cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2018-2-88-94cardiovascular-704Research ArticleОБЗОРЫREVIEWSПИТАНИЕ КАК ФАКТОР РИСКА КАРДИОВАСКУЛЯРНОЙ ПАТОЛОГИИ В АСПЕКТЕ ЭПИДЕМИОЛОГИЧЕСКИХ ИССЛЕДОВАНИЙNUTRITION AS THE RISK FACTOR FOR CARDIOVASCULAR PATHOLOGY FROM EPIDEMIOLOGICAL PERSPECTIVEhttps://orcid.org/0000-0001-6136-0518ЦыганковаД. П.TsygankovaD. P.

Цыганкова Дарья Павловна — научный сотрудник лаборатории эпидемиологии сердечно­сосудистых заболеваний ННКПССЗ, очный аспирант кафедры кардиологии и сердечно­сосудистой хирургии КГМУ.

Тел.: +7 (923) 512­89­09

SPIN: 8064-3000

darjapavlovna2014@mail.ruКривошаповаК. Е.KrivoshapovaK. Е.

Кривошапова Кристина Евгеньевна — кандидат медицинских наук,  научный сотрудник лаборатории патофизиологии мультифокального атеросклероза.

Кемерово

Kemerovo

ya.kristi89@yandex.ruhttps://orcid.org/0000-0002-4642-3610БарбарашО. Л.BarbarashO. L.

Барбараш Ольга Леонидовна — доктор медицинских наук, профессор, член­корреспондент РАН, директор ННКПССЗ, заведующая кафедрой кардиологии и сердечно­сосудистых заболеваний КГМУ

darjapavlovna2014@mail.ruФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний; ФГБОУ ВО Кемеровский государственный медицинский университет Минздрава РоссииResearch Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University of the Ministry of HealthФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийResearch Institute for Complex Issues of Cardiovascular Diseases2018200420181728894Copyright © Цыганкова Д.П., Кривошапова К.Е., Барбараш О.Л., 20182018Цыганкова Д.П., Кривошапова К.Е., Барбараш О.Л.Tsygankova D.P., Krivoshapova K.Е., Barbarash O.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/704

Питание является важнейшей составляющей лечебных и профилактических мероприятий при сердечно­сосудистых заболеваниях. В настоящее время рассматриваются разные диеты, как для профилактики ожирения, так и для снижения риска тяжелой кардиоваскулярной патологии. В большинстве стран проводятся работы по изучению различных диетических моделей среди населения. В данной статье представлен обзор крупных эпидемиологических исследований, посвященных вопросам влияния питания на кардиоваскулярную патологию. Обсуждаются задачи и основные результаты, сильные и слабые стороны представленных работ.

Nutrition is a crucial element of patient management in cardiovascular disorders. Recently, a variety of diets considered, for prevention of obesity as for risk reduction of severe cardiovascular pathology. In most countries there are ongoing studies on various diet models among the population. The review is focused on the range of large epidemiological trials of nutrition in cardiovascular pathology. The tasks discussed and the main results, stronger and weaker aspects of the works represented.

