cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2014-2-76-79cardiovascular-47Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMСРАВНИТЕЛЬНАЯ ОЦЕНКА ВЛИЯНИЯ ОСНОВНЫХ КЛАССОВ АНТИГИПЕРТЕНЗИВНЫХ ПРЕПАРАТОВ НА ЖЕСТКОСТЬ АОРТЫ У БОЛЬНЫХ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙA COMPARISON OF THE MAIN ANTIHYPERTENSIVE DRUGS FROM THE VIEWPOINT OF AORTIC STIFFNESS MODIFICATION IN ARTERIAL HYPERTENSIONШупенинаЕ. Ю.ShupeninaE. Yu.

ассистент кафедры клинической функциональной диагностики ФПДО

eshupenina@mail.ruВасюкЮ. А.VasyukYu. A.

заведующий кафедрой

eshupenina@mail.ruХадзеговаА. Б.KhadzegovaA. B.

профессор кафедры

eshupenina@mail.ruИвановаС. В.IvanovaS. V.

доцент кафедры

eshupenina@mail.ruНадинаЕ. В.NadinaE. V.

аспирант кафедры

eshupenina@mail.ruХучинаеваА. М.KhuchinaevaA. M.

аспирант кафедры

eshupenina@mail.ruГБОУ ВПО Московский государственный медико-стоматологический университет им. А. И. Евдокимова, МоскваРоссияMoscow State Medical and Stomatology University n. a. Evdokimov; Moscow, RussiaRussian Federation2014200420141327679Copyright © Шупенина Е.Ю., Васюк Ю.А., Хадзегова А.Б., Иванова С.В., Надина Е.В., Хучинаева А.М., 20142014Шупенина Е.Ю., Васюк Ю.А., Хадзегова А.Б., Иванова С.В., Надина Е.В., Хучинаева А.М.Shupenina E.Y., Vasyuk Y.A., Khadzegova A.B., Ivanova S.V., Nadina E.V., Khuchinaeva A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/47

Многочисленные исследования подтверждают важность оценки жесткости стенок аорты в определении риска развития сердечно-сосудистых осложнений, а также необходимость поиска препаратов для ее медикаментозной коррекции. Большинство антигипертензивных препаратов в разной степени оказывают прямое и опосредованное влияние на артериальную жесткость. В связи с этим использование комбинированной терапии может оказаться более эффективным. Недостаточное влияние β-адрено-блокаторов на центральное артериальное давление связано с периферической вазоконстрикцией, однако препараты этого класса с вазодилатирующими свойствами достоверно снижают давление в аорте.

A plenty of trials confirm the importance of aortic wall stiffness evaluation during estimation of the cardiovascular risk and the need for novel drugs influencing this parameter. Most of hypotensive medications modify arterial wall siffness by one or another way. So the usage of drug combination might be more effective. Insufficient impact of betaadrenoblockers on central artrial pressure is linked to peripheral vasoconstriction. The drugs within this class having vasodilatory properties significantly reduce central aortic pressure.

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The authors declare that there are no conflicts of interest present.