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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2017-5-76-80</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-647</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>КОМОРБИДНЫЙ ПАЦИЕНТ В КЛИНИКЕ ВНУТРЕННИХ БОЛЕЗНЕЙ: СЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯ И ТРЕВОГА</article-title><trans-title-group xml:lang="en"><trans-title>COMORBID PATIENT IN THE INTERNAL MEDICINE: CARDIOVASCULAR DISEASES AND ANXIETY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селиванова</surname><given-names>Г. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Selivanova</surname><given-names>G. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, профессор кафедры общей терапии ФДПО,</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">galina.selivanova@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России</institution></aff><aff xml:lang="en"><institution>N.I. Pirogov Russian National Research Medical University (RNRMU)</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>10</month><year>2017</year></pub-date><volume>16</volume><issue>5</issue><fpage>76</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Селиванова Г.Б., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Селиванова Г.Б.</copyright-holder><copyright-holder xml:lang="en">Selivanova G.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/647">https://cardiovascular.elpub.ru/jour/article/view/647</self-uri><abstract><p>Высокая распространенность тревожно-депрессивных расстройств и неуклонный рост сердечно-сосудистых заболеваний делает актуальной проблему своевременной диагностики и дифференцированной фармакотерапии коморбидных пациентов в клинике внутренних болезней. В статье представлены новые данные о взаимосвязи нарушений психоэмоциональной сферы и риска сердечно-сосудистых событий, а также проанализированы проблемы фармакотерапии. На основе представленных данных делается заключение о необходимости разработки тактики ведения таких пациентов.</p></abstract><trans-abstract xml:lang="en"><p>High prevalence of anxiety and depression disorders, as the increase of cardiovascular pathology prevalence make the problem of on time diagnostics and correction actual and important, as of the differential pharmacotherapy in internal disease practice. The article points on the data of relations in psychoemotional disorders and cardiovascular risks, as on the issues of pharmacotherapy. Based on the data presented, the conclusion done on the necessity of a specific tactics of such patients management.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тревога</kwd><kwd>депрессия</kwd><kwd>артериальная гипертензия</kwd><kwd>ишемическая болезнь сердца</kwd></kwd-group><kwd-group xml:lang="en"><kwd>anxiety</kwd><kwd>depression</kwd><kwd>arterial hypertension</kwd><kwd>ischemic heart disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.who.int/mediacentre/news/releases/2016/depression-anxietytreatment/ru (13 Apr 2016)</mixed-citation><mixed-citation xml:lang="en">http://www.who.int/mediacentre/news/releases/2016/depression-anxietytreatment/ru (13 Apr 2016)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.who.int/mediacentre/factsheets/fs369/ru (Feb 2017 )</mixed-citation><mixed-citation xml:lang="en">http://www.who.int/mediacentre/factsheets/fs369/ru (Feb 2017 )</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.who.int/mediacentre/factsheets/fs396/ru/ (Apr 2017)</mixed-citation><mixed-citation xml:lang="en">http://www.who.int/mediacentre/factsheets/fs396/ru/ (Apr 2017)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Liu MY, Li N, Li WA, et al. Association between psychosocial stress and hypertension: a systematic review and meta-analysis. Neurol Res 2017; Jun; 39 (6): 573-80.</mixed-citation><mixed-citation xml:lang="en">Liu MY, Li N, Li WA, et al. Association between psychosocial stress and hypertension: a systematic review and meta-analysis. Neurol Res 2017; Jun; 39 (6): 573-80.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fedotova AV. Anxiety-depressive disorders in general clinical practice. Rational pharmacotherapy in cardiology 2008; 3: 83-7. Russian (Федотова А.