питаниесердечно­сосудистые заболеваниясредиземноморская диетаартериальная гипертензияожирениеnutritioncardiovascular diseasesMediterranean dietReferencesGay HC, Rao SG, Vaccarino V, et al. Effects of different dietary interventions on blood pressure systematic review and meta­analysis of randomized controlled trials. Hypertension 2016; 67 (4): 733­9. DOI: 10.1161/HYPERTENSIONAHA.115.06853.Gay HC, Rao SG, Vaccarino V, et al. Effects of different dietary interventions on blood pressure systematic review and meta­analysis of randomized controlled trials. Hypertension 2016; 67 (4): 733­9. DOI: 10.1161/HYPERTENSIONAHA.115.06853.Stamler J, Elliott P, Appe L, et al. Higher blood pressure in middle­aged American adults with less education—role of multiple dietary factors: The INTERMAP Study. J Hum Hypertens 2003; 17 (9): 655­775. DOI: 10.1038/sj.jhh.1001608.Stamler J, Elliott P, Appe L, et al. Higher blood pressure in middle­aged American adults with less education—role of multiple dietary factors: The INTERMAP Study. J Hum Hypertens 2003; 17 (9): 655­775. DOI: 10.1038/sj.jhh.1001608.Pan A, Willett WC, Hu FB. Additional ways to diminish the deleterious effects of red meat­reply. Arch Intern Med 2012; 172 (18): 1424­5.Pan A, Willett WC, Hu FB. Additional ways to diminish the deleterious effects of red meat­reply. Arch Intern Med 2012; 172 (18): 1424­5.Siri­Tarino PW, Sun Q, Hu FB, et al. Meta­analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010; 91: 535­46. DOI: 10.3945/ajcn.2009.27725.Siri­Tarino PW, Sun Q, Hu FB, et al. Meta­analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 2010; 91: 535­46. DOI: 10.3945/ajcn.2009.27725.Воробьева Е. Н., Фомичева М. Л., Воробьев Р. И. и др. Питание как фактор риска развития сердечно­сосудистых заболеваний. Ульяновский медико­биологический журнал 2015; 1: 8­14.Vorobyeva EN, Fomicheva ML, Vorobyev RI, et al. Nutrition as a risk factor for cardiovascular diseases. Ulyanovsk Medico-Biological J 2015; 1: 8-14. (In Russ.)Deloukas P, Kanoni S, Willenborg C, et al. Large­scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2013; 45: 25­33.Deloukas P, Kanoni S, Willenborg C, et al. Large­scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2013; 45: 25­33.Батурин А. К., Сорокина Е. Ю., Погожева А. В., и др. Генетические подходы к персонализации питания. Вопросы питания 2012: 81 (6): 4­11.Baturin AK, Sorokina EYu, Pogozheva AV, et al. Genetic approaches to nutrition personalization. Voprosy pitaniya 2012; 81 (6): 4-11. (In Russ.)Sayols­Baixeras S, Lluis­Ganella C, Lucas G, et al. Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. Appl Clin Genet 2014; 7: 15­32.Sayols­Baixeras S, Lluis­Ganella C, Lucas G, et al. Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants. Appl Clin Genet 2014; 7: 15­32.Особенности диетотерапии больных с ишемической болезнью сердца. Павлюк Н. Б., Шарафетдинов Х. Х. Вопросы питания 2015; 84 (4): 25­36.Pavlyuk NB, Sharafetdinov KhKh. Features of dietary treatment in patients with coronary heart disease. Voprosy pitaniya 2015; 84 (4): 25-36. (in Russ.)Brenseke B, Prater MR, Bahamonde J, et al. Current thoughts on maternal nutrition and fetal programming of the metabolic syndrome. J Pregnancy 2013; 2013:368461. DOI: 10.1155/2013/368461.Brenseke B, Prater MR, Bahamonde J, et al. Current thoughts on maternal nutrition and fetal programming of the metabolic syndrome. J Pregnancy 2013; 2013:368461. DOI: 10.1155/2013/368461.Stamler J. The INTERSALT study: background, methods, findings, and implications. Am J Clin Nutr 1997; 65 (2 Suppl): 626S­42.Stamler J. The INTERSALT study: background, methods, findings, and implications. Am J Clin Nutr 1997; 65 (2 Suppl): 626S­42.The INTERSALT Co­operative research group. INTERSALT Study an international co­operative study on the relation of blood pressure to electrolyte excretion in populations. Design and methods. J Hypertens 1986; 4 (6): 781­7.The INTERSALT Co­operative research group. INTERSALT Study an international co­operative study on the relation of blood pressure to electrolyte excretion in populations. Design and methods. J Hypertens 1986; 4 (6): 781­7.Stamler J, Elliott P, Dennis B, et al. INTERMAP: