cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2018-1-87-96cardiovascular-765Research ArticleОБЗОРЫREVIEWSВОЗМОЖНОСТИ ТЕЛМИСАРТАНА В СНИЖЕНИИ СЕРДЕЧНО-СОСУДИСТОГО РИСКАTELMISARTAN IN CARDIOVASCULAR RISK REDUCTIONОстроумоваО. Д.OstroumovaО. D.

Доктор медицинских наук, профессор, профессор кафедры факультетской терапии и профболезней МГМСУ им. А.И. Евдокимова, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней ПМ ГМУ им. И.М. Сеченова.

Тел.: +7 (903) 169-68-28

ostroumova.olga@mail.ruКочетковА. И.KochetkovA. I.

Ассистент кафедры факультетской терапии и профболезней

СмолярчукЕ. А.SmolyarchukE. A.

Кандидат медицинских наук, доцент кафедры клинической фармакологии и пропедевтики внутренних болезней

КониевТ. И.KonievТ. I.

Студент 6 курса лечебного факультета

ФГБОУ ВО Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава России; ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)A. I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD); I.M. Sechenov First Moscow State Medical University of the Ministry of HealthФГБОУ ВО Московский государственный медико-стоматологический университет им. А.И. Евдокимова Минздрава РоссииA. I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD)ФГАОУ ВО Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)I.M. Sechenov First Moscow State Medical University of the Ministry of Health2018200220181718796Copyright © Остроумова О.Д., Кочетков А.И., Смолярчук Е.А., Кониев Т.И., 20182018Остроумова О.Д., Кочетков А.И., Смолярчук Е.А., Кониев Т.И.Ostroumova О.D., Kochetkov A.I., Smolyarchuk E.A., Koniev Т.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/765

В статье рассмотрены вопросы клинической эффективности телмисартана — блокатора рецепторов ангиотензина II первого типа с точки зрения его влияния на сердечно-сосудистый риск у пациентов с артериальной гипертонией. Представлены результатымногочисленных исследований, свидетельствующие о мощных антигипертензивных и органопротективных свойствах телмисартана. Описаны возможности использования этого препарата у пациентов высокого риска, его эффективность в кардио- и нефропротекции. Особое внимание уделено исключительной способности телмисартана выступать в роли агониста PPAR γ-рецепторов и тем самым корригировать нарушения углеводного и липидного обменов у пациентов с метаболическим синдромом и сахарным диабетом.

The article is focused on the issues of clinical efficacy of telmisartan — angiotensin II type 1 receptor blocker from the perspective of its influence on cardiovascular risk in systemic hypertension patients. The results presented, of a variety of studies, witnessing potent antihypertensive and protective properties of telmisartan. The opportunities described, for usage of the drug in high risk patients, its efficacy in cardio- and nephroprotection. Special attention is paid for an exclusive property of telmisartan to be an agonist of PPAR γ-receptors, hence to correct glucose and lipid metabolism in patients with metabolic syndrome and diabetes.

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The authors declare that there are no conflicts of interest present.