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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2026-4699</article-id><article-id custom-type="edn" pub-id-type="custom">DAMHMC</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-4699</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Впервые выявленные диффузный идиопатический скелетный гиперостоз и кальциноз артерий молочной железы у женщины с умеренным сердечно-сосудистым риском. Клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>First-ever identification of diffuse idiopathic skeletal hyperostosis and calcification of the mammary arteries in a woman with moderate cardiovascular risk: a case report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2960-7044</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бутина</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Butina</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с. лаборатории "Медикаментозной профилактики в первичном звене здравоохранения"</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ebutina@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0836-7539</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочкарева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bochkareva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., руководитель лаборатории "Медикаментозной профилактики в первичном звене здравоохранения"</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ebochkareva@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6890-8777</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демидова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Demidova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент кафедры факультетской терапии им. акад. А. И. Нестерова</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ndemidova03@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5122-4723</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ким</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., н.с. лаборатории "Медикаментозной профилактики в первичном звене здравоохранения"</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">ikim@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3623-5752</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молчанова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Molchanova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., в.н.с., лаборатория медикаментозной профилактики в первичном звене здравоохранения отдела первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">omolchanova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4453-8430</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, академик РАН, директор</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">odrapkina@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России<country>Россия</country></aff><aff xml:lang="en">National Medical Research Center for Therapy and Preventive Medicine<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГАОУ ВО "РНИМУ им. Н. И. Пирогова" Минздрава России (Пироговский Университет)<country>Россия</country></aff><aff xml:lang="en">Pirogov Russian National Research Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>22</day><month>02</month><year>2026</year></pub-date><volume>25</volume><issue>1</issue><fpage>4699</fpage><lpage>4699</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бутина Е.К., Бочкарева Е.В., Демидова Н.А., Ким И.В., Молчанова О.В., Драпкина О.М., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Бутина Е.К., Бочкарева Е.В., Демидова Н.А., Ким И.В., Молчанова О.В., Драпкина О.М.</copyright-holder><copyright-holder xml:lang="en">Butina E.K., Bochkareva E.V., Demidova N.A., Kim I.V., Molchanova O.V., Drapkina O.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/4699">https://cardiovascular.elpub.ru/jour/article/view/4699</self-uri><abstract><sec><title>Введение</title><p>Введение. Диффузный идиопатический скелетный гиперостоз (ДИСГ) представляет собой избыточное образование костной ткани и окостенение связочного аппарата, ассоциируется с мужским полом, возрастом, метаболическими факторами (ожирением, сахарным диабетом), кальцификацией грудного отдела аорты, повышенным риском ишемической болезни сердца. Кальциноз артерий молочной железы (КАМЖ) в настоящее время рассматривается как маркер сердечно-сосудистого риска у женщин, т.к. в многочис- ленных исследованиях продемонстрирована связь КАМЖ с ишемической болезнью сердца, ишемическим инсультом, сердечно-сосудистой смертностью. Распространенность ДИСГ и КАМЖ составляет ~10%, поэтому сочетание двух патологических состояний у пациентки представляет клинический интерес.</p></sec><sec><title>Краткое описание</title><p>Краткое описание. У женщины 49 лет во время диспансеризации при рентгенографии легких был заподозрен ДИСГ, а также впервые выявлен КАМЖ умеренной степени тяжести. Через 3 года пациентка приглашена для участия в научной программе. При осмотре отсутствуют ограничения подвижности во всех отделах по- звоночника. Имеется ожирение 2 ст. При рентгенографии грудно- го отдела позвоночника определяется обызвествление передней продольной связки с особенностями, характерными для ДИСГ. При магнитно-резонансной томографии пояснично-крестцового отдела позвоночника и крестцово-подвздошного сочленения — отсутствие распространения процесса окостенения на другие отделы позвоночника, кроме грудного. В анализах крови отсутствуют признаки воспаления, нарушения кальциевого обмена, дислипидемия 2 а, отрицательный анализ на HLAВ27, что также свидетельствует в пользу ДИСГ. При повторной маммографии отмечено прогрессирование степени тяжести КАМЖ.</p></sec><sec><title>Дискуссия</title><p>Дискуссия. При обнаружении КАМЖ и ДИСГ необходимо учитывать, что оба эти состояния ассоциируются со значимым увеличением риска сердечно-сосудистых заболеваний, поэтому важно уделять внимание имеющимся у пациента факторам риска и направить усилия на их коррекцию и выявление бессимптомных форм других хронических неинфекционных заболеваний.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Diffuse idiopathic skeletal hyperostosis (DISH) is excessive bone formation and ligamentous ossification associated with male sex, age, metabolic factors (obesity, diabetes), thoracic aortic calcification, and an increased risk of coronary artery disease. Breast arterial calcification (BAC) is currently considered a marker of cardiovascular risk in women, as numerous studies have demonstrated an association between BAC and coronary artery disease, ischemic stroke, and cardiovascular mortality. The prevalence of both DISH and BAC is approximately 10%, so the combination of these two pathological conditions in this patient is of clinical interest.</p></sec><sec><title>Brief description</title><p>Brief description. A 49-year-old woman was diagnosed with suspected DISH during a routine chest X-ray, and moderate BAC was also detected for the first time. Three years later, the patient was invited to participate in a research program. On examination, there are no limitations in mobility in any part of the spine. There was class 2 obesity. Thoracic spine radiography reveals calcification of the anterior longitudinal ligament with features characteristic of DISH. Magnetic resonance imaging of the lumbosacral spine and sacroiliac joint reveals no extension of the ossification process to other spine parts except the thoracic region. Blood tests reveal no signs of inflammation, calcium metabolism disorders, dyslipidemia 2a, and a negative HLA-B27 test, which also supports the diagnosis of DISH. Repeat mammography revealed the BAC progression.</p></sec><sec><title>Discussion</title><p>Discussion. When both DISH and BAC are detected, it is important to consider that both these conditions are associated with a significant increase in cardiovascular disease risk. Therefore, it is important to pay attention to the patient's existing risk factors and focus efforts on their correction and the identification of asymptomatic forms of other noncommunicable diseases.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>диффузный идиопатический скелетный гиперостоз</kwd><kwd>кальциноз артерий молочной железы</kwd><kwd>факторы риска сердечно-сосудистых заболеваний</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diffuse idiopathic skeletal hyperostosis</kwd><kwd>breast arterial calcification</kwd><kwd>cardiovascular risk factors</kwd><kwd>case report</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Статья выполнена в рамках госзадания "Автоматическое определение кальциноза артерий молочной железы на цифровых маммограммах для выявления женщин с вероятностью сердечно-сосудистых и других хронических неинфекционных заболеваний при проведении маммографии", госрегистрация № 124013100901-6.</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>This article was written as part of the state contract "Automated Detection of Mammary Artery Calcification on Digital Mammograms to Identify Women with Probable Cardiovascular and Other Chronic Non-Communicable Diseases During Mammography," state registration № 124013100901-6.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kim S-K, Choi B-R, Kim C, et al. 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