background, aims, design, methods, and descriptive statistics (nondietary). J Hum Hypertens 2003; 17: 591­608.Stamler J, Elliott P, Dennis B, et al. INTERMAP: background, aims, design, methods, and descriptive statistics (nondietary). J Hum Hypertens 2003; 17: 591­608.Zhou BF, Stamler J, Dennis B, et al. for the INTERMAP Research Group. Nutrient intakes of middle­aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: The INTERMAP Study. J Hum Hypertens 2003; 17: 623­30.Zhou BF, Stamler J, Dennis B, et al. for the INTERMAP Research Group. Nutrient intakes of middle­aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: The INTERMAP Study. J Hum Hypertens 2003; 17: 623­30.Shay CM, Stamler J, Dyer AR, et al. Nutrient and food intakes of middle­aged adults at low risk of cardiovascular disease: the international study of macro­/micronutrients and blood pressure (INTERMAP). Eur J Nutrit 2012; 51 (8): 917­26. DOI: 10.1007/s00394­011­0268­2.Shay CM, Stamler J, Dyer AR, et al. Nutrient and food intakes of middle­aged adults at low risk of cardiovascular disease: the international study of macro­/micronutrients and blood pressure (INTERMAP). Eur J Nutrit 2012; 51 (8): 917­26. DOI: 10.1007/s00394­011­0268­2.Chan Q, Stamler J, Brown IJ, et al. Relation of raw and cooked vegetable consumption to blood pressure: the INTERMAP study. J Hum Hypertens 2014; 28 (6): 353­9. DOI: 10.1038/jhh.2013.115.Chan Q, Stamler J, Brown IJ, et al. Relation of raw and cooked vegetable consumption to blood pressure: the INTERMAP study. J Hum Hypertens 2014; 28 (6): 353­9. DOI: 10.1038/jhh.2013.115.Sacks FM, Obarzanek E, Windhauser MM, et al. Rationale and design of the dietary approaches to stop hypertension trial (DASH) a multicenter controlled­feeding study of dietary patterns to lower blood pressure. AEP 1995; 5 (2): 108­18.Sacks FM, Obarzanek E, Windhauser MM, et al. Rationale and design of the dietary approaches to stop hypertension trial (DASH) a multicenter controlled­feeding study of dietary patterns to lower blood pressure. AEP 1995; 5 (2): 108­18.Windhauser MM, Evans MA, McCullough ML, et al. Dietary adherence in the Dietary Approaches to Stop Hypertension trial. DASH collaborative research group. J Am Diet Assoc 1999; 99 (8 Suppl): 76­83.Windhauser MM, Evans MA, McCullough ML, et al. Dietary adherence in the Dietary Approaches to Stop Hypertension trial. DASH collaborative research group. J Am Diet Assoc 1999; 99 (8 Suppl): 76­83.Appel LJ, Moore TJ, Obarzanek EN, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH collaborative research group. Engl J Med 1997; 336 (16): 1117­24.Appel LJ, Moore TJ, Obarzanek EN, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH collaborative research group. Engl J Med 1997; 336 (16): 1117­24.Martínez­González MA, Salas­Salvadó J, Estruch R, et al. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis 2015; 58 (1): 50­60. DOI: 10.1016/j.pcad.2015.04.003.Martínez­González MA, Salas­Salvadó J, Estruch R, et al. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis 2015; 58 (1): 50­60. DOI: 10.1016/j.pcad.2015.04.003.Ros E, Martínez­González MA, Estruch R, et al. Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study. Adv Nutr 2014; 5 (3): 330S­6. DOI: 10.3945/an.113.005389.Ros E, Martínez­González MA, Estruch R, et al. Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study. Adv Nutr 2014; 5 (3): 330S­6. DOI: 10.3945/an.113.005389.Widmer RJ, Flammer AJ, Lerman LO, et al. The mediterranean diet, its components, and cardiovascular disease. Am J Med 2015; 128 (3): 229­38. DOI: 10.1016/j.amjmed.2014.10.014.Widmer RJ, Flammer AJ, Lerman LO, et al. The mediterranean diet, its components, and cardiovascular disease. Am J Med 2015; 128 (3): 229­38. DOI: 10.1016/j.amjmed.2014.10.014.de Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999; 99 (6): 779­85.de Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation 1999; 99 (6): 779­85.Guasch­Ferré M, Hu FB, Martínez­González MA, et al. Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Med 2014; 12: 78. DOI: 10.1186/1741­7015­12­78 PMCID: PMC4030221.Guasch­Ferré M, Hu FB, Martínez­González MA, et al. Olive oil intake and risk of cardiovascular disease and mortality in the PREDIMED Study. BMC Med 2014; 12: 78. DOI: 10.1186/1741­7015­12­78 PMCID: PMC4030221.Estruch R, Ros E, Salas­Salvadó J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368 (14): 1279­90. DOI: 10.1056/NEJMoa1200303.Estruch R, Ros E, Salas­Salvadó J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368 (14): 1279­90. DOI: 10.1056/NEJMoa1200303.Kastorini CM, Milionis HJ, Esposito K, et al. The effect of Mediterranean diet on metabolic syndrome and its components: A meta­analysis of 50 studies and 534,906 individuals. JACC 2011; 57: 1299­313.Kastorini CM, Milionis HJ, Esposito K, et al. The effect of Mediterranean diet on metabolic syndrome and its components: A meta­analysis of 50 studies and 534,906 individuals. JACC 2011; 57: 1299­313.Salas­Salvadó J, Martinez­González MA, Bulló M, et al. The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis 2011; 21: B32­48.Salas­Salvadó J, Martinez­González MA, Bulló M, et al. The role of diet in the prevention of type 2 diabetes. Nutr Metab Cardiovasc Dis 2011; 21: B32­48.Corella D, Carrasco P, Sorlí JV, et al. Mediterranean diet reduces the adverse effect of the TCF7L2­rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: A randomized controlled trial in a high­cardiovascular­risk population. Diabetes Care 2013; 36: 3803­11.Corella D, Carrasco P, Sorlí JV, et al. Mediterranean diet reduces the adverse effect of the TCF7L2­rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: A randomized controlled trial in a high­cardiovascular­risk population. Diabetes Care 2013; 36: 3803­11.Castañer O, Corella D, Covas MI, et al. In vivo transcriptomic profile after a Mediterranean diet in high­cardiovascular risk patients: a randomized controlled trial. Am J Clin Nutr 2013; 98 (3): 845­53.Castañer O, Corella D, Covas MI, et al. In vivo transcriptomic profile after a Mediterranean diet in high­cardiovascular risk patients: a randomized controlled trial. Am J Clin Nutr 2013; 98 (3): 845­53.Corsi DJ, Subramanian SV, Chow CK, et al. Prospective Urban Rural Epidemiology (PURE) study: Baseline characteristics of the household sample and comparative analyses with national data in 17 countries. Am Heart J 2013; 166 (4): 636­46. DOI: http://dx.doi.org/10.1016/j.ahj.2013.04.019.Corsi DJ, Subramanian SV, Chow CK, et al. Prospective Urban Rural Epidemiology (PURE) study: Baseline characteristics of the household sample and comparative analyses with national data in 17 countries. Am Heart J 2013; 166 (4): 636­46. DOI: http://dx.doi.org/10.1016/j.ahj.2013.04.019.Teo K, Chow CK, Vaz M, et al. The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low­, middle­, and high­income countries. Am Heart J 2009; 158 (1): 1­7. DOI: http://dx.doi.org/10.1016/j.ahj.2009.04.019.Teo K, Chow CK, Vaz M, et al. The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic noncommunicable diseases in low­, middle­, and high­income countries. Am Heart J 2009; 158 (1): 1­7. DOI: http://dx.doi.org/10.1016/j.ahj.2009.04.019.Dehghan M, Al Hamad N, Yusufali A, et al. Development of a semi­quantitative food frequency questionnaire for use in United Arab Emirates and Kuwait based on local foods. Nutr J 2005; 4:18. DOI: 10.1186/1475­2891­4­18.Dehghan M, Al Hamad N, Yusufali A, et al. Development of a semi­quantitative food frequency questionnaire for use in United Arab Emirates and Kuwait based on local foods. Nutr J 2005; 4:18. DOI: 10.1186/1475­2891­4­18.Dehghan M, del Cerro S, Zhang X, et al. Validation of a semi­quantitative food frequency questionnaire for argentinean adults. PLoS May 2012; 7: 5.Dehghan M, del Cerro S, Zhang X, et al. Validation of a semi­quantitative food frequency questionnaire for argentinean adults. PLoS May 2012; 7: 5.Dehghan M, Ilow R, Zatonska K, et al. Development, reproducibility and validity of the food frequency questionnaire in the Poland arm of the PURE study. J of Human Nutrition and Dietetics 2012; 25 (3): 225­32. DOI: 10.1111/j.1365277X.2012.01240.xDehghan M, Ilow R, Zatonska K, et al. Development, reproducibility and validity of the food frequency questionnaire in the Poland arm of the PURE study. J of Human Nutrition and Dietetics 2012; 25 (3): 225­32. DOI: 10.1111/j.1365277X.2012.01240.xDehghan