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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2018-6-62-68</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-766</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON A PROBLEM</subject></subj-group></article-categories><title-group><article-title>Коморбидность хронической сердечной недостаточности и хронической обструктивной болезни легких: особенности патогенеза, клиники и диагностики</article-title><trans-title-group xml:lang="en"><trans-title>Comorbidity of chronic heart failure and chronic obstructive pulmonary disease: features of pathogenesis, clinic and diagnostics</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6379-4635</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токмачев</surname><given-names>Р. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Tokmachev</surname><given-names>R. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Токмачев Роман Евгеньевич — ассистент кафедры факультетской терапии.</p></bio><email xlink:type="simple">r-tokmachev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4981-8383</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухортова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhortova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухортова Маргарита Сергеевна — ординатор кафедры факультетской терапии</p></bio><email xlink:type="simple">margaritamukhortova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1171-2746</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будневский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budnevsky</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Будневский Андрей Валериевич — доктор медицинских наук, профессор, заведующий кафедрой факультетской терапии.</p></bio><email xlink:type="simple">budnev@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9155-7899</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токмачев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tokmachev</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Токмачев Евгений Викторович — кандидат медицинских наук, ассистент кафедры медицины катастроф и безопасности жизнедеятельности</p></bio><email xlink:type="simple">tokmachev-89@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8545-6255</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овсянников</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovsyannikov</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Овсянников Евгений Сергеевич — кандидат медицинских наук, доцент кафедры факультетской терапии.</p></bio><email xlink:type="simple">ovses@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Воронежский государственный медицинский университет им. Н.Н. Бурденко Минздрава России</institution></aff><aff xml:lang="en"><institution>N.N. Burdenko Voronezh State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>12</month><year>2018</year></pub-date><volume>17</volume><issue>6</issue><fpage>62</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Токмачев Р.Е., Мухортова М.С., Будневский А.В., Токмачев Е.В., Овсянников Е.С., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Токмачев Р.Е., Мухортова М.С., Будневский А.В., Токмачев Е.В., Овсянников Е.С.</copyright-holder><copyright-holder xml:lang="en">Tokmachev R.E., Mukhortova M.S., Budnevsky A.V., Tokmachev E.V., Ovsyannikov E.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/766">https://cardiovascular.elpub.ru/jour/article/view/766</self-uri><abstract><p>В представленной статье рассматривается эпидемиология хронической сердечной недостаточности (ХСН) и хронической обструктивной болезни легких (ХОБЛ). ХСН и ХОБЛ отличаются широкой распространенностью и высокой летальностью, особенно при их сочетании. В статье осуществлен анализ общих механизмов формирования этих заболеваний: взаимосвязь ХОБЛ с сердечно-сосудистыми заболеваниями объясняется общими факторами риска, включающими курение, гиподинамию, нерациональное питание и генетическую предрасположенность. Ведущую роль в патогенезе патологий играет активация и поддержание системного воспаления. Представлены особенности клинической картины и направления диагностического поиска при подозрении на сочетанную патологию, возможности современных лабораторных и инструментальных методов исследования. Диагностический поиск при коморбид-ности ХСН и ХОБЛ может быть несколько затруднен, учитывая вышеуказанные общие факторы риска, некоторые общие механизмы патогенеза и сходную клиническую симптоматику. Однако наличие у врача настороженности в отношении коморбидности исследуемых состояний, а также проведение тщательного клинического осмотра и назначение необходимых дополнительных методов исследования, позволяют уменьшить количество диагностических ошибок и улучшить прогноз у таких больных.</p></abstract><trans-abstract xml:lang="en"><p>This article discusses the epidemiology of chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD). CHF and COPD are characterized by high prevalence and high mortality, especially when they are combined. The article analyzes the general mechanisms of formation of these diseases: the relationship of COPD with cardiovascular diseases is explained by common risk factors, including smoking, physical inactivity, improper feeding and genetic predisposition. The leading role in the pathogenesis of pathologies is played by the activation and maintenance of systemic inflammation. Article presents the features of the clinical picture and the direction of the diagnostics in case of suspected combined pathology, the possibilities of modern laboratory and instrumental research methods. Diagnostics of comorbidity of CHF and COPD may be difficult, given the above common risk factors, some common pathogenesis mechanisms and similar clinical symptoms. However the caution regarding the comorbidity of the studied conditions, as well as a thorough clinical examination and the appointment of the necessary additional research methods, can reduce the number of diagnostic mistakes and improve the prognosis in such patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>хроническая обструктивная болезнь легких</kwd><kwd>системное воспаление</kwd><kwd>провоспалительные цитокины</kwd><kwd>коморбидность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>chronic obstructive pulmonary disease</kwd><kwd>systemic inflammation</kwd><kwd>proinflammatory cytokines</kwd><kwd>comorbidity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мареев В. Ю., Фомин И. В., Агеев Ф. Т. и др. Клинические рекомендации. Хроническая сердечная недостаточность (ХСН). 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