cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2016-6-83-88cardiovascular-522Research ArticleОБЗОРЖЕСТКОСТЬ СОСУДИСТОЙ СТЕНКИ ПРИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ И ВОЗМОЖНОСТИ ЕЕ МОДУЛЯЦИИVESSEL WALL STIFFNESS IN ARTERIAL HYPERTENSION AND OPPORTUNITIES FOR ITS MODULATIONКириченкоЛ. Л.KirichenkoL. L.

Доктор медицинских наук, профессор  кафедры госпитальной терапии №1

 ГацураС. В.GatsuraS. V.

Профессор  кафедры

ГолосоваА. Н.GolosovaA. N.

Доцент кафедры.

Тел.: 8 (495) 324-45-86; +7 (916) 830-90-33

golosovaalla@mail.ruДворянчиковаЖ. Ю.DvoryanchikovaZh. Yu.УльяноваЕ.  А.UlyanovaE. A.ЧуприковаК. М.ChuprikovaK. M.

Старший лаборант кафедры

Московский государственный медико-стоматологический университет имени А. И. ЕвдокимоваA. I. Evdokimov Moscow State University of Medicine and Dentistry2016201220161568388Copyright © Кириченко Л.Л.,  Гацура С.В., Голосова А.Н., Дворянчикова Ж.Ю., Ульянова Е.А., Чуприкова К.М., 20162016Кириченко Л.Л.,  Гацура С.В., Голосова А.Н., Дворянчикова Ж.Ю., Ульянова Е.А., Чуприкова К.М.Kirichenko L.L., Gatsura S.V., Golosova A.N., Dvoryanchikova Z.Y., Ulyanova E.A., Chuprikova K.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/522

Артериальная  гипертония  (АГ) представляет   собой  серьезную медико-социальную  проблему  в связи  с развитием  осложнений, приводящих к инвалидизации пациентов. В последнее  время большое внимание уделяется  определению  маркеров  патологии сердечно-сосудистой системы — эндотелиальной дисфункции, снижению эластичности артерий, повышению скорости пульсовой волны (жесткости сосудистой  стенки), а также изучению влияния на них различных комбинаций антигипертензивных препаратов.  В настоящей работе  приведены современные  данные о ремоделировании сосудистой стенки при АГ и возможностях ее фармакологической коррекции с помощью ингибиторов ангиотензин-превращающего фермента, антагонистов кальция и β-адреноблокаторов при монотерапии и в их комбинации.

 

Arterial hypertension (AH) is a serious medical and social problem due to its complications leading to disability. Recently, there is a lot of attention paid to markers evaluation for cardiovascular pathology — endothelial dysfunction,  arteries  elasticity decline,  increased  pulse  wave velocity (vascular  wall stiffness)  and  studying  of  an  influence  of  various antihypertension  treatments. Current  article  focuses  on  the  modern influences on remodeling of vessel wall in AH and opportunities  of its pharmacological   correction   with  angiotensine   converting  enzyme inhibitors, calcium channel blockers and beta-blockers as monotherapy and combination.

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The authors declare that there are no conflicts of interest present.