В. Тревожнодепрессивные расстройства в общеклинической практике. Рациональная фармакотерапия в кардиологии 2008; 3: 83-7).</mixed-citation><mixed-citation xml:lang="en">Fedotova AV. Anxiety-depressive disorders in general clinical practice. Rational pharmacotherapy in cardiology 2008; 3: 83-7. Russian (Федотова А.В. Тревожнодепрессивные расстройства в общеклинической практике. Рациональная фармакотерапия в кардиологии 2008; 3: 83-7).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pogosova GV. Psychoemotional disorders in patients with cardiovascular diseases: treatment issues. Cardovascular Therapy and Prevention 2006; 5 (2): 94-9. Russian (Погосова Г.В. Психоэмоциональные расстройства у больных сердечно-сосудистыми заболеваниями: вопросы лечения. Кардоваскулярная терапия и профилактика 2006; 5 (2): 94-9).</mixed-citation><mixed-citation xml:lang="en">Pogosova GV. Psychoemotional disorders in patients with cardiovascular diseases: treatment issues. Cardovascular Therapy and Prevention 2006; 5 (2): 94-9. Russian (Погосова Г.В. Психоэмоциональные расстройства у больных сердечно-сосудистыми заболеваниями: вопросы лечения. Кардоваскулярная терапия и профилактика 2006; 5 (2): 94-9).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.who.int/mediacentre/factsheets/fs317/ru/ (Jan 2015)</mixed-citation><mixed-citation xml:lang="en">http://www.who.int/mediacentre/factsheets/fs317/ru/ (Jan 2015)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">http://www.who.int/cardiovascular_diseases/about_cvd/ru/</mixed-citation><mixed-citation xml:lang="en">http://www.who.int/cardiovascular_diseases/about_cvd/ru/</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Soloveva SL, Uspenskyi UP, Balukova EV. Depression in the therapeutic clinic (pathopsychological, psychotherapeutic and psychopharmacological aspects). SPb.: InfomMed, 2008; 204 р. Russian (Соловьева С. Л., Успенский Ю. П., Балукова Е.В. Депрессия в терапевтический клинике (патопсихологические, психотерапевтические и психофармакологические аспекты). СПб.: ИнформМед 2008; 204 с.).</mixed-citation><mixed-citation xml:lang="en">Soloveva SL, Uspenskyi UP, Balukova EV. Depression in the therapeutic clinic (pathopsychological, psychotherapeutic and psychopharmacological aspects). SPb.: InfomMed, 2008; 204 р. Russian (Соловьева С. Л., Успенский Ю. П., Балукова Е.В. Депрессия в терапевтический клинике (патопсихологические, психотерапевтические и психофармакологические аспекты). СПб.: ИнформМед 2008; 204 с.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Medvedev VE. Therapy of anxiety disorders in patients with cardiovascular diseases (experience with afobazole). Archive of internal medicine 2013; 3 (11): 70-6. Russian (Медведев В.Э. Терапия тревожных расстройств у пациентов с сердечно-сосудистыми заболеваниями (опыт применения афобазола). Архив внутренней медицины 2013; 3 (11): 70-6).</mixed-citation><mixed-citation xml:lang="en">Medvedev VE. Therapy of anxiety disorders in patients with cardiovascular diseases (experience with afobazole). Archive of internal medicine 2013; 3 (11): 70-6. Russian (Медведев В.Э. Терапия тревожных расстройств у пациентов с сердечно-сосудистыми заболеваниями (опыт применения афобазола). Архив внутренней медицины 2013; 3 (11): 70-6).</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Yasunari K, Matsui T, Maeda K, et al. Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension. Am J Hypertens 2006; 19: 573-8.</mixed-citation><mixed-citation xml:lang="en">Yasunari K, Matsui T, Maeda K, et al. Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension. Am J Hypertens 2006; 19: 573-8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ozdoeva LD, Nebieridze DV, Pogosova GV, et al. Interrelation of risk factors of atherosclerosis and anxiety-depressive states in men from an unorganized population. Cardiovascular Therapy and Prevention 2003; 2 (1): 59-64. Russian (Оздоева Л.Д., Небиеридзе Д.В., Погосова Г.В. и др. Взаимосвязь факторов риска атеросклероза и тревожно-депрессивных состояний у мужчин из неорганизованной популяции. Кардиоваскулярная терапия и профилактика 2003; 2 (1): 59-64).