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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2017-3-75-80</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-637</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>ИЗУЧЕНИЕ  ДОЛГОЖИТЕЛЬСТВА: СОВРЕМЕННЫЙ СТАТУС ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ. ЧАСТЬ 1</article-title><trans-title-group xml:lang="en"><trans-title>THE STUDY OF LONGEVITY: RECENT UPDATES AND FURTHER DIRECTION. PART 1</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котовская</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotovskaya</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Котовская Юлия Викторовна — доктор медицинских наук РНИМУ им. Н. И. Пирогова, профессор, зав. кафедрой кардиологии и персонифицированной медицины ФПК МР Ми, руководитель лаборатории сердечно-сосудистого старения РУДН.</p><p>Москва, тел.: +7 (916) 634-67-35</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">kotovskaya@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>О. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ткачева Ольга Николаевна — доктор медицинских наук РНИМУ,  профессор,  директор ОСП РГНКЦ руководитель отдела изучения процессов старения и профилактики возраст-ассоциированных заболеваний ГНИЦПМ.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рунихина</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Runikhina</surname><given-names>N. К.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, заместитель директора.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каштанова</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashtanova</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каштанова Д. А. — аспирант отдела изучения процессов старения и профилактики возраст-ассоциированных заболеваний им. Н. И. Пирогова, младший научный сотрудник лаборатории биологии старения и биоинформатики ГНИЦПМ.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бойцов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Boytsov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бойцов С. А. — Доктор медицинских наук, профессор, член-корреспондент РАН, и. о. директора.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО “Российский университет дружбы  народов”  Министерства образования и науки Российской Федерации; ФГБОУ ВО “Российский научно-исследовательский медицинский  университет им. Н. И. Пирогова” Министерства здравоохранения Российской Федерации  — ОСП “Российский геронтологический научно-клинический центр”</institution></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia; N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО “Российский научно-исследовательский медицинский  университет им. Н. И. Пирогова” Министерства здравоохранения Российской Федерации  — ОСП “Российский геронтологический научно-клинический центр”</institution></aff><aff xml:lang="en"><institution>N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО “Российский научно-исследовательский медицинский  университет им. Н. И. Пирогова” Министерства здравоохранения Российской Федерации  — ОСП “Российский геронтологический научно-клинический центр”; ФГБУ “Государственный научно-исследовательский центр профилактической медицины” Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>N. I. Pirogov Russian National Research Medical University (RNRMU) — SD “Russian Gerontological Scientific-Clinical Center”; National Research Center for Preventive Medicine of the Ministry of Health</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБУ “Российский кардиологический научно-производственный комплекс” Минздрава России</institution></aff><aff xml:lang="en"><institution>Russian Cardiological Research-and-Production Complex of the Ministry of Health</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2017</year></pub-date><volume>16</volume><issue>3</issue><fpage>75</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Котовская Ю.В., Ткачева О.Н., Рунихина Н.К., Каштанова Д.А., Бойцов С.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Котовская Ю.В., Ткачева О.Н., Рунихина Н.К., Каштанова Д.А., Бойцов С.А.</copyright-holder><copyright-holder xml:lang="en">Kotovskaya Y.V., Tkacheva О.N., Runikhina N.К., Kashtanova D.A., Boytsov S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/637">https://cardiovascular.elpub.ru/jour/article/view/637</self-uri><abstract><p>Увеличение продолжительности жизни определяет  стремительный рост  числа  людей  пожилого и старческого  возрастов.  Различия между хронологическим и биологическим возрастом,  между скоростью старения разных людей дают основания для изучения биологических и  генетических  факторов  долгожительства.  В серии обзорных  статей  суммированы  результаты  исследований  в этих областях.  Однако помимо  фундаментального  научного интереса общее   старение   населения   и  долгожительство  тесно  связаны с медико-социальными вопросами организации гериатрической помощи. Несмотря на высокий интерес, долгожительство остается во   многом   недостаточно   изученным   и   понятным  явлением. Представленный обзор охватывает широкий спектр изучения проблем долгожительства — от генетических исследований до медикосоциальных проблем.</p></abstract><trans-abstract xml:lang="en"><p>The increase  of life duration leads to a sharp growth of the older and senile persons number. Differences in chronological and biological ages, of the velocity of ageing in different persons, make it to study biological and genetic factors of longevity. In the series of reviews we summarize the results of studies in these  areas.  However, except the fundamental scientific interest, general ageing of population and longevity are related to medical and social issues on the geriatric care organization. Regardless  the  high interest,  longevity is still underinvestigated.  The review focuses on the wide spectrum of longevity issues — from genetics to medical and social problems.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>долгожительство</kwd><kwd>старение</kwd><kwd>программы “100-летний гражданин”</kwd><kwd>комплексная гериатрическая оценка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>longevity</kwd><kwd>ageing</kwd><kwd>a  centenarian</kwd><kwd>complex  geriatrician assessment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Goldman DP, Cutler D, Rowe JW, et al. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff (Millwood) 2013; 32(10): 1698-705.</mixed-citation><mixed-citation xml:lang="en">Goldman DP, Cutler D, Rowe JW, et al. 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