cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2014-5-74-82cardiovascular-63Research ArticleОБЗОРЫREVIEWSСОСУДИСТЫЙ ВОЗРАСТ. МЕХАНИЗМЫ СТАРЕНИЯ СОСУДИСТОЙ СТЕНКИ. МЕТОДЫ ОЦЕНКИ СОСУДИСТОГО ВОЗРАСТАA VESSEL AGE. MECHANISMS OF VESSEL WALL AGEING. METHODS OF ASSESSMENThttps://orcid.org/0000-0002-4453-8430ДрапкинаО. М.DrapkinaO. M.

д. м.н., профессор кафедры пропедевтики внутренних болезней лечебного факультета, зав. отделением кардиологии Клиники пропедевтики внутренних болезней, гастроэнтерологии и гепатологии им. В. Х. Василенко

Тел./факс: +7 (910) 454-11-32 

tel./fax: +7 (910) 454-11-32 

drapkina@bk.ruМанджиеваБ. А.MandzhievaB. A.

студентка 6 курса

ГБОУ ВПО “Первый Московский государственный медицинский университет им. И. М. Сеченова” Минздрава России, МоскваSBEI HPE First Moscow State Medical University n. a. I. M. Sechenov of the Ministry of Health, Moscow2014201020141357482Copyright © Драпкина О.М., Манджиева Б.А., 20142014Драпкина О.М., Манджиева Б.А.Drapkina O.M., Mandzhieva B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/63

Возраст является общепризнанным фактором риска сердечно-сосудистых заболеваний (ССЗ). Одним из важнейших факторов старения человека служит биологический возраст сосудов. Для ранней профилактики ССЗ необходимо разработать скрининговые методы оценки сосудистого возраста у пациентов с отягощенным анамнезом по ССЗ. Основными механизмами сосудистого старения служит окислительный стресс, эндотелиальная дисфункция, хроническое воспаление, репликативное старение и апоптоз эндотелиальных клеток, повреждение функции эндотелиальных прогениторных клеток, возрастная дизрегуляция циркадианной системы. Понимание механизмов, лежащих в основе возрастных патофизиологических изменений в сосудистом русле, важно и необходимо для разработки новых методов патогенетического лечения. В перспективе – ранняя профилактика ССЗ, достижение здорового старения, улучшения качества жизни пожилых людей. 

The age is common risk factor for cardiovascular diseases (CVD). One of the main risk factors for ageing is biological age of vessels. For early prevention of CVD there must be screening methods of vessel age assessment in patients with the anamnesis prone to CVD. Main mechanisms of vessel ageing are oxidative stress, endothelial dysfunction, chronic inflammation, replication ageing and apoptosis of endothelial cells, damage of endothelial progenitory cells function, age dysregulation of circadian system. Understanding of the mechanisms that lead to ageing pathophysiological changes in vessels is important and is necessary for novel methods of pathogenetic treatment. As perspective – early prevention of CVD, achievement of healthy ageing, improve of life quality of older persons. 

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The authors declare that there are no conflicts of interest present.