</mixed-citation><mixed-citation xml:lang="en">Ozdoeva LD, Nebieridze DV, Pogosova GV, et al. Interrelation of risk factors of atherosclerosis and anxiety-depressive states in men from an unorganized population. Cardiovascular Therapy and Prevention 2003; 2 (1): 59-64. Russian (Оздоева Л.Д., Небиеридзе Д.В., Погосова Г.В. и др. Взаимосвязь факторов риска атеросклероза и тревожно-депрессивных состояний у мужчин из неорганизованной популяции. Кардиоваскулярная терапия и профилактика 2003; 2 (1): 59-64).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Piccirillo G, Viola E, Nocco M, et al. Autonomic modulation and QT interval dispersion in hypertensive subjects with anxiety. Hypertension 1999; 34: 242-6.</mixed-citation><mixed-citation xml:lang="en">Piccirillo G, Viola E, Nocco M, et al. Autonomic modulation and QT interval dispersion in hypertensive subjects with anxiety. Hypertension 1999; 34: 242-6.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Krichenko AA. Depression, anxiety and cardiovascular system. Lechashij vrach 2012; 2. Russian (Криченко A.A. Депрессия, беспокойство и сердечно-сосудистая система. Лечащий врач 2012; 2).</mixed-citation><mixed-citation xml:lang="en">Krichenko AA. Depression, anxiety and cardiovascular system. Lechashij vrach 2012; 2. Russian (Криченко A.A. Депрессия, беспокойство и сердечно-сосудистая система. Лечащий врач 2012; 2).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bromfield S, Muntner P. High blood pressure: the leading global burden of disease risk factor and the need for worldwide prevention programs. Curr Hypertens Rep 2013; 15: 134-6.</mixed-citation><mixed-citation xml:lang="en">Bromfield S, Muntner P. High blood pressure: the leading global burden of disease risk factor and the need for worldwide prevention programs. Curr Hypertens Rep 2013; 15: 134-6.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkins K, Campbell NR, Joffres MR, et al. Blood pressure in Canadianadults. Health Rep 2010; 21: 37-46.</mixed-citation><mixed-citation xml:lang="en">Wilkins K, Campbell NR, Joffres MR, et al. Blood pressure in Canadianadults. Health Rep 2010; 21: 37-46.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Roest AM, Martens EJ, de Jonge P, et al. Anxiety and risk of incident coronary heart disease: a meta-analysis. JACC 2010; 56: 38-46.</mixed-citation><mixed-citation xml:lang="en">Roest AM, Martens EJ, de Jonge P, et al. Anxiety and risk of incident coronary heart disease: a meta-analysis. JACC 2010; 56: 38-46.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: ameta-analysis of 6362 events among 146538 participants in 54 observational studies. Eur Heart J 2006; 27: 2763-74.</mixed-citation><mixed-citation xml:lang="en">Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: ameta-analysis of 6362 events among 146538 participants in 54 observational studies. Eur Heart J 2006; 27: 2763-74.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mehmet EÖ, Ebru Ö, Nazile BD, et al. Impact of anxiety level on circadian rhythm of blood pressure in hypertensive patients. J Clin Exp Med 2015; 8 (9): 16252-8.</mixed-citation><mixed-citation xml:lang="en">Mehmet EÖ, Ebru Ö, Nazile BD, et al. Impact of anxiety level on circadian rhythm of blood pressure in hypertensive patients. J Clin Exp Med 2015; 8 (9): 16252-8.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Tsartsalis D, Dragioti E, Kontoangelos K, et al. The impact of depression and cardiophobia on quality of life in patients with essential hypertension. Psychiatriki 2016 Jul-Sep; 27 (3): 192-203.</mixed-citation><mixed-citation xml:lang="en">Tsartsalis D, Dragioti E, Kontoangelos K, et al. The impact of depression and cardiophobia on quality of life in patients with essential hypertension. Psychiatriki 2016 Jul-Sep; 27 (3): 192-203.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sandström YK, Ljunggren G, Wändell P, et al. Psychiatric comorbidities in patients with hypertension - a study of registered diagnoses 2009-2013 in the total population in Stockholm County, Sweden. J Hypertens 2016; 34 (3): 414-20.