M, Martinez S, Zhang X et al. Relative validity of an FFQ to estimate daily food and nutrient intakes for Chilean adults. Public Health Nutrition 2012; 16(10), 1782–1788. DOI: 10.1017/S1368980012004107Dehghan M, Martinez S, Zhang X et al. Relative validity of an FFQ to estimate daily food and nutrient intakes for Chilean adults. Public Health Nutrition 2012; 16(10), 1782–1788. DOI: 10.1017/S1368980012004107Dehghan M, López Jaramillo P, Dueñas R, et al. Development and validation of a quantitative food frequency questionnaire among rural and urban dwelling adults in Colombia. J Nutrition Education and Behaviour 2012; 44: 609­13. DOI: 10.1016/j.jneb.2010.10.001Dehghan M, López Jaramillo P, Dueñas R, et al. Development and validation of a quantitative food frequency questionnaire among rural and urban dwelling adults in Colombia. J Nutrition Education and Behaviour 2012; 44: 609­13. DOI: 10.1016/j.jneb.2010.10.001Mahajan R, Malik M, Bharathi AV, et al. Reproducibility and validity of a quantitative food frequency questionnaire in an urban and rural area of northern India. Natl Med J India 2013; 26: 266­72.Mahajan R, Malik M, Bharathi AV, et al. Reproducibility and validity of a quantitative food frequency questionnaire in an urban and rural area of northern India. Natl Med J India 2013; 26: 266­72.Miller V, Yusuf S, Chow CK, et al. Availability, affordability, and consumption of fruits and vegetables in 18 countries across income levels: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet Glob Health 2016; 4 (10): e695­703. DOI: 10.1016/S2214­109X(16)30186­3.Miller V, Yusuf S, Chow CK, et al. Availability, affordability, and consumption of fruits and vegetables in 18 countries across income levels: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet Glob Health 2016; 4 (10): e695­703. DOI: 10.1016/S2214­109X(16)30186­3.Miller V, Mente A, Dehghan M, et al. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study; Prospective Urban Rural Epidemiology (PURE) study investigators. Lancet 2017; pii: S0140­6736(17):32253­5. DOI: 10.1016/S0140­6736(17)32253­5.Miller V, Mente A, Dehghan M, et al. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study; Prospective Urban Rural Epidemiology (PURE) study investigators. Lancet 2017; pii: S0140­6736(17):32253­5. DOI: 10.1016/S0140­6736(17)32253­5.Бойцов С. А., Чазов Е. И., Шляхто Е. В. и др. Эпидемиология сердечно­сосудистых заболеваний в различных регионах России (ЭССЕ­РФ). Обоснование и дизайн исследования. Профилактическая медицина 2013; 16 (6): 25­34.Boitsov SA, Chazov EI, Shlyakhto EV, et al. Epidemiology of cardiovascular diseases in different regions of Russia (ESSE-RF). The rationale for and design of the study. Preventive Medicine 2013; 16 (6): 25-34. (In Russ.)Баланова Ю. А., Концевая А. В., Шальнова С. А. и др. Распространенность поведенческих факторов риска сердечно­сосудистых заболеваний в российской популяции по результатам исследования ЭССЕ. Профилактическая медицина 2014; 5: 42­52.Balanova IuA, Kontsevaia AV, Shalnova SA, et al. Prevalence of behavioral risk factors for cardiovascular disease in the Russian population: Results of the ESSE-RF epidemiological study. Preventive Medicine 2014; 5: 42-52. (In Russ.)Максимов С. А., Табакаев М. В., Данильченко Я. В. и др. Стереотипы пищевого поведения и сердечно­сосудистое здоровье населения (исследование ЭССЕ­РФ в Кемеровской области). Гигиена и санитария 2017; 96 (6): 585­9.Maksimov SA, Tabakaev MV, Danilchenko YV, et al. Dietary patterns and cardiovascular health of the population (ESSE-RF) study in the Kemerovo region. Hygiene and sanitation. 2017; 96 (6): 585-9. (In Russ.)Орлов А. В., Ротарь О. П., Бояринова М. А. и др. Гендерные особенности распространенности поведенческих факторов риска у жителей Санкт­Петербурга. Вестник российской академии медицинских наук 2015; 70 (5): 585­91. DOI: 10.15690/vramn.v70.i5.1446.Orlov AV, Rotar OP, Boyarinova MA, et al. Gender differences of behavioral risk factors in Saint­Petersburg inhabitants. Annals of the Russian academy of medical sciences 2015; 70 (5): 585­91. (In Russ.). DOI: 10.15690/vramn.v70.i5.1446.

The authors declare that there are no conflicts of interest present.