<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2017-3-68-74</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-636</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>ОБСТРУКТИВНОЕ АПНОЭ СНА КАК ФАКТОР РИСКА СЕРДЕЧНОСОСУДИСТЫХ ЗАБОЛЕВАНИЙ: ЛЕЧИТЬ ИЛИ НЕ ЛЕЧИТЬ?</article-title><trans-title-group xml:lang="en"><trans-title>OBSTRUCTIVE SLEEP APNEA AS CARDIOVASCULAR RISK FACTOR: TO TREAT OR NOT?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>О. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, член-корреспондент РАН, и.о директораГНИЦПМ, профессор кафедры факультетской терапиию ПМГМУ.</p><p>Москва, тел.: +7 (910) 454-11-32</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">Drapkina@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дуболазова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubolazova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, старший научный сотрудник.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корнеева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Korneeva</surname><given-names>О. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат медицинских наук, врач-кардиолог.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Государственный научно-исследовательский центр профилактической медицины Минздрава России; ФГАОУ ВО “Первый Московский государственный медицинский  университет имени И. М. Сеченова” Минздрава России (Сеченовский  Университет)</institution></aff><aff xml:lang="en"><institution>National Research Center for Preventive Medicine of the Ministry of Health; I.M. Sechenov First Moscow State Medical University of the Ministry of Health</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ Государственный научно-исследовательский центр профилактической медицины Минздрава России</institution></aff><aff xml:lang="en"><institution>National Research Center for Preventive Medicine of the Ministry of Health</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ЗАО “Группа компаний “Медси”</institution></aff><aff xml:lang="en"><institution>LLC “Group of companies “Medsi”</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2017</year></pub-date><volume>16</volume><issue>3</issue><fpage>68</fpage><lpage>74</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Драпкина О.М., Дуболазова Ю.В., Корнеева О.Н., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Драпкина О.М., Дуболазова Ю.В., Корнеева О.Н.</copyright-holder><copyright-holder xml:lang="en">Drapkina О.M., Dubolazova Y.V., Korneeva О.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/636">https://cardiovascular.elpub.ru/jour/article/view/636</self-uri><abstract><p>В настоящее время доказано наличие взаимосвязи между обструктивным апноэ сна (ОАС) и повышенным риском сердечно-сосудистых заболеваний  (ССЗ). Распространенность этих патологических процессов  увеличивается  с возрастом.  Если  предрасполагающие факторы риска ССЗ достаточно изучены, и разработаны  меры их профилактики, то факторы риска и профилактика ОАС требуют дальнейшего изучения. В частности, особый интерес представляет собой исследование влияния ОАС на развитие и течение сердечной недостаточности, а также эффективность и безопасность  CPAP (continuous positive airway pressure) терапии у пациентов с различными фенотипами  сердечной  недостаточности.  Результаты  ряда исследований свидетельствуют о том, что пациенты с не леченным тяжелым ОАС имеют повышенный риск фатальных и нефатальных событий, по сравнению с людьми, которые храпят во сне. В обзоре представлены   данные  клинических исследований,  отражающие современное состояние проблемы.</p></abstract><trans-abstract xml:lang="en"><p>Recently, there  is thouroughly established  relation of the  obstructive sleep  apnea  (OSA) relation  with increased  cardiovascular  diseases (CVD) risk. The prevalence  of such  pathological processes increases with the age. If predisposing factors to CVD are studied well enough, and there are ways for prevention, risk factors and prevention of OSA require further investigation. Particularly, an interesting point of consideration is the influence of OSA on the development and course of heart failure, and efficacy and safety of CPAP treatment in patients with various phenotypes of heart failure. The results of a range of studies point on the increased risk of fatal and non-fatal events in patients with non-treated severe OSA, comapring to snorers. In the review, we present data of studies reflecting current state of the problem.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обструктивное апноэ сна</kwd><kwd>ожирение</kwd><kwd>сердечнососудистые заболевания</kwd><kwd>сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obstructive sleep apnea</kwd><kwd>obesity</kwd><kwd>cardiovascular disorders</kwd><kwd>heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Maeder MT, Schoch OD, Rickli H. A clinical approach to obstructive sleep apnea as a risk factor for cardiovascular disease. Vascular Health and Risk Management 2016; 12: 85-103.</mixed-citation><mixed-citation xml:lang="en">Maeder MT, Schoch OD, Rickli H. A clinical approach to obstructive sleep apnea as a risk factor for cardiovascular disease. Vascular Health and Risk Management 2016; 12: 85-103.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Young T, Finn L, Peppard PE, et al. Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort. Sleep. 2008 Aug 1; 31(8): 1071-8.</mixed-citation><mixed-citation xml:lang="en">Young T, Finn L, Peppard PE, et al. Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort. Sleep. 2008 Aug 1; 31(8): 1071-8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Downey R, Rowley JA, Wickramasinghe H, Gold P, http://emedicine.medscape.com/article/295807-overview.