</mixed-citation><mixed-citation xml:lang="en">Sandström YK, Ljunggren G, Wändell P, et al. Psychiatric comorbidities in patients with hypertension - a study of registered diagnoses 2009-2013 in the total population in Stockholm County, Sweden. J Hypertens 2016; 34 (3): 414-20.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson CA, Pathirana T, Gardiner PA. Depression, anxiety and risk of hypertension in mid-aged women: a prospective longitudinal study. J Hypertens 2016; 34 (10): 1959-66.</mixed-citation><mixed-citation xml:lang="en">Jackson CA, Pathirana T, Gardiner PA. Depression, anxiety and risk of hypertension in mid-aged women: a prospective longitudinal study. J Hypertens 2016; 34 (10): 1959-66.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Maatouk I, Herzog W, Böhlen F, et al. Association of hypertension with depression and generalized anxiety symptoms in a large population-based sample of older adults. J Hypertens 2016; 34 (9): 1711-20.</mixed-citation><mixed-citation xml:lang="en">Maatouk I, Herzog W, Böhlen F, et al. Association of hypertension with depression and generalized anxiety symptoms in a large population-based sample of older adults. J Hypertens 2016; 34 (9): 1711-20.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bulgakov MS, Avtandilova AG, Milovanova OA. The role of long-term stress and the functional state of the endothelium in the development of the syndrome of vegetative dystonia. J Neur and psych 2015; 9: 4-7. Russian (Булгаков М.С., Автандилова А.Г., Милованова О.А. Роль длительного стресса и функционального состояния эндотелия в развитии синдрома вегетативной дистонии. Журнал невр и псих 2015; 9: 4-7).</mixed-citation><mixed-citation xml:lang="en">Bulgakov MS, Avtandilova AG, Milovanova OA. The role of long-term stress and the functional state of the endothelium in the development of the syndrome of vegetative dystonia. J Neur and psych 2015; 9: 4-7. Russian (Булгаков М.С., Автандилова А.Г., Милованова О.А. Роль длительного стресса и функционального состояния эндотелия в развитии синдрома вегетативной дистонии. Журнал невр и псих 2015; 9: 4-7).</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Bhat SK, Beilin LJ, Robinson M, et al. Relationships between depression and anxiety symptoms scores and blood pressure in young adults. J Hypertens 2017; May: 12-7.</mixed-citation><mixed-citation xml:lang="en">Bhat SK, Beilin LJ, Robinson M, et al. Relationships between depression and anxiety symptoms scores and blood pressure in young adults. J Hypertens 2017; May: 12-7.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Khatib R, Schwalm JD, Yusuf S, et al. Patient and healthcare provider barriers to hypertension awareness, treatment and follow up: a systematic review and metaanalysis of qualitative and quantitative studies. PLoS One 2014; 9: e84238.</mixed-citation><mixed-citation xml:lang="en">Khatib R, Schwalm JD, Yusuf S, et al. Patient and healthcare provider barriers to hypertension awareness, treatment and follow up: a systematic review and metaanalysis of qualitative and quantitative studies. PLoS One 2014; 9: e84238.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">García-Ortiz L, Gómez-Marcos MA, Martín-Moreiras J, et al. Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study). Blood Press Monit 2009; 14: 145-51.</mixed-citation><mixed-citation xml:lang="en">García-Ortiz L, Gómez-Marcos MA, Martín-Moreiras J, et al. Pulse pressure and nocturnal fall in blood pressure are predictors of vascular, cardiac and renal target organ damage in hypertensive patients (LOD-RISK study). Blood Press Monit 2009; 14: 145-51.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P, Angeli F, Mazzotta G, et al. Day-night dip and early-morning surge in blood pressure in hypertension: prognostic implications. Hypertension 2012; 60: 34-42.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P, Angeli F, Mazzotta G, et al. Day-night dip and early-morning surge in blood pressure in hypertension: prognostic implications. Hypertension 2012; 60: 34-42.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kikuya M, Hozava A, Ohokubo T, et al. Prognostic significance of blood pressure and heart rate varisbilities: the Ohasama Study. Hypertension 2000; 36: 901-6.