="en">Rio P, Ramos R, Pereira-da-­Silva T, et al. Yield of contemporary clinical strategies to detect patients with obstructive coronary artery disease. Heart Int. 2016;10(1):e12-e19. doi:10.5301/heartint.5000224.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Galderisi M, Cosyns B, Edvardsen T, et al. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2017;18(12):1301-10. doi:10.1093/ehjci/jex244.</mixed-citation><mixed-citation xml:lang="en">Galderisi M, Cosyns B, Edvardsen T, et al. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2017;18(12):1301-10. doi:10.1093/ehjci/jex244.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
