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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2016-5-70-73</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-490</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АТЕРОСКЛЕРОЗ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ATHEROSCLEROSIS</subject></subj-group></article-categories><title-group><article-title>Жесткость артерий мышечного и эластического типов у больных с атеросклерозом периферических артерий</article-title><trans-title-group xml:lang="en"><trans-title>Stiffness of muscular and elastic type arteries in patients with peripheral atherosclerosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисенко</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisenko</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры пропедевтики внутренних болезней</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Генкель</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Genke</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры Тел.: +7 (951) 441-70-61</p></bio><email xlink:type="simple">henkel-07@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салашенко</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Salashenko</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м.н., ассистент кафедры</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Калугина</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kalugina</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. отделением кардиологии</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexeeva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м.н., ассистент кафедры</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО “Южно-Уральский государственный медицинский университет” Министерства здравоохранения Российской Федерации. Челябинск</institution></aff><aff xml:lang="en"><institution>South-Ural State Medical University of the Ministry of Health. Chelyabinsk</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МБУЗ ОТКЗ “Городская клиническая больница №1”. Челябинск, Россия</institution></aff><aff xml:lang="en"><institution>City Clinical Hospital №1. Chelyabinsk, Russia</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2016</year></pub-date><volume>15</volume><issue>5</issue><fpage>70</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Денисенко М.Н., Генкель В.В., Салашенко А.О., Калугина С.А., Алексеева О.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Денисенко М.Н., Генкель В.В., Салашенко А.О., Калугина С.А., Алексеева О.А.</copyright-holder><copyright-holder xml:lang="en">Denisenko M.N., Genke V.V., Salashenko A.O., Kalugina S.A., Alexeeva O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/490">https://cardiovascular.elpub.ru/jour/article/view/490</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучить клинико-функциональные особенности в зависимости от преобладания сосудистой жесткости артерий эластического и/или мышечного типов.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В одномоментном исследовании принял участие 61 пациент в возрасте 38-75 лет. В зависимости от преобладания сосудистой жесткости артерий мышечного или эластического типов больные были разделены на две группы. В I вошли 32 человека с преимущественным поражением артерий эластического типа, во II группу включены 29 человек с преобладанием поражения артерий мышечного типа. Артериальную жесткость оценивали путем определения скорости распространения пульсовой волны (СРПВ) по артериям эластического и мышечного типов. Проводили ультразвуковое исследование артерий каротидного бассейна и артерий нижних конечностей. Оценивали показатели липидного обмена, высокочувствительный С-реактивный белок (вчСРБ), гликированный гемоглобин, креатинин, активность антитромбина и фактора Виллебранда.</p></sec><sec><title>Результаты</title><p>Результаты. Значения СРПВ на каротидно-радиальном отрезке сосудистого русла составили 13,1±3,37 м/с и 12,2±3,61 м/с в I и II группах, соответственно (p=0,355). Каротидно-феморальная СРПВ в I группе была равна 16,3±9,41 м/с, во II — 10,54±1,90 м/с (p=0,0001). Больные с преобладанием процессов ремоделирования сосудов эластического типа имели достоверно большие значения вчСРБ — 3,90±3,17 vs 1,98±1,67 (p=0,021). Атеросклеротическое поражение сонных артерий, оцениваемое по Plaque Score, было достоверно выше у больных с преобладающим поражением эластических артерий — 2,57±2,06 vs 1,07±1,61 (p=0,039). Также пациенты с преобладанием поражения артерий эластического типа имели больший процент стенозирования артерий нижних конечностей на уровне бедренно-подколенного сегмента — 43,3±30,6% vs 13,6±32,3% в I и II группах, соответственно (p=0,019).</p></sec><sec><title>Заключение</title><p>Заключение. Пациенты со снижением демпфирующих свойств преимущественно артерий эластического типа имели более значительное атеросклеротическое поражение артерий нижних конечностей и сонных артерий, а также большие значения СРБ. Снижение эластических свойств аорты ассоциировалось с более старшим возрастом больных, снижением скорости клубочковой фильтрации и повышенными уровнями общего холестерина и триглицеридов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess clinical and functional specifics of the persons depending on the predominance of vascular stiffness of elastic and/or muscle type arteries.</p></sec><sec><title>Material and methods</title><p>Material and methods. In single-action study, totally 61 patientincluded at age 38-75 y. o. According to vascular stiffness of elastic and muscular arteries, they were selected to 2 groups. 1 group included 32 persons with mostly elastic arteries involvement, 2 group — 29 persons with muscular. Arterial stiffness was assessed by measurement of pulse wave velocity (PWV) by arteries of both types. Also ultrasound study was done of the carotid pool and lower extremities. Parameters of lipid profile, high-sensitive C-reactive protein (hsCRP), glycosylated hemoglobin, creatinine, antithrombid activity and von Willebrand factor were measured.</p></sec><sec><title>Results</title><p>Results. Values of PWV at carotid-radial distance were 13,1±3,37 m/s and 12,2±3,61 m/s in groups 1 and 2, respectively (p=0,355). Carotidfemoral PWV in group 1 was 16,3±9,41 m/s, in group 2 — 10,54±1,90 m/s (p=0,0001). Patients with predominance of elastic vessel remodelling had significantly higher hsCRP — 3,90±3,17 vs 1,98±1,67 (p=0,021). Atherosclerotic lesion of carotid arteries by Plaque Score was significantly higher among patients with predominance of elastic arteries lesion — 2,57±2,06 vs 1,07±1,61 (p=0,039). Also, patients with more leasions of elastic arteries had higher percent of lower extremities arteries stenoses at the level of femoral-popliteal segment — 43,3±30,6% vs 13,6±32,3% in groups 1 and 2, respectively (p=0,019).</p></sec><sec><title>Conclusion</title><p>Conclusion. Patients with decreased damping capacity of mostly elastic arteries had more significant atherosclerotic lesion of lower extremities arteries and of carotid arteries, and higher CRP. Decrease of aortic elasticity was associated with older age, lower glomerular filtration rate, higher total cholesterol and triglycerides.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная жесткость</kwd><kwd>скорость распространения пульсовой волны</kwd><kwd>атеросклероз периферических артерий</kwd><kwd>С-реактивный белок</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial stiffness</kwd><kwd>pulse wave velocity</kwd><kwd>peripheral atherosclerosis</kwd><kwd>C-reactive protein</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">O’Rourke MF, Staessen JA, Vlachopoulos C, et al. Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 2002; 15(5): 426-44.</mixed-citation><mixed-citation xml:lang="en">O’Rourke MF, Staessen JA, Vlachopoulos C, et al. 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