</mixed-citation><mixed-citation xml:lang="en">Kikuya M, Hozava A, Ohokubo T, et al. Prognostic significance of blood pressure and heart rate varisbilities: the Ohasama Study. Hypertension 2000; 36: 901-6.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sega R, Corrao G, Bombelli M, et al. Blood pressure variability and organ damage in a general population: results from the PAMELA Study. Hypertension 2002; 39: 710-4.</mixed-citation><mixed-citation xml:lang="en">Sega R, Corrao G, Bombelli M, et al. Blood pressure variability and organ damage in a general population: results from the PAMELA Study. Hypertension 2002; 39: 710-4.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Tully PJ, Tzourio C . Psychiatric correlates of blood pressure variability in the elderly: The Three City cohort study. Physiol Behav 2017; 168: 91-7.</mixed-citation><mixed-citation xml:lang="en">Tully PJ, Tzourio C . Psychiatric correlates of blood pressure variability in the elderly: The Three City cohort study. Physiol Behav 2017; 168: 91-7.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Gustad LT, Bjerkeset O, Strand LB, et al. Cardiac function associated with previous, current and repeated depression and anxiety symptoms in a healthy population: the HUNT study. Open Heart 2016; Feb 15: 3 (1).</mixed-citation><mixed-citation xml:lang="en">Gustad LT, Bjerkeset O, Strand LB, et al. Cardiac function associated with previous, current and repeated depression and anxiety symptoms in a healthy population: the HUNT study. Open Heart 2016; Feb 15: 3 (1).</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Barker MJ, Greenwood KM, Jackson M, Crowe SF. Cognitive effects of long-term benzodiazepine use: a meta-analysis. CNS Drugs 2004; 18 (1): 37-48.</mixed-citation><mixed-citation xml:lang="en">Barker MJ, Greenwood KM, Jackson M, Crowe SF. Cognitive effects of long-term benzodiazepine use: a meta-analysis. CNS Drugs 2004; 18 (1): 37-48.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Smulevich AB, Andrushchenko AV, Romanov DV. Psychopharmacotherapy of borderline anxiety disorders (comparative study of the anxiolytic effect of afobazole and oxazepam in patients with adaptation disorders and generalized anxiety disorder). Rus Med J 2006; 14 (9): 725-9. Russian (Смулевич А.Б., Андрющенко А.В., Романов Д.В. Психофармакотерапия тревожных расстройств пограничного уровня (сравнительное исследование анксиолитического эффекта афобазола и оксазепама у больных с расстройствами адаптации и генерализованным тревожным расстройством). Русский медицинский ж 2006; 14 (9): 725-9).</mixed-citation><mixed-citation xml:lang="en">Smulevich AB, Andrushchenko AV, Romanov DV. Psychopharmacotherapy of borderline anxiety disorders (comparative study of the anxiolytic effect of afobazole and oxazepam in patients with adaptation disorders and generalized anxiety disorder). Rus Med J 2006; 14 (9): 725-9. Russian (Смулевич А.Б., Андрющенко А.В., Романов Д.В. Психофармакотерапия тревожных расстройств пограничного уровня (сравнительное исследование анксиолитического эффекта афобазола и оксазепама у больных с расстройствами адаптации и генерализованным тревожным расстройством). Русский медицинский ж 2006; 14 (9): 725-9).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Bhattacharyya D, Jana U, Debnath PK, et al. Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report. Nepal Med Coll J 2007; 9 (1): 36-9.</mixed-citation><mixed-citation xml:lang="en">Bhattacharyya D, Jana U, Debnath PK, et al. Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report. Nepal Med Coll J 2007; 9 (1): 36-9.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Cases J, Ibarra A, Feuillère N, et al. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterranean Journal of Nutrition and Metabolism 2011; 4 (3): 211-8.</mixed-citation><mixed-citation xml:lang="en">Cases J, Ibarra A, Feuillère N, et al. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterranean Journal of Nutrition and Metabolism 2011; 4 (3): 211-8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