</mixed-citation><mixed-citation xml:lang="en">Downey R, Rowley JA, Wickramasinghe H, Gold P, http://emedicine.medscape.com/article/295807-overview.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Shahar E, Redline S, Young T, et al. Hormone replacement therapy and sleep-disordered breathing. Am J Respir Crit Care Med 2003; 167(9): 1186-92.</mixed-citation><mixed-citation xml:lang="en">Shahar E, Redline S, Young T, et al. Hormone replacement therapy and sleep-disordered breathing. Am J Respir Crit Care Med 2003; 167(9): 1186-92.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Young T, Finn L, Austin D, Peterson A. Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med 2003; 167(9): 1181-5.</mixed-citation><mixed-citation xml:lang="en">Young T, Finn L, Austin D, Peterson A. Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med 2003; 167(9): 1181-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA 2004; 291(16): 2013-6.</mixed-citation><mixed-citation xml:lang="en">Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA 2004; 291(16): 2013-6.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365 (9464): 1046-53.</mixed-citation><mixed-citation xml:lang="en">Marin JM, Carrizo SJ, Vicente E, Agusti AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005; 365 (9464): 1046-53.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Yaggi HK, Concato J, Kernan WN, et al. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353(19): 2034-41.</mixed-citation><mixed-citation xml:lang="en">Yaggi HK, Concato J, Kernan WN, et al. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353(19): 2034-41.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Campos-Rodriguez F, Martinez-Garcia MA, de la Cruz-Moron I, et al. Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: A cohort study. Ann Intern Med 2012; 156(2): 115-22.</mixed-citation><mixed-citation xml:lang="en">Campos-Rodriguez F, Martinez-Garcia MA, de la Cruz-Moron I, et al. Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: A cohort study. Ann Intern Med 2012; 156(2): 115-22.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez-Garcia MA, Campos-Rodriguez F, Catalan-Serra P, et al. Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment: a prospective observational study. Am J Respir Crit Care Med 2012; 186(9): 909-16.</mixed-citation><mixed-citation xml:lang="en">Martinez-Garcia MA, Campos-Rodriguez F, Catalan-Serra P, et al. Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment: a prospective observational study. Am J Respir Crit Care Med 2012; 186(9): 909-16.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Butt M, Dwivedi G, Shantsila A, et al. Left ventricular systolic and diastolic function in obstructive sleep apnea: Impact of continuous positive airway pressure therapy. Circ Heart Fail 2012; 5(2): 226-33.</mixed-citation><mixed-citation xml:lang="en">Butt M, Dwivedi G, Shantsila A, et al. Left ventricular systolic and diastolic function in obstructive sleep apnea: Impact of continuous positive airway pressure therapy. Circ Heart Fail 2012; 5(2): 226-33.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Haruki N, Takeuchi M, Kanazawa Y, et al. Continuous positive airway pressure ameliorates sleep-induced subclinical left ventricular systolic dysfunction: Demonstration by two-dimensional speckle-tracking echocardiography. Eur J Echocardiogr 2010; 11(4): 352-8.</mixed-citation><mixed-citation xml:lang="en">Haruki N, Takeuchi M, Kanazawa Y, et al. Continuous positive airway pressure ameliorates sleep-induced subclinical left ventricular systolic dysfunction: Demonstration by two-dimensional speckle-tracking echocardiography. Eur J Echocardiogr 2010; 11(4): 352-8.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D, Ma GS, Wang XY, et al. Left ventricular subclinical dysfunction associated with myocardial deformation changes in obstructive sleep apnea patients estimated by real-time 3d speckle-tracking echocardiography. Sleep Breath. Epub 2015 May 24.</mixed-citation><mixed-citation xml:lang="en">Wang D, Ma GS, Wang XY, et al. Left ventricular subclinical dysfunction associated with myocardial deformation changes in obstructive sleep apnea patients estimated by real-time 3d speckle-tracking echocardiography. Sleep Breath. Epub 2015 May 24.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Arias MA, Garcia-Rio F, Alonso-Fernandez A, et al. Obstructive sleep apnea syndrome affects left ventricular diastolic function: Effects of nasal continuous positive airway pressure in men. Circulation 2005; 112(3): 375-83.</mixed-citation><mixed-citation xml:lang="en">Arias MA, Garcia-Rio F, Alonso-Fernandez A, et al. Obstructive sleep apnea syndrome affects left ventricular diastolic function: Effects of nasal continuous positive airway pressure in men. Circulation 2005; 112(3): 375-83.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Oliveira W, Campos O, Bezerra Lira-Filho E, et al. Left atrial volume and function in patients with obstructive sleep apnea assessed by real-time three-dimensional echocardiography. J Am Soc Echocardiogr 2008; 21(12): 1355-61.</mixed-citation><mixed-citation xml:lang="en">Oliveira W, Campos O, Bezerra Lira-Filho E, et al. Left atrial volume and function in patients with obstructive sleep apnea assessed by real-time three-dimensional echocardiography. J Am Soc Echocardiogr 2008; 21(12): 1355-61.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Colish J, Walker JR, Elmayergi N, et al. Obstructive sleep apnea: Effects of continuous positive airway pressure on cardiac remodeling as assessed by cardiac biomarkers, echocardiography, and cardiac MRI. Chest 2012; 141(3): 674-81.</mixed-citation><mixed-citation xml:lang="en">Colish J, Walker JR, Elmayergi N, et al. Obstructive sleep apnea: Effects of continuous positive airway pressure on cardiac remodeling as assessed by cardiac biomarkers, echocardiography, and cardiac MRI. Chest 2012; 141(3): 674-81.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shahar E, Whitney CW, Redline S, et al. Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study. Am J Respir Crit Care Med 2001; 163(1): 19-25.</mixed-citation><mixed-citation xml:lang="en">Shahar E, Whitney CW, Redline S, et al. Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the sleep heart health study. Am J Respir Crit Care Med 2001; 163(1): 19-25.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gottlieb DJ, Yenokyan G, Newman AB, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation 2010; 122(4): 352-60.</mixed-citation><mixed-citation xml:lang="en">Gottlieb DJ, Yenokyan G, Newman AB, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation 2010; 122(4): 352-60.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Roca GQ, Redline S, Claggett B, et al. Sex-specific association of sleep apnea severity with subclinical myocardial injury, ventricular hypertrophy, and heart failure risk in a community-dwelling cohort: The atherosclerosis risk in communities-sleep heart health study. Circulation 2015; 132(14): 1329-37.</mixed-citation><mixed-citation xml:lang="en">Roca GQ, Redline S, Claggett B, et al. Sex-specific association of sleep apnea severity with subclinical myocardial injury, ventricular hypertrophy, and heart failure risk in a community-dwelling cohort: The atherosclerosis risk in communities-sleep heart health study. Circulation 2015; 132(14): 1329-37.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cowie MR, Woehrle H, Wegscheider K, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 2015; 373(12): 1095-105.</mixed-citation><mixed-citation xml:lang="en">Cowie MR, Woehrle H, Wegscheider K, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 2015; 373(12): 1095-105.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Spaak J, Egri ZJ, Kubo T, et al. Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension 2005; 46(6): 1327-32.</mixed-citation><mixed-citation xml:lang="en">Spaak J, Egri ZJ, Kubo T, et al. Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension 2005; 46(6): 1327-32.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Usui K, Bradley TD, Spaak J, et al. Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure. JACC 2005; 45(12): 2008-11.</mixed-citation><mixed-citation xml:lang="en">Usui K, Bradley TD, Spaak J, et al. Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure. JACC 2005; 45(12): 2008-11.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gilman MP, Floras JS, Usui K, et al. Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci(Lond) 2008; 114(3): 243-9.</mixed-citation><mixed-citation xml:lang="en">Gilman MP, Floras JS, Usui K, et al. Continuous positive airway pressure increases heart rate variability in heart failure patients with obstructive sleep apnoea. Clin Sci(Lond) 2008; 114(3): 243-9.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ruttanaumpawan P, Gilman MP, Usui K, et al. Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea. J Hypertens 2008; 26(6): 1163-8.</mixed-citation><mixed-citation xml:lang="en">Ruttanaumpawan P, Gilman MP, Usui K, et al. Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea. J Hypertens 2008; 26(6): 1163-8.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H, Parker JD, Newton GE, et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. JACC 2007; 49(15): 1625-31.</mixed-citation><mixed-citation xml:lang="en">Wang H, Parker JD, Newton GE, et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. JACC 2007; 49(15): 1625-31.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Mansfield DR, Gollogly NC, Kaye DM, et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 2004; 169: 361-6.</mixed-citation><mixed-citation xml:lang="en">Mansfield DR, Gollogly NC, Kaye DM, et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 2004; 169: 361-6.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Paulus WJ, Tschope C. A novel paradigm for heart failure with preserved ejection fraction: Comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. JACC 2013; 62(4): 263-71.</mixed-citation><mixed-citation xml:lang="en">Paulus WJ, Tschope C. A novel paradigm for heart failure with preserved ejection fraction: Comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. JACC 2013; 62(4): 263-71.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Samson R, Jaiswal A, Ennezat PV, et al. Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc 2016; 5(1): e002477.</mixed-citation><mixed-citation xml:lang="en">Samson R, Jaiswal A, Ennezat PV, et al. Clinical Phenotypes in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc 2016; 5(1): e002477.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shah RV, Abbasi SA, Heydari B, et al. Obesity and sleep apnea are independently associated with adverse left ventricular remodeling and clinical outcome in patients with atrial fibrillation and preserved ventricular function. Am Heart J 2014; 167(4): 620-6.</mixed-citation><mixed-citation xml:lang="en">Shah RV, Abbasi SA, Heydari B, et al. Obesity and sleep apnea are independently associated with adverse left ventricular remodeling and clinical outcome in patients with atrial fibrillation and preserved ventricular function. Am Heart J 2014; 167(4): 620-6.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">McEvoy D, Antic NA, Heeley E, et al. CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea. NEJM N Engl J Med 2016; 375: 919-31.</mixed-citation><mixed-citation xml:lang="en">McEvoy D, Antic NA, Heeley E, et al. CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea. NEJM N Engl J Med 2016; 375: 919-31.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
